YU31600A - Pseudopolimorfni oblici 2-(2-(4-bis(4-fluorofenil)metil)-1-piperazinil)etoksi)sirćetne kiseline dihidrohlorida - Google Patents

Pseudopolimorfni oblici 2-(2-(4-bis(4-fluorofenil)metil)-1-piperazinil)etoksi)sirćetne kiseline dihidrohlorida

Info

Publication number
YU31600A
YU31600A YU31600A YU31600A YU31600A YU 31600 A YU31600 A YU 31600A YU 31600 A YU31600 A YU 31600A YU 31600 A YU31600 A YU 31600A YU 31600 A YU31600 A YU 31600A
Authority
YU
Yugoslavia
Prior art keywords
piperazinyl
fluorophenyl
bis
methyl
acetic acid
Prior art date
Application number
YU31600A
Other languages
English (en)
Inventor
Monique Berwaer
Guy Bodson
Michel Deleers
Charles Dogimont
Domenico Fanara
Jacques Timmermans
Original Assignee
Ucb S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb S.A. filed Critical Ucb S.A.
Publication of YU31600A publication Critical patent/YU31600A/sh
Publication of RS49904B publication Critical patent/RS49904B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Predmetni pronalazak se odnosi na nove pseudopolimorfne oblike dihidrohlorida 2-[2-[4-[bis(4-fluorofenil)metil]-1-piperazinil]etoksi]-sirćetne kiseline i monohidratdihidrohlorida 2-[2-[4-[bis(4-fluorofenil)metil]-1-piperazinil]etoksi]-sirćetne kiseline. Pronalazak se takođe odnosi na postupke za dobijanje ovih pseudopolimorfnih oblika i na farmaceutske preparate koji ih sadrže.[The present invention relates to new pseudopolymorphic forms of 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride, namely, anhydrous 2-[2-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride and 2-[2-[4- [bis(4-fluorophenyl)methyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride monohydrate. It also relates to processes for the preparation of these pseudopolymorphic forms and to pharmaceutical compositions containing them.
YUP-316/00A 1997-11-26 1998-11-26 Pseudopolimorfni oblici 2-[2-[ 4- [bis( 4-fluorofenil)metil]-1-piperazinil]etoksi] sirćetne kiseline dihidrohlorida RS49904B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97870193A EP0919550A1 (en) 1997-11-26 1997-11-26 Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride

Publications (2)

Publication Number Publication Date
YU31600A true YU31600A (sh) 2002-03-18
RS49904B RS49904B (sr) 2008-08-07

Family

ID=8231072

Country Status (39)

Country Link
US (2) US6262057B1 (sh)
EP (2) EP0919550A1 (sh)
JP (2) JP3996348B2 (sh)
KR (1) KR100557711B1 (sh)
CN (1) CN100406448C (sh)
AR (1) AR017676A1 (sh)
AT (1) ATE203237T1 (sh)
AU (1) AU735819B2 (sh)
BG (1) BG64155B1 (sh)
BR (1) BR9815405A (sh)
CA (1) CA2310318C (sh)
CO (1) CO4980892A1 (sh)
CZ (1) CZ295972B6 (sh)
DE (1) DE69801163T2 (sh)
DK (1) DK1034171T3 (sh)
EG (1) EG23776A (sh)
ES (1) ES2161552T3 (sh)
GC (1) GC0000094A (sh)
GR (1) GR3036702T3 (sh)
HU (1) HUP0100343A3 (sh)
ID (1) ID24964A (sh)
IL (1) IL135544A (sh)
MA (1) MA26569A1 (sh)
MY (1) MY119653A (sh)
NO (1) NO314692B1 (sh)
NZ (1) NZ504461A (sh)
PE (1) PE134899A1 (sh)
PL (1) PL190871B1 (sh)
PT (1) PT1034171E (sh)
RS (1) RS49904B (sh)
RU (1) RU2182575C2 (sh)
SI (1) SI20325A (sh)
SK (1) SK283237B6 (sh)
TN (1) TNSN98214A1 (sh)
TR (1) TR200001505T2 (sh)
TW (1) TWI225053B (sh)
UA (1) UA54568C2 (sh)
WO (1) WO1999028310A1 (sh)
ZA (1) ZA9810780B (sh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002221854A1 (en) * 2000-12-15 2002-06-24 U C B, S.A. Use of cetirizine or efletirizine for preventing urticaria
CA2454564A1 (en) * 2001-07-26 2003-02-06 Ucb, S.A. Process for the preparation of 2-(2-(4-(bis(4-fluorophenyl)methyl)-piperazin-1-yl)ethoxy)acetic acid derivatives or corresponding salt forms thereof and intermediates therefor
US20050181032A1 (en) * 2002-06-25 2005-08-18 Acrux Dds Pty Ltd. Metastable pharmaceutical compositions
KR20100055542A (ko) * 2002-06-25 2010-05-26 애크럭스 디디에스 피티와이 리미티드 비정질 약학적 조성물을 이용한 경피전달속도의 제어
WO2004105760A1 (en) * 2003-05-28 2004-12-09 Ucb Farchim, S.A. Use of efletirizine for treating persistent allergic rhinitis
WO2006050909A1 (en) * 2004-11-10 2006-05-18 Ucb Farchim Sa Novel forms of efletirizine dihydrochloride, processes for making them and pharmaceutical compositions including them
WO2008155777A2 (en) * 2007-06-18 2008-12-24 Cadila Healthcare Limited Process for preparing efletrizine
KR101006760B1 (ko) * 2008-07-17 2011-01-11 주식회사 진영테크 모터 순간 정전 복원 장치

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH505116A (it) * 1966-11-21 1971-03-31 Crc Ricerca Chim Metodo per l'ottenimento di derivati della piperazina
SE409706B (sv) 1976-05-21 1979-09-03 Astra Pharma Prod Forfarande for framstellning av n,n-dimetyl-3-(4-bromfenyl)-3-3(3-pyridyl)-allylamin dihydroklorid monohydrat
JPS57149282A (en) * 1981-02-06 1982-09-14 Ucb Sa 2-(4-(diphenylmethyl)-1-piperazinyl)acetic acid and their derivatives as medicine
NO155805C (no) 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
GB8827391D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8827390D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
TW401300B (en) * 1992-12-25 2000-08-11 Senju Pharma Co Antiallergic composition for ophthalmic or nasal use
US5625358A (en) * 1993-09-13 1997-04-29 Analog Devices, Inc. Digital phase-locked loop utilizing a high order sigma-delta modulator
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.

Also Published As

Publication number Publication date
CZ20001787A3 (cs) 2000-09-13
ES2161552T3 (es) 2001-12-01
PE134899A1 (es) 2000-01-11
HUP0100343A2 (hu) 2001-07-30
MY119653A (en) 2005-06-30
DK1034171T3 (da) 2001-11-05
CN1279676A (zh) 2001-01-10
PT1034171E (pt) 2001-11-30
NZ504461A (en) 2001-06-29
IL135544A (en) 2004-02-08
SK283237B6 (sk) 2003-04-01
CA2310318A1 (en) 1999-06-10
AR017676A1 (es) 2001-09-12
PL340724A1 (en) 2001-02-26
US6262057B1 (en) 2001-07-17
CO4980892A1 (es) 2000-11-27
DE69801163D1 (en) 2001-08-23
SK5942000A3 (en) 2000-10-09
AU1327799A (en) 1999-06-16
US20010021712A1 (en) 2001-09-13
UA54568C2 (uk) 2003-03-17
EP1034171A1 (en) 2000-09-13
SI20325A (sl) 2001-02-28
BG64155B1 (bg) 2004-02-27
JP2001524548A (ja) 2001-12-04
BR9815405A (pt) 2000-10-10
KR20010032420A (ko) 2001-04-16
JP2007224042A (ja) 2007-09-06
TR200001505T2 (tr) 2000-09-21
TWI225053B (en) 2004-12-11
NO314692B1 (no) 2003-05-05
RS49904B (sr) 2008-08-07
JP3996348B2 (ja) 2007-10-24
CZ295972B6 (cs) 2005-12-14
KR100557711B1 (ko) 2006-03-07
GR3036702T3 (en) 2001-12-31
EG23776A (en) 2007-08-08
PL190871B1 (pl) 2006-02-28
TNSN98214A1 (fr) 2005-03-15
NO20002631L (no) 2000-05-23
EP1034171B1 (en) 2001-07-18
ZA9810780B (en) 1999-05-31
HUP0100343A3 (en) 2001-09-28
CN100406448C (zh) 2008-07-30
RU2182575C2 (ru) 2002-05-20
CA2310318C (en) 2003-10-21
US6335331B2 (en) 2002-01-01
MA26569A1 (fr) 2004-12-20
EP0919550A1 (en) 1999-06-02
AU735819B2 (en) 2001-07-19
IL135544A0 (en) 2001-05-20
GC0000094A (en) 2005-06-29
WO1999028310A1 (en) 1999-06-10
DE69801163T2 (de) 2002-03-28
BG104424A (en) 2001-01-31
ID24964A (id) 2000-08-31
NO20002631D0 (no) 2000-05-23
ATE203237T1 (de) 2001-08-15

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