RU93035829A - Производные аминохинолона, замещенные арильной или гетероароматической группой, и анти-вич средства - Google Patents
Производные аминохинолона, замещенные арильной или гетероароматической группой, и анти-вич средстваInfo
- Publication number
- RU93035829A RU93035829A RU93035829/04A RU93035829A RU93035829A RU 93035829 A RU93035829 A RU 93035829A RU 93035829/04 A RU93035829/04 A RU 93035829/04A RU 93035829 A RU93035829 A RU 93035829A RU 93035829 A RU93035829 A RU 93035829A
- Authority
- RU
- Russia
- Prior art keywords
- aryl
- aminoquinolone
- heteroaromatic group
- derivatives substituted
- hiv drugs
- Prior art date
Links
- KWMUSDDZNYHIBR-UHFFFAOYSA-N 3-amino-1H-quinolin-2-one Chemical group C1=CC=C2NC(=O)C(N)=CC2=C1 KWMUSDDZNYHIBR-UHFFFAOYSA-N 0.000 title claims 2
- 125000003118 aryl group Chemical group 0.000 title claims 2
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 2
- 206010000565 Acquired immunodeficiency syndrome Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
Claims (1)
- Раскрываются соединения аминохинолона, замещенные арильными или гетероциклическими группами, изображаемые формулами (1а), (1b) или (1с), в которых каждый из заместителей имеет значения, установленные в описании, или соли этих соединений, и средство для лечения СПИДа, содержащее такие соединения в качестве эффективного ингредиента.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP158912/92 | 1992-05-27 | ||
JP15891292 | 1992-05-27 | ||
JP158912/1992 | 1992-05-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU93035829A true RU93035829A (ru) | 1996-06-20 |
RU2124510C1 RU2124510C1 (ru) | 1999-01-10 |
Family
ID=15682065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU93035829A RU2124510C1 (ru) | 1992-05-27 | 1993-05-26 | Производные аминохинолона, замещенные фенильной или гетероароматической группой |
Country Status (18)
Country | Link |
---|---|
US (2) | US5519016A (ru) |
EP (1) | EP0572259A1 (ru) |
KR (1) | KR100266305B1 (ru) |
CN (1) | CN1042936C (ru) |
AU (1) | AU656859B2 (ru) |
CA (1) | CA2096998A1 (ru) |
CZ (1) | CZ99693A3 (ru) |
FI (1) | FI932412A (ru) |
HU (1) | HUT64051A (ru) |
ID (1) | ID20476A (ru) |
IL (1) | IL105806A (ru) |
MX (1) | MX9303158A (ru) |
NO (1) | NO304832B1 (ru) |
NZ (1) | NZ247720A (ru) |
PH (1) | PH31078A (ru) |
RU (1) | RU2124510C1 (ru) |
TW (1) | TW234121B (ru) |
ZA (1) | ZA933732B (ru) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4329600A1 (de) * | 1993-09-02 | 1995-03-09 | Bayer Ag | Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate |
AU683569B2 (en) * | 1994-07-18 | 1997-11-13 | Sankyo Company Limited | Trifluoromethylquinolinecarboxylic acid derivative |
DE4425649A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Neue 1-[4-(Aminomethyl)phenyl] substituierte Chinoloncarbonsäuren |
DE4425660A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | 7-substituierte 1-[4-(1H-1,2,4-triazol-1-yl-methyl)phenyl] substituierte Chinoloncarbonsäuren |
DE4425647A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Heterocyclyl-1-phenyl substituierte Chinoloncarbonsäuren |
CA2205406C (en) * | 1994-11-24 | 2008-02-05 | F. Hoffmann-La Roche Ag | Novel benzyl pyrimidines |
US5620997A (en) * | 1995-05-31 | 1997-04-15 | Warner-Lambert Company | Isothiazolones |
ATE222906T1 (de) * | 1995-09-22 | 2002-09-15 | Wakunaga Pharma Co Ltd | Pyridoncarbonsäurederivate als antibakterielle wirkstoffe |
US6001863A (en) * | 1996-11-26 | 1999-12-14 | Warner-Lambert Company | Isothiazolones |
US6387928B1 (en) | 1997-09-15 | 2002-05-14 | The Procter & Gamble Co. | Antimicrobial quinolones, their compositions and uses |
JP4669607B2 (ja) * | 1997-09-15 | 2011-04-13 | ザ プロクター アンド ギャンブル カンパニー | 抗微生物キノロン類、その組成物およびその使用 |
DE19751948A1 (de) * | 1997-11-24 | 1999-05-27 | Bayer Ag | Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren |
IL124195A (en) * | 1998-04-23 | 2000-08-31 | Chemagis Ltd | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
DE69931974D1 (de) * | 1998-08-12 | 2006-07-27 | Ihara Chemical Ind Co | N-Cyclopropyl-2-difluormethoxy-3-bromanilin und ein Zwischenprodukt zu seiner Herstellung |
AU1783700A (en) * | 1998-12-21 | 2000-07-12 | Aventis Pharma S.A. | 1,8-benzonaphthyridine derivatives |
PT1262477E (pt) * | 2000-02-09 | 2008-11-14 | Daiichi Sankyo Co Ltd | Agentes anti-bacterianos resistentes a ácidos contendo, como princípio activo, ácidos piridinocarboxílicos |
US6514529B2 (en) | 2000-03-22 | 2003-02-04 | Pharmacia & Upjohn Company | Oxazolidinone tablet formulation |
MY127336A (en) | 2000-03-22 | 2006-11-30 | Upjohn Co | Container for linezolid iv solution |
US6608078B2 (en) | 2000-05-08 | 2003-08-19 | Wockhardt Limited | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
US7098219B2 (en) | 2000-08-01 | 2006-08-29 | Wockhart Limited | Inhibitors of cellular efflux pumps of microbes |
PE20020578A1 (es) | 2000-10-10 | 2002-08-14 | Upjohn Co | Una composicion de antibiotico topico para el tratamiento de infecciones oculares |
NZ525571A (en) | 2000-12-14 | 2004-09-24 | Procter & Gamble | Antimicrobial quinolones |
IL155678A0 (en) | 2000-12-14 | 2003-11-23 | Procter & Gamble | Antimicrobial 2-pyridones, their compositions and uses |
US6964966B2 (en) | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US6878713B2 (en) | 2001-04-25 | 2005-04-12 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
BR0307898A (pt) * | 2002-02-22 | 2004-12-07 | Pharmacia Corp | Formulações de droga antibiótica oftálmica contendo um composto de ciclodextrina e cloreto de cetil piridìnio |
TW200400055A (en) * | 2002-02-22 | 2004-01-01 | Pharmacia Corp | Ophthalmic formulation with novel gum composition |
US6664267B1 (en) | 2002-05-28 | 2003-12-16 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
EP3406596A1 (en) * | 2002-11-20 | 2018-11-28 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
TW200510425A (en) * | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
ATE366734T1 (de) | 2003-09-04 | 2007-08-15 | Wockhardt Ltd | Benzochinolizin-2-carbonsäureargininsalz- tetrahydrat |
ES2232309B1 (es) * | 2003-11-13 | 2006-08-01 | Quimica Sintetica, S.A. | Procedimiento simplificado para la obtencion de gatifloxacino. |
US7776883B2 (en) * | 2004-03-10 | 2010-08-17 | The United States Of America As Represented By The Department Of Health And Human Services | Quinolin-4-ones as inhibitors of retroviral integrase for the treatment of HIV, AIDS and AIDS related complex (ARC) |
MY134672A (en) * | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
WO2005113509A1 (en) * | 2004-05-20 | 2005-12-01 | Japan Tobacco Inc. | Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
KR100589429B1 (ko) | 2004-08-31 | 2006-06-14 | 한국화학연구원 | N-1 위치에 아미노피리딜기가 치환된 퀴놀론 유도체의 제조방법 |
US20090156577A1 (en) * | 2004-09-09 | 2009-06-18 | Benjamin Davis | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
US7732612B2 (en) * | 2004-09-09 | 2010-06-08 | Janssen Pharmaceutica, N.V. | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
KR20070085791A (ko) * | 2004-11-11 | 2007-08-27 | 아칠리온 파르마세우티칼스 인코포레이티드 | 항감염성 제제로서8a,9-디히드로-4a-h-이소티아졸로[5,4-b]퀴놀린-3,4-디온 및 관련 화합물 |
US7659399B2 (en) * | 2005-01-05 | 2010-02-09 | Achillion Pharmaceuticals, Inc. | 1-thia-2,4a-diaza-cyclopenta[b]napththalene-3,4-diones and related compounds as anti-infective agents |
US7199128B2 (en) * | 2005-02-02 | 2007-04-03 | Achillion Pharmaceuticals, Inc. | 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents |
NZ561005A (en) * | 2005-02-16 | 2011-04-29 | Achillion Pharmaceuticals Inc | New isothiazoloquinolones and related compounds as anti-infective agents |
CA2616768C (en) * | 2005-07-27 | 2014-05-06 | Achillion Pharmaceuticals, Inc. | 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents |
US8383819B2 (en) * | 2006-03-06 | 2013-02-26 | Japan Tobacco Inc. | Method for producing 4-oxoquinoline compound |
MX2008012488A (es) | 2006-03-28 | 2008-10-10 | Procter & Gamble | Un proceso de acoplamiento para preparar intermedios de quinolona. |
CN101045724B (zh) * | 2006-03-28 | 2011-08-17 | 宝洁公司 | 用于制备喹诺酮中间体的偶联方法 |
US8039485B2 (en) | 2006-03-28 | 2011-10-18 | Warner Chilcott Company, Llc | Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid |
US7528264B2 (en) * | 2006-03-28 | 2009-05-05 | The Procter & Gamble Company | Hydride reduction process for preparing quinolone intermediates |
CN101801190A (zh) * | 2007-06-22 | 2010-08-11 | 赛林药物股份有限公司 | 治疗异常细胞增殖性疾病的方法 |
WO2009002838A1 (en) * | 2007-06-22 | 2008-12-31 | Cylene Pharmaceuticals, Inc. | Methods for treating ophthalmic disorders |
US7902227B2 (en) * | 2007-07-27 | 2011-03-08 | Janssen Pharmaceutica Nv. | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents |
EP2203458B1 (en) * | 2007-09-11 | 2011-11-02 | Kyorin Pharmaceutical Co., Ltd. | Cyanoaminoquinolones as gsk-3 inhibitors |
US8476261B2 (en) | 2007-09-12 | 2013-07-02 | Kyorin Pharmaceutical Co., Ltd. | Spirocyclic aminoquinolones as GSK-3 inhibitors |
WO2009049030A1 (en) * | 2007-10-09 | 2009-04-16 | Triton Biopharma, Llc | Method to use compositions having antidepressant anxiolytic and other neurological activity and compositions of matter |
EP2222662A4 (en) * | 2007-11-15 | 2011-08-03 | Univ Maryland | INHIBITORS OF KYNURENINE AMINO TRANSFERASE |
CA2711500A1 (en) * | 2008-01-07 | 2009-07-16 | Huanming Chen | Novel hiv integrase inhibitors and methods of use |
BRPI1015079A2 (pt) * | 2009-04-03 | 2015-09-01 | Achillion Pharmaceuticals Inc | Hidroxitienoquinolonas e compostos relacionados como agentes anti-infecciosos |
KR20120025519A (ko) | 2009-05-15 | 2012-03-15 | 레드엑스 파마 리미티드 | 산화환원 약물 유도체 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5097032A (en) * | 1984-07-20 | 1992-03-17 | Warner-Lambert Company | Antibacterial agents - II |
US5210193A (en) * | 1986-01-17 | 1993-05-11 | American Cyanamid Company | Piperazine derivatives |
US4840956A (en) * | 1986-02-18 | 1989-06-20 | Warner-Lambert Company | Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents |
DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
IT1197841B (it) * | 1986-10-14 | 1988-12-06 | Mediolanum Farmaceutici Srl | Derivati pirido-benzotiazinici ad attivita' antibatterica ed a lunga durata di azione |
JPH0751579B2 (ja) * | 1987-11-07 | 1995-06-05 | 日本新薬株式会社 | キノリンカルボン酸誘導体 |
EP0470252A4 (en) * | 1989-04-28 | 1992-12-02 | Daiichi Pharmaceutical Co., Ltd. | Anti-hiv drug |
DE3934082A1 (de) * | 1989-10-12 | 1991-04-18 | Bayer Ag | Chinoloncarbonsaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung als antivirale mittel |
JPH0754830Y2 (ja) * | 1990-01-24 | 1995-12-18 | 株式会社ユニシアジェックス | 荷重センサ取付構造 |
KR920004385A (ko) * | 1990-08-09 | 1992-03-27 | 와꾸나가 기스께 | 신규 삼환화합물 또는 그의 염, 이의 제조방법 및 이를 함유하는 항균제 |
RU2100351C1 (ru) * | 1991-05-28 | 1997-12-27 | Дайити Фармасьютикал Ко., Лтд. | Производные пиридонкарбоновой кислоты и композиция на их основе |
-
1993
- 1993-05-24 NO NO931867A patent/NO304832B1/no not_active IP Right Cessation
- 1993-05-25 IL IL105806A patent/IL105806A/en not_active IP Right Cessation
- 1993-05-26 RU RU93035829A patent/RU2124510C1/ru active
- 1993-05-26 PH PH46240A patent/PH31078A/en unknown
- 1993-05-26 CZ CZ93996A patent/CZ99693A3/cs unknown
- 1993-05-26 TW TW082104157A patent/TW234121B/zh active
- 1993-05-26 HU HU9301536A patent/HUT64051A/hu unknown
- 1993-05-26 CA CA002096998A patent/CA2096998A1/en not_active Abandoned
- 1993-05-26 FI FI932412A patent/FI932412A/fi unknown
- 1993-05-26 AU AU39815/93A patent/AU656859B2/en not_active Ceased
- 1993-05-27 NZ NZ247720A patent/NZ247720A/en unknown
- 1993-05-27 CN CN93108210A patent/CN1042936C/zh not_active Expired - Fee Related
- 1993-05-27 EP EP93304139A patent/EP0572259A1/en not_active Ceased
- 1993-05-27 MX MX9303158A patent/MX9303158A/es not_active IP Right Cessation
- 1993-05-27 ZA ZA933732A patent/ZA933732B/xx unknown
- 1993-05-27 KR KR1019930009397A patent/KR100266305B1/ko not_active IP Right Cessation
- 1993-05-27 ID IDP98154193A patent/ID20476A/id unknown
-
1994
- 1994-11-15 US US08/341,295 patent/US5519016A/en not_active Expired - Fee Related
-
1995
- 1995-09-11 US US08/526,225 patent/US5688791A/en not_active Expired - Fee Related
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU93035829A (ru) | Производные аминохинолона, замещенные арильной или гетероароматической группой, и анти-вич средства | |
MX9306831A (es) | Nuevos compuestos heterociclicos. | |
NO900306D0 (no) | Fremgangsmaate for fremstilling av nye pyrazolopyridin-forbindelser. | |
EP0244115A3 (en) | Phenyl-piperazine anti-arrhythmia agents | |
DE69624437T2 (de) | 4,6-diarylpyrimidin-derivate und deren salze | |
NO985711L (no) | Farmas°ytikum for behandling av neurologiske og neuropsykiatriske mangler | |
NO912411D0 (no) | Fremgangsmaate for fremstilling av bicykliske heterocykliske forbindelser. | |
BR9302643A (pt) | Compostos,seu processo de preparacao,seu uso e composicao farmaceutica | |
NO910395L (no) | Analogifremgangsmaate for fremstilling av terapeutisk virksomme 4-isoxazolcarboxamidderivater. | |
ATE122654T1 (de) | Behandlung von hiv-infizierungen und nützliche verbindungen dafür. | |
SE8204237D0 (sv) | Karbostyrilforeningar, kompositioner innehallande dessa samt forfaranden for framstellning derav | |
NO911600D0 (no) | Fremgangsmaate for fremstilling av n-(3-fluor-2-fosfonyl-metoksypropyl)-derivater av heterocykliske purin- og pyrimidinbaser. | |
DK0513675T3 (da) | Hidtil ukendt peptidforbindelse samt fremgangsmåde til fremstilling deraf | |
FR2681067B1 (fr) | Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant. | |
FI834451A (fi) | Foerfarande foer framstaellning av nya substituerade 1,4-dihydropyridiner. | |
ES2151488T3 (es) | Derivado de acido piridonacarboxilico. | |
IE45051L (en) | Quinazolines | |
DE69330601D1 (de) | Serotoninergische ergolin derivate | |
ATE122562T1 (de) | Derivate von penciclovir zur behandlung von hepatitis-b-infektionen. | |
RU93005302A (ru) | 5,6-дизамещенные-3-пиридилметиламмонийгалоидные соединения, применяемые для получения 5-(замещенный метил)-2,3-пиридинкарбоновых кислот | |
ATE83481T1 (de) | Fuenfgliedrige heterocyclische derivate von n'substituiertenn,n'-diacylhydrazinen. | |
SE8201019L (sv) | Amino-2,1,3-bensotiadiazol- och -bensooxadiazolderivat, deras framstellningoch lekemedel innehallande desamma | |
KR940005618A (ko) | 치환된 1, 2, 4-트리아진-3, 5-디온 유도체 및 활성성분으로 이를 함유하는 구충류 구제용 약물 조성물 | |
RU93051079A (ru) | Фармацевтические соединения, способ получения, фармацевтическая композиция | |
DK0784973T3 (da) | Quinoxalinderivater til behandling af tinnitus |