ES2076215T3 - Nuevos derivados de imidazol. - Google Patents
Nuevos derivados de imidazol.Info
- Publication number
- ES2076215T3 ES2076215T3 ES89308119T ES89308119T ES2076215T3 ES 2076215 T3 ES2076215 T3 ES 2076215T3 ES 89308119 T ES89308119 T ES 89308119T ES 89308119 T ES89308119 T ES 89308119T ES 2076215 T3 ES2076215 T3 ES 2076215T3
- Authority
- ES
- Spain
- Prior art keywords
- combined
- alkyl
- substitute
- halogen
- imidazol derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE DESCRIBEN NUEVOS DERIVADOS DE IMIDAZOL, QUE TIENEN LA FORMULA: (FIG. A), DONDE R1 Y R2 SON H, ALQUILO, CICLOALQUILO, ARILO, ARALQUILO O ALQUILO HALOGENO-SUSTITUIDO; O R1 Y R2 SE COMBINAN PARA FORMAR UN ANILLO HETEROCICLICO; R3, R4, R5 Y R6 SON H, HALOGENO, ALCOXI, ARALQUILOXI, ALQUILO, ALCOXICARBONILO, NITRO, AMINO, ACILO, FLUOROALQUILO O FLUOROALCOXI; O R3 ESTA COMBINADO CON R2 PARA FORMAR UN ANILLO HETEROCICLICO; R8 Y R9 SON H, HALOGENO, ALCOXI, ALQUILO, ALCOXICARBONILO, NITRO, AMINO, ACILO, FLUOROALQUILO, FLUOROALCOXI O ARILO, QUE PUEDE TENER UN SUSTITUYENTE; O R8 Y R9 ESTAN COMBINADOS PARA FORMAR UN ANILLO ALICICLICO; CUANDO R8 Y R9 NO ESTAN COMBINADOS, R7 ES H Y CUANDO R8 Y R9 ESTAN COMBINADOS ES H, ALQUILO QUE PUEDE TENER UN SUSTITUYENTE, ARILO QUE PUEDE TENER UN SUSTITUYENTE, ARILCARBONILO QUE PUEDE TENER UN SUSTTUYENTE O UN GRUPO HETEROCICLICO QUE COTIENE AZUFRE; Y N ES 0 O 1. LOS NUEVOS DERIVADOS DE IMIDAZOL SON EFICACES ESPECIALMENTE COMO AGENTES ANTIULCERA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19952888 | 1988-08-10 | ||
JP63297856A JP2614756B2 (ja) | 1988-08-10 | 1988-11-24 | イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2076215T3 true ES2076215T3 (es) | 1995-11-01 |
Family
ID=26511585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89308119T Expired - Lifetime ES2076215T3 (es) | 1988-08-10 | 1989-08-10 | Nuevos derivados de imidazol. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5082943A (es) |
EP (1) | EP0354788B1 (es) |
JP (1) | JP2614756B2 (es) |
KR (1) | KR940007314B1 (es) |
AR (1) | AR247555A1 (es) |
AT (1) | ATE127793T1 (es) |
AU (1) | AU624406B2 (es) |
CA (1) | CA1338599C (es) |
DE (1) | DE68924221T2 (es) |
DK (1) | DK392889A (es) |
ES (1) | ES2076215T3 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0412529T3 (da) * | 1989-08-10 | 1994-04-05 | Nippon Chemiphar Co | Hidtil ukendte imidazolderivater, fremgangsmåde til fremstilling deraf og midler mod mavesår indeholdende disse |
DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
JPH0770083A (ja) * | 1993-07-05 | 1995-03-14 | Nippon Chemiphar Co Ltd | イミダゾール誘導体を有効成分とする血圧降下剤 |
WO1995013268A1 (en) * | 1993-11-12 | 1995-05-18 | Gyógyszerkutató Intézet Kft. | Ulcer-inhibiting triazole derivatives, pharmaceutical compositions containing them and process for preparing same |
US5945425A (en) * | 1994-04-29 | 1999-08-31 | G.D. Searle & Co. | Method of using (H+ /K+)ATPase inhibitors as antiviral agents |
JP3015702B2 (ja) * | 1995-02-21 | 2000-03-06 | 株式会社アラクス | イミダゾール誘導体及びそれらの薬剤として許容される酸付加塩及びその製造法並びにそれらを有効成分とする抗潰瘍剤 |
JP3046924B2 (ja) * | 1995-03-27 | 2000-05-29 | 株式会社アラクス | イミダゾリン誘導体又はそれらの可能な互変異性体及びそれらの製造方法並びにそれらを有効成分とする創傷治療薬 |
AU2743800A (en) * | 1999-01-28 | 2000-08-18 | Bion, Inc. | High-throughput screening assays for modulators of na+-k+atpase |
KR102225072B1 (ko) * | 2019-10-18 | 2021-03-09 | 동명대학교산학협력단 | 기계식 현수 장치용 연결구 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3025484A1 (de) * | 1980-07-03 | 1982-02-04 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
AU4640985A (en) * | 1984-08-31 | 1986-03-06 | Nippon Chemiphar Co. Ltd. | Benzimidazole derivatives |
AU619444B2 (en) * | 1986-06-02 | 1992-01-30 | Nippon Chemiphar Co. Ltd. | 2-(2-aminobenzylsulfinyl)- benzimidazole derivatives |
WO1988002367A1 (en) * | 1986-09-27 | 1988-04-07 | Fisons Plc | Compounds |
FI91754C (fi) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
IT1222412B (it) * | 1987-07-31 | 1990-09-05 | Chiesi Farma Spa | Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono |
DK0412529T3 (da) * | 1989-08-10 | 1994-04-05 | Nippon Chemiphar Co | Hidtil ukendte imidazolderivater, fremgangsmåde til fremstilling deraf og midler mod mavesår indeholdende disse |
-
1988
- 1988-11-24 JP JP63297856A patent/JP2614756B2/ja not_active Expired - Lifetime
-
1989
- 1989-08-09 AU AU39461/89A patent/AU624406B2/en not_active Ceased
- 1989-08-09 CA CA000607847A patent/CA1338599C/en not_active Expired - Fee Related
- 1989-08-10 ES ES89308119T patent/ES2076215T3/es not_active Expired - Lifetime
- 1989-08-10 KR KR1019890011400A patent/KR940007314B1/ko not_active IP Right Cessation
- 1989-08-10 DE DE68924221T patent/DE68924221T2/de not_active Expired - Fee Related
- 1989-08-10 AT AT89308119T patent/ATE127793T1/de active
- 1989-08-10 EP EP89308119A patent/EP0354788B1/en not_active Expired - Lifetime
- 1989-08-10 AR AR89314632A patent/AR247555A1/es active
- 1989-08-10 DK DK392889A patent/DK392889A/da not_active Application Discontinuation
-
1991
- 1991-02-20 US US07/658,424 patent/US5082943A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE127793T1 (de) | 1995-09-15 |
DK392889A (da) | 1990-02-11 |
DK392889D0 (da) | 1989-08-10 |
KR900003135A (ko) | 1990-03-23 |
DE68924221D1 (de) | 1995-10-19 |
JP2614756B2 (ja) | 1997-05-28 |
EP0354788B1 (en) | 1995-09-13 |
AU624406B2 (en) | 1992-06-11 |
AU3946189A (en) | 1990-02-15 |
JPH02138263A (ja) | 1990-05-28 |
CA1338599C (en) | 1996-09-17 |
DE68924221T2 (de) | 1996-02-15 |
KR940007314B1 (ko) | 1994-08-12 |
EP0354788A1 (en) | 1990-02-14 |
AR247555A1 (es) | 1995-01-31 |
US5082943A (en) | 1992-01-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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