ES8504199A1 - Un procedimiento para la preparacion de nuevos analogos de mitomicina - Google Patents
Un procedimiento para la preparacion de nuevos analogos de mitomicinaInfo
- Publication number
- ES8504199A1 ES8504199A1 ES529585A ES529585A ES8504199A1 ES 8504199 A1 ES8504199 A1 ES 8504199A1 ES 529585 A ES529585 A ES 529585A ES 529585 A ES529585 A ES 529585A ES 8504199 A1 ES8504199 A1 ES 8504199A1
- Authority
- ES
- Spain
- Prior art keywords
- mitomycin
- activity against
- antitumor activity
- experimental animal
- produce
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ANALOGOS DE MITOMICINA, DE FORMULA (I), EN LA QUE A Y R PUEDEN SER VARIOS RADICALES; B ES AMINO; Y N VALE 0-3.CONSISTE EN LA REACCION DE IMTOMICINA C, DISUELTA EN DIMETILFORMAMIDA, CON 1 A 1,5 MOLES DE HIDRURO SODICO POR MOL DE MITOMICINA C; SEGUIDA DE LA REACCION DE LA FORMA ANIONICA DE LA MITOMICINA FORMADA CON UN REACTIVO ELECTROFILO CAPAZ DE FORMAR EL GRUPO AMIDINO.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTITUMORAL.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38514982A | 1982-06-04 | 1982-06-04 | |
US06/492,903 US4487769A (en) | 1982-06-04 | 1983-05-09 | Amidines |
Publications (2)
Publication Number | Publication Date |
---|---|
ES529585A0 ES529585A0 (es) | 1985-04-16 |
ES8504199A1 true ES8504199A1 (es) | 1985-04-16 |
Family
ID=27010906
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522948A Expired ES8407493A1 (es) | 1982-06-04 | 1983-06-03 | Un procedimiento para la preparacion de nuevos analogos mitomicina. |
ES529585A Expired ES8504199A1 (es) | 1982-06-04 | 1984-02-09 | Un procedimiento para la preparacion de nuevos analogos de mitomicina |
ES529584A Granted ES529584A0 (es) | 1982-06-04 | 1984-02-09 | Un procedimiento para la preparacion de un 7-amino sustituido-9a-metoximitosano |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES522948A Expired ES8407493A1 (es) | 1982-06-04 | 1983-06-03 | Un procedimiento para la preparacion de nuevos analogos mitomicina. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES529584A Granted ES529584A0 (es) | 1982-06-04 | 1984-02-09 | Un procedimiento para la preparacion de un 7-amino sustituido-9a-metoximitosano |
Country Status (27)
Country | Link |
---|---|
US (1) | US4487769A (es) |
KR (1) | KR870000932B1 (es) |
AR (1) | AR241438A1 (es) |
AT (1) | AT394853B (es) |
AU (1) | AU571179B2 (es) |
CA (1) | CA1230333A (es) |
CH (1) | CH657856A5 (es) |
DD (1) | DD210275A5 (es) |
DE (1) | DE3319992A1 (es) |
DK (2) | DK161023C (es) |
ES (3) | ES8407493A1 (es) |
FI (1) | FI78700C (es) |
FR (1) | FR2528048B1 (es) |
GB (1) | GB2121796B (es) |
GR (1) | GR78277B (es) |
HU (1) | HU198936B (es) |
IE (1) | IE56107B1 (es) |
IL (1) | IL68852A0 (es) |
IT (1) | IT1206452B (es) |
LU (1) | LU84843A1 (es) |
NL (1) | NL8301949A (es) |
NO (1) | NO161676C (es) |
NZ (1) | NZ204352A (es) |
OA (1) | OA07452A (es) |
PT (1) | PT76810B (es) |
SE (1) | SE455504B (es) |
YU (2) | YU42866B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ206932A (en) * | 1983-02-07 | 1987-08-31 | University Patents Inc | Certain 6-(heterocyclyl or amino) mitosanes and pharmaceutical compositions |
US4803212A (en) * | 1983-04-11 | 1989-02-07 | Bristol-Myers Company | Amino disulfides |
US4579737A (en) * | 1983-05-09 | 1986-04-01 | Bristol-Myers Company | Bis-amidines |
US4642352A (en) * | 1983-12-23 | 1987-02-10 | Bristol-Myers Company | Acylamino mitosanes |
AU581673B2 (en) * | 1984-09-04 | 1989-03-02 | Bristol-Myers Company | Substituted 7-oxomitosanes |
US4814445A (en) * | 1984-09-04 | 1989-03-21 | Bristol-Myers Company | Process for preparing mitomycin analogs |
JPS61176590A (ja) * | 1985-01-31 | 1986-08-08 | Kyowa Hakko Kogyo Co Ltd | 7−n−アミノメチレンマイトマイシン誘導体、製造法及び抗腫瘍剤 |
AT396688B (de) * | 1985-02-21 | 1993-11-25 | Bristol Myers Squibb Co | Verfahren zur herstellung von kristallinem |
US4639528A (en) * | 1985-02-21 | 1987-01-27 | Bristol-Myers Company | Crystalline form of 7-(dimethylaminomethylene-amino-9a-methoxymitosane |
ZA86308B (en) * | 1985-02-25 | 1986-11-26 | Bristol Myers Co | In-vial deposition of 7-(dimethylaminomethylene)amino-9a-methoxy-mitosane |
US4652644A (en) * | 1985-04-29 | 1987-03-24 | Bristol-Myers Company | Process for preparation of N7 -amidino substituted mitomycin C derivatives |
JPH066592B2 (ja) * | 1986-04-18 | 1994-01-26 | 協和醗酵工業株式会社 | マイトマイシン誘導体 |
US4791113A (en) * | 1986-05-14 | 1988-12-13 | Kyowa Hakko Kogyo Kabushiki Kaisha | Mitomycin derivatives as antileukemia agents |
JPS6354380A (ja) * | 1986-08-26 | 1988-03-08 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体 |
JPS63150282A (ja) * | 1986-12-13 | 1988-06-22 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体 |
IL86665A0 (en) * | 1987-06-12 | 1988-11-30 | Bristol Myers Co | Mitomycin analogs |
IL89203A0 (en) * | 1988-02-11 | 1989-09-10 | Univ Houston | 7-substituted hydrazine mitomycin analogs and pharmaceutical compositions containing them |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3660578A (en) * | 1957-04-06 | 1972-05-02 | Kyowa Hakko Kogyo Kk | Mitomycin c |
US3121084A (en) * | 1962-09-17 | 1964-02-11 | Du Pont | Selected n, n, n'-trisubstituted amidines and their preparation by reaction of compounds with-nh2 groups with amide acetals |
NL129868C (es) * | 1963-06-07 | |||
DE1570029A1 (de) * | 1964-07-09 | 1970-04-09 | Kyowa Hakko Kogyo Kk | Verfahren zur Herstellung von Mitosanverbindungen |
US3420846A (en) * | 1964-08-25 | 1969-01-07 | Kyowa Hakko Kogyo Kk | 7-substituted mitomycin a |
US3332944A (en) * | 1964-11-02 | 1967-07-25 | American Cyanamid Co | Antibiotic derivatives of mitomycins a, b, c and porfiromycin |
JPS5439098A (en) * | 1977-08-31 | 1979-03-24 | Kyowa Hakko Kogyo Co Ltd | Mitomycin c derivatives |
US4268676A (en) * | 1979-12-05 | 1981-05-19 | University Patents, Inc. | Mitomycin analogs |
NZ206932A (en) * | 1983-02-07 | 1987-08-31 | University Patents Inc | Certain 6-(heterocyclyl or amino) mitosanes and pharmaceutical compositions |
US4803212A (en) * | 1983-04-11 | 1989-02-07 | Bristol-Myers Company | Amino disulfides |
JPS6073085A (ja) * | 1983-09-28 | 1985-04-25 | Matsushita Refrig Co | ロ−タリ−コンプレツサ |
US4642352A (en) * | 1983-12-23 | 1987-02-10 | Bristol-Myers Company | Acylamino mitosanes |
-
1983
- 1983-05-09 US US06/492,903 patent/US4487769A/en not_active Expired - Fee Related
- 1983-05-25 NZ NZ204352A patent/NZ204352A/en unknown
- 1983-05-26 AU AU15014/83A patent/AU571179B2/en not_active Ceased
- 1983-05-27 FR FR8308807A patent/FR2528048B1/fr not_active Expired
- 1983-06-01 FI FI831972A patent/FI78700C/fi not_active IP Right Cessation
- 1983-06-01 IL IL68852A patent/IL68852A0/xx not_active IP Right Cessation
- 1983-06-01 DE DE19833319992 patent/DE3319992A1/de active Granted
- 1983-06-01 NL NL8301949A patent/NL8301949A/nl not_active Application Discontinuation
- 1983-06-02 GB GB08315205A patent/GB2121796B/en not_active Expired
- 1983-06-03 DK DK253083A patent/DK161023C/da not_active IP Right Cessation
- 1983-06-03 IE IE1320/83A patent/IE56107B1/en not_active IP Right Cessation
- 1983-06-03 ES ES522948A patent/ES8407493A1/es not_active Expired
- 1983-06-03 HU HU834817A patent/HU198936B/hu unknown
- 1983-06-03 DD DD83251741A patent/DD210275A5/de not_active IP Right Cessation
- 1983-06-03 PT PT76810A patent/PT76810B/pt not_active IP Right Cessation
- 1983-06-03 LU LU84843A patent/LU84843A1/fr unknown
- 1983-06-03 NO NO832022A patent/NO161676C/no unknown
- 1983-06-03 OA OA58018A patent/OA07452A/xx unknown
- 1983-06-03 GR GR71552A patent/GR78277B/el unknown
- 1983-06-03 YU YU1241/83A patent/YU42866B/xx unknown
- 1983-06-03 IT IT8321461A patent/IT1206452B/it active
- 1983-06-03 CA CA000429642A patent/CA1230333A/en not_active Expired
- 1983-06-03 SE SE8303160A patent/SE455504B/sv not_active IP Right Cessation
- 1983-06-04 KR KR1019830002499A patent/KR870000932B1/ko not_active IP Right Cessation
- 1983-06-06 AT AT0206483A patent/AT394853B/de not_active IP Right Cessation
- 1983-06-10 CH CH3099/83A patent/CH657856A5/de not_active IP Right Cessation
-
1984
- 1984-02-09 ES ES529585A patent/ES8504199A1/es not_active Expired
- 1984-02-09 ES ES529584A patent/ES529584A0/es active Granted
-
1985
- 1985-08-16 AR AR85301300A patent/AR241438A1/es active
-
1986
- 1986-02-05 YU YU164/86A patent/YU43427B/xx unknown
-
1990
- 1990-11-27 DK DK281490A patent/DK162167C/da not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20041004 |