ATE466873T1 - Verfahren zur herstellung eines rekombinanten peptids aus spinnengift, und das peptid enthaltende analgetische zusammensetzung - Google Patents
Verfahren zur herstellung eines rekombinanten peptids aus spinnengift, und das peptid enthaltende analgetische zusammensetzungInfo
- Publication number
- ATE466873T1 ATE466873T1 AT06799316T AT06799316T ATE466873T1 AT E466873 T1 ATE466873 T1 AT E466873T1 AT 06799316 T AT06799316 T AT 06799316T AT 06799316 T AT06799316 T AT 06799316T AT E466873 T1 ATE466873 T1 AT E466873T1
- Authority
- AT
- Austria
- Prior art keywords
- peptide
- gsmtx4
- producing
- recombinant
- present
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 230000000202 analgesic effect Effects 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 239000002708 spider venom Substances 0.000 title abstract 2
- 101000623875 Grammostola rosea M-theraphotoxin-Gr1a Proteins 0.000 abstract 4
- WVDNTWXIIKNMHY-UHFFFAOYSA-N GsMTx4 Chemical compound O=C1NC(CC=2C3=CC=CC=C3NC=2)C(=O)NC(CC=2C3=CC=CC=C3NC=2)C(=O)NC(CCCCN)C(=O)NC(C(NC(CC(N)=O)C(=O)N2CCCC2C(=O)NC(CC(N)=O)C(=O)NC(CC(O)=O)C(=O)NC(CC(O)=O)C(=O)NC(CCCCN)C(=O)NC(CSSCC(NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CC=2C=CC=CC=2)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(CO)NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CO)C(=O)NC(CC=3C=CC=CC=3)C(N)=O)C(=O)N3)=O)CSSCC2NC(=O)C(CCCCN)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C2CCCN2C(=O)C(CCCNC(N)=N)NC(=O)C3CSSCC(NC(=O)CN)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC1CC1=CC=CC=C1 WVDNTWXIIKNMHY-UHFFFAOYSA-N 0.000 abstract 4
- 108010025188 Alcohol oxidase Proteins 0.000 abstract 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 102000004310 Ion Channels Human genes 0.000 abstract 1
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- IXKSXJFAGXLQOQ-XISFHERQSA-N WHWLQLKPGQPMY Chemical compound C([C@@H](C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)C1=CNC=N1 IXKSXJFAGXLQOQ-XISFHERQSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000013613 expression plasmid Substances 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 210000005253 yeast cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Insects & Arthropods (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020050098082A KR100761790B1 (ko) | 2005-10-18 | 2005-10-18 | ＧｓＭＴｘ4 유전자를 포함하는 효모 발현용 재조합플라스미드 및 이를 이용한 칠레산 타란툴라 거미독펩타이드 ＧｓＭＴｘ4의 생산 방법 |
| KR1020060001918A KR100761792B1 (ko) | 2006-01-06 | 2006-01-06 | ＧｓＭＴｘ4 펩타이드 및 그 유도체를 유효성분으로함유하는 통증치료용 조성물 |
| PCT/KR2006/004242 WO2007046634A1 (en) | 2005-10-18 | 2006-10-18 | Method for preparing recombinant peptide from spider venom and analgesic composition containing the peptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE466873T1 true ATE466873T1 (de) | 2010-05-15 |
Family
ID=37962693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06799316T ATE466873T1 (de) | 2005-10-18 | 2006-10-18 | Verfahren zur herstellung eines rekombinanten peptids aus spinnengift, und das peptid enthaltende analgetische zusammensetzung |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20090023183A1 (de) |
| EP (1) | EP1948679B1 (de) |
| AT (1) | ATE466873T1 (de) |
| DE (1) | DE602006014186D1 (de) |
| WO (1) | WO2007046634A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0605484A8 (pt) * | 2006-11-21 | 2017-03-07 | Fund Amparo Pesquisa Estado Minas Gerais Fapemig | Toxina ph(alfa)1b, cdna do gene da toxina ph(alfa)1b, composições farmacêuticas contendo a toxina ph(alfa)1b, processo para sua obtenção, processo para obtenção do cdna, e produto |
| CN104838437B (zh) | 2012-10-04 | 2017-12-22 | 纳米技术有限公司 | 使用量子点的照明标识 |
| US9551718B2 (en) | 2014-06-20 | 2017-01-24 | The Royal Institution For The Advancement Of Learning/Mcgill University | TMEM120A ion channel modulator |
| WO2017068388A2 (pt) * | 2015-09-18 | 2017-04-27 | Universidade Federal De Minas Gerais - Ufmg | Uso do peptideo sintetico pntx-19 para tratamento de dor |
| CN106632603B (zh) * | 2016-12-09 | 2019-05-17 | 唐琼瑶 | 一组肽及其药物组合物和应用 |
| CN110475867A (zh) | 2017-04-04 | 2019-11-19 | 贝勒大学 | 靶向型杀蚊毒素 |
| CN113214376B (zh) * | 2021-03-30 | 2023-09-19 | 青岛大学 | 一种新的合成蜈蚣毒素RhTx和蜘蛛毒素GsMTx4的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993004061A1 (en) * | 1991-08-14 | 1993-03-04 | Procter & Gamble Pharmaceuticals | Novel 4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents |
| KR0127776B1 (ko) * | 1994-10-11 | 1997-12-29 | 허영섭 | 신규한 단백질 분해효소의 cDNA 서열 및 그로 부터 유래된 단백질 |
| US5756663A (en) * | 1996-01-03 | 1998-05-26 | Zeneca Limited | Antiarrhythmic peptide from venom of spider Grammostola spatulata |
| US7125847B1 (en) * | 2000-04-07 | 2006-10-24 | The Research Foundation Of State University Of New York At Buffalo | Mechanically activated channel blocker |
-
2006
- 2006-10-18 AT AT06799316T patent/ATE466873T1/de not_active IP Right Cessation
- 2006-10-18 WO PCT/KR2006/004242 patent/WO2007046634A1/en not_active Ceased
- 2006-10-18 EP EP06799316A patent/EP1948679B1/de not_active Not-in-force
- 2006-10-18 US US12/090,664 patent/US20090023183A1/en not_active Abandoned
- 2006-10-18 DE DE602006014186T patent/DE602006014186D1/de active Active
-
2010
- 2010-10-19 US US12/907,475 patent/US20120015886A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007046634A1 (en) | 2007-04-26 |
| EP1948679B1 (de) | 2010-05-05 |
| EP1948679A4 (de) | 2009-06-17 |
| US20120015886A1 (en) | 2012-01-19 |
| EP1948679A1 (de) | 2008-07-30 |
| US20090023183A1 (en) | 2009-01-22 |
| DE602006014186D1 (de) | 2010-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |