AU765703B2 - Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items - Google Patents

Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items Download PDF

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Publication number
AU765703B2
AU765703B2 AU32103/99A AU3210399A AU765703B2 AU 765703 B2 AU765703 B2 AU 765703B2 AU 32103/99 A AU32103/99 A AU 32103/99A AU 3210399 A AU3210399 A AU 3210399A AU 765703 B2 AU765703 B2 AU 765703B2
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AU
Australia
Prior art keywords
luciferase
seq
nucleic acid
sequence
renilla
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU32103/99A
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English (en)
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AU3210399A (en
Inventor
Bruce J. Bryan
Christopher Szent-Gyorgyi
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Prolume Ltd
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Prolume Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27373514&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU765703(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Prolume Ltd filed Critical Prolume Ltd
Publication of AU3210399A publication Critical patent/AU3210399A/en
Application granted granted Critical
Publication of AU765703B2 publication Critical patent/AU765703B2/en
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6853—Carcino-embryonic antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
AU32103/99A 1998-03-27 1999-03-26 Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items Ceased AU765703B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US7962498P 1998-03-27 1998-03-27
US60/079624 1998-03-27
US8936798P 1998-06-15 1998-06-15
US60/089367 1998-06-15
US10293998P 1998-10-01 1998-10-01
US60/102939 1998-10-01
PCT/US1999/006698 WO1999049019A2 (en) 1998-03-27 1999-03-26 Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics

Publications (2)

Publication Number Publication Date
AU3210399A AU3210399A (en) 1999-10-18
AU765703B2 true AU765703B2 (en) 2003-09-25

Family

ID=27373514

Family Applications (1)

Application Number Title Priority Date Filing Date
AU32103/99A Ceased AU765703B2 (en) 1998-03-27 1999-03-26 Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items

Country Status (8)

Country Link
US (2) US6232107B1 (US06436682-20020820-C00006.png)
EP (1) EP1064360B1 (US06436682-20020820-C00006.png)
JP (2) JP2002507410A (US06436682-20020820-C00006.png)
AT (1) ATE388224T1 (US06436682-20020820-C00006.png)
AU (1) AU765703B2 (US06436682-20020820-C00006.png)
CA (1) CA2324648C (US06436682-20020820-C00006.png)
DE (1) DE69938293T2 (US06436682-20020820-C00006.png)
WO (1) WO1999049019A2 (US06436682-20020820-C00006.png)

Families Citing this family (301)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7090976B2 (en) 1999-11-10 2006-08-15 Rigel Pharmaceuticals, Inc. Methods and compositions comprising Renilla GFP
US7297482B2 (en) * 1998-10-08 2007-11-20 Rigel Pharmaceuticals, Inc. Structurally biased random peptide libraries based on different scaffolds
US6936421B2 (en) 1998-10-08 2005-08-30 Rigel Pharmaceuticals, Inc. Structurally biased random peptide libraries based on different scaffolds
US6180343B1 (en) * 1998-10-08 2001-01-30 Rigel Pharmaceuticals, Inc. Green fluorescent protein fusions with random peptides
US9834584B2 (en) 1998-12-11 2017-12-05 Takara Bio Usa, Inc. Nucleic acids encoding chromophores/fluorophores and methods for using the same
US7338784B2 (en) 1998-12-11 2008-03-04 Clontech Laboratories, Inc Nucleic acids encoding chromophores/fluorophores and methods for using the same
US20030087492A1 (en) 2001-11-02 2003-05-08 Promos Technologies, Inc. Semiconductor device and method of manufacturing the same
AUPP846399A0 (en) * 1999-02-02 1999-02-25 University Of Sydney, The Pigment protein from coral tissue
GB9903767D0 (en) * 1999-02-18 1999-04-14 Univ Glasgow Receptor assay
US7135613B1 (en) 1999-02-18 2006-11-14 The National University Of Singapore Chimeric gene constructs for generation of fluorescent transgenic ornamental fish
US6673554B1 (en) * 1999-06-14 2004-01-06 Trellie Bioinformatics, Inc. Protein localization assays for toxicity and antidotes thereto
AU783767B2 (en) 1999-10-14 2005-12-01 Takara Bio Usa, Inc. Anthozoa derived chromophores/fluorophores and methods for using the same
WO2001032688A1 (en) * 1999-10-29 2001-05-10 Rutgers, The State University Of New Jersey Renilla reniformis green fluorescent protein
US20030013849A1 (en) * 1999-10-29 2003-01-16 Ward William W. Renilla reniformis green fluorescent protein
WO2001034824A2 (en) * 1999-11-10 2001-05-17 Rigel Pharmaceuticals, Inc. Methods and compositions comprising renilla gfp
AU2137101A (en) * 1999-12-22 2001-07-03 Biosignal Packard Inc. A bioluminescence resonance energy transfer (bret) fusion molecule and method ofuse
US20020064842A1 (en) * 2000-06-09 2002-05-30 Sorge Joseph A. Renilla reniformis green fluorescent protein and mutants thereof
JP2003525605A (ja) * 2000-02-28 2003-09-02 ストラタジーン レニラ・レニフォルミスの緑蛍光タンパク質およびその変異体
DE60117761T2 (de) * 2000-03-15 2006-08-31 Prolume, Ltd. Luciferase, Fluoreszenzproteine, für Luciferase und Fluoreszenzproteine Kodierend Nukleinsäure und ihre Verwendung in der Diagnose, Hoch-Durchsatz Screeningsverfahren
US7109315B2 (en) * 2000-03-15 2006-09-19 Bruce J. Bryan Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
CA2411304C (en) * 2000-06-01 2014-07-29 Institut Pasteur Chimeric gfp-aequorin as bioluminescent ca++ reporters at the single cell level
AU2001275138A1 (en) * 2000-06-02 2001-12-17 The University Of Utah Research Foundation Active needle devices with integrated functionality
WO2002020749A2 (en) * 2000-09-07 2002-03-14 Owman Christer S O Chimeric reporter system for cell surface receptor-ligand binding
JP4330338B2 (ja) 2000-10-12 2009-09-16 クローンテック ラボラトリーズ インク． 大きく赤側にシフトした蛍光タンパク質
AU2003267309A1 (en) 2000-11-16 2004-04-08 Microspherix Llc Flexible and/or elastic brachytherapy seed or strand
DE10058091A1 (de) 2000-11-23 2002-06-06 Bayer Ag Isolierte Luziferasen Lu164, LuAL und Lu22, sowie deren Verwendung
WO2002048403A2 (en) * 2000-12-11 2002-06-20 Hk Pharmaceuticals, Inc. Multiplexed protein expression and activity assay
CA2328684A1 (en) * 2000-12-15 2002-06-15 Yahia Gawad Photon-triggered luminescent assay
EP1349867A4 (en) 2000-12-15 2004-10-27 Stratagene California DIMER FLUORESCENT POLYPEPTIDES
US6645761B1 (en) * 2000-12-22 2003-11-11 Stratagene Humanized polynucleotide sequence encoding Renilla mulleri green fluorescent protein
WO2002060941A2 (en) * 2001-01-29 2002-08-08 Anticancer, Inc. Fluorescent proteins
US20040191786A1 (en) * 2001-02-16 2004-09-30 Yue David T. Three cube fret method (3-fret) for detecting fluorescence energy transfer
US6969597B2 (en) 2001-02-21 2005-11-29 Clontech Laboratories, Inc. Nucleic acids encoding non aggregating fluorescent proteins and methods for using the same
JP2004537280A (ja) * 2001-03-07 2004-12-16 ゼノジェン コーポレイション 標的細胞中へのｄｎａの導入についてのスクリーニング方法
US7244232B2 (en) * 2001-03-07 2007-07-17 Biomed Solutions, Llc Process for identifying cancerous and/or metastatic cells of a living organism
US20030170642A1 (en) * 2001-03-12 2003-09-11 Irm, Llc Identification of cellular targets for biologically active molecules
US20040076954A1 (en) * 2001-03-12 2004-04-22 Irm, Llc Genomics-driven high speed cellular assays, development thereof, and collections of cellular reporters
SE0101519D0 (sv) * 2001-04-27 2001-04-27 Astrazeneca Ab Nucleic ACID
US20050009205A1 (en) * 2003-07-11 2005-01-13 Ye Fang Fluorescent ligands for GPCR arrays
US6780974B2 (en) * 2001-06-12 2004-08-24 Cellomics, Inc. Synthetic DNA encoding an orange seapen-derived green fluorescent protein with codon preference of mammalian expression systems and biosensors
US8709412B2 (en) 2001-06-29 2014-04-29 The Board Of Trustees Of The Leland Stanford Junior University Modulation of TIM receptor activity in combination with cytoreductive therapy
WO2003002722A2 (en) * 2001-06-29 2003-01-09 The Board Of Trustees Of The Leland Stanford Junior University T cell regulatory genes and methods of use thereof
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
US6544729B2 (en) * 2001-07-20 2003-04-08 University Of Tennessee Bioluminescent biosensor device
US20030053951A1 (en) * 2001-07-26 2003-03-20 Millennium Pharmaceuticals, Inc. Use of non-invasive imaging technologies to monitor in vivo gene-expression
US8048644B1 (en) * 2001-08-01 2011-11-01 The University Of North Carolina At Charlotte Biological indicator for monitoring the transport of micro-organisms in the environment
AU2003270548B2 (en) 2002-09-09 2008-09-25 Arbor Vita Corporation Methods of diagnosing cervical cancer
WO2003031590A2 (en) 2001-10-12 2003-04-17 Clontech Laboratories, Inc. Nucleic acids encoding linked chromo/fluorescent domains and methods for using the same
US20030157519A1 (en) * 2001-10-15 2003-08-21 Stratagene Recombinant renilla reniformis system for bioluminescence resonance energy transfer
US7268229B2 (en) * 2001-11-02 2007-09-11 Promega Corporation Compounds to co-localize luminophores with luminescent proteins
CA2454031A1 (en) 2001-11-13 2003-05-22 Clontech Laboratories, Inc. Novel chromophores/fluorophores and methods for using the same
US6815178B1 (en) * 2001-11-19 2004-11-09 Antony R. Shoaf Endospore detection method
DE10158904A1 (de) * 2001-11-30 2003-06-12 Roche Diagnostics Gmbh Verfahren zur Herstellung von linearen DNA Fragmenten für die in vitro Expression von Proteinen
ES2329666T3 (es) 2001-12-19 2009-11-30 The University Of Chicago Proteinas fluorescentes de maduracion rapida y procedimientos de uso de las mismas.
AU2002367391A1 (en) * 2001-12-26 2003-07-24 Clontech Laboratories, Inc. Mutant chromophores/fluorophores and methods for making and using the same
CA2472030A1 (en) * 2002-01-24 2003-07-31 Pointilliste, Inc. Use of collections of binding sites for sample profiling and other applications
AU2003219477A1 (en) * 2002-03-07 2003-09-16 Zephyr Proteomix Ltd. Microarrays of cellulose binding chimeric proteins and methods of use thereof
AU2003224694A1 (en) * 2002-03-25 2003-10-13 Chemicon International Inc. Modified aequorins having enhanced glowing kinetics and methods of using same
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
DE10225932B4 (de) * 2002-06-11 2007-01-11 Deutsches Krebsforschungszentrum (Dkfz) Bildgebendes Verfahren und Vorrichtung zu dessen Durchführung
US20050182250A1 (en) * 2002-07-10 2005-08-18 Stratagene Humanized renilla reniformis green fluorescent protein as a scaffold
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
EP1585806A2 (en) * 2002-10-30 2005-10-19 Pointilliste, Inc. Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides
AU2003285844A1 (en) 2002-11-12 2004-06-03 Zakrytoe Aktsionernoe Obschestvo "Evrogen" Fluorescent proteins and chromoproteins from non-aequorea hydrozoa species and methods for using same
US20040209370A1 (en) * 2002-12-19 2004-10-21 Wonchul Suh Method for chromosomal engineering
US7678893B2 (en) * 2002-12-26 2010-03-16 Zakrytoe Aktsionernoe Obschestvo “Evrogen” Fluorescent proteins from Copepoda species and methods for using same
US20040241748A1 (en) * 2003-02-10 2004-12-02 Dana Ault-Riche Self-assembling arrays and uses thereof
WO2004076685A2 (en) * 2003-02-28 2004-09-10 Lux Biotechnology Limited Fungal biosensor and assay
WO2004081189A2 (en) * 2003-03-07 2004-09-23 Stanford University Multimodality imaging of reporter gene expression using a novel fusion vector in living cells and organisms
WO2004090115A2 (en) * 2003-04-04 2004-10-21 Stratagene Renilla gfp mutants with increased fluorescent intensity and special shift
GB2400659B8 (en) * 2003-04-17 2007-07-09 Cambrex Bio Science Nottingham Assay methods and materials
WO2004096998A2 (en) * 2003-04-29 2004-11-11 Vanderbilt University Nanoparticular tumor targeting and therapy
AU2004265226A1 (en) * 2003-05-16 2005-02-24 Receptor Biologix, Inc. Intron fusion proteins, and methods of identifying and using same
WO2005019252A2 (en) 2003-05-22 2005-03-03 University Of Florida Research Foundation, Inc. Novel fluorescent and colored proteins, and polynucleotides that encode these proteins
US8338180B2 (en) 2003-06-10 2012-12-25 The J. David Gladstone Institutes Methods for treating lentivirus infections
GB0314856D0 (en) * 2003-06-25 2003-07-30 Unitargeting Res As Protein expression system
US8399618B2 (en) 2004-10-21 2013-03-19 Xencor, Inc. Immunoglobulin insertions, deletions, and substitutions
US8883147B2 (en) 2004-10-21 2014-11-11 Xencor, Inc. Immunoglobulins insertions, deletions, and substitutions
US20050095648A1 (en) * 2003-10-30 2005-05-05 Mario Geysen Method for designing linear epitopes and algorithm therefor and polypeptide epitopes
US7166154B2 (en) * 2003-11-06 2007-01-23 Hewlett-Packard Development Company, L.P. System and a method for an edible, optically invisible ink
WO2005067980A2 (en) * 2004-01-12 2005-07-28 Pointilliste, Inc. Design of therapeutics and therapeutics
US20050217527A1 (en) * 2004-02-06 2005-10-06 Ciesiun Paul M Bioluminescent paintball
US7481997B1 (en) 2004-02-12 2009-01-27 Montana State University Snow mountain virus genome sequence, virus-like particles and methods of use
EP1732944B1 (en) 2004-04-07 2012-09-05 The University of Chicago Monomeric red fluorescent proteins
JP2008506366A (ja) * 2004-05-14 2008-03-06 レセプター バイオロジックス インコーポレイテッド 細胞表面受容体アイソフォームならびにその同定および使用方法
CA2574953A1 (en) 2004-07-26 2006-02-09 Dow Global Technolgies Inc. Process for improved protein expression by strain engineering
US20060044781A1 (en) * 2004-08-31 2006-03-02 Hanley Brian P Bioluminescent fog for military and law enforcement
US7399607B2 (en) * 2004-09-22 2008-07-15 Allergan, Inc. Fluorescence polarization assays for determining clostridial toxin activity
KR101027427B1 (ko) 2004-11-12 2011-04-11 젠코어 인코포레이티드 ＦcRn에 대하여 증가된 결합력을 갖는 Ｆc 변이체
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
US7871803B2 (en) 2004-12-09 2011-01-18 Nec Soft, Ltd. Gene encoding novel luciferase
US20060127455A1 (en) * 2004-12-14 2006-06-15 Yorktown Technologies, Inc. Optimized food for expressing luminescent proteins in animals
US7230080B2 (en) 2005-02-16 2007-06-12 University Of Florida Research Foundation, Inc. Fluorescent and colored proteins, and polynucleotides that encode these proteins
WO2006096735A2 (en) * 2005-03-07 2006-09-14 New England Biolabs Inc Enhancing a luminescent signal
US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
US20070087406A1 (en) * 2005-05-04 2007-04-19 Pei Jin Isoforms of receptor for advanced glycation end products (RAGE) and methods of identifying and using same
US20090170769A1 (en) * 2005-05-13 2009-07-02 Pei Jin Cell surface receptor isoforms and methods of identifying and using the same
ES2371664T3 (es) * 2005-06-03 2012-01-09 Beacon Biotechnology Llc Ensayo de ácidos nucleicos de proximidad de quimioluminiscencia.
WO2007035213A2 (en) 2005-08-09 2007-03-29 Revivicor, Inc. Transgenic ungulates expressing ctla4-ig and uses thereof
JP2009505642A (ja) 2005-08-19 2009-02-12 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼイション アラクノカンパのルシフェラーゼ
WO2007058776A2 (en) * 2005-11-10 2007-05-24 Receptor Biologix, Inc. Hepatocyte growth factor intron fusion proteins
EP1785434A1 (en) * 2005-11-11 2007-05-16 Ludwig-Maximilians-Universität München Targeting and tracing of antigens in living cells
US10183986B2 (en) 2005-12-15 2019-01-22 Industrial Technology Research Institute Trimeric collagen scaffold antibodies
US20070161031A1 (en) * 2005-12-16 2007-07-12 The Board Of Trustees Of The Leland Stanford Junior University Functional arrays for high throughput characterization of gene expression regulatory elements
EP1840570A1 (en) * 2006-03-31 2007-10-03 F. Hoffmann-La Roche Ag Tumor models employing green fluorescent protein
EP3796002B1 (en) 2006-07-14 2023-11-22 The Regents of The University of California Cancer biomarkers and methods of use thereof
US20080293086A1 (en) * 2006-09-18 2008-11-27 Cobalt Technologies, Inc. A Delaware Corporation Real time monitoring of microbial enzymatic pathways
US7833527B2 (en) 2006-10-02 2010-11-16 Amgen Inc. Methods of treating psoriasis using IL-17 Receptor A antibodies
US20080081332A1 (en) * 2006-10-03 2008-04-03 Jun Amano Methods and devices for conducting diagnostic testing
WO2008066608A2 (en) * 2006-10-12 2008-06-05 The General Hospital Corporation A secreted luciferase fluorescent protein conjugate nucleic acid construct and uses thereof
US20080090263A1 (en) * 2006-10-13 2008-04-17 National Institute Of Advanced Industrial Science And Technology Two secretory luciferases
JP4849540B2 (ja) * 2006-10-16 2012-01-11 独立行政法人産業技術総合研究所 ２つの分泌ルシフェラーゼ
WO2008112127A2 (en) * 2007-03-08 2008-09-18 Switchgear Genomics Functional arrays for high throughput characterization of regulatory elements in untranslated regions of genes
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
WO2008134461A2 (en) 2007-04-27 2008-11-06 Dow Global Technologies, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US8727554B2 (en) 2007-06-25 2014-05-20 Yorktown Technologies, L.P. Aquarium with adjustable lighting
US20090006219A1 (en) * 2007-06-29 2009-01-01 Alan Blake Method for distribution of an aquarium kit
EP2179037A4 (en) 2007-08-21 2010-12-22 Nodality Inc DIAGNOSIS, FORECASTING AND TREATMENT PROCEDURES
TWI595005B (zh) 2007-08-21 2017-08-11 安健股份有限公司 人類ｃ－ｆｍｓ抗原結合蛋白質
WO2009032218A1 (en) * 2007-08-29 2009-03-12 Biolume Inc. Bioluminescent endoscopy methods and compounds
US20090081715A1 (en) * 2007-09-07 2009-03-26 Cobalt Technologies, Inc., A Delaware Corporation Engineered Light-Emitting Reporter Genes
TW200918553A (en) 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
CN104297507B (zh) 2007-10-02 2017-10-10 赛拉诺斯股份有限公司 模块化现场护理装置及其应用
WO2009059305A2 (en) 2007-11-01 2009-05-07 The University Of Chicago Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
CA2958185C (en) 2007-12-26 2020-08-25 Xencor, Inc. Fc variants with altered binding to fcrn
US20090236541A1 (en) * 2008-03-24 2009-09-24 General Electric Company System and Methods for Optical Imaging
CN102057046A (zh) 2008-04-09 2011-05-11 钴技术有限公司 固定的产物耐受的微生物
ES2442024T3 (es) 2008-07-15 2014-02-07 Academia Sinica Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados
US8309306B2 (en) 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
JO3382B1 (ar) 2008-12-23 2019-03-13 Amgen Inc أجسام مضادة ترتبط مع مستقبل cgrp بشري
EP2382470B1 (en) 2009-01-29 2014-12-10 Commonwealth Scientific and Industrial Research Organisation Measuring g protein coupled receptor activation
JP5572972B2 (ja) 2009-03-16 2014-08-20 Ｊｎｃ株式会社 インスリン分泌促進剤などの薬物のスクリーニング方法
US8242248B2 (en) 2009-03-23 2012-08-14 Nodality, Inc. Kits for multiparametric phospho analysis
WO2010119721A1 (ja) 2009-04-17 2010-10-21 独立行政法人産業技術総合研究所 超高輝度で安定な人工生物発光酵素
JP5703545B2 (ja) * 2009-06-15 2015-04-22 Jnc株式会社 発光触媒活性を有する融合蛋白質
CA2804912A1 (en) 2009-06-26 2012-12-29 Cobalt Technologies, Inc. Integrated system and process for bioproduct production
WO2011002924A2 (en) 2009-06-30 2011-01-06 The General Hospital Corporation Gaussia luciferase variant for high-throughput screening
US8815779B2 (en) 2009-09-16 2014-08-26 SwitchGear Genomics, Inc. Transcription biomarkers of biological responses and methods
US8207651B2 (en) 2009-09-16 2012-06-26 Tyco Healthcare Group Lp Low energy or minimum disturbance method for measuring frequency response functions of ultrasonic surgical devices in determining optimum operating point
TW201117824A (en) 2009-10-12 2011-06-01 Amgen Inc Use of IL-17 receptor a antigen binding proteins
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
JP5764921B2 (ja) 2009-12-24 2015-08-19 Jnc株式会社 発光活性を有する融合蛋白質
WO2011102178A1 (ja) * 2010-02-19 2011-08-25 独立行政法人産業技術総合研究所 改良されたレポーター遺伝子を用いる分析システム
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
CA2796055A1 (en) 2010-04-15 2011-10-20 Amgen Inc. Human fgf receptor and .beta.-klotho binding proteins
WO2011139721A1 (en) 2010-04-27 2011-11-10 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
WO2012030738A2 (en) 2010-08-30 2012-03-08 Beckman Coulter, Inc. Complex phosphoprotein activation profiles
CN102008732B (zh) * 2010-11-08 2012-10-24 武汉华耀生物医药有限公司 一种叶酸偶联抗体药物及其制备方法与应用
JP2012110283A (ja) * 2010-11-25 2012-06-14 Olympus Corp 発光タンパク質およびカルシウム応答性セレンテラジン結合タンパク質並びにこれらを用いた研究方法
JP6147669B2 (ja) 2010-12-03 2017-06-14 ジーン・ストリーム・ピーティワイ・リミテッド 改良光放射分子
AU2012207090B2 (en) 2011-01-21 2015-04-23 Labrador Diagnostics Llc Systems and methods for sample use maximization
WO2012155071A1 (en) 2011-05-12 2012-11-15 Gilead Biologics, Inc. Methods of identifying lysyl oxidase - like - 2 (loxl2) binding partners
US9574002B2 (en) 2011-06-06 2017-02-21 Amgen Inc. Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
WO2012178136A2 (en) 2011-06-24 2012-12-27 University Of Houston System Fusion proteins of bacterial luciferase as multicolor luminescent sensors
US20140234330A1 (en) 2011-07-22 2014-08-21 Amgen Inc. Il-17 receptor a is required for il-17c biology
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
EA201790757A1 (ru) 2011-09-22 2017-07-31 Эмджен Инк. Связывающие антиген cd27l белки
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
WO2013086443A1 (en) 2011-12-08 2013-06-13 Amgen Inc. Agonistic human lcat antigen binding proteins and their use in therapy
WO2013094359A1 (ja) * 2011-12-19 2013-06-27 独立行政法人産業技術総合研究所 セルロース／キチン系高分子発光材料
US8435777B1 (en) 2012-01-20 2013-05-07 Cayla CPG-free gene for a new secreted reporter protein
WO2013113061A1 (en) * 2012-01-31 2013-08-08 Bioconst Pty Ltd A fluorescent composition for use in marking objects, such as flowers.
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
AU2013204332B2 (en) 2012-04-16 2015-07-16 Commonwealth Scientific And Industrial Research Organisation Methods and systems for detecting an analyte or classifying a sample
JO3623B1 (ar) 2012-05-18 2020-08-27 Amgen Inc البروتينات المرتبطة بمولد المستضاد st2
US9645151B2 (en) 2012-08-17 2017-05-09 California Institute Of Technology Targeting phosphofructokinase and its glycosylation form for cancer
AU2013306098A1 (en) 2012-08-18 2015-02-12 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
US9624425B2 (en) 2012-09-01 2017-04-18 Prolume, Ltd. Substituted benzo[f]imidazo[1,2-a]quinoxalines and imidazo[1,2-a]pyrazines
AU2013334075B2 (en) 2012-10-26 2018-11-29 Memorial Sloan-Kettering Cancer Center Androgen receptor variants and methods for making and using
TW201425336A (zh) 2012-12-07 2014-07-01 Amgen Inc Ｂｃｍａ抗原結合蛋白質
EP2948478B1 (en) 2013-01-25 2019-04-03 Amgen Inc. Antibodies targeting cdh19 for melanoma
JO3519B1 (ar) 2013-01-25 2020-07-05 Amgen Inc تركيبات أجسام مضادة لأجل cdh19 و cd3
CA2904337A1 (en) 2013-03-14 2014-10-02 Amgen Inc. Chrdl-1 antigen binding proteins and methods of treatment
EP2970446A1 (en) 2013-03-15 2016-01-20 Amgen Research (Munich) GmbH Antibody constructs for influenza m2 and cd3
ES2753950T3 (es) 2013-03-15 2020-04-15 Amgen Res Munich Gmbh Moléculas de unión monocatenarias que comprenden ABP del extremo N
ES2770976T3 (es) 2013-03-15 2020-07-06 Amgen Inc Anticuerpos PAC1 humanos
WO2014144553A1 (en) 2013-03-15 2014-09-18 Amgen Inc. Secreted frizzle-related protein 5 (sfrp5) binding proteins and methods of treatment
US9159094B2 (en) 2013-03-15 2015-10-13 Panera, Llc Methods and apparatus for facilitation of orders of food items
US9070175B2 (en) 2013-03-15 2015-06-30 Panera, Llc Methods and apparatus for facilitation of a food order
NZ713636A (en) 2013-05-30 2022-07-01 Kiniksa Pharmaceuticals Ltd Oncostatin m receptor antigen binding proteins
WO2014210397A1 (en) 2013-06-26 2014-12-31 Academia Sinica Rm2 antigens and use thereof
US9981030B2 (en) 2013-06-27 2018-05-29 Academia Sinica Glycan conjugates and use thereof
US10227370B2 (en) 2013-08-02 2019-03-12 California Institute Of Technology Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity
US9770461B2 (en) 2013-08-02 2017-09-26 California Institute Of Technology Tailored glycopolymers as anticoagulant heparin mimetics
TW201605896A (zh) 2013-08-30 2016-02-16 安美基股份有限公司 Gitr抗原結合蛋白
JP6486368B2 (ja) 2013-09-06 2019-03-20 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 改変されたグリコシル基を含む糖脂質を用いたヒトｉＮＫＴ細胞の活性化
AR097648A1 (es) 2013-09-13 2016-04-06 Amgen Inc Combinación de factores epigenéticos y compuestos biespecíficos que tienen como diana cd33 y cd3 en el tratamiento de leucemia mieloide
US9257150B2 (en) 2013-09-20 2016-02-09 Panera, Llc Techniques for analyzing operations of one or more restaurants
US9798987B2 (en) 2013-09-20 2017-10-24 Panera, Llc Systems and methods for analyzing restaurant operations
US10019686B2 (en) 2013-09-20 2018-07-10 Panera, Llc Systems and methods for analyzing restaurant operations
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
EP3094352B1 (en) 2014-01-16 2020-09-23 Academia Sinica Compositions and methods for treatment and detection of cancers
RU2019119862A (ru) 2014-02-20 2019-07-15 Аллерган, Инк. Антитела к компоненту комплемента c5
CN106232624B (zh) 2014-02-27 2020-01-21 阿勒根公司 补体因子Bb抗体
TWI687428B (zh) 2014-03-27 2020-03-11 中央研究院 反應性標記化合物及其用途
WO2015184002A1 (en) 2014-05-27 2015-12-03 Academia Sinica Anti-her2 glycoantibodies and uses thereof
JP6894239B2 (ja) 2014-05-27 2021-06-30 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 増強された抗体の有効性のための普遍的グリコフォームに関する組成物および方法
TWI670078B (zh) 2014-05-27 2019-09-01 中央研究院 抗ｃｄ２０醣抗體及其用途
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
AU2015267044A1 (en) 2014-05-28 2016-12-15 Academia Sinica Anti-TNF-alpha glycoantibodies and uses thereof
AU2015294834B2 (en) 2014-07-31 2021-04-29 Amgen Research (Munich) Gmbh Optimized cross-species specific bispecific single chain antibody constructs
TW201609811A (zh) 2014-07-31 2016-03-16 安美基研究（慕尼黑）公司 具有增強之組織分布之雙特異性單鏈抗體構築體
AR101669A1 (es) 2014-07-31 2017-01-04 Amgen Res (Munich) Gmbh Constructos de anticuerpos para cdh19 y cd3
EP3191500A4 (en) 2014-09-08 2018-04-11 Academia Sinica HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS
JP6824594B2 (ja) 2014-09-11 2021-02-03 Jnc株式会社 合成遺伝子の設計方法
WO2016040767A2 (en) 2014-09-12 2016-03-17 Amgen Inc. Chrdl-1 epitopes and antibodies
US9879328B2 (en) * 2014-11-21 2018-01-30 GeneWeave Biosciences, Inc. Mechanisms of antimicrobial susceptibility
EP3227687A4 (en) 2014-12-05 2018-10-24 Prelude, Inc. Dcis recurrence and invasive breast cancer
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
EP3789766A1 (en) 2015-01-24 2021-03-10 Academia Sinica Novel glycan conjugates and methods of use thereof
WO2016124568A1 (en) 2015-02-03 2016-08-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-rho gtpase conformational single domain antibodies and uses thereof
EP3056902B1 (en) 2015-02-16 2020-04-01 Universite De Bordeaux Novel voltage dependent ion channel fusions and method of use thereof
DK3283524T3 (da) 2015-04-17 2023-05-30 Amgen Res Munich Gmbh BISPECIFIKKE ANTISTOFKONSTRUKTIONER MOD CDH3 og CD3
WO2016189118A1 (en) 2015-05-28 2016-12-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of prognosis and treatment of patients suffering from acute myeloid leukemia
WO2016207313A1 (en) 2015-06-24 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for detecting protein-protein interactions
TWI796283B (zh) 2015-07-31 2023-03-21 德商安美基研究（慕尼黑）公司 Ｍｓｌｎ及ｃｄ３抗體構築體
TW202346349A (zh) 2015-07-31 2023-12-01 德商安美基研究（慕尼黑）公司 Dll3及cd3抗體構築體
TWI717375B (zh) 2015-07-31 2021-02-01 德商安美基研究（慕尼黑）公司 Ｃｄ７０及ｃｄ３抗體構築體
TWI744242B (zh) 2015-07-31 2021-11-01 德商安美基研究（慕尼黑）公司 Egfrviii及cd3抗體構築體
TWI829617B (zh) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Ｆｌｔ３及ｃｄ３抗體構築體
EP3331536A4 (en) 2015-08-03 2019-03-27 The Regents of The University of California COMPOSITIONS AND METHODS FOR MODULATING ABHD2 ACTIVITY
KR20180108602A (ko) 2015-12-23 2018-10-04 암젠 인크 위 억제 펩티드 수용체 (gipr)에 대한 결합 단백질을 glp-1 효능제와 조합하여 사용하여 대사 장애를 치료하거나 개선시키는 방법
TWI797073B (zh) 2016-01-25 2023-04-01 德商安美基研究（慕尼黑）公司 包含雙特異性抗體建構物之醫藥組合物
KR101661913B1 (ko) * 2016-01-29 2016-10-04 (주)넥스젠바이오텍 해파리 유래 녹색형광단백질을 유효성분으로 포함하는 항산화 활성을 갖는 화장료 조성물
KR101661912B1 (ko) * 2016-01-29 2016-10-04 (주)넥스젠바이오텍 녹색형광단백질-인간 상피세포재생인자 융합단백질을 유효성분으로 포함하는 주름 개선 및 항노화 화장료 조성물
US10781264B2 (en) 2016-02-03 2020-09-22 Amgen Research (Munich) Gmbh PSMA and CD3 bispecific T cell engaging antibody constructs
EA039859B1 (ru) 2016-02-03 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
AU2017216230B2 (en) 2016-02-03 2023-07-06 Amgen Inc. BCMA and CD3 bispecific T cell engaging antibody constructs
US10336784B2 (en) 2016-03-08 2019-07-02 Academia Sinica Methods for modular synthesis of N-glycans and arrays thereof
CN105861559B (zh) 2016-04-11 2018-05-01 苏州奥特铭医药科技有限公司 一种能直接反应i型干扰素应答的慢病毒载体及其制备方法与应用
US20190120838A1 (en) 2016-04-13 2019-04-25 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and kits for the rapid detection of the escherichia coli o25b-st131 clone
JOP20170091B1 (ar) 2016-04-19 2021-08-17 Amgen Res Munich Gmbh إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية
EP3480320A4 (en) 2016-06-30 2020-03-11 Biois Co., Ltd. BICATENARY NUCLEIC ACID SIGNAL PROBE AND TARGET MOLECULE DETECTION METHOD USING THE SAME
US10538592B2 (en) 2016-08-22 2020-01-21 Cho Pharma, Inc. Antibodies, binding fragments, and methods of use
US10435695B2 (en) * 2016-09-08 2019-10-08 The Government of the United States of America, as represented by the Secretary of Homeland Security Fusion protein comprising Gaussia luciferase, translation interrupter sequence, and interferon amino acid sequences
US10385319B2 (en) 2016-09-08 2019-08-20 The Governement of the United States of America, as represented by the Secretary of Homeland Security Modified foot-and-mouth disease virus 3C proteases, compositions and methods thereof
PL3529616T3 (pl) 2016-10-20 2024-03-18 President And Fellows Of Harvard College Testy in vitro i komórkowe do pomiaru aktywności neurotoksyn botulinowych
AU2017358067B2 (en) 2016-11-14 2024-04-18 PPB Technology Pty Ltd Protease sensor molecules
JOP20190177A1 (ar) 2017-01-17 2019-07-16 Amgen Inc طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr)
JOP20190189A1 (ar) 2017-02-02 2019-08-01 Amgen Res Munich Gmbh تركيبة صيدلانية ذات درجة حموضة منخفضة تتضمن بنيات جسم مضاد يستهدف الخلية t
CA3053906A1 (en) 2017-02-16 2018-08-23 Sonnet BioTherapeutics, Inc. Albumin binding domain fusion proteins
KR102018248B1 (ko) * 2017-03-15 2019-09-05 한양대학교 산학협력단 생물발광 강도가 증폭된 변이 가우시아 루시퍼라아제
AU2018250336A1 (en) 2017-04-07 2019-09-26 Juno Therapeutics, Inc. Engineered cells expressing prostate-specific membrane antigen (PSMA) or a modified form thereof and related methods
EP3618864A1 (en) 2017-05-05 2020-03-11 Amgen Inc. Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration
JOP20190259A1 (ar) 2017-05-31 2019-10-31 Amgen Inc بروتينات ربط مولد ضد مضادة لـ jagged1
UY37753A (es) 2017-06-02 2018-11-30 Amgen Inc Antagonistas de péptido pac1
MX2019013919A (es) 2017-06-20 2020-01-21 Amgen Inc Metodo para tratar o mejorar trastornos metabolicos con proteinas de union para el receptor peptidico inhibidor gastrico (gipr) en combinacion con agonistas de glp-1.
US20210346513A1 (en) 2017-08-04 2021-11-11 Amgen Inc. Method of conjugation of cys-mabs
AR112932A1 (es) 2017-08-08 2020-01-08 Commw Scient Ind Res Org Sensores de carbohidratos
WO2019075556A1 (en) 2017-10-18 2019-04-25 Université de Montréal SYSTEMS AND METHODS FOR ASSESSING G PROTEIN ACTIVATION
US11851679B2 (en) 2017-11-01 2023-12-26 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
EA202091422A1 (ru) 2017-12-11 2020-08-28 Эмджен Инк. Способ непрерывного производства продуктов на основе биспецифических антител
UY38041A (es) 2017-12-29 2019-06-28 Amgen Inc Construcción de anticuerpo biespecífico dirigida a muc17 y cd3
CA3004436C (en) 2018-05-09 2021-06-01 Paige Whitehead Biodegradable light wand
MX2021001221A (es) 2018-07-30 2021-06-23 Amgen Res Munich Gmbh Administración prolongada de un constructo de anticuerpo biespecífico que se une a cd33 y cd3.
MA53330A (fr) 2018-08-03 2021-06-09 Amgen Inc Constructions d'anticorps pour cldn18.2 et cd3
CA3112792A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
WO2020069303A1 (en) 2018-09-28 2020-04-02 Amgen Inc. Antibodies against soluble bcma
WO2020077212A1 (en) 2018-10-11 2020-04-16 Amgen Inc. Downstream processing of bispecific antibody constructs
EP3877413A1 (en) 2018-11-06 2021-09-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of acute myeloid leukemia by eradicating leukemic stem cells
MX2021008144A (es) 2019-01-03 2021-10-13 Invetx Inc Composiciones para aumentar la media vida de un agente terapeutico en caninos y metodos de uso.
KR102245664B1 (ko) * 2019-05-16 2021-04-27 인하대학교 산학협력단 에어로졸 증착 공정을 이용한 고상 단결정의 제조 방법
JP2022537650A (ja) 2019-06-13 2022-08-29 アムジエン・インコーポレーテツド 生物製剤の製造における自動化された生物量に基づく灌流制御
US20220306741A1 (en) 2019-09-10 2022-09-29 Amgen Inc. Purification Method for Bispecific antigen-binding Polypeptides with Enhanced Protein L Capture Dynamic Binding Capacity
AU2020381536A1 (en) 2019-11-13 2022-04-21 Amgen Inc. Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules
EP4077376A2 (en) * 2019-12-19 2022-10-26 Quidel Corporation Monoclonal antibody fusions
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
EP4093771A1 (en) 2020-01-22 2022-11-30 Amgen Research (Munich) GmbH Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof
EP3882632A1 (en) 2020-03-18 2021-09-22 Universite De Bordeaux Novel ion conducting channel fusion subunits and methods of use thereof
IL296601A (en) 2020-03-19 2022-11-01 Amgen Inc Antibodies against mucin 17 and their uses
US11434276B2 (en) 2020-05-11 2022-09-06 Invetx, Inc. Polypeptides with altered binding to neonatal Fc receptor (FcRn) and methods of use
US20220017636A1 (en) 2020-05-19 2022-01-20 Amgen Inc. Mageb2 binding constructs
TW202210101A (zh) 2020-05-29 2022-03-16 美商安進公司 與ｃｄ３３和ｃｄ３結合的雙特異性構建體的減輕不良反應投與
WO2022008488A1 (en) 2020-07-06 2022-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of slamf1 as a biomarker in colorectal cancer
BR112022027028A2 (pt) 2020-07-10 2023-03-07 Invetx Inc Composições para aumentar a meia-vida de um agente terapêutico em felinos e métodos de uso
WO2022013256A1 (en) 2020-07-15 2022-01-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of cd160 as a biomarker in acute myeloid leukemia
WO2022094393A1 (en) * 2020-10-30 2022-05-05 Albert Einstein College Of Medicine Reporter mycobacteriophage, assays and methods comprising the reporter mycobacteriophage
CN116635421A (zh) 2020-11-06 2023-08-22 安进公司 与cd3结合的多肽构建体
IL302586A (en) 2020-11-06 2023-07-01 Amgen Res Munich Gmbh Polypeptide selectively binds to CLDN6 and CD3
KR20230098335A (ko) 2020-11-06 2023-07-03 암젠 인크 클리핑 비율이 감소된 항원 결합 도메인
EP4240768A2 (en) 2020-11-06 2023-09-13 Amgen Inc. Multitargeting bispecific antigen-binding molecules of increased selectivity
WO2022159520A2 (en) 2021-01-20 2022-07-28 Nautilus Biotechnology, Inc. Systems and methods for biomolecule quantitation
JP2024511420A (ja) 2021-03-22 2024-03-13 ジュノー セラピューティクス インコーポレイテッド ウイルスベクター粒子の効力を評価する方法
AU2022246675A1 (en) 2021-04-02 2023-10-19 Amgen Inc. Mageb2 binding constructs
EP4334358A1 (en) 2021-05-06 2024-03-13 Amgen Research (Munich) GmbH Cd20 and cd22 targeting antigen-binding molecules for use in proliferative diseases
CN113552102B (zh) * 2021-07-16 2022-05-17 上海交通大学 一种基于荧光相关光谱检测有机溶剂诱导蛋白聚集的药物筛选方法
TW202346368A (zh) 2022-05-12 2023-12-01 德商安美基研究（慕尼黑）公司 具有增加的選擇性的多鏈多靶向性雙特異性抗原結合分子
WO2024059675A2 (en) 2022-09-14 2024-03-21 Amgen Inc. Bispecific molecule stabilizing composition

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5418155A (en) * 1989-12-29 1995-05-23 University Of Georgia Research Foundation, Inc. Isolated Renilla luciferase and method of use thereof
WO1997029319A2 (en) * 1996-02-06 1997-08-14 Bryan Bruce J Bioluminescent novelty items

Family Cites Families (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2541851A (en) 1944-12-23 1951-02-13 Gen Electric Process for making puttylike elastic plastic, siloxane derivative composition containing zinc hydroxide
US3384498A (en) 1967-01-04 1968-05-21 Oil Ct Res Inc Plastic modeling composition
US3511612A (en) 1967-03-20 1970-05-12 American Cyanamid Co Chemiluminescent systems
US3565815A (en) 1967-12-28 1971-02-23 Ind Mfg Co Inc Phosphor containing plastic polystyrene
US3584211A (en) 1968-10-07 1971-06-08 American Cyanamid Co Chemiluminescent liquid dispensing or display container
US3634280A (en) 1968-12-31 1972-01-11 Peter Hodgson Glowing bouncing putty
GB1317183A (en) 1969-05-30 1973-05-16 Unilever Ltd Cleansing compositions
US3649029A (en) 1969-07-09 1972-03-14 Eugene N Worrell Golf practice apparatus
US3661790A (en) 1969-10-20 1972-05-09 Arnold Clark Glowing bouncing putty
US3727236A (en) 1971-06-15 1973-04-17 K Lloyd Disposable apron
CH594444A5 (US06436682-20020820-C00006.png) 1972-12-04 1978-01-13 Gerd Birrenbach
US3873485A (en) 1974-04-01 1975-03-25 A Thomas Fichera Moldable aqueous plastic mass of polyethylene oxide fumed silica and polyglycol
US4313843A (en) 1974-04-26 1982-02-02 American Cyanamid Company Superior oxalate ester chemical lighting system
FR2292595A1 (fr) 1974-11-28 1976-06-25 Jourdain Jean Fontaine a mousse
DK143689C (da) 1975-03-20 1982-03-15 J Kreuter Fremgangsmaade til fremstilling af en adsorberet vaccine
US4324683A (en) 1975-08-20 1982-04-13 Damon Corporation Encapsulation of labile biological material
DE2621974A1 (de) 1976-05-18 1977-11-24 Max Planck Gesellschaft Verfahren zur herstellung eines zur kovalenten bindung mit biologisch aktivem material befaehigten traegermaterials
US4175183A (en) 1977-03-01 1979-11-20 Development Finance Corporation Of New Zealand Hydroxyalkylated cross-linked regenerated cellulose and method of preparation thereof
SE7811630L (sv) 1977-11-17 1979-05-18 Welsh Nat School Med Metod for uppteckt eller mengdbestemning av substanser med anvendning av merkningsteknik
US4229790A (en) 1978-10-16 1980-10-21 Denelcor, Inc. Concurrent task and instruction processor and method
EP0025350A3 (en) 1979-09-05 1981-06-10 Dynatech Ag Apparatus for detecting luminescent reactions
US4282287A (en) 1980-01-24 1981-08-04 Giese Roger W Biochemical avidin-biotin multiple-layer system
US4882165A (en) 1981-11-09 1989-11-21 The Regents Of The University Of California Light sensitive liposomes
US4870009A (en) 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
US4581335A (en) 1982-12-01 1986-04-08 Texas A&M University System Process for producing a cloned luciferase-synthesizing microorganism
US4528180A (en) 1983-03-01 1985-07-09 Schaeffer Hans A Dental preparation, article and method for storage and delivery thereof
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4745051A (en) 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4542102A (en) 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
DE8335529U1 (de) 1983-12-10 1984-03-08 Upat Gmbh & Co, 7830 Emmendingen Spritz-kartusche
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US4789633A (en) 1984-04-19 1988-12-06 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
US4563726A (en) 1984-08-20 1986-01-07 Newcomb Nelson F Illuminated chemiluminescent drinking mug
US4534317A (en) 1984-08-30 1985-08-13 Cape Cod Research Procedures for monitoring fish food consumption
FR2570703B1 (fr) 1984-09-26 1988-07-08 Commissariat Energie Atomique Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents
US4767206A (en) 1984-12-24 1988-08-30 Flow Cytometry Standards Corporation Calibration method for flow cytometry using fluorescent microbeads and synthesis thereof
US4774189A (en) 1984-12-24 1988-09-27 Flow Cytometry Standards Corp. Fluorescent calibration microbeads simulating stained cells
US5422266A (en) 1984-12-31 1995-06-06 University Of Georgia Research Foundation, Inc. Recombinant DNA vectors capable of expressing apoaequorin
NZ214563A (en) 1984-12-31 1991-05-28 Univ Georgia Production of apoaeqorin using recombinant dna
DE3500180A1 (de) 1985-01-04 1986-07-10 Ernst Prof. Dr. 7400 Tübingen Bayer Pfropfcopolymerisate aus vernetzten polymeren und polyoxyethylen, verfahren zu ihrer herstellung und ihre verwendung
US4681870A (en) 1985-01-11 1987-07-21 Imre Corporation Protein A-silica immunoadsorbent and process for its production
US4772453A (en) 1985-03-01 1988-09-20 Lisenbee Wayne F Luminiscence measurement arrangement
US5096807A (en) 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
US4921757A (en) 1985-04-26 1990-05-01 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
US4861709A (en) 1985-05-31 1989-08-29 Technicon Research A.G. Detection and/or identification of microorganisms in a test sample using bioluminescence or other exogenous genetically-introduced marker
US4853327A (en) 1985-07-10 1989-08-01 Molecular Diagnostics, Inc. Enhanced phthalazinedione chemiluminescence
US4950588A (en) 1985-07-10 1990-08-21 Molecular Diagnostics, Inc. Prolonged enhanced chemiluminescence
US5279943A (en) 1985-08-02 1994-01-18 Compagnie Oris Industrie Homogeneous process for the detection and/or determination by luminescence of an analyte in a medium in which it may be present
DE3537877A1 (de) 1985-10-24 1987-04-30 Geiger Reinhard Luciferin-derivate und immunoassays unter einsatz derartiger luciferin-derivate
US4714682A (en) 1985-12-11 1987-12-22 Flow Cytometry Standards Corporation Fluorescent calibration microbeads simulating stained cells
JPS62171695A (ja) 1985-12-14 1987-07-28 Chisso Corp 発光蛋白アクアリン遺伝子を用いるアクアリン活性を有する蛋白質の製造法
FR2597725B1 (fr) 1986-04-29 1990-06-15 Noirot Extraits Procede pour l'obtention d'un effet de phosphorescence et produits obtenus selon ce procede.
JPS62261942A (ja) 1986-05-08 1987-11-14 Chisso Corp 金属の検出方法
US4777128A (en) 1986-05-27 1988-10-11 Ethigen Corporation Fluorescence immunoassay involving energy transfer between two fluorophores
US4717158A (en) 1986-06-26 1988-01-05 Pennisi Anthony J Game footbag
US5004565A (en) 1986-07-17 1991-04-02 The Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US5221623A (en) 1986-07-22 1993-06-22 Boyce Thompson Institute For Plant Research, Inc. Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms
US4867908A (en) 1986-08-29 1989-09-19 Becton, Dickinson And Company Method and materials for calibrating flow cytometers and other analysis instruments
US5093240A (en) 1986-10-15 1992-03-03 Chisso Corporation Variant aequorin genes and process for producing variant aequorin proteins
US5268463A (en) 1986-11-11 1993-12-07 Jefferson Richard A Plant promoter α-glucuronidase gene construct
US4762881A (en) 1987-01-09 1988-08-09 E. I. Du Pont De Nemours And Company Photoreactive benzoylphenylalanines and related peptides
US5128256A (en) 1987-01-12 1992-07-07 Stratagene DNA cloning vectors with in vivo excisable plasmids
US4765510A (en) 1987-04-07 1988-08-23 Rende Vincent N Multiple color fluid dispensing gun
US4781647A (en) 1987-05-04 1988-11-01 Hasbro, Inc. Toy doll construction with phosphorescent hair fibers
US4891043A (en) 1987-05-28 1990-01-02 Board Of Trustees Of The University Of Illinois System for selective release of liposome encapsulated material via laser radiation
US4735660A (en) 1987-06-26 1988-04-05 Mattel, Inc. Cross-linked gel modeling composition
US4968613A (en) 1987-07-29 1990-11-06 Kikkoman Corporation Luciferase gene and novel recombinant DNA as well as a method of producing luciferase
JPS6447379A (en) 1987-08-19 1989-02-21 Chisso Corp Preparation of calcium-dependent oxygenation enzyme
JP2592623B2 (ja) 1987-11-18 1997-03-19 チッソ株式会社 アポエクオリンの製造法
US5182202A (en) 1987-11-30 1993-01-26 Kikkoman Corporation Purified luciferase from luciola cruciata
US5162508A (en) 1987-12-18 1992-11-10 Compagnie Oris Industrie Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers
JPH088864B2 (ja) 1988-04-12 1996-01-31 キッコーマン株式会社 ルシフェラーゼ
WO1990001542A1 (en) 1988-08-09 1990-02-22 Toray Industries, Inc. Luciferase, luciferase-coding gene, and process for preparing luciferase
US5604123A (en) 1988-08-09 1997-02-18 Toray Industries, Inc. Luciferase, gene encoding the same and production process of the same
US4924358A (en) 1988-09-12 1990-05-08 Inventech Licensing Co. Safety-sparkler wand w/chemiluminescent or electric-light illumination
US5196524A (en) 1989-01-06 1993-03-23 Eli Lilly And Company Fusion reporter gene for bacterial luciferase
JPH02234698A (ja) 1989-03-08 1990-09-17 Toyobo Co Ltd 細菌ルシフェラーゼ系によるｄｎａプローブの検出法
US5360726A (en) 1989-09-12 1994-11-01 Board Of Trustees Operating Michigan State University Polypeptides enabling sorting of proteins to vacuoles in plants
US5288623A (en) 1989-10-26 1994-02-22 Chisso Corporation Process for secretory production of a calcium-binding protein
DE3935974A1 (de) 1989-10-28 1991-05-02 Mueller Klieser Wolfgang Prof Verfahren zur bestimmung von metaboliten in gewebeproben, enzymcocktail und vorrichtung zu dessen durchfuehrung
US4963117A (en) 1989-10-30 1990-10-16 Gualdoni Kevin G Selectively illuminated toy ball
JP2626738B2 (ja) 1990-03-13 1997-07-02 三共株式会社 化学発光検出装置
US5219737A (en) 1990-03-27 1993-06-15 Kikkoman Corporation Mutant luciferase of a firefly, mutant luciferase genes, recombinant dnas containing the genes and a method of producing mutant luciferase
US5433896A (en) 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5189029A (en) 1990-04-23 1993-02-23 Bo-Dekk Ventures, Ltd. Indacene compounds and methods for using the same
US5196318A (en) 1990-06-26 1993-03-23 The Texas A&M University System Precisely regulated expression of deleterious genes
DK0537270T3 (da) 1990-07-02 1999-06-07 Univ California Påvisning af analytter ved overføring af fluorescensenergi
US5374534A (en) 1990-07-19 1994-12-20 Charm Sciences, Inc. Method of preparing D-luciferin derivatives
BE1005073A7 (fr) 1990-08-30 1993-04-13 Collet Marcel Georges Procede d'illumination des liquides et dispositifs appropries a un tel procede.
JPH06501099A (ja) 1990-09-11 1994-01-27 ヴォアヒーズ・テクノロジース・インコーポレーテッド 被覆された毛管
US5169784A (en) 1990-09-17 1992-12-08 The Texas A & M University System Baculovirus dual promoter expression vector
US5266317A (en) 1990-10-04 1993-11-30 University Of Georgia Research Foundation, Inc. Insect-specific paralytic neurotoxin genes for use in biological insect control: methods and compositions
JP2856339B2 (ja) 1991-02-21 1999-02-10 キッコーマン株式会社 酵素免疫測定法
DK0575319T3 (da) * 1991-03-11 2000-07-10 Univ Georgia Res Found Kloning og ekspression af Renilla-luciferase
WO1992017995A1 (fr) 1991-04-02 1992-10-15 Alcatel Cable Materiau pour ecran semi-conducteur
US5229285A (en) 1991-06-27 1993-07-20 Kikkoman Corporation Thermostable luciferase of firefly, thermostable luciferase gene of firefly, novel recombinant dna, and process for the preparation of thermostable luciferase of firefly
US5158349A (en) 1991-07-03 1992-10-27 Lexington & Associates, Inc. Multi-color chemical lighting device
US5383100A (en) 1991-08-02 1995-01-17 Kikos; J. Peter Multi-channel tubular display package
US5243041A (en) 1991-08-22 1993-09-07 Fernandez Pol Jose A DNA vector with isolated CDNA gene encoding metallopanstimulin
US5277913A (en) 1991-09-09 1994-01-11 Thompson David H Liposomal delivery system with photoactivatable triggered release
US5222797A (en) 1991-10-31 1993-06-29 Lexington & Associates Multi-chamber chemiluminescent optical display device
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5413098A (en) 1991-12-24 1995-05-09 Sextant Medical Corporation Path constrained spectrophotometer and method for determination of spatial distribution of light or other radiation scattering and absorbing substances in a radiation scattering medium
DE4210759A1 (de) 1992-04-01 1993-10-07 Boehringer Mannheim Gmbh Substituierte Thiazolin-Dioxetan-Substrate, Verfahren zur Herstellung und Verwendung
US5310421A (en) 1992-02-07 1994-05-10 Mattel, Inc. Play material
DE69327593T2 (de) 1992-02-14 2000-06-29 Nycomed Amersham Plc Little Ch Fluoreszente Verbundstoffe
US5337745A (en) 1992-03-10 1994-08-16 Benaron David A Device and method for in vivo qualitative or quantative measurement of blood chromophore concentration using blood pulse spectrophotometry
US5171081A (en) 1992-05-29 1992-12-15 Pita Joe W Chemiluminescent reactive vessel
EP0651814B1 (en) 1992-07-09 1997-01-08 Pioneer Hi-Bred International, Inc. Maize pollen-specific polygalacturonase gene
US5323492A (en) 1992-08-10 1994-06-28 Demars Robert A Illuminated article of wearing apparel with afterglow
US5360728A (en) 1992-12-01 1994-11-01 Woods Hole Oceanographic Institution (W.H.O.I.) Modified apoaequorin having increased bioluminescent activity
US5405958A (en) 1992-12-21 1995-04-11 Transitions Optical, Inc. Photochromic spiro(indoline)naphthoxazine compounds
ATE217086T1 (de) 1993-02-12 2002-05-15 Sealite Sciences Inc Herstellung von photoprotein konjugaten und verfahren zu ihrer verwendung
US5366881A (en) 1993-02-23 1994-11-22 The United States Of America As Represented By The Secretary Of The Navy Polymerizable lipids for preparing vesicles that controllably release an encapsulant
US5496934A (en) 1993-04-14 1996-03-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nucleic acids encoding a cellulose binding domain
US5364797A (en) 1993-05-20 1994-11-15 Mobil Oil Corp. Sensor device containing mesoporous crystalline material
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5451347A (en) 1993-06-24 1995-09-19 Lumigen, Inc. Methods and compositions providing enhanced chemiluminescence from chemiluminescent compounds using dicationic surfactants
JPH0779783A (ja) 1993-06-28 1995-03-28 Chisso Corp ビブリオ フィシエリ由来のフラビン還元酵素遺伝子
US5424216A (en) 1993-08-16 1995-06-13 Jasco Corporation No radical measuring method and apparatus
US5362865A (en) 1993-09-02 1994-11-08 Monsanto Company Enhanced expression in plants using non-translated leader sequences
US5491084A (en) 1993-09-10 1996-02-13 The Trustees Of Columbia University In The City Of New York Uses of green-fluorescent protein
US5415151A (en) 1993-09-20 1995-05-16 Jcf Research Associates, Inc. Phosphor-containing projectile and launcher therefor
US5405905A (en) 1993-11-26 1995-04-11 Hy-Tec Enterprises Artificial soil and soil-forming composition
ES2301160T3 (es) * 1994-01-03 2008-06-16 Promega Corporation Luciferasas mutantes.
FI95484C (fi) 1994-01-17 1996-02-12 Marko Virta Menetelmä näytteessä olevan metallin määrittämiseksi
WO1995021191A1 (en) 1994-02-04 1995-08-10 William Ward Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
GB9501170D0 (en) * 1994-03-23 1995-03-08 Secr Defence Luciferases
GB2288232A (en) 1994-04-06 1995-10-11 Brf International Photosensitive derivatives of ATP as assay control standards
US5413332A (en) 1994-05-26 1995-05-09 Amber Forrest, Inc. Eggball
JP3030678B2 (ja) 1994-06-17 2000-04-10 崇 近藤 自動車ドアの補助開閉機構
US5777079A (en) 1994-11-10 1998-07-07 The Regents Of The University Of California Modified green fluorescent proteins
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
JPH08136546A (ja) 1994-11-15 1996-05-31 Bio Sensor Kenkyusho:Kk 物質分析法
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
ES2139329T3 (es) * 1995-09-22 2000-02-01 Bioimage A S Nuevas variantes de la proteina fluorescente verde, gfp.
US5730321A (en) 1995-12-13 1998-03-24 Mcallister; Todd Glow-in-the-dark water emitters
US5874304A (en) 1996-01-18 1999-02-23 University Of Florida Research Foundation, Inc. Humanized green fluorescent protein genes and methods
US6803188B1 (en) * 1996-01-31 2004-10-12 The Regents Of The University Of California Tandem fluorescent protein constructs
US5804387A (en) 1996-02-01 1998-09-08 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US5912137A (en) 1996-07-16 1999-06-15 The Regents Of The University Of California Assays for protein kinases using fluorescent
US5976796A (en) 1996-10-04 1999-11-02 Loma Linda University Construction and expression of renilla luciferase and green fluorescent protein fusion genes
PT1199564E (pt) * 1997-04-07 2004-10-29 Bioimage A S Um metodo para rastrear substancias que tem um efeito na translocacao intracelular
US5891646A (en) 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5418155A (en) * 1989-12-29 1995-05-23 University Of Georgia Research Foundation, Inc. Isolated Renilla luciferase and method of use thereof
WO1997029319A2 (en) * 1996-02-06 1997-08-14 Bryan Bruce J Bioluminescent novelty items

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MITRA ET AL,GENE, 1996, 173: 13-17 *

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Free format text: IN VOL 17, NO 38, PAGE(S) 1268 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX IN THE NAME OF PROLUME, LTD., BRYAN, B.J., SERIAL NO. 765703, INID (22), AMEND THE FILING DATE TO READ 19990326

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