NO178431C - Substituerte pyrimidinderivater - Google Patents

Substituerte pyrimidinderivater

Info

Publication number
NO178431C
NO178431C NO900822A NO900822A NO178431C NO 178431 C NO178431 C NO 178431C NO 900822 A NO900822 A NO 900822A NO 900822 A NO900822 A NO 900822A NO 178431 C NO178431 C NO 178431C
Authority
NO
Norway
Prior art keywords
pyrimidine derivatives
substituted pyrimidine
sorbitol
salts
tool
Prior art date
Application number
NO900822A
Other languages
English (en)
Other versions
NO900822L (no
NO900822D0 (no
NO178431B (no
Inventor
Karl Geisen
Hans-Jochen Lang
Hildegard Nimmesgern
Klaus Weidmann
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO900822D0 publication Critical patent/NO900822D0/no
Publication of NO900822L publication Critical patent/NO900822L/no
Publication of NO178431B publication Critical patent/NO178431B/no
Publication of NO178431C publication Critical patent/NO178431C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO900822A 1989-02-22 1990-02-21 Substituerte pyrimidinderivater NO178431C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3905364A DE3905364A1 (de) 1989-02-22 1989-02-22 Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool

Publications (4)

Publication Number Publication Date
NO900822D0 NO900822D0 (no) 1990-02-21
NO900822L NO900822L (no) 1990-08-23
NO178431B NO178431B (no) 1995-12-18
NO178431C true NO178431C (no) 1996-03-27

Family

ID=6374628

Family Applications (1)

Application Number Title Priority Date Filing Date
NO900822A NO178431C (no) 1989-02-22 1990-02-21 Substituerte pyrimidinderivater

Country Status (18)

Country Link
US (1) US5138058A (no)
EP (1) EP0384370B1 (no)
JP (1) JP2955318B2 (no)
KR (1) KR0142189B1 (no)
AT (1) ATE96787T1 (no)
AU (1) AU634751B2 (no)
CA (1) CA2010588C (no)
DE (2) DE3905364A1 (no)
DK (1) DK0384370T3 (no)
ES (1) ES2060829T3 (no)
FI (1) FI95694C (no)
IE (1) IE63570B1 (no)
IL (1) IL93465A (no)
NO (1) NO178431C (no)
NZ (1) NZ232601A (no)
PH (1) PH27222A (no)
PT (1) PT93224B (no)
ZA (1) ZA901309B (no)

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FR2662607B1 (fr) * 1990-05-30 1992-08-28 Oreal Composition destinee a etre utilisee pour freiner la chute des cheveux et pour induire et stimuler leur croissance, contenant des derives d'alkyl-2 amino-4 (ou dialkyl-2-4) pyrimidine oxyde-3 .
DE4025387A1 (de) * 1990-08-10 1992-02-13 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als reagenzien
DE4142191A1 (de) * 1991-12-20 1993-06-24 Bayer Ag Verfahren zur herstellung von 3-alkoxy-acrylestern
US5538976A (en) * 1992-04-28 1996-07-23 Yamanouchi Pharmaceutical Co., Ltd. Substituted tertiary amino compound or salt thereof
KR950703539A (ko) * 1992-09-28 1995-09-20 알렌 제이. 스피겔 당뇨병 합병증 치료용 치환된 피리미딘(substituted pyrimidines for control or diabetic complications)
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US6313127B1 (en) 1996-02-02 2001-11-06 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
DE69711965T2 (de) * 1996-02-29 2003-01-23 Pfizer Verwendung von Sorbitol-Dehydrogenase-Inhibitoren zum Reduzieren von Ischämie-assozierten Gewebeschäden
JPH09301868A (ja) * 1996-05-10 1997-11-25 Senju Pharmaceut Co Ltd 抗白内障剤
ATE230399T1 (de) * 1996-08-14 2003-01-15 Astrazeneca Ab Substituierte pyrimidinderivate und ihre pharmazeutische anwendung
WO1998014430A1 (fr) * 1996-10-02 1998-04-09 Sumitomo Pharmaceuticals Co., Ltd. Derives de pyrimidine
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
JP2001511798A (ja) 1997-02-13 2001-08-14 ゼネカ・リミテッド オキシド−スクアレンシクラーゼ抑制剤として有用な複素環化合物
AU5999798A (en) 1997-02-13 1998-09-08 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
DE19710435A1 (de) * 1997-03-13 1998-09-17 Hoechst Ag Verwendung von Pyrimidinderivaten zur Prävention von Krebs allein oder in Kombination mit anderen therapeutischen Maßnahmen
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
CA2366858A1 (en) 1999-04-01 2000-10-12 Margaret Yuhua Chu-Moyer Sorbitol dehydrogenase inhibitors
ATE264311T1 (de) 1999-04-01 2004-04-15 Pfizer Prod Inc Verbindungen zur behandlung und vorsorge bei diabetes
NZ524100A (en) * 2000-08-08 2005-01-28 Ortho Mcneil Pharm Inc 4-pyrimidinamine derivatives, pharmaceutical compositions and related methods
KR100545430B1 (ko) 2000-11-02 2006-01-24 에프. 호프만-라 로슈 아게 콜레스테롤 저하성 벤조[ｂ]티오펜 및 벤조[ｄ]이소티아졸
US6503907B2 (en) 2000-11-28 2003-01-07 Hoffmann-La Roche Inc. Indole and dihydroindole derivatives
EP1247809A3 (en) * 2001-03-30 2003-12-17 Pfizer Products Inc. Triazine compounds useful as sorbitol dehydrogenase inhibitors
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
WO2004000820A2 (en) * 2002-06-21 2003-12-31 Cellular Genomics, Inc. Certain aromatic monocycles as kinase modulators
AU2003249369A1 (en) * 2002-06-21 2004-01-06 Cellular Genomics, Inc. Certain amino-substituted monocycles as kinase modulators
GB0323137D0 (en) * 2003-10-03 2003-11-05 Chang Lisa C W 2,4,6- Trisubstituted pyrimidines and their different uses
US7434592B2 (en) * 2003-10-10 2008-10-14 Millennial Medical Equipment, L.L.C. Ergonomic collapsible crutch
US7104271B2 (en) * 2003-10-10 2006-09-12 Millennial Medical Equipment, L.L.C. Ergonomic collapsible crutch
US20080058356A1 (en) * 2003-12-15 2008-03-06 Neurocrine Biosciences, Inc. 2,6 Bisheteroaryl-4-Aminopyrimidines as Adenosine Receptor Antagonists
TWI355894B (en) * 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
EP1888565B1 (en) * 2005-04-11 2011-03-23 Almirall, S.A. 2, 6-di (hetero) aryl -4-amido-pyrimidines as adenosine receptor antagonists
WO2007070506A2 (en) * 2005-12-14 2007-06-21 Amgen Inc. Diaza heterocyclic sulfonamide derivatives and their uses
JP2010511727A (ja) * 2006-12-04 2010-04-15 ニューロクライン バイオサイエンシーズ，インコーポレイテッド アデノシン受容体アンタゴニストとしての置換ピリミジン
EP2537830A1 (en) * 2006-12-08 2012-12-26 Irm Llc Compounds and compositions as protein kinase inhibitors
US20100249084A1 (en) * 2007-03-21 2010-09-30 Youngsheng Chen Substituted pyrimidines as adenosine receptor antagonists
PL2142529T3 (pl) * 2007-04-27 2014-06-30 Purdue Pharma Lp Antagoniści trpv1 i ich zastosowania
RU2621708C2 (ru) 2011-06-22 2017-06-07 ПУРДЬЮ ФАРМА Эл. Пи. Антагонисты trpv1, включающие дигидроксигруппу в качестве заместителя, и их применение
CN102675217A (zh) * 2012-05-24 2012-09-19 盛世泰科生物医药技术(苏州)有限公司 一种5-溴-2-甲基-4(1h)-嘧啶酮的制备方法
CN110372602A (zh) * 2019-06-24 2019-10-25 南京普锐达医药科技有限公司 一种4-氯-2-甲基嘧啶的合成方法

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
GB959699A (en) * 1961-06-09 1964-06-03 May & Baker Ltd New pyrimidine derivatives
GB1143167A (en) * 1967-01-25 1969-02-19 Ucb Sa Derivatives of pyrimidine
US3707560A (en) * 1970-10-05 1972-12-26 Pfizer Certain 4-amino-6-aryl-pyrimidines
US3859288A (en) * 1970-10-05 1975-01-07 Pfizer Arylpyrimidines - inhibitors of platelet aggregation and bronchodilators
JPS5031157B1 (no) * 1970-10-22 1975-10-07
NL7103449A (no) * 1971-03-15 1972-09-19
DE2263052A1 (de) * 1972-12-22 1974-07-04 Wacker Chemie Gmbh Neue pyrimidine
CH595061A5 (no) * 1974-05-10 1978-01-31 Ciba Geigy Ag
DE2433176C3 (de) * 1974-07-10 1979-06-07 Daiichi Seiyaku Co., Ltd., Tokio N-Cyano-cyano-acetimidate und Verfahren zur Herstellung von 2-Halopyrinüdinderivaten
US4191553A (en) 1978-03-02 1980-03-04 E. I. Du Pont De Nemours And Company Herbicidal sulfamates
CH643583A5 (de) * 1979-08-16 1984-06-15 Sandoz Ag Reaktivfarbstoffe sowie deren herstellung.
US4323681A (en) * 1980-09-29 1982-04-06 American Home Products Corporation 4-Amino-2-substituted-5-pyrimidinecarboxamidoximes and carbothioamides
LU86695A1 (fr) * 1986-12-01 1988-07-14 Oreal Nouveaux derives de piperazinyl-1 pyrimidine,leur preparation et leur application en therapeutique et cosmetique
US4900813A (en) * 1987-07-02 1990-02-13 Ciba-Geigy Corporation Fiber-reactive azo dyes having a 4,6-diaminopyridine coupling component
US4931455A (en) * 1988-01-07 1990-06-05 Ube Industries, Ltd. Alkylaminopyrimidine derivative and insecticide, acaricide and fungicide containing the same as active ingredient
EP0330263A1 (en) * 1988-02-25 1989-08-30 Merck & Co. Inc. Piperazinylalkylpyrimidines as hypoglycemic agents

Also Published As

Publication number Publication date
JP2955318B2 (ja) 1999-10-04
IL93465A (en) 1995-03-30
PT93224B (pt) 1996-09-30
FI95694C (fi) 1996-03-11
US5138058A (en) 1992-08-11
IE900627L (en) 1990-08-22
NO900822L (no) 1990-08-23
PH27222A (en) 1993-05-04
FI95694B (fi) 1995-11-30
NO900822D0 (no) 1990-02-21
IL93465A0 (en) 1990-11-29
DE3905364A1 (de) 1990-08-23
IE63570B1 (en) 1995-05-17
CA2010588C (en) 2000-01-18
DK0384370T3 (da) 1994-03-07
KR0142189B1 (ko) 1998-06-01
DE59003274D1 (de) 1993-12-09
EP0384370A1 (de) 1990-08-29
EP0384370B1 (de) 1993-11-03
ZA901309B (en) 1990-10-31
NO178431B (no) 1995-12-18
CA2010588A1 (en) 1990-08-22
JPH02255662A (ja) 1990-10-16
PT93224A (pt) 1990-08-31
AU634751B2 (en) 1993-03-04
ATE96787T1 (de) 1993-11-15
NZ232601A (en) 1991-12-23
KR900012916A (ko) 1990-09-03
ES2060829T3 (es) 1994-12-01
FI900839A0 (fi) 1990-02-20
AU4997590A (en) 1990-08-30

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Legal Events

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