IL93465A - Transformed pyrimidine history, process for preparation and preparations containing them causing sorbitol accumulation in pharmacological models - Google Patents

Transformed pyrimidine history, process for preparation and preparations containing them causing sorbitol accumulation in pharmacological models

Info

Publication number
IL93465A
IL93465A IL9346590A IL9346590A IL93465A IL 93465 A IL93465 A IL 93465A IL 9346590 A IL9346590 A IL 9346590A IL 9346590 A IL9346590 A IL 9346590A IL 93465 A IL93465 A IL 93465A
Authority
IL
Israel
Prior art keywords
formula
alkyl
hydrogen
compound
substituted
Prior art date
Application number
IL9346590A
Other languages
English (en)
Hebrew (he)
Other versions
IL93465A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL93465A0 publication Critical patent/IL93465A0/xx
Publication of IL93465A publication Critical patent/IL93465A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
IL9346590A 1989-02-22 1990-02-20 Transformed pyrimidine history, process for preparation and preparations containing them causing sorbitol accumulation in pharmacological models IL93465A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3905364A DE3905364A1 (de) 1989-02-22 1989-02-22 Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool

Publications (2)

Publication Number Publication Date
IL93465A0 IL93465A0 (en) 1990-11-29
IL93465A true IL93465A (en) 1995-03-30

Family

ID=6374628

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9346590A IL93465A (en) 1989-02-22 1990-02-20 Transformed pyrimidine history, process for preparation and preparations containing them causing sorbitol accumulation in pharmacological models

Country Status (18)

Country Link
US (1) US5138058A (no)
EP (1) EP0384370B1 (no)
JP (1) JP2955318B2 (no)
KR (1) KR0142189B1 (no)
AT (1) ATE96787T1 (no)
AU (1) AU634751B2 (no)
CA (1) CA2010588C (no)
DE (2) DE3905364A1 (no)
DK (1) DK0384370T3 (no)
ES (1) ES2060829T3 (no)
FI (1) FI95694C (no)
IE (1) IE63570B1 (no)
IL (1) IL93465A (no)
NO (1) NO178431C (no)
NZ (1) NZ232601A (no)
PH (1) PH27222A (no)
PT (1) PT93224B (no)
ZA (1) ZA901309B (no)

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FR2662607B1 (fr) * 1990-05-30 1992-08-28 Oreal Composition destinee a etre utilisee pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives d'alkyl-2 amino-4 (ou dialkyl-2-4) pyrimidine oxyde-3 .
DE4025387A1 (de) * 1990-08-10 1992-02-13 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als reagenzien
DE4142191A1 (de) * 1991-12-20 1993-06-24 Bayer Ag Verfahren zur herstellung von 3-alkoxy-acrylestern
DK0640595T3 (da) * 1992-04-28 1999-10-11 Yamanouchi Pharma Co Ltd Substituerede tertiære aminoforbindelser og salte heraf
AU683620B2 (en) * 1992-09-28 1997-11-20 Pfizer Inc. Substituted pyrimidines for control of diabetic complications
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
AU1608397A (en) * 1996-02-02 1997-08-22 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
PT791355E (pt) * 1996-02-29 2002-08-30 Pfizer Metodo para diminuir os daos associados com a isquemia nos tecidos
JPH09301868A (ja) * 1996-05-10 1997-11-25 Senju Pharmaceut Co Ltd 抗白内障剤
CN1228087A (zh) * 1996-08-14 1999-09-08 曾尼卡有限公司 取代的嘧啶衍生物和它们的药物用途
WO1998014430A1 (fr) * 1996-10-02 1998-04-09 Sumitomo Pharmaceuticals Co., Ltd. Derives de pyrimidine
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
EP0966460A1 (en) 1997-02-13 1999-12-29 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
JP2001511799A (ja) 1997-02-13 2001-08-14 ゼネカ・リミテッド オキシド−スクアレンシクラーゼ阻害剤として有用なヘテロ環式化合物
DE19710435A1 (de) * 1997-03-13 1998-09-17 Hoechst Ag Verwendung von Pyrimidinderivaten zur Prävention von Krebs allein oder in Kombination mit anderen therapeutischen Maßnahmen
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
YU71101A (sh) 1999-04-01 2004-07-15 Pfizer Products Inc. Aminopirimidini kao inhibitori sorbitol dehidrogenaze
DE60009777T2 (de) 1999-04-01 2004-08-19 Pfizer Products Inc., Groton Verbindung für Behandlung und Vorsorge bei Diabetes
ATE398109T1 (de) * 2000-08-08 2008-07-15 Ortho Mcneil Pharm Inc 4-pyrimidinamine derivate, pharmazeutische zusammenstellungen und verwandte methoden
EP1334094B1 (en) 2000-11-02 2004-12-29 F. Hoffmann-La Roche Ag Cholesterol lowering benzo[b]thiophenes and benzo[d]isothiazoles
US6503907B2 (en) 2000-11-28 2003-01-07 Hoffmann-La Roche Inc. Indole and dihydroindole derivatives
EP1247809A3 (en) 2001-03-30 2003-12-17 Pfizer Products Inc. Triazine compounds useful as sorbitol dehydrogenase inhibitors
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
US20040082627A1 (en) * 2002-06-21 2004-04-29 Darrow James W. Certain aromatic monocycles as kinase modulators
AU2003249369A1 (en) * 2002-06-21 2004-01-06 Cellular Genomics, Inc. Certain amino-substituted monocycles as kinase modulators
GB0323137D0 (en) * 2003-10-03 2003-11-05 Chang Lisa C W 2,4,6- Trisubstituted pyrimidines and their different uses
US7434592B2 (en) * 2003-10-10 2008-10-14 Millennial Medical Equipment, L.L.C. Ergonomic collapsible crutch
US7104271B2 (en) * 2003-10-10 2006-09-12 Millennial Medical Equipment, L.L.C. Ergonomic collapsible crutch
BRPI0417478A (pt) * 2003-12-15 2007-05-08 Almirall Prodesfarma Ag 2,6-bis-heteroaril-4-aminopirimidinas como antagonistas de receptor de adenosina
TWI355894B (en) * 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
EP1888565B1 (en) * 2005-04-11 2011-03-23 Almirall, S.A. 2, 6-di (hetero) aryl -4-amido-pyrimidines as adenosine receptor antagonists
CA2632027A1 (en) * 2005-12-14 2007-06-21 Amgen Inc. Diaza heterocyclic sulfonamide derivatives and their uses
WO2008070661A1 (en) * 2006-12-04 2008-06-12 Neurocrine Biosciences, Inc. Substituted pyrimidines as adenosine receptor antagonists
EA019966B1 (ru) * 2006-12-08 2014-07-30 АйАрЭм ЭлЭлСи Соединения и композиции в качестве ингибиторов протеинкиназы
CN101687850A (zh) * 2007-03-21 2010-03-31 艾美罗股份公司 作为腺苷受体拮抗剂的取代的嘧啶
PL2142529T3 (pl) * 2007-04-27 2014-06-30 Purdue Pharma Lp Antagoniści trpv1 i ich zastosowania
MY185061A (en) 2011-06-22 2021-04-30 Shionogi & Co Trpv1 antagonists including dihydroxy substituent and uses thereof
CN102675217A (zh) * 2012-05-24 2012-09-19 盛世泰科生物医药技术(苏州)有限公司 一种5-溴-2-甲基-4(1h)-嘧啶酮的制备方法
CN110372602A (zh) * 2019-06-24 2019-10-25 南京普锐达医药科技有限公司 一种4-氯-2-甲基嘧啶的合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB959699A (en) * 1961-06-09 1964-06-03 May & Baker Ltd New pyrimidine derivatives
GB1143167A (en) * 1967-01-25 1969-02-19 Ucb Sa Derivatives of pyrimidine
US3859288A (en) * 1970-10-05 1975-01-07 Pfizer Arylpyrimidines - inhibitors of platelet aggregation and bronchodilators
US3707560A (en) * 1970-10-05 1972-12-26 Pfizer Certain 4-amino-6-aryl-pyrimidines
JPS5031157B1 (no) * 1970-10-22 1975-10-07
NL7103449A (no) * 1971-03-15 1972-09-19
DE2263052A1 (de) * 1972-12-22 1974-07-04 Wacker Chemie Gmbh Neue pyrimidine
CH595061A5 (no) * 1974-05-10 1978-01-31 Ciba Geigy Ag
DE2433176C3 (de) * 1974-07-10 1979-06-07 Daiichi Seiyaku Co., Ltd., Tokio N-Cyano-cyano-acetimidate und Verfahren zur Herstellung von 2-Halopyrinüdinderivaten
US4191553A (en) 1978-03-02 1980-03-04 E. I. Du Pont De Nemours And Company Herbicidal sulfamates
CH643583A5 (de) * 1979-08-16 1984-06-15 Sandoz Ag Reaktivfarbstoffe sowie deren herstellung.
US4323681A (en) * 1980-09-29 1982-04-06 American Home Products Corporation 4-Amino-2-substituted-5-pyrimidinecarboxamidoximes and carbothioamides
LU86695A1 (fr) * 1986-12-01 1988-07-14 Oreal Nouveaux derives de piperazinyl-1 pyrimidine,leur preparation et leur application en therapeutique et cosmetique
US4900813A (en) * 1987-07-02 1990-02-13 Ciba-Geigy Corporation Fiber-reactive azo dyes having a 4,6-diaminopyridine coupling component
US4931455A (en) * 1988-01-07 1990-06-05 Ube Industries, Ltd. Alkylaminopyrimidine derivative and insecticide, acaricide and fungicide containing the same as active ingredient
EP0330263A1 (en) * 1988-02-25 1989-08-30 Merck & Co. Inc. Piperazinylalkylpyrimidines as hypoglycemic agents

Also Published As

Publication number Publication date
EP0384370A1 (de) 1990-08-29
IE900627L (en) 1990-08-22
US5138058A (en) 1992-08-11
CA2010588C (en) 2000-01-18
KR900012916A (ko) 1990-09-03
EP0384370B1 (de) 1993-11-03
IE63570B1 (en) 1995-05-17
PH27222A (en) 1993-05-04
NZ232601A (en) 1991-12-23
ZA901309B (en) 1990-10-31
NO178431B (no) 1995-12-18
PT93224A (pt) 1990-08-31
FI95694B (fi) 1995-11-30
ATE96787T1 (de) 1993-11-15
NO900822L (no) 1990-08-23
ES2060829T3 (es) 1994-12-01
FI95694C (fi) 1996-03-11
JP2955318B2 (ja) 1999-10-04
JPH02255662A (ja) 1990-10-16
KR0142189B1 (ko) 1998-06-01
DE3905364A1 (de) 1990-08-23
AU4997590A (en) 1990-08-30
PT93224B (pt) 1996-09-30
IL93465A0 (en) 1990-11-29
FI900839A0 (fi) 1990-02-20
CA2010588A1 (en) 1990-08-22
AU634751B2 (en) 1993-03-04
NO900822D0 (no) 1990-02-21
NO178431C (no) 1996-03-27
DK0384370T3 (da) 1994-03-07
DE59003274D1 (de) 1993-12-09

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