RU94003397A - Производные 2-/4-(4-азолилбутил)-1-пиперазинил/-пиримидина, способ их получения и фармацевтическая композиция на их основе - Google Patents
Производные 2-/4-(4-азолилбутил)-1-пиперазинил/-пиримидина, способ их получения и фармацевтическая композиция на их основеInfo
- Publication number
- RU94003397A RU94003397A RU94003397/04A RU94003397A RU94003397A RU 94003397 A RU94003397 A RU 94003397A RU 94003397/04 A RU94003397/04 A RU 94003397/04A RU 94003397 A RU94003397 A RU 94003397A RU 94003397 A RU94003397 A RU 94003397A
- Authority
- RU
- Russia
- Prior art keywords
- pyrimidine
- derivatives
- azolilbutyl
- piperasinyl
- basis
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- LAADFGZWQBMKJN-UHFFFAOYSA-N 2-[4-[4-(1H-pyrrol-2-yl)butyl]piperazin-1-yl]pyrimidine Chemical class C1CN(C=2N=CC=CN=2)CCN1CCCCC1=CC=CN1 LAADFGZWQBMKJN-UHFFFAOYSA-N 0.000 claims 1
- 230000000949 anxiolytic Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000001624 sedative Effects 0.000 claims 1
Claims (1)
- Изобретение относится к новым производным 2- [4-(4-азолилбутил)-1-пиперазинил] -пиримидина, обладающим анксиолитической или успокаивающей активностью, а также к способу получения новых соединений.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9301293A FR2701260B1 (fr) | 1993-02-05 | 1993-02-05 | Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments. |
FR9301293 | 1993-02-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU94003397A true RU94003397A (ru) | 1995-09-10 |
RU2118318C1 RU2118318C1 (ru) | 1998-08-27 |
Family
ID=9443776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94003397A RU2118318C1 (ru) | 1993-02-05 | 1994-02-04 | Производные 2-[4-(4-азолилбутил)-1-пиперазинил]-пиримидина или их физиологически приемлемые соли, способ их получения и фармацевтическая композиция на их основе |
Country Status (15)
Country | Link |
---|---|
US (1) | US5444059A (ru) |
EP (1) | EP0610140B1 (ru) |
JP (1) | JPH06234762A (ru) |
KR (1) | KR940019705A (ru) |
AT (1) | ATE188693T1 (ru) |
AU (1) | AU684479B2 (ru) |
BR (1) | BR1100847A (ru) |
CA (1) | CA2115016A1 (ru) |
DE (1) | DE69422532D1 (ru) |
ES (1) | ES2076894B1 (ru) |
FR (1) | FR2701260B1 (ru) |
HU (1) | HU218211B (ru) |
NO (1) | NO305082B1 (ru) |
RU (1) | RU2118318C1 (ru) |
ZA (1) | ZA94775B (ru) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5646281A (en) | 1990-12-28 | 1997-07-08 | Neurogen Corporation | Certain 4-piperidino- and piperazinomethyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands |
US5681956A (en) * | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
US5773616A (en) * | 1995-02-15 | 1998-06-30 | Neurogen Corporation | Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands |
US6011052A (en) * | 1996-04-30 | 2000-01-04 | Warner-Lambert Company | Pyrazolone derivatives as MCP-1 antagonists |
US6166205A (en) * | 1998-09-02 | 2000-12-26 | Neurogen Corporation | 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands |
DE19951960C2 (de) * | 1999-10-28 | 2002-06-27 | Gruenenthal Gmbh | Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate |
AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
KR100465649B1 (ko) * | 2002-09-17 | 2005-01-13 | 한국포리올 주식회사 | 일체형 연마 패드 및 그 제조 방법 |
ES2377406T3 (es) * | 2003-07-30 | 2012-03-27 | Xenon Pharmaceuticals Inc. | Derivados de la piperazina y su uso como agentes terapéuticos |
WO2011030139A1 (en) | 2009-09-11 | 2011-03-17 | Astrazeneca Ab | 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4423049A (en) * | 1981-12-28 | 1983-12-27 | Mead Johnson & Company | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines |
US5187276A (en) * | 1983-06-18 | 1993-02-16 | Troponwerke Gmbh & Co. Kg. | 2-pyrimidinyl-1-piperazine derivatives |
DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
FR2642759B1 (fr) * | 1989-02-09 | 1991-05-17 | Laboratorios Esteve Sa | Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante |
FR2654621B1 (fr) * | 1989-11-22 | 1994-09-23 | Esteve Labor Dr | Inhibition du syndrome d'abstinence. |
FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
FR2665161B1 (fr) * | 1990-07-26 | 1992-11-27 | Esteve Labor Dr | Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments. |
DK0482696T3 (da) * | 1990-10-23 | 1996-05-20 | Akzo Nobel Nv | 4-(4- eller 6-(trifluormethyl-2-pyridinyl))-1-piperazinylalkyl-substituerede lactamer |
FR2671972B1 (fr) * | 1991-01-25 | 1995-03-03 | Esteve Labor Dr | Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives. |
FR2673628B1 (fr) * | 1991-03-07 | 1993-07-09 | Esteve Labor Dr | Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles. |
FR2705098B1 (fr) * | 1993-05-10 | 1995-08-04 | Esteve Labor Dr | Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) . |
-
1993
- 1993-02-05 FR FR9301293A patent/FR2701260B1/fr not_active Expired - Fee Related
-
1994
- 1994-01-26 NO NO940274A patent/NO305082B1/no unknown
- 1994-02-03 KR KR1019940001980A patent/KR940019705A/ko not_active IP Right Cessation
- 1994-02-03 ES ES09400191A patent/ES2076894B1/es not_active Expired - Fee Related
- 1994-02-04 AT AT94400238T patent/ATE188693T1/de active
- 1994-02-04 CA CA002115016A patent/CA2115016A1/fr not_active Abandoned
- 1994-02-04 AU AU54889/94A patent/AU684479B2/en not_active Ceased
- 1994-02-04 HU HU9400321A patent/HU218211B/hu not_active IP Right Cessation
- 1994-02-04 RU RU94003397A patent/RU2118318C1/ru active
- 1994-02-04 JP JP6012842A patent/JPH06234762A/ja active Pending
- 1994-02-04 EP EP94400238A patent/EP0610140B1/fr not_active Expired - Lifetime
- 1994-02-04 DE DE69422532T patent/DE69422532D1/de not_active Expired - Lifetime
- 1994-02-04 ZA ZA94775A patent/ZA94775B/xx unknown
- 1994-02-04 US US08/192,142 patent/US5444059A/en not_active Expired - Fee Related
-
1997
- 1997-05-12 BR BR1100847-4A patent/BR1100847A/pt active IP Right Grant
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