FR2528048B1 - Amidines de la famille des mitosanes et leur application pharmacologique - Google Patents

Amidines de la famille des mitosanes et leur application pharmacologique

Info

Publication number
FR2528048B1
FR2528048B1 FR8308807A FR8308807A FR2528048B1 FR 2528048 B1 FR2528048 B1 FR 2528048B1 FR 8308807 A FR8308807 A FR 8308807A FR 8308807 A FR8308807 A FR 8308807A FR 2528048 B1 FR2528048 B1 FR 2528048B1
Authority
FR
France
Prior art keywords
mitosan
amidines
pharmacological application
pharmacological
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8308807A
Other languages
English (en)
Other versions
FR2528048A1 (fr
Inventor
Dolatrai Mohanlal Vyas
Takushi Kaneko
Terrence William Doyle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2528048A1 publication Critical patent/FR2528048A1/fr
Application granted granted Critical
Publication of FR2528048B1 publication Critical patent/FR2528048B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR8308807A 1982-06-04 1983-05-27 Amidines de la famille des mitosanes et leur application pharmacologique Expired FR2528048B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38514982A 1982-06-04 1982-06-04
US06/492,903 US4487769A (en) 1982-06-04 1983-05-09 Amidines

Publications (2)

Publication Number Publication Date
FR2528048A1 FR2528048A1 (fr) 1983-12-09
FR2528048B1 true FR2528048B1 (fr) 1986-12-12

Family

ID=27010906

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8308807A Expired FR2528048B1 (fr) 1982-06-04 1983-05-27 Amidines de la famille des mitosanes et leur application pharmacologique

Country Status (27)

Country Link
US (1) US4487769A (fr)
KR (1) KR870000932B1 (fr)
AR (1) AR241438A1 (fr)
AT (1) AT394853B (fr)
AU (1) AU571179B2 (fr)
CA (1) CA1230333A (fr)
CH (1) CH657856A5 (fr)
DD (1) DD210275A5 (fr)
DE (1) DE3319992A1 (fr)
DK (2) DK161023C (fr)
ES (3) ES8407493A1 (fr)
FI (1) FI78700C (fr)
FR (1) FR2528048B1 (fr)
GB (1) GB2121796B (fr)
GR (1) GR78277B (fr)
HU (1) HU198936B (fr)
IE (1) IE56107B1 (fr)
IL (1) IL68852A0 (fr)
IT (1) IT1206452B (fr)
LU (1) LU84843A1 (fr)
NL (1) NL8301949A (fr)
NO (1) NO161676C (fr)
NZ (1) NZ204352A (fr)
OA (1) OA07452A (fr)
PT (1) PT76810B (fr)
SE (1) SE455504B (fr)
YU (2) YU42866B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ206932A (en) * 1983-02-07 1987-08-31 University Patents Inc Certain 6-(heterocyclyl or amino) mitosanes and pharmaceutical compositions
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
US4579737A (en) * 1983-05-09 1986-04-01 Bristol-Myers Company Bis-amidines
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes
US4814445A (en) * 1984-09-04 1989-03-21 Bristol-Myers Company Process for preparing mitomycin analogs
AU581673B2 (en) * 1984-09-04 1989-03-02 Bristol-Myers Company Substituted 7-oxomitosanes
JPS61176590A (ja) * 1985-01-31 1986-08-08 Kyowa Hakko Kogyo Co Ltd ７−ｎ−アミノメチレンマイトマイシン誘導体、製造法及び抗腫瘍剤
AT396688B (de) * 1985-02-21 1993-11-25 Bristol Myers Squibb Co Verfahren zur herstellung von kristallinem
US4639528A (en) * 1985-02-21 1987-01-27 Bristol-Myers Company Crystalline form of 7-(dimethylaminomethylene-amino-9a-methoxymitosane
ZA86308B (en) * 1985-02-25 1986-11-26 Bristol Myers Co In-vial deposition of 7-(dimethylaminomethylene)amino-9a-methoxy-mitosane
US4652644A (en) * 1985-04-29 1987-03-24 Bristol-Myers Company Process for preparation of N7 -amidino substituted mitomycin C derivatives
JPH066592B2 (ja) * 1986-04-18 1994-01-26 協和醗酵工業株式会社 マイトマイシン誘導体
US4791113A (en) * 1986-05-14 1988-12-13 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives as antileukemia agents
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS63150282A (ja) * 1986-12-13 1988-06-22 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
IL86665A0 (en) * 1987-06-12 1988-11-30 Bristol Myers Co Mitomycin analogs
IL89203A0 (en) * 1988-02-11 1989-09-10 Univ Houston 7-substituted hydrazine mitomycin analogs and pharmaceutical compositions containing them

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3660578A (en) * 1957-04-06 1972-05-02 Kyowa Hakko Kogyo Kk Mitomycin c
US3121084A (en) * 1962-09-17 1964-02-11 Du Pont Selected n, n, n'-trisubstituted amidines and their preparation by reaction of compounds with-nh2 groups with amide acetals
NL129868C (fr) * 1963-06-07
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
US3420846A (en) * 1964-08-25 1969-01-07 Kyowa Hakko Kogyo Kk 7-substituted mitomycin a
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin
JPS5439098A (en) * 1977-08-31 1979-03-24 Kyowa Hakko Kogyo Co Ltd Mitomycin c derivatives
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
NZ206932A (en) * 1983-02-07 1987-08-31 University Patents Inc Certain 6-(heterocyclyl or amino) mitosanes and pharmaceutical compositions
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
JPS6073085A (ja) * 1983-09-28 1985-04-25 Matsushita Refrig Co ロ−タリ−コンプレツサ
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes

Also Published As

Publication number Publication date
GB2121796A (en) 1984-01-04
FI78700C (fi) 1989-09-11
FI831972L (fi) 1983-12-05
DK281490D0 (da) 1990-11-27
SE8303160L (sv) 1984-01-27
ES529585A0 (es) 1985-04-16
SE8303160D0 (sv) 1983-06-03
IE56107B1 (en) 1991-04-24
YU124183A (en) 1986-06-30
DE3319992C2 (fr) 1991-11-21
ATA206483A (de) 1991-12-15
HU198936B (en) 1989-12-28
ES8504198A1 (es) 1985-04-16
KR840005143A (ko) 1984-11-03
OA07452A (fr) 1984-03-31
YU42866B (en) 1988-12-31
ES8504199A1 (es) 1985-04-16
LU84843A1 (fr) 1984-03-07
NO161676B (no) 1989-06-05
YU16486A (en) 1986-12-31
IT1206452B (it) 1989-04-27
AU571179B2 (en) 1988-04-14
DE3319992A1 (de) 1983-12-08
NO832022L (no) 1983-12-05
DK281490A (da) 1990-11-27
ES529584A0 (es) 1985-04-16
DK161023C (da) 1991-10-28
IE831320L (en) 1983-12-04
FR2528048A1 (fr) 1983-12-09
DD210275A5 (de) 1984-06-06
CH657856A5 (de) 1986-09-30
IT8321461A0 (it) 1983-06-03
PT76810A (en) 1983-07-01
US4487769A (en) 1984-12-11
NL8301949A (nl) 1984-01-02
GR78277B (fr) 1984-09-26
YU43427B (en) 1989-06-30
DK162167B (da) 1991-09-23
NZ204352A (en) 1987-07-31
DK162167C (da) 1992-02-24
GB2121796B (en) 1986-03-12
SE455504B (sv) 1988-07-18
AT394853B (de) 1992-07-10
AR241438A1 (es) 1992-07-31
NO161676C (no) 1989-09-13
ES522948A0 (es) 1984-10-01
FI78700B (fi) 1989-05-31
DK253083D0 (da) 1983-06-03
PT76810B (en) 1986-04-09
IL68852A0 (en) 1983-10-31
GB8315205D0 (en) 1983-07-06
AU1501483A (en) 1983-12-08
KR870000932B1 (ko) 1987-05-11
DK253083A (da) 1983-12-05
CA1230333A (fr) 1987-12-15
FI831972A0 (fi) 1983-06-01
ES8407493A1 (es) 1984-10-01
DK161023B (da) 1991-05-21

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