AR017676A1 - Derivado seudopolimorfico de dihidrocloruro del acido 2-[2-[4-[bis(4-fluorofenil)metil]-1-piperazinil]etoxi]acetico, procedimiento para su preparacion y composicion farmaceutica que lo comprende - Google Patents
Derivado seudopolimorfico de dihidrocloruro del acido 2-[2-[4-[bis(4-fluorofenil)metil]-1-piperazinil]etoxi]acetico, procedimiento para su preparacion y composicion farmaceutica que lo comprendeInfo
- Publication number
- AR017676A1 AR017676A1 ARP980105975A ARP980105975A AR017676A1 AR 017676 A1 AR017676 A1 AR 017676A1 AR P980105975 A ARP980105975 A AR P980105975A AR P980105975 A ARP980105975 A AR P980105975A AR 017676 A1 AR017676 A1 AR 017676A1
- Authority
- AR
- Argentina
- Prior art keywords
- piperazinyl
- fluorophenyl
- bis
- methyl
- acetic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Formas pseudopolimorficas derivadas del dihidrocloruro del ácido 2-[2-[4-[bis(4-fluorofenil)metil]-1-piperazinil]etoxi]acético a saber, anhídrico deldihidrocloruro del ácido 2-[2-[4-[bis(4-fluorofenil)metil]-1-piperazinil]etoxi]acético, cuyo patron de difraccion de Rayos X presenta picos a valores de 2theta de: 13,710,5; 13,910,5; 16,310,5; 18,010,5; 18,60,5; 19,110,5; 23,110,5; 24,110,5; 25,610,5; y 30,210,5; y monohidrato deldihidrocloruro del ácido 2-[2-[4-[bis(4-fluorofenil)metil]-1-piperazinil]etoxi]acético, cuyo patron de difraccion de Rayos X presenta picos a valores de 2theta de: 7,510,5; 9,710,5; 10,510,5; 10,710,5; 15,710,5; 18,910,5; 19,610,5; 19,910,5; 20,410,5; 20,910,5; 22,210,5; 22,510,5;24,610,5; 24,710,5; 25,910,5; y 29,310,5. El ácido 2-[2-[4-[bis(4-fluorofenil)metil]-1-piperazinil]etoxi]acético, también conocido y denominado en losucesivo efletirizina es el compuesto de la formula (I). Este compuesto posee excelentes propiedades antihistamínicas. Pertenece a la clasefarmacologica deantagonistas del receptor H1 de la histamina de segunda generacion y muestra alta afinidad in vitro y selectividad por los receptores H1. Procedimientos parala preparacion de estas formas pseudopolimorficas y composiciones farmacéuticas que las contienen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97870193A EP0919550A1 (en) | 1997-11-26 | 1997-11-26 | Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR017676A1 true AR017676A1 (es) | 2001-09-12 |
Family
ID=8231072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980105975A AR017676A1 (es) | 1997-11-26 | 1998-11-25 | Derivado seudopolimorfico de dihidrocloruro del acido 2-[2-[4-[bis(4-fluorofenil)metil]-1-piperazinil]etoxi]acetico, procedimiento para su preparacion y composicion farmaceutica que lo comprende |
Country Status (39)
| Country | Link |
|---|---|
| US (2) | US6262057B1 (es) |
| EP (2) | EP0919550A1 (es) |
| JP (2) | JP3996348B2 (es) |
| KR (1) | KR100557711B1 (es) |
| CN (1) | CN100406448C (es) |
| AR (1) | AR017676A1 (es) |
| AT (1) | ATE203237T1 (es) |
| AU (1) | AU735819B2 (es) |
| BG (1) | BG64155B1 (es) |
| BR (1) | BR9815405A (es) |
| CA (1) | CA2310318C (es) |
| CO (1) | CO4980892A1 (es) |
| CZ (1) | CZ295972B6 (es) |
| DE (1) | DE69801163T2 (es) |
| DK (1) | DK1034171T3 (es) |
| EG (1) | EG23776A (es) |
| ES (1) | ES2161552T3 (es) |
| GC (1) | GC0000094A (es) |
| GR (1) | GR3036702T3 (es) |
| HU (1) | HUP0100343A3 (es) |
| ID (1) | ID24964A (es) |
| IL (1) | IL135544A (es) |
| MA (1) | MA26569A1 (es) |
| MY (1) | MY119653A (es) |
| NO (1) | NO314692B1 (es) |
| NZ (1) | NZ504461A (es) |
| PE (1) | PE134899A1 (es) |
| PL (1) | PL190871B1 (es) |
| PT (1) | PT1034171E (es) |
| RS (1) | RS49904B (es) |
| RU (1) | RU2182575C2 (es) |
| SI (1) | SI20325A (es) |
| SK (1) | SK283237B6 (es) |
| TN (1) | TNSN98214A1 (es) |
| TR (1) | TR200001505T2 (es) |
| TW (1) | TWI225053B (es) |
| UA (1) | UA54568C2 (es) |
| WO (1) | WO1999028310A1 (es) |
| ZA (1) | ZA9810780B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002047689A2 (en) * | 2000-12-15 | 2002-06-20 | Ucb, S.A. | Use of cetirizine or efletirizine for preventing urticaria |
| WO2003009849A1 (en) * | 2001-07-26 | 2003-02-06 | Ucb, S.A. | Process for the preparation of 2-(2-(4-(bis(4-fluorophenyl)methyl)-piperazin-1-yl)ethoxy)acetic acid derivatives or corresponding salt forms thereof and intermediates therefor |
| US20050181032A1 (en) * | 2002-06-25 | 2005-08-18 | Acrux Dds Pty Ltd. | Metastable pharmaceutical compositions |
| KR20050045946A (ko) | 2002-06-25 | 2005-05-17 | 애크럭스 디디에스 피티와이 리미티드 | 비정질 약학적 조성물을 이용한 경피전달속도의 제어 |
| JP2007500197A (ja) * | 2003-05-28 | 2007-01-11 | ユセベ ファルシム ソシエテ アノニム | 持続性アレルギー性鼻炎の治療のためのエフレチリジンの使用 |
| WO2006050909A1 (en) * | 2004-11-10 | 2006-05-18 | Ucb Farchim Sa | Novel forms of efletirizine dihydrochloride, processes for making them and pharmaceutical compositions including them |
| WO2008155777A2 (en) * | 2007-06-18 | 2008-12-24 | Cadila Healthcare Limited | Process for preparing efletrizine |
| KR101006760B1 (ko) * | 2008-07-17 | 2011-01-11 | 주식회사 진영테크 | 모터 순간 정전 복원 장치 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH505116A (it) * | 1966-11-21 | 1971-03-31 | Crc Ricerca Chim | Metodo per l'ottenimento di derivati della piperazina |
| SE409706B (sv) | 1976-05-21 | 1979-09-03 | Astra Pharma Prod | Forfarande for framstellning av n,n-dimetyl-3-(4-bromfenyl)-3-3(3-pyridyl)-allylamin dihydroklorid monohydrat |
| FI75816C (fi) * | 1981-02-06 | 1988-08-08 | Ucb Sa | Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid. |
| UA8337A1 (uk) * | 1981-02-06 | 1996-03-29 | Бальтес Ежен | 2-[4-(дифенілметіл)-1-піперазиніл]-оцтові кислоти або їх аміди, або їх нетоксичні фармацевтично прийняті солі, що проявляють спазмолітичну і антигістамінну активність |
| GB8827391D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
| GB8827390D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
| US5968551A (en) * | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| TW401300B (en) * | 1992-12-25 | 2000-08-11 | Senju Pharma Co | Antiallergic composition for ophthalmic or nasal use |
| US5625358A (en) * | 1993-09-13 | 1997-04-29 | Analog Devices, Inc. | Digital phase-locked loop utilizing a high order sigma-delta modulator |
| BE1010095A3 (fr) * | 1996-04-10 | 1997-12-02 | Ucb Sa | Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels. |
| BE1010094A3 (fr) * | 1996-04-10 | 1997-12-02 | Ucb Sa | Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues. |
-
1997
- 1997-11-26 EP EP97870193A patent/EP0919550A1/en not_active Withdrawn
-
1998
- 1998-11-17 MY MYPI98005218A patent/MY119653A/en unknown
- 1998-11-23 PE PE1998001137A patent/PE134899A1/es not_active Application Discontinuation
- 1998-11-24 CO CO98069203A patent/CO4980892A1/es unknown
- 1998-11-25 TN TNTNSN98214A patent/TNSN98214A1/fr unknown
- 1998-11-25 EG EG147698A patent/EG23776A/xx active
- 1998-11-25 ZA ZA9810780A patent/ZA9810780B/xx unknown
- 1998-11-25 GC GCP199836 patent/GC0000094A/xx active
- 1998-11-25 AR ARP980105975A patent/AR017676A1/es not_active Application Discontinuation
- 1998-11-25 MA MA25361A patent/MA26569A1/fr unknown
- 1998-11-26 SK SK594-2000A patent/SK283237B6/sk unknown
- 1998-11-26 RS YUP-316/00A patent/RS49904B/sr unknown
- 1998-11-26 PT PT80901733T patent/PT1034171E/pt unknown
- 1998-11-26 UA UA2000063689A patent/UA54568C2/uk unknown
- 1998-11-26 AU AU13277/99A patent/AU735819B2/en not_active Ceased
- 1998-11-26 JP JP2000523202A patent/JP3996348B2/ja not_active Expired - Fee Related
- 1998-11-26 RU RU2000116106/04A patent/RU2182575C2/ru not_active IP Right Cessation
- 1998-11-26 EP EP98956725A patent/EP1034171B1/en not_active Expired - Lifetime
- 1998-11-26 HU HU0100343A patent/HUP0100343A3/hu unknown
- 1998-11-26 KR KR1020007005660A patent/KR100557711B1/ko not_active IP Right Cessation
- 1998-11-26 ID IDW20000985A patent/ID24964A/id unknown
- 1998-11-26 ES ES98956725T patent/ES2161552T3/es not_active Expired - Lifetime
- 1998-11-26 DK DK98956725T patent/DK1034171T3/da active
- 1998-11-26 CN CNB988114909A patent/CN100406448C/zh not_active Expired - Fee Related
- 1998-11-26 AT AT98956725T patent/ATE203237T1/de not_active IP Right Cessation
- 1998-11-26 BR BR9815405-2A patent/BR9815405A/pt not_active Application Discontinuation
- 1998-11-26 NZ NZ504461A patent/NZ504461A/en unknown
- 1998-11-26 CA CA002310318A patent/CA2310318C/en not_active Expired - Fee Related
- 1998-11-26 TR TR2000/01505T patent/TR200001505T2/xx unknown
- 1998-11-26 SI SI9820072A patent/SI20325A/sl not_active IP Right Cessation
- 1998-11-26 CZ CZ20001787A patent/CZ295972B6/cs not_active IP Right Cessation
- 1998-11-26 DE DE69801163T patent/DE69801163T2/de not_active Expired - Fee Related
- 1998-11-26 US US09/555,021 patent/US6262057B1/en not_active Expired - Fee Related
- 1998-11-26 PL PL340724A patent/PL190871B1/pl not_active IP Right Cessation
- 1998-11-26 WO PCT/BE1998/000184 patent/WO1999028310A1/en active IP Right Grant
- 1998-11-26 IL IL13554498A patent/IL135544A/en not_active IP Right Cessation
-
1999
- 1999-01-19 TW TW088100770A patent/TWI225053B/zh not_active IP Right Cessation
-
2000
- 2000-05-11 BG BG104424A patent/BG64155B1/bg unknown
- 2000-05-23 NO NO20002631A patent/NO314692B1/no unknown
-
2001
- 2001-03-08 US US09/800,665 patent/US6335331B2/en not_active Expired - Fee Related
- 2001-09-26 GR GR20010401559T patent/GR3036702T3/el not_active IP Right Cessation
-
2007
- 2007-04-18 JP JP2007109494A patent/JP2007224042A/ja active Pending
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