ES2180537T3 - Nuevas ureas 4-oxociclicas, utilizables como agentes antiarritmicos o antifibrilantes. - Google Patents

Nuevas ureas 4-oxociclicas, utilizables como agentes antiarritmicos o antifibrilantes.

Info

Publication number
ES2180537T3
ES2180537T3 ES92918467T ES92918467T ES2180537T3 ES 2180537 T3 ES2180537 T3 ES 2180537T3 ES 92918467 T ES92918467 T ES 92918467T ES 92918467 T ES92918467 T ES 92918467T ES 2180537 T3 ES2180537 T3 ES 2180537T3
Authority
ES
Spain
Prior art keywords
saturated
null
replaced
substituted
nitrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92918467T
Other languages
English (en)
Inventor
Stanford Salvatore Pelosi Jr
Chia-Nien Yu
Mark Arthur Calcagno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Chilcott Pharmaceuticals Inc
Original Assignee
Procter and Gamble Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Pharmaceuticals Inc filed Critical Procter and Gamble Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2180537T3 publication Critical patent/ES2180537T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LAS NUEVAS UREAS 4 RMACEUTICAMENTE ACEPTABLES DE LAS MISMAS DE LA PRESENTE INVENCION SON UTILES COMO AGENTES ANTIARRITMICOS Y ANTIFIBRILATORIOS, Y TIENEN LA SIGUIENTE ESTRUCTURA GENERAL: (I), DONDE (A) X ES UN CARBOCICLO O HETEROCICLO DE 5, 6 O 7 MIEMBROS, SATURADO O NO SATURADO; (B) R SE SELECCIONA DE UN GRUPO FORMADO POR ENLACE COVALENTE, NULO, HETEROATOMO, (C) Y ES UN ANILLO CARBOCICLICO O ANILLO HETEROCICLICO, DE 5, 6 O 7 MIEMBROS, SATURADO O NO SATURADO, SUSTITUIDO O NO SUSTITUIDO, O ES NULO; Y DONDE CUANDO R ES NULO, X E Y SON SISTEMAS DE ANILLOS CONDENSADOS; Y CUANDO R ES UN ENLACE COVALENTE, X E Y SON SISTEMAS DE ANILLOS UNIDOS A TRAVES DE UN ENLACE COVALENTE; Y CUANDO Y ES NULO, R ES UN ENLACE COVALENTE, Y X ESTA UNIDO A L A TRAVES DE R; (D) R1, R2 Y R3 SE SELECCIONAN INDEPENDIENTEMENTE DEL GRUPO FORMADO POR NULO, CL, F, BR, NH2, CF3, OH, SO3H, CH3SO2NH, COOH, ALCOXI, ALQUILO, ALCOXICARBONILO, HIDROXIALQUILO, CARBOXIALQUILO, AMINOALQUILO, ACILAMINO Y ACILOXI; (E) L SE SELECCIONA DEL GRUPO FORMADO POR ALQUILAMINO, ALQUENILAMINO, ALQUILIMINO, ALQUENILIMINO Y ACILAMINO; EN DONDE EL ATOMO DE NITROGENO DEL MISMO SE UNE AL ATOMO DE NITROGENO, EN LA POSICION 1 DE LA MITAD DE UREA 4 LO, ALQUENILO, ALQUILINO, ALQUILACILO Y HETEROALQUILO; (G) A ES UN HETEROALQUILO C1 ADO O NO SATURADO, SUSTITUIDO O NO SUSTITUIDO; O UN HETEROCICLO SATURADO O NO SATURADO, SUSTITUIDO O NO SUSTITUIDO, QUE TIENE 5, 6 O 7 MIEMBROS; Y A TIENE UN ATOMO DE NITROGENO, QUE ES ADYACENTE A R4; Y (H) R5 ES UN ALQUILO C1 O C2, SUSTITUIDO O NO SUSTITUIDO.
ES92918467T 1991-08-14 1992-08-10 Nuevas ureas 4-oxociclicas, utilizables como agentes antiarritmicos o antifibrilantes. Expired - Lifetime ES2180537T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74486791A 1991-08-14 1991-08-14

Publications (1)

Publication Number Publication Date
ES2180537T3 true ES2180537T3 (es) 2003-02-16

Family

ID=24994275

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92918467T Expired - Lifetime ES2180537T3 (es) 1991-08-14 1992-08-10 Nuevas ureas 4-oxociclicas, utilizables como agentes antiarritmicos o antifibrilantes.

Country Status (27)

Country Link
US (1) US5462940A (es)
EP (2) EP0598061B1 (es)
JP (1) JP3040473B2 (es)
KR (2) KR100273605B1 (es)
AT (1) ATE220675T1 (es)
AU (1) AU668360B2 (es)
BR (1) BR9206369A (es)
CA (1) CA2115427C (es)
CZ (1) CZ282368B6 (es)
DE (1) DE69232681T2 (es)
DK (1) DK0598061T3 (es)
ES (1) ES2180537T3 (es)
FI (1) FI109696B (es)
HK (1) HK1048806A1 (es)
HU (1) HU221317B1 (es)
IL (1) IL102793A (es)
MX (1) MX9204730A (es)
MY (1) MY109205A (es)
NO (5) NO306676B1 (es)
NZ (1) NZ243938A (es)
PH (1) PH31451A (es)
PL (2) PL170984B1 (es)
PT (1) PT100777B (es)
RU (2) RU2130935C1 (es)
SK (1) SK282656B6 (es)
TW (1) TW232691B (es)
WO (1) WO1993004061A1 (es)

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* Cited by examiner, † Cited by third party
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US6083945A (en) * 1995-06-07 2000-07-04 The Procter & Gamble Company Cyclic ureas useful as antiarrhythmic and antifibrillatory agents
WO1998037068A1 (en) 1997-02-21 1998-08-27 Bristol-Myers Squibb Company Benzoic acid derivatives and related compounds as antiarrhythmic agents
US6048877A (en) * 1997-02-21 2000-04-11 Bristol-Myers Squibb Company Tetralone derivatives as antiarrhythmic agents
US6262068B1 (en) 1997-02-21 2001-07-17 Bristol-Myers Squibb Company Lactam derivatives as antiarrhythmic agents
US6664250B2 (en) 1998-01-20 2003-12-16 Bristol-Myers Squibb Co. Lactam derivatives as antiarrhythmic agents
EP1056726A1 (en) 1998-02-20 2000-12-06 The Procter & Gamble Company Solid phase synthesis of 1-aminohydantoins
BR9910074A (pt) * 1998-04-29 2000-12-26 Procter & Gamble Processo para fabricação de uréias 1,3-di-substituìdas-4-oxocìclicas
PL198951B1 (pl) 1998-04-29 2008-08-29 Procter & Gamble Sposób wytwarzania 1,3-dipodstawionych-4-oksocyklicznych moczników
CN100443473C (zh) * 2005-04-30 2008-12-17 中国药科大学 1-氨基-3-(氮杂环基烷基)-2,4-咪唑二酮的合成方法
ATE466873T1 (de) * 2005-10-18 2010-05-15 Seoul Nat Univ Ind Foundation Verfahren zur herstellung eines rekombinanten peptids aus spinnengift, und das peptid enthaltende analgetische zusammensetzung
US20120178762A1 (en) 2006-12-15 2012-07-12 Warner Chilcott Company, Llc Compositions of azimilide dihydrochloride
TW200840578A (en) * 2006-12-15 2008-10-16 Procter & Gamble Compositions of azimilide dihydrochloride
CN101735203B (zh) * 2009-12-17 2012-05-23 天津药物研究院 盐酸阿齐利特的晶型ⅱ及其制备方法和用途
CN101735202B (zh) * 2009-12-17 2012-05-30 天津药物研究院 盐酸阿齐利特的晶型ⅰ及其制备方法和用途
CN101735205B (zh) * 2009-12-17 2013-05-15 天津药物研究院 盐酸阿齐利特的晶型ⅴ及其制备方法和用途

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US4775670A (en) * 1980-09-29 1988-10-04 E. R. Squibb & Sons, Inc. 2-oxo-1-azetidinesulfonic acid salts
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Also Published As

Publication number Publication date
RU2130935C1 (ru) 1999-05-27
IL102793A (en) 1996-12-05
DE69232681D1 (de) 2002-08-22
SK282656B6 (sk) 2002-11-06
FI940657A0 (fi) 1994-02-11
PL170961B1 (en) 1997-02-28
DE69232681T2 (de) 2003-02-13
NO992898L (no) 1994-02-14
NO992897L (no) 1994-02-14
WO1993004061A1 (en) 1993-03-04
AU2471792A (en) 1993-03-16
PH31451A (en) 1998-11-03
NZ243938A (en) 1996-10-28
AU668360B2 (en) 1996-05-02
FI109696B (fi) 2002-09-30
FI940657A (fi) 1994-02-11
KR100273605B1 (ko) 2000-12-15
CZ282368B6 (cs) 1997-07-16
NO940497L (no) 1994-02-14
NO992899D0 (no) 1999-06-14
PL170984B1 (pl) 1997-02-28
SK17194A3 (en) 1995-03-08
NO992900D0 (no) 1999-06-14
NO992900L (no) 1994-02-14
MX9204730A (es) 1994-03-31
NO940497D0 (no) 1994-02-14
NO992899L (no) 1994-02-14
NO310145B1 (no) 2001-05-28
EP1231208A2 (en) 2002-08-14
NO310148B1 (no) 2001-05-28
TW232691B (es) 1994-10-21
EP1231208A3 (en) 2003-12-10
PT100777B (pt) 1999-07-30
NO992897D0 (no) 1999-06-14
NO310147B1 (no) 2001-05-28
DK0598061T3 (da) 2002-11-11
KR100295946B1 (ko) 2001-07-03
HUT70152A (en) 1995-09-28
US5462940A (en) 1995-10-31
MY109205A (en) 1996-12-31
CA2115427C (en) 2000-05-02
EP0598061B1 (en) 2002-07-17
IL102793A0 (en) 1993-01-31
HU221317B1 (en) 2002-09-28
EP0598061A1 (en) 1994-05-25
CA2115427A1 (en) 1993-03-04
JPH06509804A (ja) 1994-11-02
NO310146B1 (no) 2001-05-28
NO992898D0 (no) 1999-06-14
CZ30694A3 (en) 1995-01-18
ATE220675T1 (de) 2002-08-15
HU9400396D0 (en) 1994-05-30
BR9206369A (pt) 1995-05-30
HK1048806A1 (zh) 2003-04-17
RU2221788C2 (ru) 2004-01-20
NO306676B1 (no) 1999-12-06
JP3040473B2 (ja) 2000-05-15
PT100777A (pt) 1993-12-31

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