ATE188693T1 - 2-(4-(4-azolylbutyl)-1-piperazinyl)-5- hydroxypyrimidin-derivate, deren herstellung und deren verwendung als heilmittel - Google Patents

2-(4-(4-azolylbutyl)-1-piperazinyl)-5- hydroxypyrimidin-derivate, deren herstellung und deren verwendung als heilmittel

Info

Publication number
ATE188693T1
ATE188693T1 AT94400238T AT94400238T ATE188693T1 AT E188693 T1 ATE188693 T1 AT E188693T1 AT 94400238 T AT94400238 T AT 94400238T AT 94400238 T AT94400238 T AT 94400238T AT E188693 T1 ATE188693 T1 AT E188693T1
Authority
AT
Austria
Prior art keywords
azolylbutyl
piperazinyl
preparation
remedies
group
Prior art date
Application number
AT94400238T
Other languages
English (en)
Inventor
Jordi Frigola-Constansa
Ramon Merce-Vidal
Original Assignee
Esteve Labor Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr
Application granted granted Critical
Publication of ATE188693T1 publication Critical patent/ATE188693T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT94400238T 1993-02-05 1994-02-04 2-(4-(4-azolylbutyl)-1-piperazinyl)-5- hydroxypyrimidin-derivate, deren herstellung und deren verwendung als heilmittel ATE188693T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9301293A FR2701260B1 (fr) 1993-02-05 1993-02-05 Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments.

Publications (1)

Publication Number Publication Date
ATE188693T1 true ATE188693T1 (de) 2000-01-15

Family

ID=9443776

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94400238T ATE188693T1 (de) 1993-02-05 1994-02-04 2-(4-(4-azolylbutyl)-1-piperazinyl)-5- hydroxypyrimidin-derivate, deren herstellung und deren verwendung als heilmittel

Country Status (15)

Country Link
US (1) US5444059A (de)
EP (1) EP0610140B1 (de)
JP (1) JPH06234762A (de)
KR (1) KR940019705A (de)
AT (1) ATE188693T1 (de)
AU (1) AU684479B2 (de)
BR (1) BR1100847A (de)
CA (1) CA2115016A1 (de)
DE (1) DE69422532D1 (de)
ES (1) ES2076894B1 (de)
FR (1) FR2701260B1 (de)
HU (1) HU218211B (de)
NO (1) NO305082B1 (de)
RU (1) RU2118318C1 (de)
ZA (1) ZA94775B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5633377A (en) * 1990-12-28 1997-05-27 Neurogen Corporation 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands
US5773616A (en) * 1995-02-15 1998-06-30 Neurogen Corporation Certain bridged 4-phenyl-2-aminomethylimidazoles; new dopamine receptor subtype specific ligands
US6011052A (en) * 1996-04-30 2000-01-04 Warner-Lambert Company Pyrazolone derivatives as MCP-1 antagonists
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
DE19951960C2 (de) * 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
CA2396066A1 (en) * 2000-01-19 2001-07-26 Akzo Nobel N.V. Drug combination for the treatment of depression and related disorders comprising mirtazapine and gepirone
ES2167276B1 (es) * 2000-10-20 2003-04-01 Esteve Labor Dr Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos.
AR038957A1 (es) 2001-08-15 2005-02-02 Pharmacia Corp Terapia de combinacion para el tratamiento del cancer
KR100465649B1 (ko) * 2002-09-17 2005-01-13 한국포리올 주식회사 일체형 연마 패드 및 그 제조 방법
US7456180B2 (en) * 2003-07-30 2008-11-25 Xenon Pharmaceuticals Inc. Piperazine derivatives and their use as therapeutic agents
WO2011030139A1 (en) 2009-09-11 2011-03-17 Astrazeneca Ab 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4423049A (en) * 1981-12-28 1983-12-27 Mead Johnson & Company 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US5187276A (en) * 1983-06-18 1993-02-16 Troponwerke Gmbh & Co. Kg. 2-pyrimidinyl-1-piperazine derivatives
FR2642759B1 (fr) * 1989-02-09 1991-05-17 Laboratorios Esteve Sa Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante
JPH078795B2 (ja) * 1989-09-06 1995-02-01 日立化成工業株式会社 排尿障害治療剤
FR2654621B1 (fr) * 1989-11-22 1994-09-23 Esteve Labor Dr Inhibition du syndrome d'abstinence.
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
FR2665161B1 (fr) * 1990-07-26 1992-11-27 Esteve Labor Dr Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments.
DK0482696T3 (da) * 1990-10-23 1996-05-20 Akzo Nobel Nv 4-(4- eller 6-(trifluormethyl-2-pyridinyl))-1-piperazinylalkyl-substituerede lactamer
FR2671972B1 (fr) * 1991-01-25 1995-03-03 Esteve Labor Dr Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives.
FR2673628B1 (fr) * 1991-03-07 1993-07-09 Esteve Labor Dr Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles.
FR2705098B1 (fr) * 1993-05-10 1995-08-04 Esteve Labor Dr Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) .

Also Published As

Publication number Publication date
NO940274D0 (no) 1994-01-26
BR1100847A (pt) 1999-12-07
JPH06234762A (ja) 1994-08-23
ZA94775B (en) 1994-09-29
US5444059A (en) 1995-08-22
DE69422532D1 (de) 2000-02-17
KR940019705A (ko) 1994-09-14
RU2118318C1 (ru) 1998-08-27
ES2076894A1 (es) 1995-11-01
AU5488994A (en) 1994-08-11
EP0610140B1 (de) 2000-01-12
HU218211B (hu) 2000-06-28
EP0610140A1 (de) 1994-08-10
FR2701260A1 (fr) 1994-08-12
HUT70196A (en) 1995-09-28
CA2115016A1 (fr) 1994-08-06
ES2076894B1 (es) 1996-10-16
NO305082B1 (no) 1999-03-29
AU684479B2 (en) 1997-12-18
FR2701260B1 (fr) 1995-05-05
HU9400321D0 (en) 1994-05-30
NO940274L (no) 1994-08-08

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