BG104096A - Производни на 4-оксо-3,5-дихидро-4н-пиридазино [4,5-b] индол-1- ацетамид, тяхното получаване и използването им в терапията - Google Patents

Производни на 4-оксо-3,5-дихидро-4н-пиридазино [4,5-b] индол-1- ацетамид, тяхното получаване и използването им в терапията

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Publication number
BG104096A
BG104096A BG104096A BG10409600A BG104096A BG 104096 A BG104096 A BG 104096A BG 104096 A BG104096 A BG 104096A BG 10409600 A BG10409600 A BG 10409600A BG 104096 A BG104096 A BG 104096A
Authority
BG
Bulgaria
Prior art keywords
group
pyridazino
acetamide
indole
dihydro
Prior art date
Application number
BG104096A
Other languages
English (en)
Other versions
BG64283B1 (bg
Inventor
Yannick Evanno
Laurent Dubois
Mireille Sevrin
Frank Marguet
Jacques Froissant
Regine Bartsch
Catherine Gille
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of BG104096A publication Critical patent/BG104096A/bg
Publication of BG64283B1 publication Critical patent/BG64283B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретението се отнася до съединения с обща формула@@в която Х означава водороден или халогенен атом, или метилова, метокси, или фенилметокси група,Y означава водороден атом, 1 или 2 халогенни атома или хидроксилна, метокси, нитро или метилова група, R1 е водороден атом или (С1-С4) алкилова група, R2 и R3 означават независимо един от друг водороден атом, (С1-С4) алкилова група или фенилметиловагрупа, или R2 и R3 образуват заедно с азотния атом, към който са свързани, азетидинилова, пиролидинилова, 3-етоксипиролидинилова, пиперидинилова, морфолинилова, 4-метилпиперазинилова или 1,3-тиазолидинилова група. Съединенията се използват за лечение на заболявания, свързани с нарушения на GABA ергичния пренос.
BG104096A 1997-07-30 2000-01-20 ПРОИЗВОДНИ НА 4-ОК'О-3,5-ДИХИДРО-4Н-ПИРИДАЗИНО[4,5-b] ИНДОЛ-1-А-...'АМИД, 'ЯХНО'О ПОЛ"-АВАН... И ИЗПОЛЗВАН...'О ИМ В '...РАПИЯ'А BG64283B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9709692A FR2766823B1 (fr) 1997-07-30 1997-07-30 Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
PCT/FR1998/001667 WO1999006406A1 (fr) 1997-07-30 1998-07-28 DERIVES DE 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b] INDOLE-1-ACETAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (2)

Publication Number Publication Date
BG104096A true BG104096A (bg) 2000-08-31
BG64283B1 BG64283B1 (bg) 2004-08-31

Family

ID=9509801

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104096A BG64283B1 (bg) 1997-07-30 2000-01-20 ПРОИЗВОДНИ НА 4-ОК'О-3,5-ДИХИДРО-4Н-ПИРИДАЗИНО[4,5-b] ИНДОЛ-1-А-...'АМИД, 'ЯХНО'О ПОЛ"-АВАН... И ИЗПОЛЗВАН...'О ИМ В '...РАПИЯ'А

Country Status (33)

Country Link
US (1) US6262045B1 (bg)
EP (1) EP1000063B1 (bg)
JP (1) JP4322421B2 (bg)
KR (1) KR100497782B1 (bg)
CN (1) CN1134440C (bg)
AR (1) AR013264A1 (bg)
AT (1) ATE226584T1 (bg)
AU (1) AU736600B2 (bg)
BG (1) BG64283B1 (bg)
BR (1) BR9811582B1 (bg)
CA (1) CA2298522C (bg)
CO (1) CO5210883A1 (bg)
CZ (1) CZ290011B6 (bg)
DE (1) DE69808921T2 (bg)
DK (1) DK1000063T3 (bg)
EE (1) EE04317B1 (bg)
ES (1) ES2186212T3 (bg)
FR (1) FR2766823B1 (bg)
HK (1) HK1028027A1 (bg)
HU (1) HU229430B1 (bg)
IL (1) IL133633A (bg)
NO (1) NO313963B1 (bg)
NZ (1) NZ502361A (bg)
PL (1) PL194245B1 (bg)
PT (1) PT1000063E (bg)
RU (1) RU2197490C2 (bg)
SI (1) SI1000063T1 (bg)
SK (1) SK283075B6 (bg)
TR (1) TR200000278T2 (bg)
TW (1) TW506971B (bg)
UA (1) UA57088C2 (bg)
WO (1) WO1999006406A1 (bg)
ZA (1) ZA986786B (bg)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2788696B1 (fr) * 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
FR2788776B1 (fr) 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
GB0000564D0 (en) 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2833953B1 (fr) * 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr) * 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
KR20080015077A (ko) * 2005-05-05 2008-02-18 사노피-아벤티스 유.에스. 엘엘씨 안정한 나노입자 제형
WO2007027494A2 (en) * 2005-08-29 2007-03-08 Sanofi-Aventis U.S. Llc Morphous solid dispersions of 7-chloro-n,n, 5-trimethyl-4-oxo-3-phenyl-3, 5,-dihydro-4h-pyridazino [4, 5-b] indole-1-acetamide
AU2006285142B2 (en) 2005-08-29 2012-06-14 Sanofi-Aventis U.S. Llc Novel crystalline form of a pyridazino [4 , 5-b] indole derivative
WO2007038209A2 (en) * 2005-09-23 2007-04-05 Schering Corporation Fused tetracyclic mglur1 antagonists as therapeutic agents
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
RU2011110241A (ru) * 2008-08-18 2012-09-27 САНОФИ-АВЕНТИС Ю.Эс. ЭлЭлСи (US) СПОСОБ ПОЛУЧЕНИЯ ПОЛИМОРФА 7-ХЛОР-N,N,5-ТРИМЕТИЛ-4-ОКСО-3-ФЕНИЛ-3,5-ДИГИДРО-4Н-ПИРИДАЗИНО[4,5-b]ИНДОЛ-1-АЦЕТАМИДА
EP2181717A1 (en) 2008-10-28 2010-05-05 Sanofi-Aventis Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4985560A (en) * 1990-01-12 1991-01-15 American Home Products Corporation Pyridazino(4,5-b)indolizines
GB9411955D0 (en) * 1994-06-15 1994-08-03 Merck Sharp & Dohme Therapeutic agents
US5756501A (en) * 1995-12-13 1998-05-26 American Home Products Corporation Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
PT1000063E (pt) 2003-03-31
TW506971B (en) 2002-10-21
RU2197490C2 (ru) 2003-01-27
NO20000462L (no) 2000-03-29
ES2186212T3 (es) 2003-05-01
NZ502361A (en) 2001-06-29
JP2001512122A (ja) 2001-08-21
DE69808921T2 (de) 2003-07-03
PL194245B1 (pl) 2007-05-31
SK1292000A3 (en) 2000-08-14
UA57088C2 (uk) 2003-06-16
SI1000063T1 (en) 2003-04-30
WO1999006406A1 (fr) 1999-02-11
DK1000063T3 (da) 2003-02-24
NO313963B1 (no) 2003-01-06
BR9811582A (pt) 2000-09-26
US6262045B1 (en) 2001-07-17
EP1000063B1 (fr) 2002-10-23
CN1265108A (zh) 2000-08-30
CZ290011B6 (cs) 2002-05-15
IL133633A0 (en) 2001-04-30
EE200000056A (et) 2000-10-16
EE04317B1 (et) 2004-06-15
FR2766823B1 (fr) 1999-10-08
CN1134440C (zh) 2004-01-14
JP4322421B2 (ja) 2009-09-02
HU229430B1 (en) 2013-12-30
CO5210883A1 (es) 2002-10-30
KR100497782B1 (ko) 2005-06-27
TR200000278T2 (tr) 2000-08-21
HUP0002650A3 (en) 2002-09-30
SK283075B6 (sk) 2003-02-04
DE69808921D1 (de) 2002-11-28
ZA986786B (en) 1999-02-02
BG64283B1 (bg) 2004-08-31
PL338445A1 (en) 2000-11-06
CZ2000320A3 (cs) 2000-05-17
IL133633A (en) 2004-02-08
HUP0002650A2 (hu) 2001-01-29
CA2298522A1 (en) 1999-02-11
EP1000063A1 (fr) 2000-05-17
ATE226584T1 (de) 2002-11-15
AU736600B2 (en) 2001-08-02
CA2298522C (en) 2008-07-15
NO20000462D0 (no) 2000-01-28
AR013264A1 (es) 2000-12-13
BR9811582B1 (pt) 2010-10-19
KR20010022356A (ko) 2001-03-15
FR2766823A1 (fr) 1999-02-05
HK1028027A1 (en) 2001-02-02
AU8983298A (en) 1999-02-22

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