AR247555A1 - Procedimiento para obtener nuevos derivados de imidazol - Google Patents

Procedimiento para obtener nuevos derivados de imidazol

Info

Publication number
AR247555A1
AR247555A1 AR89314632A AR31463289A AR247555A1 AR 247555 A1 AR247555 A1 AR 247555A1 AR 89314632 A AR89314632 A AR 89314632A AR 31463289 A AR31463289 A AR 31463289A AR 247555 A1 AR247555 A1 AR 247555A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
alcoxy
halogen
aryl
Prior art date
Application number
AR89314632A
Other languages
English (en)
Original Assignee
Nippon Chemiphar Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co filed Critical Nippon Chemiphar Co
Application granted granted Critical
Publication of AR247555A1 publication Critical patent/AR247555A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PREPARACION DE DERIVADOS DE IMIDAZOL DE FORMULA (I), EN DONDE R1 Y R2 SON HIDROGENO, ALQUILO, CICLOALQUILO, ARILO, ARALQUILO, ALQUILO SUSTITUIDO POR HALOGENO, O R1 Y R2 JUNTO CON EL NITROGENO FORMAN UN ANILLO; R3, R4, R5 Y R6 IGUALES O INDEPENDIENTE SON HIDROGENO, HALOGENO, ALCOXI, ARALQUILOXI, ALQUILO, ALCOXICARBONILO, AMINO, NITRO, AMINO O ALQUILO SUSTITUIDO POR FLUOR; R2 COMBINADO CON R3 FORMAN UN ANILLO JUNTO CON EL NITROGENO AL QUE ESTA LIGADO R2 Y LOS ATOMOS DE CARBONO DEL GRUPO FENILO AL QUE ESTA LIGADO R3; R8 Y R9 SON HIDROGENO, HALOGENO, ALCOXI, ALQUILO, ALCOXICARBONILNITRO, AMINO, ACILO, ALQUILO SUSTITUIDO POR FLUOR CON UN ALCOXI SUSTITUIDO POR FLUOR O ARILO SUSTITUIDO O NO POR ALQUILO, ALCOXI O HALOGENO, O R8 Y R9 JUNTO CON DOS ATOMOS DE CARBONO DEL ANILLO IMIDAZOL FORMAN ANILLOS NO AROMATICOS; R7 ES HIDROGENO, ALQUILO SUSTITUIDO O NO POR ARILO, HIDROXILO, ALCOXI, HALOGENO, ARILO SUSTITUIDO O NO POR ALQUILO, ALCOXI, HALOGENO, ARILCARBONILO SUSTITUIDO O NO POR ALQUILO, A LCOXI O HALOGENO, O UN HETEROCICLICO CON AZUFRE; QUE COMPRENDE HACER REACCIONAR COMPUESTOS DE FORMULA II: DONDE X ES UN GRUPO SALIENTE, CON COMPUESTO DE FORMULA III; PARA DAR COMPUESTOS DE FORMULA (IV) Y OXIDAR LOS DERIVADOS DE IMIDAZOL DE FORMULA (IV).
AR89314632A 1988-08-10 1989-08-10 Procedimiento para obtener nuevos derivados de imidazol AR247555A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19952888 1988-08-10
JP63297856A JP2614756B2 (ja) 1988-08-10 1988-11-24 イミダゾール誘導体およびその製造法ならびにこれを含有する抗潰瘍剤

Publications (1)

Publication Number Publication Date
AR247555A1 true AR247555A1 (es) 1995-01-31

Family

ID=26511585

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89314632A AR247555A1 (es) 1988-08-10 1989-08-10 Procedimiento para obtener nuevos derivados de imidazol

Country Status (11)

Country Link
US (1) US5082943A (es)
EP (1) EP0354788B1 (es)
JP (1) JP2614756B2 (es)
KR (1) KR940007314B1 (es)
AR (1) AR247555A1 (es)
AT (1) ATE127793T1 (es)
AU (1) AU624406B2 (es)
CA (1) CA1338599C (es)
DE (1) DE68924221T2 (es)
DK (1) DK392889A (es)
ES (1) ES2076215T3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0412529B1 (en) * 1989-08-10 1994-03-09 Nippon Chemiphar Co., Ltd. Imidazole derivatives, process for the preparation of the same and antiulcer agents containing the same
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
JPH0770083A (ja) * 1993-07-05 1995-03-14 Nippon Chemiphar Co Ltd イミダゾール誘導体を有効成分とする血圧降下剤
WO1995013268A1 (en) * 1993-11-12 1995-05-18 Gyógyszerkutató Intézet Kft. Ulcer-inhibiting triazole derivatives, pharmaceutical compositions containing them and process for preparing same
US5945425A (en) 1994-04-29 1999-08-31 G.D. Searle & Co. Method of using (H+ /K+)ATPase inhibitors as antiviral agents
JP3015702B2 (ja) * 1995-02-21 2000-03-06 株式会社アラクス イミダゾール誘導体及びそれらの薬剤として許容される酸付加塩及びその製造法並びにそれらを有効成分とする抗潰瘍剤
JP3046924B2 (ja) * 1995-03-27 2000-05-29 株式会社アラクス イミダゾリン誘導体又はそれらの可能な互変異性体及びそれらの製造方法並びにそれらを有効成分とする創傷治療薬
WO2000044931A2 (en) * 1999-01-28 2000-08-03 Bion, Inc. High-throughput screening assays for modulators of atpase
KR102225072B1 (ko) * 2019-10-18 2021-03-09 동명대학교산학협력단 기계식 현수 장치용 연결구

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3025484A1 (de) * 1980-07-03 1982-02-04 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
AU4640985A (en) * 1984-08-31 1986-03-06 Nippon Chemiphar Co. Ltd. Benzimidazole derivatives
AU619444B2 (en) * 1986-06-02 1992-01-30 Nippon Chemiphar Co. Ltd. 2-(2-aminobenzylsulfinyl)- benzimidazole derivatives
JPH01501473A (ja) * 1986-09-27 1989-05-25 フアイソンズ・ピーエルシー 化合物
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
IT1222412B (it) * 1987-07-31 1990-09-05 Chiesi Farma Spa Tiometil e sulfinil metil derivati ad azione antisecretiva acida gastrica,loro procedimento di preparazione e composizioni farmaceutiche che li contengono
EP0412529B1 (en) * 1989-08-10 1994-03-09 Nippon Chemiphar Co., Ltd. Imidazole derivatives, process for the preparation of the same and antiulcer agents containing the same

Also Published As

Publication number Publication date
DK392889D0 (da) 1989-08-10
DE68924221D1 (de) 1995-10-19
AU3946189A (en) 1990-02-15
KR940007314B1 (ko) 1994-08-12
DE68924221T2 (de) 1996-02-15
DK392889A (da) 1990-02-11
JP2614756B2 (ja) 1997-05-28
US5082943A (en) 1992-01-21
ATE127793T1 (de) 1995-09-15
JPH02138263A (ja) 1990-05-28
ES2076215T3 (es) 1995-11-01
KR900003135A (ko) 1990-03-23
EP0354788A1 (en) 1990-02-14
AU624406B2 (en) 1992-06-11
EP0354788B1 (en) 1995-09-13
CA1338599C (en) 1996-09-17

Similar Documents

Publication Publication Date Title
DK135791A (da) 1h-imidazooe4,5-caaquinolin-4-amin, farmaceutisk praeparat indeholdende en saadan forbindelse og fremga ngsmaade til fremstilling af forbindelsen
PT96897A (pt) Processo para a preparacao de novos compostos aril-e heteroariletilenicos e de composicoes farmaceuticas que os contem
ES2055056T3 (es) Derivados de pirimidopirimidina.
AR240798A2 (es) Procedimiento para preparar compuestos de trans-1,2-diaminociclohexilamida substituidos
AR018917A1 (es) Compuestos derivados de adenosina que son agonistas en el receptor adenosina a1, proceso para su preparacion, composiciones farmaceuticas que los contienen.
ES2038678T3 (es) Procedimiento para la preparacion de n-(2-alquil-3-mercapto-glutaril)-alfamino-acidos.
AR247555A1 (es) Procedimiento para obtener nuevos derivados de imidazol
DK164554C (da) 3-vinyl- og 3-ethynyl-beta-carbolinderivater og fremgangsmaade til fremstilling heraf
AR246962A1 (es) Procedimiento para preparar derivados alquilamino-alquilenicos de ciertos 2h-1-benzopiranos.
DE69430667D1 (de) Verfahren zur herstellung von fluoralkenylthio heterozyclische derivate
PT83726B (pt) Processo para preparacao de derivados da beta-carbolina substituidas por grupos fenoxi e de composicoes farmaceuticas que os contem
KR960022476A (ko) 디페닐 디설파이드 화합물
EA200301171A1 (ru) Новые соединения трициклических дигидрохинолинов, способ их получения и фармацевтические композиции, содержащие их
MX9307561A (es) Procedimiento para preparar lactonas.
ES8800663A1 (es) Procedimiento para preparar compuestos arilsulfonicos.
YU47071B (sh) Spiro jedinjenje