DE60217118D1 - 2-anilino-pyrimidin-derivate als cyclin-abhängige kinase hemmer - Google Patents

2-anilino-pyrimidin-derivate als cyclin-abhängige kinase hemmer

Info

Publication number
DE60217118D1
DE60217118D1 DE60217118T DE60217118T DE60217118D1 DE 60217118 D1 DE60217118 D1 DE 60217118D1 DE 60217118 T DE60217118 T DE 60217118T DE 60217118 T DE60217118 T DE 60217118T DE 60217118 D1 DE60217118 D1 DE 60217118D1
Authority
DE
Germany
Prior art keywords
sup
cyclin
anilino
dependent kinase
pyrimidine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60217118T
Other languages
English (en)
Other versions
DE60217118T2 (de
Inventor
John Newcombe
Peter Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60217118D1 publication Critical patent/DE60217118D1/de
Publication of DE60217118T2 publication Critical patent/DE60217118T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
DE60217118T 2001-05-30 2002-05-24 2-anilino-pyrimidin-derivate als cyclin-abhängige kinase hemmer Expired - Lifetime DE60217118T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0113041.8A GB0113041D0 (en) 2001-05-30 2001-05-30 Chemical compounds
GB0113041 2001-05-30
PCT/GB2002/002428 WO2002096887A1 (en) 2001-05-30 2002-05-24 2-anilino-pyrimidine derivatives as cyclin dependent kinase inhibitors

Publications (2)

Publication Number Publication Date
DE60217118D1 true DE60217118D1 (de) 2007-02-08
DE60217118T2 DE60217118T2 (de) 2007-06-28

Family

ID=9915495

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60217118T Expired - Lifetime DE60217118T2 (de) 2001-05-30 2002-05-24 2-anilino-pyrimidin-derivate als cyclin-abhängige kinase hemmer

Country Status (19)

Country Link
US (1) US6939872B2 (de)
EP (1) EP1406876B1 (de)
JP (1) JP2004533458A (de)
KR (1) KR20040030644A (de)
CN (1) CN1286821C (de)
AT (1) ATE349432T1 (de)
BR (1) BR0210071A (de)
CA (1) CA2448305A1 (de)
DE (1) DE60217118T2 (de)
DK (1) DK1406876T3 (de)
ES (1) ES2278023T3 (de)
GB (1) GB0113041D0 (de)
IL (1) IL158975A0 (de)
MX (1) MXPA03010877A (de)
NO (1) NO20035210L (de)
NZ (1) NZ529763A (de)
PT (1) PT1406876E (de)
WO (1) WO2002096887A1 (de)
ZA (1) ZA200309165B (de)

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HUE037844T2 (hu) 2010-11-10 2018-09-28 Genentech Inc Pirazol-aminopirimidin-származékok mint LRRK2 modulátorok
MX2018006250A (es) 2015-11-18 2018-09-05 Genzyme Corp Biomarcador de enfermedad poliquistica renal y usos del mismo.
CN110452179A (zh) * 2019-06-25 2019-11-15 南京普锐达医药科技有限公司 一种2-氯-4-甲氧基-5-氰基嘧啶的合成方法
CN110372584A (zh) * 2019-06-25 2019-10-25 南京普锐达医药科技有限公司 一种2,4-二氯-6-氰基嘧啶的合成方法
CA3202990A1 (en) * 2020-11-27 2022-06-02 Anrui Biomedical Technology (Guangzhou) Co., Ltd. Aminoheteroaryl kinase inhibitors
CN116023367A (zh) * 2021-10-25 2023-04-28 优领医药科技(香港)有限公司 含四氢呋喃多环类衍生物、其药学上可接受的盐及其制备方法和应用
WO2023226920A1 (en) * 2022-05-27 2023-11-30 Anrui Biomedical Technology (Guangzhou) Co.,Ltd. Aminoheteroaryl kinase inhibitors

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Also Published As

Publication number Publication date
ES2278023T3 (es) 2007-08-01
US20040198757A1 (en) 2004-10-07
CN1286821C (zh) 2006-11-29
IL158975A0 (en) 2004-05-12
US6939872B2 (en) 2005-09-06
DE60217118T2 (de) 2007-06-28
PT1406876E (pt) 2007-02-28
WO2002096887A1 (en) 2002-12-05
EP1406876B1 (de) 2006-12-27
GB0113041D0 (en) 2001-07-18
DK1406876T3 (da) 2007-04-02
BR0210071A (pt) 2004-06-22
KR20040030644A (ko) 2004-04-09
JP2004533458A (ja) 2004-11-04
NO20035210D0 (no) 2003-11-24
ATE349432T1 (de) 2007-01-15
NZ529763A (en) 2006-01-27
EP1406876A1 (de) 2004-04-14
ZA200309165B (en) 2005-03-10
NO20035210L (no) 2003-11-27
MXPA03010877A (es) 2004-02-17
CN1541208A (zh) 2004-10-27
CA2448305A1 (en) 2002-12-05

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