BE1002226A5 - Derives de 4h-benzopyranne-1 one-4 et leurs sels, leurs procedes de fabrication et compositions pharmaceutiques les comprenant en tant qu'ingredients actifs. - Google Patents
Derives de 4h-benzopyranne-1 one-4 et leurs sels, leurs procedes de fabrication et compositions pharmaceutiques les comprenant en tant qu'ingredients actifs. Download PDFInfo
- Publication number
- BE1002226A5 BE1002226A5 BE8801158A BE8801158A BE1002226A5 BE 1002226 A5 BE1002226 A5 BE 1002226A5 BE 8801158 A BE8801158 A BE 8801158A BE 8801158 A BE8801158 A BE 8801158A BE 1002226 A5 BE1002226 A5 BE 1002226A5
- Authority
- BE
- Belgium
- Prior art keywords
- substituted
- alkyl
- phenyl
- benzopyran
- derivatives
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
- C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3
- C07D311/54—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3 substituted in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
- C07D311/56—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 without hydrogen atoms in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
Ce dérivé, à activité anti-inflammatoire, antipyrétique, analgésique et antirhumatismale, est représenté par la formule suivante (cfr. Fig. Abstr.) : où R1 = alkyle inf., alcényle inf. ou aryle, non substitué ou substitué par hal.; R2 = H, alkyle ou acyle; R3 = H, hal., CN, N3, COOH, OH, HCO ou alcoxycarbonyle ou alkyle, alcoxy, phénoxy, cycloalkyle, carbamoyle, NH2 ou phényle substitué ou non; R4 = H, hal., NO2, CN, COOH, acyle, OH ou alcoxycarbonyle, alkyle, alcoxy, alkylthio, phénylthio, alcynyle inf., alcényle inf., sulfamoyle, alkylsulfinyle, alkylsulfonyle, amidino, phényle ou groupe hétérocyclique, substitué ou non, ou -(N=)R6, R7 ou -(C-O-N=)R6, R7 (R6 = H, OH, CN ou alcoxycarbonyle ou alkyle, cycloalkyle, phényle, NH2, acyle, carbamoyle, alkylsulfonyle, iminométhyle ou amidino, substitué ou non; R7 = H, alkyle, alcoxy, phényle, cycloalkyle ou groupe hétérocyclique, substitué ou non, ou R6 et R7 forment avec le N adjacent un groupe hétérocyclique, à 3-7 chaînons, substitué ou non); R5 = phényle, thiényle, furyle ou pyridyle, substitué ou non; Z = O, S ou imino.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP25425187 | 1987-10-08 | ||
JP11999088 | 1988-05-17 | ||
JP63250811A JPH0753725B2 (ja) | 1987-10-08 | 1988-10-06 | 4h―1―ベンゾピラン―4―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE1002226A5 true BE1002226A5 (fr) | 1990-10-23 |
Family
ID=27313952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE8801158A BE1002226A5 (fr) | 1987-10-08 | 1988-10-07 | Derives de 4h-benzopyranne-1 one-4 et leurs sels, leurs procedes de fabrication et compositions pharmaceutiques les comprenant en tant qu'ingredients actifs. |
Country Status (16)
Country | Link |
---|---|
US (1) | US4954518A (fr) |
JP (1) | JPH0753725B2 (fr) |
KR (1) | KR910007970B1 (fr) |
AT (1) | AT397088B (fr) |
AU (1) | AU605363B2 (fr) |
BE (1) | BE1002226A5 (fr) |
CA (1) | CA1320959C (fr) |
CH (1) | CH679397A5 (fr) |
DE (1) | DE3834204A1 (fr) |
ES (8) | ES2013801A6 (fr) |
FI (1) | FI98460C (fr) |
FR (1) | FR2621585B1 (fr) |
GB (1) | GB2210879B (fr) |
IT (1) | IT1235048B (fr) |
NL (1) | NL194914C (fr) |
SE (1) | SE468595B (fr) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3924417A1 (de) * | 1989-07-24 | 1991-01-31 | Merck Patent Gmbh | Chromanderivate |
EP0419410A3 (en) * | 1989-09-19 | 1991-08-14 | Ciba-Geigy Ag | Alkanophenones |
CA2091172C (fr) * | 1990-09-07 | 1997-05-20 | Adriano Afonso | Composes antiviraux et composes antihypertensifs |
FR2695387B1 (fr) * | 1992-09-09 | 1994-10-21 | Adir | Nouveaux composés benzopyraniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
PT695547E (pt) * | 1993-04-09 | 2001-12-28 | Toyama Chemical Co Ltd | Imunomodulador inibidor da adesao celular e agente para tratamento e prevencao de doencas auto-imunes |
WO1995033462A1 (fr) * | 1994-06-02 | 1995-12-14 | Smithkline Beecham Corporation | Composes anti-inflammatoires |
IT1288123B1 (it) | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
EP2017266A1 (fr) | 1997-11-19 | 2009-01-21 | Kowa Co., Ltd. | Dérivés de pyridazine et medicaments les contenant comme principe actif |
TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
US6649645B1 (en) * | 1998-12-23 | 2003-11-18 | Pharmacia Corporation | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia |
JP2000247959A (ja) | 1999-02-26 | 2000-09-12 | Kowa Co | ピリダジン−3−オン誘導体及びこれを含有する医薬 |
JP2001055331A (ja) * | 1999-06-11 | 2001-02-27 | Toyama Chem Co Ltd | アトピー性皮膚炎治療剤 |
US6664256B1 (en) | 2000-07-10 | 2003-12-16 | Kowa Co., Ltd. | Phenylpyridazine compounds and medicines containing the same |
GB0119865D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
GB0119863D0 (en) * | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
JP3972663B2 (ja) * | 2002-01-22 | 2007-09-05 | 松下電器産業株式会社 | 高周波信号受信装置 |
US7049313B2 (en) * | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
US6924376B2 (en) * | 2002-04-17 | 2005-08-02 | Cytokinetics, Inc. | Compounds, compositions and methods |
EP1507756B1 (fr) | 2002-05-24 | 2015-07-22 | Millennium Pharmaceuticals, Inc. | Inhibiteurs de ccr9 et utilisation de ceux-ci |
ATE423110T1 (de) * | 2002-07-17 | 2009-03-15 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren zur behandlung von zellulären proliferativen erkrankungen |
EP1554265A4 (fr) * | 2002-09-13 | 2008-05-07 | Cytokinetics Inc | Compos s, compositions et m thodes |
JP4611746B2 (ja) * | 2002-11-18 | 2011-01-12 | ケモセントリックス, インコーポレイテッド | アリールスルホンアミド |
US20070021466A1 (en) * | 2002-11-18 | 2007-01-25 | Solomon Ungashe | CCR2 inhibitors and methods of use thereof |
US7741519B2 (en) * | 2007-04-23 | 2010-06-22 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
US7227035B2 (en) * | 2002-11-18 | 2007-06-05 | Chemocentryx | Bis-aryl sulfonamides |
US7420055B2 (en) | 2002-11-18 | 2008-09-02 | Chemocentryx, Inc. | Aryl sulfonamides |
DE10256182A1 (de) * | 2002-12-02 | 2004-06-24 | Merck Patent Gmbh | 2-Oxadiazolchromonderivate |
JP4589868B2 (ja) * | 2003-03-14 | 2010-12-01 | 富山化学工業株式会社 | N−[3−(ホルミルアミノ)−4−オキソ−6−フェノキシ−4h−クロメン−7−イル]メタンスルホンアミドの新規な結晶 |
MXPA05009972A (es) * | 2003-03-18 | 2005-11-04 | Kowa Co | Derivado de fenilpiridazina soluble en agua y medicina que contiene el mismo. |
CN100387231C (zh) * | 2003-03-24 | 2008-05-14 | 天津药物研究院 | 一种制备古拉替莫固体制剂的工艺及其固体制剂 |
DE602004026071D1 (de) * | 2003-08-13 | 2010-04-29 | Kudos Pharm Ltd | Aminopyrone und ihre verwendung als atm inhibitoren |
EP1670456A2 (fr) * | 2003-10-06 | 2006-06-21 | Cytokinetics, Inc. | Composes, compositions et procedes |
BRPI0515498A (pt) * | 2004-09-20 | 2008-07-29 | Kudos Pharm Ltd | inibidores de dna-pk |
JP2008529995A (ja) * | 2005-02-09 | 2008-08-07 | クドス ファーマシューティカルズ リミテッド | Atm阻害剤 |
AR053358A1 (es) * | 2005-04-15 | 2007-05-02 | Cancer Rec Tech Ltd | Inhibidores de adn - pk |
KR100704009B1 (ko) * | 2005-08-30 | 2007-04-04 | 한국화학연구원 | 염증억제 활성을 가지는6-알킬아미노-2-메틸-2'-(n-메틸치환술폰아미도)메틸-2h-1-벤조피란 유도체 |
UY29774A1 (es) * | 2005-08-31 | 2007-03-30 | Kudos Pharm Ltd | Inhibidor de atm |
CN101891726B (zh) * | 2005-10-09 | 2012-05-23 | 天津药物研究院 | 艾拉莫德结晶形态及其组合物 |
CN101885718B (zh) * | 2005-10-09 | 2012-05-23 | 天津药物研究院 | 艾拉莫德结晶形态及其组合物 |
CN101885717B (zh) * | 2005-10-09 | 2012-05-23 | 天津药物研究院 | 艾拉莫德结晶形态及其组合物 |
JP4788955B2 (ja) * | 2006-01-13 | 2011-10-05 | 住友金属工業株式会社 | 鉄道車両における操舵用アクチュエータの制御方法 |
AU2006233256B2 (en) * | 2006-10-30 | 2012-01-19 | Armaron Bio Pty Ltd | Improved flavonols |
US7960567B2 (en) * | 2007-05-02 | 2011-06-14 | Amgen Inc. | Compounds and methods useful for treating asthma and allergic inflammation |
UY31232A1 (es) * | 2007-07-19 | 2009-03-02 | Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones | |
JP5828235B2 (ja) | 2011-07-21 | 2015-12-02 | 新日鐵住金株式会社 | 鉄道車両用操舵台車 |
HUE029800T2 (en) | 2013-07-18 | 2017-04-28 | Toyama Chemical Co Ltd | A therapeutic agent for a disease based on inhibition of macrophage migration reduction factor |
CN107021891A (zh) * | 2017-04-24 | 2017-08-08 | 常州佳德医药科技有限公司 | 一种艾拉莫德中间体的制备方法 |
CN106986797B (zh) * | 2017-04-24 | 2018-09-28 | 常州佳德医药科技有限公司 | N-(2-(4-乙酰苯氧基)-5-甲氧基苯基)甲磺酰胺及其制备方法 |
CN111170914B (zh) * | 2018-11-09 | 2021-12-21 | 成都大学 | 硒/硫化磺酰芳胺类化合物及其硒/硫化方法 |
CN109705000A (zh) * | 2019-02-26 | 2019-05-03 | 南京红杉生物科技有限公司 | 艾拉莫德中间体及其合成方法 |
JP7453365B2 (ja) * | 2020-05-29 | 2024-03-19 | 富士フイルム富山化学株式会社 | 高純度のn-(5-メトキシ―2-フェノキシフェニル)メタンスルホンアミド及びその製造方法 |
CN113968836A (zh) * | 2020-07-25 | 2022-01-25 | 华创合成制药股份有限公司 | 一种苯并吡喃衍生物及其在类风湿性关节炎治疗中的应用 |
CN113968838B (zh) * | 2020-07-25 | 2024-04-02 | 华创合成制药股份有限公司 | 一种硫代苯并吡喃类化合物及其在类风湿性关节炎治疗中的应用 |
CN114539104A (zh) * | 2022-03-09 | 2022-05-27 | 常州佳德医药科技有限公司 | 一种艾拉莫德中间体的制备方法 |
Citations (2)
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---|---|---|---|---|
EP0059884A1 (fr) * | 1981-03-11 | 1982-09-15 | Schering Aktiengesellschaft | Dérivés du benzofuranne, leur préparation et leur usage |
EP0125195A1 (fr) * | 1983-03-24 | 1984-11-14 | Cortial S.A. | Nouveaux acides flavonecarboxyliques-4', leur méthode de préparation et leur application thérapeutique |
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DE2537204A1 (de) * | 1974-08-23 | 1976-03-04 | Fisons Ltd | Neue benzopyrane und verfahren zu ihrer herstellung |
EP0009554B1 (fr) * | 1978-07-27 | 1983-04-27 | Schering Aktiengesellschaft | Dérivés de l'indane, procédé pour leur préparation et compositions pharmaceutiques contenantes ces composés |
DE3208079A1 (de) * | 1982-03-04 | 1983-09-08 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue indanyl-derivate, ihre herstellung und verwendung |
DE3343331A1 (de) * | 1983-11-28 | 1985-06-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur herstellung von indanyl-derivaten und deren verwendung |
US4713393A (en) * | 1985-04-25 | 1987-12-15 | Merck & Co., Inc. | Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents |
PT86407B (pt) * | 1986-12-31 | 1990-11-20 | Fujisawa Pharmaceutical Co | Processo para a preparacao de novos derivados de alcano-sulfonanilida, e de composicoes farmaceuticas compreendendo os mesmos |
-
1988
- 1988-10-06 JP JP63250811A patent/JPH0753725B2/ja not_active Expired - Lifetime
- 1988-10-07 FR FR8813205A patent/FR2621585B1/fr not_active Expired - Lifetime
- 1988-10-07 CA CA000579624A patent/CA1320959C/fr not_active Expired - Lifetime
- 1988-10-07 DE DE3834204A patent/DE3834204A1/de active Granted
- 1988-10-07 NL NL8802464A patent/NL194914C/nl not_active IP Right Cessation
- 1988-10-07 US US07/255,121 patent/US4954518A/en not_active Expired - Lifetime
- 1988-10-07 ES ES8803062A patent/ES2013801A6/es not_active Expired - Fee Related
- 1988-10-07 BE BE8801158A patent/BE1002226A5/fr not_active IP Right Cessation
- 1988-10-07 FI FI884626A patent/FI98460C/fi not_active IP Right Cessation
- 1988-10-07 AU AU23489/88A patent/AU605363B2/en not_active Expired
- 1988-10-07 SE SE8803570A patent/SE468595B/sv not_active IP Right Cessation
- 1988-10-07 GB GB8823567A patent/GB2210879B/en not_active Expired - Lifetime
- 1988-10-07 CH CH3763/88A patent/CH679397A5/de not_active IP Right Cessation
- 1988-10-08 KR KR1019880013144A patent/KR910007970B1/ko not_active IP Right Cessation
- 1988-10-10 IT IT8848441A patent/IT1235048B/it active
- 1988-10-10 AT AT0249588A patent/AT397088B/de not_active IP Right Cessation
-
1989
- 1989-10-13 ES ES8903464A patent/ES2017836A6/es not_active Expired - Fee Related
- 1989-10-13 ES ES8903469A patent/ES2018113A6/es not_active Expired - Fee Related
- 1989-10-13 ES ES8903466A patent/ES2017837A6/es not_active Expired - Fee Related
- 1989-10-13 ES ES8903467A patent/ES2017838A6/es not_active Expired - Fee Related
- 1989-10-13 ES ES8903468A patent/ES2017839A6/es not_active Expired - Fee Related
- 1989-10-13 ES ES8903465A patent/ES2018112A6/es not_active Expired - Fee Related
- 1989-10-13 ES ES8903463A patent/ES2018111A6/es not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0059884A1 (fr) * | 1981-03-11 | 1982-09-15 | Schering Aktiengesellschaft | Dérivés du benzofuranne, leur préparation et leur usage |
EP0125195A1 (fr) * | 1983-03-24 | 1984-11-14 | Cortial S.A. | Nouveaux acides flavonecarboxyliques-4', leur méthode de préparation et leur application thérapeutique |
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Legal Events
Date | Code | Title | Description |
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RE20 | Patent expired |
Owner name: *TOYAMA CHEMICAL CO. LTD Effective date: 20081007 |