ATE194338T1 - Diphenylthiazolderivate mit antiinflammatorischer aktivität - Google Patents
Diphenylthiazolderivate mit antiinflammatorischer aktivitätInfo
- Publication number
- ATE194338T1 ATE194338T1 AT91905483T AT91905483T ATE194338T1 AT E194338 T1 ATE194338 T1 AT E194338T1 AT 91905483 T AT91905483 T AT 91905483T AT 91905483 T AT91905483 T AT 91905483T AT E194338 T1 ATE194338 T1 AT E194338T1
- Authority
- AT
- Austria
- Prior art keywords
- alkanesulfonyl
- halogenated
- inflammatory activity
- represents hydrogen
- diphenylthiazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/50—Nitrogen atoms bound to hetero atoms
- C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP1991/000310 WO1992015570A1 (fr) | 1991-03-07 | 1991-03-07 | Nouveau derive de diphenylthiazole |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE194338T1 true ATE194338T1 (de) | 2000-07-15 |
Family
ID=14014315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT91905483T ATE194338T1 (de) | 1991-03-07 | 1991-03-07 | Diphenylthiazolderivate mit antiinflammatorischer aktivität |
Country Status (7)
Country | Link |
---|---|
US (1) | US5449783A (de) |
EP (1) | EP0592664B1 (de) |
KR (1) | KR960009425B1 (de) |
AT (1) | ATE194338T1 (de) |
AU (1) | AU654125B2 (de) |
DE (1) | DE69132293D1 (de) |
WO (1) | WO1992015570A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0790057B1 (de) * | 1994-11-29 | 2002-06-05 | Hisamitsu Pharmaceutical Co., Inc. | Antibakterielle oder bakterizide mittel, die 2-aminothiazolderivate und deren salze enthalten |
AU5886296A (en) | 1995-06-02 | 1996-12-18 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclo oxygenase-2 and 5-lipoxygenase inhibitors |
US6512121B2 (en) | 1998-09-14 | 2003-01-28 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US6515014B2 (en) | 1995-06-02 | 2003-02-04 | G. D. Searle & Co. | Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US6677364B2 (en) | 1998-04-20 | 2004-01-13 | G.D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
WO2003015777A1 (en) * | 2001-08-13 | 2003-02-27 | Lion Bioscience Ag | Nr1h4 nuclear receptor binding compounds |
US7329401B2 (en) | 2002-04-15 | 2008-02-12 | The Regents Of The University Of California | Cyclooxygenase-2 selective agents useful as imaging probes and related methods |
EP1608365B1 (de) * | 2003-03-31 | 2013-10-02 | R-Tech Ueno, Ltd. | Methoden zur behandlung von hyperpermeablen vaskularerkrankungen |
EP4058439A1 (de) * | 2019-11-12 | 2022-09-21 | Genzyme Corporation | 5-gliedrige heteroarylaminosulfonamide zur behandlung von durch mangelnde cftr aktivität vermittelten erkrankungen |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3458526A (en) * | 1966-09-26 | 1969-07-29 | Upjohn Co | Certain 2-amino-4,5-bis(p-methoxyphenyl)thiazoles |
CH587836A5 (de) * | 1974-01-31 | 1977-05-13 | Serono Lab | |
US4168315A (en) * | 1977-09-28 | 1979-09-18 | The Upjohn Company | Dianisyl thiazole compound, compositions and method of antithrombotic treatment |
DK150068C (da) * | 1978-06-02 | 1987-06-29 | Pfizer | Analogifremgangsmaade til fremstilling af aminothiazoler |
JPS57118574A (en) * | 1981-01-13 | 1982-07-23 | Mitsui Toatsu Chem Inc | N-(4-phenylthiazol-2-yl)carbamate derivative, its preparation and medicinal composition containing the same |
JPS5857366A (ja) * | 1981-10-02 | 1983-04-05 | Yamanouchi Pharmaceut Co Ltd | 3,5−ジ−tert−ブチル−4−ヒドロキシフエニル置換複素環化合物 |
JPS58198474A (ja) * | 1982-05-13 | 1983-11-18 | Mitsui Toatsu Chem Inc | アミノメチレンマロン酸エステル誘導体と製造法及び殺菌剤 |
DD225130A1 (de) * | 1983-08-31 | 1985-07-24 | Univ Berlin Humboldt | Verfahren zur herstellung n-funktionalisierter 2-aminothiazole |
JPH0753666B2 (ja) * | 1987-09-14 | 1995-06-07 | 久光製薬株式会社 | 置換ジフェニルチアゾール誘導体からなる抗炎症剤 |
JP3003148B2 (ja) * | 1989-01-05 | 2000-01-24 | 藤沢薬品工業株式会社 | チアゾール化合物、その製造法およびそれを含有する医薬組成物 |
EP0388909A3 (de) * | 1989-03-22 | 1991-05-08 | Fujisawa Pharmaceutical Co., Ltd. | Thiazolderivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten |
JPH078863B2 (ja) * | 1989-09-21 | 1995-02-01 | 久光製薬株式会社 | 新規なジフェニルチアゾール誘導体 |
JPH04173782A (ja) * | 1990-11-08 | 1992-06-22 | Taisho Pharmaceut Co Ltd | 2―スルホンアミド―4,5―ジフェニルチアゾール誘導体 |
GB2253297B (en) * | 1991-02-27 | 1994-11-16 | Mars Inc | Coin validation |
-
1991
- 1991-03-07 WO PCT/JP1991/000310 patent/WO1992015570A1/ja active IP Right Grant
- 1991-03-07 AU AU74527/91A patent/AU654125B2/en not_active Ceased
- 1991-03-07 EP EP91905483A patent/EP0592664B1/de not_active Expired - Lifetime
- 1991-03-07 AT AT91905483T patent/ATE194338T1/de not_active IP Right Cessation
- 1991-03-07 DE DE69132293T patent/DE69132293D1/de not_active Expired - Lifetime
-
1992
- 1992-03-07 US US08/108,572 patent/US5449783A/en not_active Expired - Fee Related
-
1993
- 1993-08-26 KR KR93702563A patent/KR960009425B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0592664B1 (de) | 2000-07-05 |
WO1992015570A1 (fr) | 1992-09-17 |
KR960009425B1 (en) | 1996-07-19 |
KR930703278A (ko) | 1993-11-29 |
US5449783A (en) | 1995-09-12 |
EP0592664A1 (de) | 1994-04-20 |
DE69132293D1 (de) | 2000-08-10 |
EP0592664A4 (en) | 1994-06-22 |
AU654125B2 (en) | 1994-10-27 |
AU7452791A (en) | 1992-10-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |