ES2001108A6 - Un procedimiento para la preparacion de un derivado de gem-dihalo-1,8-diamino -4 -aza-octano. - Google Patents
Un procedimiento para la preparacion de un derivado de gem-dihalo-1,8-diamino -4 -aza-octano.Info
- Publication number
- ES2001108A6 ES2001108A6 ES8601227A ES8601227A ES2001108A6 ES 2001108 A6 ES2001108 A6 ES 2001108A6 ES 8601227 A ES8601227 A ES 8601227A ES 8601227 A ES8601227 A ES 8601227A ES 2001108 A6 ES2001108 A6 ES 2001108A6
- Authority
- ES
- Spain
- Prior art keywords
- dihalo
- gem
- aza
- diamino
- octanes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DE GEM-DIHALO-1,8-DIAMINO-4-AZA-OCTANO. COMPRENDE: 1) REACCION DE (II) CON BROMURO DE BENCILO DANDO (III), SEPARACION DE LOS ISOMEROS Y REACCION CON FTALIMIDURO POTASICO DANDO (IV) QUE REACCIONA CON HIDRAZINA SEGUIDO DE PROTECCION DANDO (V) QUE SE ALQUILA PARA DAR (VI), SEGUIDO DE REACCION CON CLORURO DE METANOSULFONILO Y CON FTALIMIDURO DE POTASIO DANDO (VII) QUE REACCIONA CON HIDRAZINA DE CALEFACCION CON HBR PARA DAR (VIII); 2) REACCION DE UN 2,2-DIHALO-1,4-BUTANODIOL CON CLORURO DE METANOSULFONILO SEGUIDO DE CALEFACCION CON DIAZABICICLOUNDECENO DANDO (IX) QUE REACCIONA CON FTALIMIDURO POTASICO SEGUIDO DE RUPTURA DANDO (X) QUE SE PROTEGE Y ALQUILA DANDO (XI) QUE SE OXIDA Y REDUCE DANDO (XII) EL CUAL REACCIONA CON CLORURO DE METANOSULFONILO Y CON FTALIMIDURO POTASIDO DANDO (XIII) QUE SE CALIENTA CON HIDRAZINA Y CON HBR DANDO (XIV). LOS COMPUESTOS (I) SON UTILES COMO AGENTES ANTIPROLIFERATIVOS O ANTITUMORALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/767,928 US4695654A (en) | 1985-08-21 | 1985-08-21 | Gem-dihalo-1,8-diamino-4-aza-octanes |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2001108A6 true ES2001108A6 (es) | 1988-04-16 |
Family
ID=25080994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8601227A Expired ES2001108A6 (es) | 1985-08-21 | 1986-08-20 | Un procedimiento para la preparacion de un derivado de gem-dihalo-1,8-diamino -4 -aza-octano. |
Country Status (20)
Country | Link |
---|---|
US (2) | US4695654A (es) |
EP (1) | EP0215319B1 (es) |
JP (1) | JPH0667880B2 (es) |
KR (1) | KR900006132B1 (es) |
CN (1) | CN1012732B (es) |
AR (1) | AR242018A1 (es) |
AT (1) | ATE68471T1 (es) |
AU (1) | AU584730B2 (es) |
CA (1) | CA1265159C (es) |
DE (1) | DE3682007D1 (es) |
DK (1) | DK396886A (es) |
ES (1) | ES2001108A6 (es) |
FI (1) | FI84816C (es) |
GR (1) | GR862149B (es) |
HU (1) | HU200987B (es) |
IL (1) | IL79752A0 (es) |
NO (1) | NO164972C (es) |
NZ (1) | NZ217248A (es) |
PT (1) | PT83231B (es) |
ZA (1) | ZA866181B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1274547C (en) * | 1985-08-21 | 1990-09-25 | GEM-DIHALO AND TETRAHALO-1,12-DIAMINO-4,9-DIAZA- DODECANES | |
FI884720A (fi) * | 1987-10-15 | 1989-04-16 | Univ Moskovsk | Kompositioner foer anvaendning som kontrastmedel. |
EP0338168A1 (en) * | 1988-04-19 | 1989-10-25 | Merrell Dow Pharmaceuticals Inc. | Phosphonoalkylpurine derivatives |
GB9301898D0 (en) * | 1993-01-30 | 1993-03-17 | Univ Liverpool | Method for localising and measuring the profileration of cancer and compositions for same |
US5834456A (en) * | 1996-02-23 | 1998-11-10 | The Dow Chemical Company | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
CN114685325B (zh) * | 2020-12-29 | 2024-05-28 | 苏州瑞博生物技术股份有限公司 | 一种含胺化合物及其制备方法和用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4004996A (en) * | 1974-12-23 | 1977-01-25 | Merck & Co., Inc. | Fluorination of organic compounds |
GB2082579B (en) * | 1980-08-23 | 1984-02-08 | Merrell Toraude & Co | Fluorinated diaminobutane derivatives |
US4720489A (en) * | 1984-10-15 | 1988-01-19 | Douglas Shander | Hair growth modification with ornithine decarboxylase inhibitors |
CA1274547C (en) * | 1985-08-21 | 1990-09-25 | GEM-DIHALO AND TETRAHALO-1,12-DIAMINO-4,9-DIAZA- DODECANES |
-
1985
- 1985-08-21 US US06/767,928 patent/US4695654A/en not_active Expired - Lifetime
-
1986
- 1986-08-14 CA CA515965A patent/CA1265159C/en not_active Expired
- 1986-08-15 ZA ZA866181A patent/ZA866181B/xx unknown
- 1986-08-18 AU AU61558/86A patent/AU584730B2/en not_active Ceased
- 1986-08-18 NZ NZ217248A patent/NZ217248A/xx unknown
- 1986-08-18 IL IL79752A patent/IL79752A0/xx not_active IP Right Cessation
- 1986-08-18 GR GR862149A patent/GR862149B/el unknown
- 1986-08-18 HU HU863619A patent/HU200987B/hu not_active IP Right Cessation
- 1986-08-19 JP JP61192210A patent/JPH0667880B2/ja not_active Expired - Lifetime
- 1986-08-19 AR AR86304958A patent/AR242018A1/es active
- 1986-08-19 FI FI863352A patent/FI84816C/fi not_active IP Right Cessation
- 1986-08-20 DK DK396886A patent/DK396886A/da not_active Application Discontinuation
- 1986-08-20 NO NO863343A patent/NO164972C/no unknown
- 1986-08-20 ES ES8601227A patent/ES2001108A6/es not_active Expired
- 1986-08-20 CN CN86105154A patent/CN1012732B/zh not_active Expired
- 1986-08-20 DE DE8686111503T patent/DE3682007D1/de not_active Expired - Fee Related
- 1986-08-20 PT PT83231A patent/PT83231B/pt not_active IP Right Cessation
- 1986-08-20 AT AT86111503T patent/ATE68471T1/de not_active IP Right Cessation
- 1986-08-20 EP EP86111503A patent/EP0215319B1/en not_active Expired - Lifetime
- 1986-08-21 KR KR1019860006895A patent/KR900006132B1/ko not_active IP Right Cessation
-
1987
- 1987-06-15 US US07/062,302 patent/US4851448A/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20100528 |