BG102569A - Нови таксоиди, получаването им и фармацевтични състави, които ги съдържат - Google Patents
Нови таксоиди, получаването им и фармацевтични състави, които ги съдържатInfo
- Publication number
- BG102569A BG102569A BG102569A BG10256998A BG102569A BG 102569 A BG102569 A BG 102569A BG 102569 A BG102569 A BG 102569A BG 10256998 A BG10256998 A BG 10256998A BG 102569 A BG102569 A BG 102569A
- Authority
- BG
- Bulgaria
- Prior art keywords
- radical
- hydrogen atom
- together form
- alkynyl
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Съединенията имат противотуморни и противолевкемични свойства. Новите таксоиди са с обща формула, вкоято Z означава водороден атом или радикал с формула, в която R1 представлява евентуално заместен бензоилов, фурилов или теноилов радикал, или радикала R2-0-CI-, в който R2 е алкилов, алкенилов, алкинилов, циклоалкилов, циклоалкенилов, бициклоалкилов радикал, евентуално заместен фенилов радикал или хетероциклично ядро, R3 е алкилов, алкенилов, алкинилов, циклоалкилов, циклоалкенилов, фенилов, нафтилов или хетероцикличен ароматен радикал, R4 е водороден атом, R6 и R7 заедно образуват една кетонова функция и R и R5 заедно образуват една връзка или R4 означава водороден атом или хидроксирадикалили алкокси, алкенилокси, евентуално заместен алкинилокси, алканоилокси, арилокси, алкеноилокси, алкинилокси, циклоалканоилокси, алкоксиацетилов, алкилтиоацетилов, алкилоксикарбонилокси, циклоалкилокси, циклоалкенилокси, карбамоилокси, алкилкарбамоилокси или диалкилкарбамоилоксирадикал, R5 е водороден атом, или R4 и R5 заедно образуват една кетонова функция, R6 представлява водороден атом и R и R7 заедно образуват една връзка.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9515379A FR2742751B1 (fr) | 1995-12-22 | 1995-12-22 | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
PCT/FR1996/002031 WO1997023473A1 (fr) | 1995-12-22 | 1996-12-19 | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
BG102569A true BG102569A (bg) | 1999-04-30 |
BG63204B1 BG63204B1 (bg) | 2001-06-29 |
Family
ID=9485871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG102569A BG63204B1 (bg) | 1995-12-22 | 1998-06-22 | Нови таксоиди, получаването им и фармацевтични състави, които ги съдържат |
Country Status (41)
Country | Link |
---|---|
US (1) | US5728849A (bg) |
EP (1) | EP0876362B1 (bg) |
JP (1) | JP3953106B2 (bg) |
KR (1) | KR100500351B1 (bg) |
CN (1) | CN1103766C (bg) |
AR (1) | AR005197A1 (bg) |
AT (1) | ATE250593T1 (bg) |
AU (1) | AU712597B2 (bg) |
BG (1) | BG63204B1 (bg) |
BR (1) | BR9612135A (bg) |
CA (1) | CA2238884C (bg) |
CO (1) | CO4520184A1 (bg) |
CZ (1) | CZ294972B6 (bg) |
DE (1) | DE69630145T2 (bg) |
DK (1) | DK0876362T3 (bg) |
DZ (1) | DZ2149A1 (bg) |
EA (1) | EA001533B1 (bg) |
ES (1) | ES2202490T3 (bg) |
FR (1) | FR2742751B1 (bg) |
HK (1) | HK1017895A1 (bg) |
HU (1) | HU225032B1 (bg) |
IL (1) | IL124994A (bg) |
IN (4) | IN186768B (bg) |
MA (1) | MA26412A1 (bg) |
MX (1) | MX9804688A (bg) |
MY (1) | MY113934A (bg) |
NO (1) | NO317358B1 (bg) |
NZ (1) | NZ324337A (bg) |
OA (1) | OA10700A (bg) |
PE (1) | PE25198A1 (bg) |
PL (1) | PL189311B1 (bg) |
PT (1) | PT876362E (bg) |
RO (1) | RO116194B1 (bg) |
SK (1) | SK282835B6 (bg) |
TN (1) | TNSN96169A1 (bg) |
TR (1) | TR199801179T2 (bg) |
TW (1) | TW371659B (bg) |
UA (1) | UA48205C2 (bg) |
UY (1) | UY24386A1 (bg) |
WO (1) | WO1997023473A1 (bg) |
ZA (1) | ZA9610737B (bg) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9920548D0 (en) * | 1999-08-31 | 1999-11-03 | Rhone Poulenc Rorer Sa | Treatment of hepatocellular carcinoma |
CN1186340C (zh) | 2000-02-02 | 2005-01-26 | 佛罗里达州立大学研究基金有限公司 | 用作抗肿瘤剂的c10碳酸酯取代的紫杉烷 |
NZ528216A (en) * | 2001-02-24 | 2006-12-22 | Boehringer Ingelheim Pharma | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
WO2004103344A1 (en) * | 2003-05-20 | 2004-12-02 | Aronex Pharmaceuticals, Inc. | Combination chemotherapy comprising a liposomal platinum complex |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
EP1669358A1 (en) * | 2004-12-07 | 2006-06-14 | Aventis Pharma S.A. | Cytotoxic agents comprising new taxanes |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
EA030606B1 (ru) | 2006-05-04 | 2018-08-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Способы приготовления лекарственного средства, содержащего полиморфы |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
US20080207743A1 (en) * | 2007-02-28 | 2008-08-28 | Rodger Lamb | Biologically Active Taxane Analogs and Methods of Treatment |
KR101610005B1 (ko) * | 2007-08-17 | 2016-04-08 | 베링거 인겔하임 인터내셔날 게엠베하 | Fab 관련 질환의 치료에 사용하기 위한 푸린 유도체 |
PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
EA031225B1 (ru) * | 2008-08-15 | 2018-12-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Ингибиторы дпп-4 для заживления ран |
EP2344195A2 (en) | 2008-09-10 | 2011-07-20 | Boehringer Ingelheim International GmbH | Combination therapy for the treatment of diabetes and related conditions |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
BRPI0923121A2 (pt) | 2008-12-23 | 2015-08-11 | Boehringer Ingelheim Int | Formas salinas de compostos orgânico |
TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
ES2760917T3 (es) | 2009-11-27 | 2020-05-18 | Boehringer Ingelheim Int | Tratamiento de pacientes diabéticos genotipificados con inhibidores DPP-IV como la linagliptina |
JP6034781B2 (ja) | 2010-05-05 | 2016-11-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 併用療法 |
EA201991014A1 (ru) | 2010-06-24 | 2019-09-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Лечение диабета |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
MX366629B (es) | 2011-07-15 | 2019-07-17 | Boehringer Ingelheim Int | Quinazolinas sustituidas, su preparación y su uso en composiciones farmacéuticas. |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
JP6133431B2 (ja) | 2012-11-24 | 2017-05-24 | ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. | 親水性連結体及び薬物分子と細胞結合分子との共役反応における親水性連結体の使用 |
FR3010839B1 (fr) * | 2013-09-17 | 2017-04-21 | Schneider Electric Ind Sas | Dispositif de raccordement electrique d'au moins un conducteur dans une borne appartenant a un appareil electrique |
US10464955B2 (en) | 2014-02-28 | 2019-11-05 | Hangzhou Dac Biotech Co., Ltd. | Charged linkers and their uses for conjugation |
US9526728B2 (en) | 2014-02-28 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Medical use of a DPP-4 inhibitor |
AU2015242213A1 (en) | 2015-07-12 | 2018-03-08 | Hangzhou Dac Biotech Co., Ltd | Bridge linkers for conjugation of cell-binding molecules |
US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
JP2019517542A (ja) | 2016-06-10 | 2019-06-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | リナグリプチンおよびメトホルミンの組合せ |
KR20220147720A (ko) | 2016-11-14 | 2022-11-03 | 항저우 디에이씨 바이오테크 씨오, 엘티디 | 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2017724C1 (ru) * | 1990-07-12 | 1994-08-15 | Дзе Юниверсити оф Канзас | Способ получения производных таксола |
US5059699A (en) * | 1990-08-28 | 1991-10-22 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
FR2678930B1 (fr) * | 1991-07-10 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii. |
RU2059631C1 (ru) * | 1991-11-29 | 1996-05-10 | Дзе Юниверсити оф Канзас | Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью |
WO1993021173A1 (en) * | 1992-04-17 | 1993-10-28 | Abbott Laboratories | Taxol derivatives |
US5254580A (en) * | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
MX9307777A (es) * | 1992-12-15 | 1994-07-29 | Upjohn Co | 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. |
-
1995
- 1995-12-22 FR FR9515379A patent/FR2742751B1/fr not_active Expired - Fee Related
-
1996
- 1996-12-04 PE PE1996000871A patent/PE25198A1/es not_active Application Discontinuation
- 1996-12-18 MA MA24431A patent/MA26412A1/fr unknown
- 1996-12-19 ZA ZA9610737A patent/ZA9610737B/xx unknown
- 1996-12-19 RO RO98-01093A patent/RO116194B1/ro unknown
- 1996-12-19 EP EP96942433A patent/EP0876362B1/fr not_active Expired - Lifetime
- 1996-12-19 DK DK96942433T patent/DK0876362T3/da active
- 1996-12-19 WO PCT/FR1996/002031 patent/WO1997023473A1/fr active IP Right Grant
- 1996-12-19 BR BR9612135A patent/BR9612135A/pt not_active IP Right Cessation
- 1996-12-19 PT PT96942433T patent/PT876362E/pt unknown
- 1996-12-19 IL IL12499496A patent/IL124994A/xx not_active IP Right Cessation
- 1996-12-19 UA UA98063216A patent/UA48205C2/uk unknown
- 1996-12-19 CA CA002238884A patent/CA2238884C/fr not_active Expired - Fee Related
- 1996-12-19 JP JP52336197A patent/JP3953106B2/ja not_active Expired - Fee Related
- 1996-12-19 TW TW085115683A patent/TW371659B/zh not_active IP Right Cessation
- 1996-12-19 CN CN96199168A patent/CN1103766C/zh not_active Expired - Fee Related
- 1996-12-19 HU HU9904046A patent/HU225032B1/hu not_active IP Right Cessation
- 1996-12-19 SK SK853-98A patent/SK282835B6/sk not_active IP Right Cessation
- 1996-12-19 AU AU11809/97A patent/AU712597B2/en not_active Ceased
- 1996-12-19 PL PL96327405A patent/PL189311B1/pl not_active IP Right Cessation
- 1996-12-19 EA EA199800588A patent/EA001533B1/ru not_active IP Right Cessation
- 1996-12-19 ES ES96942433T patent/ES2202490T3/es not_active Expired - Lifetime
- 1996-12-19 CZ CZ19981961A patent/CZ294972B6/cs not_active IP Right Cessation
- 1996-12-19 NZ NZ324337A patent/NZ324337A/xx not_active IP Right Cessation
- 1996-12-19 AT AT96942433T patent/ATE250593T1/de active
- 1996-12-19 TR TR1998/01179T patent/TR199801179T2/xx unknown
- 1996-12-19 KR KR10-1998-0704792A patent/KR100500351B1/ko not_active IP Right Cessation
- 1996-12-19 DE DE69630145T patent/DE69630145T2/de not_active Expired - Lifetime
- 1996-12-20 CO CO96067023A patent/CO4520184A1/es unknown
- 1996-12-20 TN TNTNSN96169A patent/TNSN96169A1/fr unknown
- 1996-12-20 US US08/771,751 patent/US5728849A/en not_active Expired - Lifetime
- 1996-12-20 IN IN2893DE1996 patent/IN186768B/en unknown
- 1996-12-20 MY MYPI96005421A patent/MY113934A/en unknown
- 1996-12-20 AR ARP960105851A patent/AR005197A1/es active IP Right Grant
- 1996-12-21 DZ DZ960194A patent/DZ2149A1/fr active
-
1998
- 1998-06-05 NO NO19982580A patent/NO317358B1/no not_active IP Right Cessation
- 1998-06-11 MX MX9804688A patent/MX9804688A/es not_active IP Right Cessation
- 1998-06-19 OA OA9800087A patent/OA10700A/fr unknown
- 1998-06-22 BG BG102569A patent/BG63204B1/bg unknown
-
1999
- 1999-07-13 HK HK99102999A patent/HK1017895A1/xx not_active IP Right Cessation
-
2000
- 2000-04-10 IN IN419DE2000 patent/IN188680B/en unknown
- 2000-04-10 IN IN420DE2000 patent/IN188469B/en unknown
- 2000-04-10 IN IN421DE2000 patent/IN188470B/en unknown
- 2000-12-02 UY UY24386A patent/UY24386A1/es unknown
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