ATE94534T1 - Antiarrhythmische verbindungen. - Google Patents

Antiarrhythmische verbindungen.

Info

Publication number
ATE94534T1
ATE94534T1 AT87300978T AT87300978T ATE94534T1 AT E94534 T1 ATE94534 T1 AT E94534T1 AT 87300978 T AT87300978 T AT 87300978T AT 87300978 T AT87300978 T AT 87300978T AT E94534 T1 ATE94534 T1 AT E94534T1
Authority
AT
Austria
Prior art keywords
group
alkyl
formula
amino
substituted
Prior art date
Application number
AT87300978T
Other languages
English (en)
Inventor
Peter Edward Cross
Roger Peter Dickinson
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Application granted granted Critical
Publication of ATE94534T1 publication Critical patent/ATE94534T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Organic Insulating Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
AT87300978T 1986-02-07 1987-02-04 Antiarrhythmische verbindungen. ATE94534T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868603120A GB8603120D0 (en) 1986-02-07 1986-02-07 Anti-dysrhythmia agents
EP87300978A EP0233051B1 (de) 1986-02-07 1987-02-04 Antiarrhythmische Verbindungen

Publications (1)

Publication Number Publication Date
ATE94534T1 true ATE94534T1 (de) 1993-10-15

Family

ID=10592722

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87300978T ATE94534T1 (de) 1986-02-07 1987-02-04 Antiarrhythmische verbindungen.

Country Status (21)

Country Link
US (1) US4806536A (de)
EP (1) EP0233051B1 (de)
JP (1) JPH0670015B2 (de)
KR (1) KR890002290B1 (de)
CN (1) CN87100652A (de)
AT (1) ATE94534T1 (de)
AU (1) AU575740B2 (de)
CA (1) CA1303042C (de)
DE (1) DE3787384T2 (de)
DK (1) DK165445C (de)
ES (1) ES2058105T3 (de)
FI (1) FI89265C (de)
GB (1) GB8603120D0 (de)
HU (1) HU196990B (de)
IE (1) IE60300B1 (de)
IL (1) IL81483A0 (de)
NO (1) NO870483L (de)
NZ (1) NZ219193A (de)
PL (1) PL263972A1 (de)
PT (1) PT84248B (de)
ZA (1) ZA87871B (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
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GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
US4956382A (en) * 1987-02-07 1990-09-11 Pfizer Inc. Sulfonamide anti-arrhythmic agents
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US5162347A (en) * 1987-08-24 1992-11-10 Eisai Co., Ltd. Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same
GB8800694D0 (en) * 1988-01-13 1988-02-10 Pfizer Ltd Antiarrhythmic agents
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
US5032598A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents
US5112824A (en) * 1989-12-08 1992-05-12 Merck & Co., Inc. Benzofuran compounds as class III antiarrhythmic agents
US5206240A (en) * 1989-12-08 1993-04-27 Merck & Co., Inc. Nitrogen-containing spirocycles
US5215989A (en) * 1989-12-08 1993-06-01 Merck & Co., Inc. Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
US4994459A (en) * 1989-12-11 1991-02-19 American Home Products Corporation Aryloxypropane substituted piperazine derivatives with antiarrhythmic and antifibrillatory activity
ES2180537T3 (es) * 1991-08-14 2003-02-16 Procter & Gamble Pharma Nuevas ureas 4-oxociclicas, utilizables como agentes antiarritmicos o antifibrilantes.
US5569659A (en) * 1991-09-11 1996-10-29 Mcneilab, Inc. 4-arylpiperazines and 4-arylpiperidines
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
CA2155307A1 (en) * 1993-03-29 1994-10-13 Michael Garth Wayne Heterocyclic compounds as platelet aggregation inhibitors
ATE202345T1 (de) * 1993-03-29 2001-07-15 Astrazeneca Ab Heterozyklische derivate als plätchenaggregationsinhibitoren
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5382587A (en) * 1993-06-30 1995-01-17 Merck & Co., Inc. Spirocycles
US5403846A (en) * 1993-11-22 1995-04-04 Merck & Co., Inc. Spirocycles
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US5700801A (en) * 1994-12-23 1997-12-23 Karl Thomae, Gmbh Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
AU1608397A (en) * 1996-02-02 1997-08-22 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
PL331599A1 (en) * 1996-08-14 1999-08-02 Zeneca Ltd Substituted derivatives of pyrimidine and their pharmaceutical application
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
AU5999698A (en) 1997-02-13 1998-09-08 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
ATE242774T1 (de) 1997-02-13 2003-06-15 Astrazeneca Ab Heterozyklische verbindungen die als oxido- squalen-zyklase-inhibitoren anwendung finden
US6083991A (en) 1997-06-04 2000-07-04 University Of Florida Research Foundation, Inc. Anti-arrhythmic composition and methods of treatment
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
JP4570773B2 (ja) * 1997-10-27 2010-10-27 ニューロサーチ、アクティーゼルスカブ ニコチン性アセチルコリンレセプターに於けるコリン作動性リガンドとしてのヘテロアリールジアザシクロアルカン
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
ATE245153T1 (de) * 1999-04-26 2003-08-15 Neurosearch As Heteroaryl-diazacycloalkane, ihre herstellung und verwendung
JP2005515961A (ja) * 2001-05-22 2005-06-02 ニューロジェン コーポレイション メラニン凝集ホルモン受容体リガンド：置換１−ベンジル−４−アリールピペラジン類似体
CN1181065C (zh) * 2002-05-08 2004-12-22 上海医药工业研究院 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用
CN1172919C (zh) 2002-06-03 2004-10-27 上海医药工业研究院 芳烷醇哌嗪衍生物及其在制备抗抑郁症药物中的应用
US20050239791A1 (en) * 2004-04-07 2005-10-27 Hutchison Alan J Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues
WO2005110982A2 (en) * 2004-04-07 2005-11-24 Neurogen Corporation Substituted 1-benzyl-4-substituted piperazine analogues
TW200609219A (en) * 2004-06-17 2006-03-16 Neurogen Corp Aryl-substituted piperazine derivatives
CN101080392B (zh) * 2004-12-16 2010-05-05 霍夫曼-拉罗奇有限公司 作为抗肥胖药剂的哌嗪基吡啶衍生物
GB0818241D0 (en) * 2008-10-06 2008-11-12 Cancer Res Technology Compounds and their use
GB0902173D0 (en) 2009-02-10 2009-03-25 Takeda Pharmaceutical Compounds and their use
US8673920B2 (en) * 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US8614201B2 (en) 2009-06-05 2013-12-24 Janssen Pharmaceutica Nv Heterocyclic amides as modulators of TRPA1
EP2632465B1 (de) 2010-10-27 2015-12-30 Merck Sharp & Dohme Corp. Inhibitoren des renalen kaliumkanals der äusseren medulla
US9056859B2 (en) 2010-10-29 2015-06-16 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
ES2605164T3 (es) 2011-08-19 2017-03-13 Merck Sharp & Dohme Corp. Inhibidores del canal de potasio de la médula renal externa
US9527830B2 (en) 2011-09-16 2016-12-27 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US8999991B2 (en) 2011-10-25 2015-04-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2771005B1 (de) 2011-10-25 2016-05-18 Merck Sharp & Dohme Corp. Inhibitoren des renalen kaliumkanals der äusseren medulla
EP2773206B1 (de) 2011-10-31 2018-02-21 Merck Sharp & Dohme Corp. Inhibitoren des renalen kaliumkanals der äusseren medulla
WO2013066718A2 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9139585B2 (en) 2011-10-31 2015-09-22 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
US9206199B2 (en) 2011-12-16 2015-12-08 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
EP2925322B1 (de) 2012-11-29 2018-10-24 Merck Sharp & Dohme Corp. Inhibitoren des renalen kaliumkanals der äusseren medulla
CN103087009B (zh) * 2012-12-17 2016-09-14 上海现代制药股份有限公司 羧酸衍生物类化合物及其制备方法和应用
US9573961B2 (en) 2012-12-19 2017-02-21 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2014126944A2 (en) 2013-02-18 2014-08-21 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9765074B2 (en) 2013-03-15 2017-09-19 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2015017305A1 (en) 2013-07-31 2015-02-05 Merck Sharp & Dohme Corp Inhibitors of the renal outer medullary potassium channel
EP3063142B1 (de) 2013-10-31 2019-01-30 Merck Sharp & Dohme Corp. Inhibitoren des renalen kaliumkanals der äusseren medulla
RU2565404C1 (ru) * 2014-12-02 2015-10-20 Общество с ограниченной ответственностью "Научно-исследовательский центр "Парк активных молекул" Средство, проявляющее антиаритмическую активность
WO2016127358A1 (en) 2015-02-12 2016-08-18 Merck Sharp & Dohme Corp. Inhibitors of renal outer medullary potassium channel

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Also Published As

Publication number Publication date
IL81483A0 (en) 1987-09-16
DK165445C (da) 1993-04-13
EP0233051A2 (de) 1987-08-19
CA1303042C (en) 1992-06-09
AU575740B2 (en) 1988-08-04
IE60300B1 (en) 1994-06-29
PL263972A1 (en) 1988-07-21
US4806536A (en) 1989-02-21
GB8603120D0 (en) 1986-03-12
JPH0670015B2 (ja) 1994-09-07
NO870483D0 (no) 1987-02-06
IE870318L (en) 1987-08-07
DK60887A (da) 1987-10-05
EP0233051B1 (de) 1993-09-15
DE3787384T2 (de) 1994-01-13
HUT43584A (en) 1987-11-30
PT84248A (en) 1987-03-01
DE3787384D1 (de) 1993-10-21
CN87100652A (zh) 1987-08-19
PT84248B (pt) 1989-09-14
DK165445B (da) 1992-11-30
KR870007916A (ko) 1987-09-22
FI89265C (fi) 1993-09-10
EP0233051A3 (en) 1990-03-21
JPS62185073A (ja) 1987-08-13
NZ219193A (en) 1989-01-06
ZA87871B (en) 1988-09-28
AU6858887A (en) 1987-08-13
ES2058105T3 (es) 1994-11-01
HU196990B (en) 1989-02-28
FI89265B (fi) 1993-05-31
FI870499A7 (fi) 1987-08-08
KR890002290B1 (ko) 1989-06-28
NO870483L (no) 1987-08-10
DK60887D0 (da) 1987-02-06
FI870499A0 (fi) 1987-02-06

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee