AR241438A1 - Procedimiento para obtener amidino derivados de mitomicina. - Google Patents
Procedimiento para obtener amidino derivados de mitomicina.Info
- Publication number
- AR241438A1 AR241438A1 AR85301300A AR30130085A AR241438A1 AR 241438 A1 AR241438 A1 AR 241438A1 AR 85301300 A AR85301300 A AR 85301300A AR 30130085 A AR30130085 A AR 30130085A AR 241438 A1 AR241438 A1 AR 241438A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- formula
- ilo
- obtaining
- oando
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCEDIMIENTO PARA OBTENER AMIDINO DERIVADOS DE MITOMICINA DE FORMULA I, DONDE A ES FORMULA II, DONDE R3 Y R4 SON ALQUILO EN CONJUNTO CON EL N FORMAN UN GRUPO PIRROLIDIN-1-ILO O PIPERIDIN-1-ILO;O UN GRUPO DE FORMULA III, IV, V Y VI EN UN SOLVENTE APROTICO POLAR, REACCIONA (I) DONDE A=H2N CON NAH, OANDO, OBTENIENDO UNA FORMA ANIONICA Y LA HACE REACCIONAR CON UN REACTIVO ELECTROFILO CAPAZDE FORMAR DICHO GRUPO AMIDINO, ELEGIDO ENTRE HALUROS DE LOS SUSTITUYENTES YA MENCIONADOS PARA A. ESTOS COMPUESTOS TIENEN MARCADA ACTIVIDAD ANTITUMORAL.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38514982A | 1982-06-04 | 1982-06-04 | |
US06/492,903 US4487769A (en) | 1982-06-04 | 1983-05-09 | Amidines |
Publications (1)
Publication Number | Publication Date |
---|---|
AR241438A1 true AR241438A1 (es) | 1992-07-31 |
Family
ID=27010906
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR85301300A AR241438A1 (es) | 1982-06-04 | 1985-08-16 | Procedimiento para obtener amidino derivados de mitomicina. |
Country Status (27)
Country | Link |
---|---|
US (1) | US4487769A (es) |
KR (1) | KR870000932B1 (es) |
AR (1) | AR241438A1 (es) |
AT (1) | AT394853B (es) |
AU (1) | AU571179B2 (es) |
CA (1) | CA1230333A (es) |
CH (1) | CH657856A5 (es) |
DD (1) | DD210275A5 (es) |
DE (1) | DE3319992A1 (es) |
DK (2) | DK161023C (es) |
ES (3) | ES522948A0 (es) |
FI (1) | FI78700C (es) |
FR (1) | FR2528048B1 (es) |
GB (1) | GB2121796B (es) |
GR (1) | GR78277B (es) |
HU (1) | HU198936B (es) |
IE (1) | IE56107B1 (es) |
IL (1) | IL68852A0 (es) |
IT (1) | IT1206452B (es) |
LU (1) | LU84843A1 (es) |
NL (1) | NL8301949A (es) |
NO (1) | NO161676C (es) |
NZ (1) | NZ204352A (es) |
OA (1) | OA07452A (es) |
PT (1) | PT76810B (es) |
SE (1) | SE455504B (es) |
YU (2) | YU42866B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ206932A (en) * | 1983-02-07 | 1987-08-31 | University Patents Inc | Certain 6-(heterocyclyl or amino) mitosanes and pharmaceutical compositions |
US4803212A (en) * | 1983-04-11 | 1989-02-07 | Bristol-Myers Company | Amino disulfides |
US4579737A (en) * | 1983-05-09 | 1986-04-01 | Bristol-Myers Company | Bis-amidines |
US4642352A (en) * | 1983-12-23 | 1987-02-10 | Bristol-Myers Company | Acylamino mitosanes |
US4814445A (en) * | 1984-09-04 | 1989-03-21 | Bristol-Myers Company | Process for preparing mitomycin analogs |
AU581673B2 (en) * | 1984-09-04 | 1989-03-02 | Bristol-Myers Company | Substituted 7-oxomitosanes |
JPS61176590A (ja) * | 1985-01-31 | 1986-08-08 | Kyowa Hakko Kogyo Co Ltd | 7−n−アミノメチレンマイトマイシン誘導体、製造法及び抗腫瘍剤 |
US4639528A (en) * | 1985-02-21 | 1987-01-27 | Bristol-Myers Company | Crystalline form of 7-(dimethylaminomethylene-amino-9a-methoxymitosane |
AT396688B (de) * | 1985-02-21 | 1993-11-25 | Bristol Myers Squibb Co | Verfahren zur herstellung von kristallinem |
ZA86308B (en) * | 1985-02-25 | 1986-11-26 | Bristol Myers Co | In-vial deposition of 7-(dimethylaminomethylene)amino-9a-methoxy-mitosane |
US4652644A (en) * | 1985-04-29 | 1987-03-24 | Bristol-Myers Company | Process for preparation of N7 -amidino substituted mitomycin C derivatives |
JPH066592B2 (ja) * | 1986-04-18 | 1994-01-26 | 協和醗酵工業株式会社 | マイトマイシン誘導体 |
US4791113A (en) * | 1986-05-14 | 1988-12-13 | Kyowa Hakko Kogyo Kabushiki Kaisha | Mitomycin derivatives as antileukemia agents |
JPS6354380A (ja) * | 1986-08-26 | 1988-03-08 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体 |
JPS63150282A (ja) * | 1986-12-13 | 1988-06-22 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体 |
IL86665A0 (en) * | 1987-06-12 | 1988-11-30 | Bristol Myers Co | Mitomycin analogs |
IL89203A0 (en) * | 1988-02-11 | 1989-09-10 | Univ Houston | 7-substituted hydrazine mitomycin analogs and pharmaceutical compositions containing them |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3660578A (en) * | 1957-04-06 | 1972-05-02 | Kyowa Hakko Kogyo Kk | Mitomycin c |
US3121084A (en) * | 1962-09-17 | 1964-02-11 | Du Pont | Selected n, n, n'-trisubstituted amidines and their preparation by reaction of compounds with-nh2 groups with amide acetals |
NL129868C (es) * | 1963-06-07 | |||
DE1570029A1 (de) * | 1964-07-09 | 1970-04-09 | Kyowa Hakko Kogyo Kk | Verfahren zur Herstellung von Mitosanverbindungen |
US3420846A (en) * | 1964-08-25 | 1969-01-07 | Kyowa Hakko Kogyo Kk | 7-substituted mitomycin a |
US3332944A (en) * | 1964-11-02 | 1967-07-25 | American Cyanamid Co | Antibiotic derivatives of mitomycins a, b, c and porfiromycin |
JPS5439098A (en) * | 1977-08-31 | 1979-03-24 | Kyowa Hakko Kogyo Co Ltd | Mitomycin c derivatives |
US4268676A (en) * | 1979-12-05 | 1981-05-19 | University Patents, Inc. | Mitomycin analogs |
NZ206932A (en) * | 1983-02-07 | 1987-08-31 | University Patents Inc | Certain 6-(heterocyclyl or amino) mitosanes and pharmaceutical compositions |
US4803212A (en) * | 1983-04-11 | 1989-02-07 | Bristol-Myers Company | Amino disulfides |
JPS6073085A (ja) * | 1983-09-28 | 1985-04-25 | Matsushita Refrig Co | ロ−タリ−コンプレツサ |
US4642352A (en) * | 1983-12-23 | 1987-02-10 | Bristol-Myers Company | Acylamino mitosanes |
-
1983
- 1983-05-09 US US06/492,903 patent/US4487769A/en not_active Expired - Fee Related
- 1983-05-25 NZ NZ204352A patent/NZ204352A/en unknown
- 1983-05-26 AU AU15014/83A patent/AU571179B2/en not_active Ceased
- 1983-05-27 FR FR8308807A patent/FR2528048B1/fr not_active Expired
- 1983-06-01 DE DE19833319992 patent/DE3319992A1/de active Granted
- 1983-06-01 NL NL8301949A patent/NL8301949A/nl not_active Application Discontinuation
- 1983-06-01 IL IL68852A patent/IL68852A0/xx not_active IP Right Cessation
- 1983-06-01 FI FI831972A patent/FI78700C/fi not_active IP Right Cessation
- 1983-06-02 GB GB08315205A patent/GB2121796B/en not_active Expired
- 1983-06-03 HU HU834817A patent/HU198936B/hu unknown
- 1983-06-03 SE SE8303160A patent/SE455504B/sv not_active IP Right Cessation
- 1983-06-03 IE IE1320/83A patent/IE56107B1/en not_active IP Right Cessation
- 1983-06-03 DD DD83251741A patent/DD210275A5/de not_active IP Right Cessation
- 1983-06-03 CA CA000429642A patent/CA1230333A/en not_active Expired
- 1983-06-03 YU YU1241/83A patent/YU42866B/xx unknown
- 1983-06-03 IT IT8321461A patent/IT1206452B/it active
- 1983-06-03 ES ES522948A patent/ES522948A0/es active Granted
- 1983-06-03 NO NO832022A patent/NO161676C/no unknown
- 1983-06-03 GR GR71552A patent/GR78277B/el unknown
- 1983-06-03 OA OA58018A patent/OA07452A/xx unknown
- 1983-06-03 LU LU84843A patent/LU84843A1/fr unknown
- 1983-06-03 DK DK253083A patent/DK161023C/da not_active IP Right Cessation
- 1983-06-03 PT PT76810A patent/PT76810B/pt not_active IP Right Cessation
- 1983-06-04 KR KR1019830002499A patent/KR870000932B1/ko not_active IP Right Cessation
- 1983-06-06 AT AT0206483A patent/AT394853B/de not_active IP Right Cessation
- 1983-06-10 CH CH3099/83A patent/CH657856A5/de not_active IP Right Cessation
-
1984
- 1984-02-09 ES ES529585A patent/ES529585A0/es active Granted
- 1984-02-09 ES ES529584A patent/ES8504198A1/es not_active Expired
-
1985
- 1985-08-16 AR AR85301300A patent/AR241438A1/es active
-
1986
- 1986-02-05 YU YU164/86A patent/YU43427B/xx unknown
-
1990
- 1990-11-27 DK DK281490A patent/DK162167C/da not_active IP Right Cessation
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