AU634751B2 - Substituted pyrimidine derivatives, a process for the preparation thereof, and the use thereof as a tool - Google Patents

Substituted pyrimidine derivatives, a process for the preparation thereof, and the use thereof as a tool Download PDF

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Publication number
AU634751B2
AU634751B2 AU49975/90A AU4997590A AU634751B2 AU 634751 B2 AU634751 B2 AU 634751B2 AU 49975/90 A AU49975/90 A AU 49975/90A AU 4997590 A AU4997590 A AU 4997590A AU 634751 B2 AU634751 B2 AU 634751B2
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AU
Australia
Prior art keywords
formula
alkyl
hydrogen
compound
arylcarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU49975/90A
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English (en)
Other versions
AU4997590A (en
Inventor
Karl Geisen
Hans-Jochen Lang
Hildegard Nimmesgern
Klaus Weidmann
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Hoechst AG
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Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU4997590A publication Critical patent/AU4997590A/en
Application granted granted Critical
Publication of AU634751B2 publication Critical patent/AU634751B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU49975/90A 1989-02-22 1990-02-20 Substituted pyrimidine derivatives, a process for the preparation thereof, and the use thereof as a tool Expired AU634751B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3905364 1989-02-22
DE3905364A DE3905364A1 (de) 1989-02-22 1989-02-22 Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool

Publications (2)

Publication Number Publication Date
AU4997590A AU4997590A (en) 1990-08-30
AU634751B2 true AU634751B2 (en) 1993-03-04

Family

ID=6374628

Family Applications (1)

Application Number Title Priority Date Filing Date
AU49975/90A Expired AU634751B2 (en) 1989-02-22 1990-02-20 Substituted pyrimidine derivatives, a process for the preparation thereof, and the use thereof as a tool

Country Status (18)

Country Link
US (1) US5138058A (no)
EP (1) EP0384370B1 (no)
JP (1) JP2955318B2 (no)
KR (1) KR0142189B1 (no)
AT (1) ATE96787T1 (no)
AU (1) AU634751B2 (no)
CA (1) CA2010588C (no)
DE (2) DE3905364A1 (no)
DK (1) DK0384370T3 (no)
ES (1) ES2060829T3 (no)
FI (1) FI95694C (no)
IE (1) IE63570B1 (no)
IL (1) IL93465A (no)
NO (1) NO178431C (no)
NZ (1) NZ232601A (no)
PH (1) PH27222A (no)
PT (1) PT93224B (no)
ZA (1) ZA901309B (no)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2662607B1 (fr) * 1990-05-30 1992-08-28 Oreal Composition destinee a etre utilisee pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives d'alkyl-2 amino-4 (ou dialkyl-2-4) pyrimidine oxyde-3 .
DE4025387A1 (de) * 1990-08-10 1992-02-13 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als reagenzien
DE4142191A1 (de) * 1991-12-20 1993-06-24 Bayer Ag Verfahren zur herstellung von 3-alkoxy-acrylestern
KR0163624B1 (ko) * 1992-04-28 1998-12-01 오노다 마사요시 신규의 치환된 3급 아미노 화합물 또는 이의 염
JP2789134B2 (ja) * 1992-09-28 1998-08-20 ファイザー・インク． 糖尿病の合併症を制御する置換ピリミジン類
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US6313127B1 (en) 1996-02-02 2001-11-06 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
EP0791355B1 (en) * 1996-02-29 2002-04-17 Pfizer Inc. Method of reducing tissue damage associated with ischemia
JPH09301868A (ja) * 1996-05-10 1997-11-25 Senju Pharmaceut Co Ltd 抗白内障剤
CZ45699A3 (cs) * 1996-08-14 1999-05-12 Zeneca Limited Substituované deriváty pyrimidinu, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
WO1998014430A1 (fr) * 1996-10-02 1998-04-09 Sumitomo Pharmaceuticals Co., Ltd. Derives de pyrimidine
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
US6440972B1 (en) 1997-02-13 2002-08-27 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
DE69815509T2 (de) 1997-02-13 2004-05-13 Astrazeneca Ab Heterozyklische verbindungen die als oxido-squalen-zyklase-inhibitoren anwendung finden
DE19710435A1 (de) * 1997-03-13 1998-09-17 Hoechst Ag Verwendung von Pyrimidinderivaten zur Prävention von Krebs allein oder in Kombination mit anderen therapeutischen Maßnahmen
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
MXPA01009871A (es) * 1999-04-01 2002-04-24 Pfizer Prod Inc Aminopiridinas como inhibidores de la sorbitol deshidrogenasa.
DE60009777T2 (de) * 1999-04-01 2004-08-19 Pfizer Products Inc., Groton Verbindung für Behandlung und Vorsorge bei Diabetes
BR0113165A (pt) * 2000-08-08 2003-07-15 Ortho Mcneil Pharm Inc Derivados de 4-pirimidinamina, composições farmacêuticas e métodos relacionados
EP1334094B1 (en) 2000-11-02 2004-12-29 F. Hoffmann-La Roche Ag Cholesterol lowering benzo[b]thiophenes and benzo[d]isothiazoles
US6503907B2 (en) 2000-11-28 2003-01-07 Hoffmann-La Roche Inc. Indole and dihydroindole derivatives
EP1247809A3 (en) * 2001-03-30 2003-12-17 Pfizer Products Inc. Triazine compounds useful as sorbitol dehydrogenase inhibitors
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
US20040082627A1 (en) * 2002-06-21 2004-04-29 Darrow James W. Certain aromatic monocycles as kinase modulators
AU2003249369A1 (en) * 2002-06-21 2004-01-06 Cellular Genomics, Inc. Certain amino-substituted monocycles as kinase modulators
GB0323137D0 (en) * 2003-10-03 2003-11-05 Chang Lisa C W 2,4,6- Trisubstituted pyrimidines and their different uses
US7434592B2 (en) * 2003-10-10 2008-10-14 Millennial Medical Equipment, L.L.C. Ergonomic collapsible crutch
US7104271B2 (en) * 2003-10-10 2006-09-12 Millennial Medical Equipment, L.L.C. Ergonomic collapsible crutch
BRPI0417478A (pt) * 2003-12-15 2007-05-08 Almirall Prodesfarma Ag 2,6-bis-heteroaril-4-aminopirimidinas como antagonistas de receptor de adenosina
TWI355894B (en) * 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
EP1888565B1 (en) * 2005-04-11 2011-03-23 Almirall, S.A. 2, 6-di (hetero) aryl -4-amido-pyrimidines as adenosine receptor antagonists
AU2006326540A1 (en) * 2005-12-14 2007-06-21 Amgen Inc. Diaza heterocyclic sulfonamide derivatives and their uses
EP2121662A1 (en) * 2006-12-04 2009-11-25 Neurocrine Biosciences, Inc. Substituted pyrimidines as adenosine receptor antagonists
MY148427A (en) * 2006-12-08 2013-04-30 Irm Llc Compounds and compositions as protein kinase inhibitors
EP2132197A2 (en) * 2007-03-21 2009-12-16 Almirall, S.A. Substituted pyrimidines as adenosine receptor antagonists
DK2142529T3 (da) 2007-04-27 2014-02-10 Purdue Pharma Lp Trpv1-antagonister og anvendelser deraf
EP2723732B1 (en) 2011-06-22 2017-01-18 Purdue Pharma LP Trpv1 antagonists including dihydroxy substituent and uses thereof
CN102675217A (zh) * 2012-05-24 2012-09-19 盛世泰科生物医药技术(苏州)有限公司 一种5-溴-2-甲基-4(1h)-嘧啶酮的制备方法
CN110372602A (zh) * 2019-06-24 2019-10-25 南京普锐达医药科技有限公司 一种4-氯-2-甲基嘧啶的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU465734B2 (en) * 1970-10-05 1975-10-09 Pfizer Inc Arylpyrimidines-inhibitors of platelet aggregation and bronchodilators
AU498132B2 (en) * 1974-05-10 1979-02-15 Ciba-Geigy Ag 5 - nitro - pyrimidine derivatives

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB959699A (en) * 1961-06-09 1964-06-03 May & Baker Ltd New pyrimidine derivatives
GB1143167A (en) * 1967-01-25 1969-02-19 Ucb Sa Derivatives of pyrimidine
US3859288A (en) * 1970-10-05 1975-01-07 Pfizer Arylpyrimidines - inhibitors of platelet aggregation and bronchodilators
JPS5031157B1 (no) * 1970-10-22 1975-10-07
NL7103449A (no) * 1971-03-15 1972-09-19
DE2263052A1 (de) * 1972-12-22 1974-07-04 Wacker Chemie Gmbh Neue pyrimidine
DE2433176C3 (de) * 1974-07-10 1979-06-07 Daiichi Seiyaku Co., Ltd., Tokio N-Cyano-cyano-acetimidate und Verfahren zur Herstellung von 2-Halopyrinüdinderivaten
US4191553A (en) 1978-03-02 1980-03-04 E. I. Du Pont De Nemours And Company Herbicidal sulfamates
CH643583A5 (de) * 1979-08-16 1984-06-15 Sandoz Ag Reaktivfarbstoffe sowie deren herstellung.
US4323681A (en) * 1980-09-29 1982-04-06 American Home Products Corporation 4-Amino-2-substituted-5-pyrimidinecarboxamidoximes and carbothioamides
LU86695A1 (fr) * 1986-12-01 1988-07-14 Oreal Nouveaux derives de piperazinyl-1 pyrimidine,leur preparation et leur application en therapeutique et cosmetique
US4900813A (en) * 1987-07-02 1990-02-13 Ciba-Geigy Corporation Fiber-reactive azo dyes having a 4,6-diaminopyridine coupling component
US4931455A (en) * 1988-01-07 1990-06-05 Ube Industries, Ltd. Alkylaminopyrimidine derivative and insecticide, acaricide and fungicide containing the same as active ingredient
EP0330263A1 (en) * 1988-02-25 1989-08-30 Merck & Co. Inc. Piperazinylalkylpyrimidines as hypoglycemic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU465734B2 (en) * 1970-10-05 1975-10-09 Pfizer Inc Arylpyrimidines-inhibitors of platelet aggregation and bronchodilators
AU498132B2 (en) * 1974-05-10 1979-02-15 Ciba-Geigy Ag 5 - nitro - pyrimidine derivatives

Also Published As

Publication number Publication date
ES2060829T3 (es) 1994-12-01
US5138058A (en) 1992-08-11
CA2010588A1 (en) 1990-08-22
NO178431C (no) 1996-03-27
CA2010588C (en) 2000-01-18
JP2955318B2 (ja) 1999-10-04
PH27222A (en) 1993-05-04
IL93465A (en) 1995-03-30
NO900822D0 (no) 1990-02-21
PT93224B (pt) 1996-09-30
IL93465A0 (en) 1990-11-29
FI95694B (fi) 1995-11-30
KR0142189B1 (ko) 1998-06-01
ATE96787T1 (de) 1993-11-15
NZ232601A (en) 1991-12-23
DE59003274D1 (de) 1993-12-09
KR900012916A (ko) 1990-09-03
AU4997590A (en) 1990-08-30
NO900822L (no) 1990-08-23
ZA901309B (en) 1990-10-31
PT93224A (pt) 1990-08-31
JPH02255662A (ja) 1990-10-16
DE3905364A1 (de) 1990-08-23
EP0384370B1 (de) 1993-11-03
IE900627L (en) 1990-08-22
FI900839A0 (fi) 1990-02-20
FI95694C (fi) 1996-03-11
NO178431B (no) 1995-12-18
IE63570B1 (en) 1995-05-17
DK0384370T3 (da) 1994-03-07
EP0384370A1 (de) 1990-08-29

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