IL133633A - History of 4-oxo - 5,3-dihydro-3 - phenyl - 4H - pyridazino b] -5, 4] - indole - 1 acetamide, their preparation and use in healing - Google Patents

History of 4-oxo - 5,3-dihydro-3 - phenyl - 4H - pyridazino b] -5, 4] - indole - 1 acetamide, their preparation and use in healing

Info

Publication number
IL133633A
IL133633A IL13363398A IL13363398A IL133633A IL 133633 A IL133633 A IL 133633A IL 13363398 A IL13363398 A IL 13363398A IL 13363398 A IL13363398 A IL 13363398A IL 133633 A IL133633 A IL 133633A
Authority
IL
Israel
Prior art keywords
mmol
methyl
phenyl
dihydro
pyridazino
Prior art date
Application number
IL13363398A
Other languages
English (en)
Hebrew (he)
Other versions
IL133633A0 (en
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of IL133633A0 publication Critical patent/IL133633A0/xx
Publication of IL133633A publication Critical patent/IL133633A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL13363398A 1997-07-30 1998-07-28 History of 4-oxo - 5,3-dihydro-3 - phenyl - 4H - pyridazino b] -5, 4] - indole - 1 acetamide, their preparation and use in healing IL133633A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9709692A FR2766823B1 (fr) 1997-07-30 1997-07-30 Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
PCT/FR1998/001667 WO1999006406A1 (fr) 1997-07-30 1998-07-28 DERIVES DE 4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b] INDOLE-1-ACETAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (2)

Publication Number Publication Date
IL133633A0 IL133633A0 (en) 2001-04-30
IL133633A true IL133633A (en) 2004-02-08

Family

ID=9509801

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13363398A IL133633A (en) 1997-07-30 1998-07-28 History of 4-oxo - 5,3-dihydro-3 - phenyl - 4H - pyridazino b] -5, 4] - indole - 1 acetamide, their preparation and use in healing

Country Status (33)

Country Link
US (1) US6262045B1 (bg)
EP (1) EP1000063B1 (bg)
JP (1) JP4322421B2 (bg)
KR (1) KR100497782B1 (bg)
CN (1) CN1134440C (bg)
AR (1) AR013264A1 (bg)
AT (1) ATE226584T1 (bg)
AU (1) AU736600B2 (bg)
BG (1) BG64283B1 (bg)
BR (1) BR9811582B1 (bg)
CA (1) CA2298522C (bg)
CO (1) CO5210883A1 (bg)
CZ (1) CZ290011B6 (bg)
DE (1) DE69808921T2 (bg)
DK (1) DK1000063T3 (bg)
EE (1) EE04317B1 (bg)
ES (1) ES2186212T3 (bg)
FR (1) FR2766823B1 (bg)
HK (1) HK1028027A1 (bg)
HU (1) HU229430B1 (bg)
IL (1) IL133633A (bg)
NO (1) NO313963B1 (bg)
NZ (1) NZ502361A (bg)
PL (1) PL194245B1 (bg)
PT (1) PT1000063E (bg)
RU (1) RU2197490C2 (bg)
SI (1) SI1000063T1 (bg)
SK (1) SK283075B6 (bg)
TR (1) TR200000278T2 (bg)
TW (1) TW506971B (bg)
UA (1) UA57088C2 (bg)
WO (1) WO1999006406A1 (bg)
ZA (1) ZA986786B (bg)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2788776B1 (fr) * 1999-01-26 2001-02-23 Synthelabo Derives de 4-oxo-3, 5-dihydro-4h-pyridazino [4,5-b] indole-1 -carboxamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) * 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
GB0000564D0 (en) * 2000-01-11 2000-03-01 Merck Sharp & Dohme Therapeutic agents
FR2811897A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo UTILISATION DE DERIVES DE PYRIDAZINO[4,5-b]INDOLE-1- ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
FR2811990A1 (fr) * 2000-07-24 2002-01-25 Sanofi Synthelabo DERIVES DE 1-(4-OXO-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-b]INDOLE-1 -CARBONYL)PIPERAZINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2833953B1 (fr) * 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2838124B1 (fr) 2002-04-03 2004-05-28 Sanofi Synthelabo Derives de 3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino [4,5-b]indole-1-acetamide, leur preparation et leur application en therapeutique
WO2007086911A2 (en) * 2005-05-05 2007-08-02 Sanofi-Aventis U.S. Llc Stable nanoparticle formulations
PL1926476T3 (pl) * 2005-08-29 2013-08-30 Sanofi Aventis Us Llc Amorficzne stałe dyspersje 7-chloro-N,N,5-trimetylo-4-okso-3-fenylo-3,5-dihydro-4H-pirydazyno[4,5-b]indolo-1-acetamidu
EP1924585B1 (en) 2005-08-29 2011-11-02 Sanofi-Aventis U.S. LLC Novel crystalline form of a pyridazino [4 , 5-b] indole derivative
JP2009508966A (ja) * 2005-09-23 2009-03-05 シェーリング コーポレイション 治療薬としての縮合四環性ｍＧｌｕＲ１アンタゴニスト
CN1946120B (zh) * 2006-10-20 2010-05-12 华为技术有限公司 实现话单关联的方法及系统
AU2009283039A1 (en) * 2008-08-18 2010-02-25 Sanofi-Aventis U.S. Llc Process for preparing polymorph of 7-chloro-N, N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydr0-4H-pyridazin0[4,5-b]indole-1-acetamide
EP2181717A1 (en) 2008-10-28 2010-05-05 Sanofi-Aventis Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4985560A (en) * 1990-01-12 1991-01-15 American Home Products Corporation Pyridazino(4,5-b)indolizines
GB9411955D0 (en) * 1994-06-15 1994-08-03 Merck Sharp & Dohme Therapeutic agents
US5756501A (en) * 1995-12-13 1998-05-26 American Home Products Corporation Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
FR2754262B1 (fr) * 1996-10-08 1998-10-30 Synthelabo Derives de 1h-pyrido[3,4-b]indole-4-carboxamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
CO5210883A1 (es) 2002-10-30
SI1000063T1 (en) 2003-04-30
NZ502361A (en) 2001-06-29
JP4322421B2 (ja) 2009-09-02
IL133633A0 (en) 2001-04-30
KR100497782B1 (ko) 2005-06-27
FR2766823B1 (fr) 1999-10-08
ES2186212T3 (es) 2003-05-01
EE04317B1 (et) 2004-06-15
UA57088C2 (uk) 2003-06-16
CN1134440C (zh) 2004-01-14
AR013264A1 (es) 2000-12-13
DK1000063T3 (da) 2003-02-24
PL338445A1 (en) 2000-11-06
AU8983298A (en) 1999-02-22
CN1265108A (zh) 2000-08-30
BG64283B1 (bg) 2004-08-31
PT1000063E (pt) 2003-03-31
DE69808921T2 (de) 2003-07-03
TR200000278T2 (tr) 2000-08-21
BG104096A (bg) 2000-08-31
CA2298522A1 (en) 1999-02-11
CZ2000320A3 (cs) 2000-05-17
AU736600B2 (en) 2001-08-02
HUP0002650A3 (en) 2002-09-30
CZ290011B6 (cs) 2002-05-15
SK1292000A3 (en) 2000-08-14
BR9811582A (pt) 2000-09-26
NO20000462L (no) 2000-03-29
RU2197490C2 (ru) 2003-01-27
DE69808921D1 (de) 2002-11-28
NO20000462D0 (no) 2000-01-28
NO313963B1 (no) 2003-01-06
KR20010022356A (ko) 2001-03-15
EE200000056A (et) 2000-10-16
TW506971B (en) 2002-10-21
EP1000063A1 (fr) 2000-05-17
BR9811582B1 (pt) 2010-10-19
US6262045B1 (en) 2001-07-17
ZA986786B (en) 1999-02-02
HUP0002650A2 (hu) 2001-01-29
ATE226584T1 (de) 2002-11-15
SK283075B6 (sk) 2003-02-04
HU229430B1 (en) 2013-12-30
JP2001512122A (ja) 2001-08-21
EP1000063B1 (fr) 2002-10-23
PL194245B1 (pl) 2007-05-31
HK1028027A1 (en) 2001-02-02
WO1999006406A1 (fr) 1999-02-11
FR2766823A1 (fr) 1999-02-05
CA2298522C (en) 2008-07-15

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