DE69627042D1 - Isocumarinderivate und deren verwendung in medikamenten - Google Patents
Isocumarinderivate und deren verwendung in medikamentenInfo
- Publication number
- DE69627042D1 DE69627042D1 DE69627042T DE69627042T DE69627042D1 DE 69627042 D1 DE69627042 D1 DE 69627042D1 DE 69627042 T DE69627042 T DE 69627042T DE 69627042 T DE69627042 T DE 69627042T DE 69627042 D1 DE69627042 D1 DE 69627042D1
- Authority
- DE
- Germany
- Prior art keywords
- isocumar
- medications
- derivatives
- pharmaceutical preparations
- vascularization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6333769A JPH08176138A (ja) | 1994-12-19 | 1994-12-19 | イソクマリン誘導体 |
PCT/JP1996/001657 WO1997048693A1 (fr) | 1994-12-19 | 1996-06-17 | Derives d'isocoumarine et utilisation de ces derniers dans des medicaments |
CA002259621A CA2259621C (en) | 1994-12-19 | 1996-06-17 | Isocoumarin derivatives and their use in medicines |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69627042D1 true DE69627042D1 (de) | 2003-04-30 |
DE69627042T2 DE69627042T2 (de) | 2003-11-20 |
Family
ID=27170918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69627042T Expired - Fee Related DE69627042T2 (de) | 1994-12-19 | 1996-06-17 | Isocumarinderivate und deren verwendung in medikamenten |
Country Status (9)
Country | Link |
---|---|
US (1) | US6020363A (de) |
EP (1) | EP0930310B1 (de) |
JP (2) | JPH08176138A (de) |
AT (1) | ATE235482T1 (de) |
AU (1) | AU6017296A (de) |
CA (1) | CA2259621C (de) |
DE (1) | DE69627042T2 (de) |
ES (1) | ES2190469T3 (de) |
WO (1) | WO1997048693A1 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010001270A (ko) | 1999-06-03 | 2001-01-05 | 복성해 | 혈관신생을 억제하는 새로운 이소쿠마린 유도체 |
WO2001007429A1 (en) * | 1999-07-22 | 2001-02-01 | Mercian Corporation | Process for producing isocoumarins and intermediates for the same |
JP2001122870A (ja) * | 1999-10-27 | 2001-05-08 | Mercian Corp | イソクマリン誘導体およびそれらの製造方法 |
US6473960B1 (en) | 2000-01-07 | 2002-11-05 | Storage Technology Corporation | Method of making nitrided active elements |
US6589981B2 (en) * | 2000-02-29 | 2003-07-08 | Ilex Oncology, Inc. | Tumor radiosensitization and/or chemopotentiation using isocoumarin derivatives |
US6900239B2 (en) * | 2000-02-29 | 2005-05-31 | Ilwz Ilex Products, Inc. | Tumor chemopotentiation using isocoumarin derivatives |
DE60140461D1 (de) * | 2000-09-11 | 2009-12-24 | Genzyme Corp | Muc1 extrazelluläre domäne und zusammensetzungen für krebsbehandlung, und davon abgeleitete verfahren |
US20040018181A1 (en) * | 2000-09-11 | 2004-01-29 | KUFE Donald W. | MUC1 interference RNA compositions and methods derived therefrom |
ES2282299T3 (es) | 2000-10-20 | 2007-10-16 | EISAI R&D MANAGEMENT CO., LTD. | Compuestos aromaticos con anillos de nitrogeno como agentes anticancerigenos. |
US6740406B2 (en) * | 2000-12-15 | 2004-05-25 | Kimberly-Clark Worldwide, Inc. | Coated activated carbon |
US20040166248A1 (en) * | 2000-12-15 | 2004-08-26 | Sheng-Hsin Hu | Coated activated carbon |
EP1958642A1 (de) * | 2000-12-22 | 2008-08-20 | Dana-Farber Cancer Institute | Regulierung des Zellwachstums durch MUC1 |
US6900340B2 (en) * | 2001-02-02 | 2005-05-31 | Mercian Corporation | Preparation of isocoumarin derivatives and intermediates for the synthesis thereof |
US6664401B2 (en) | 2001-07-06 | 2003-12-16 | Ilex Products, Inc. | Process for preparing isocoumarins |
US20060122387A1 (en) * | 2002-06-13 | 2006-06-08 | Cti Europe S.R.L. | Derivatives of chromen-2-one as inhibitors of vegf production in mammalian cells |
WO2004092339A2 (en) * | 2003-04-11 | 2004-10-28 | Ilex Products, Inc. | Modulation of muc1 mediated signal transduction |
US8129506B2 (en) | 2003-10-24 | 2012-03-06 | Genzyme Corporation | Modulation of the interaction of MUC1 with MUC1 ligands |
CN100450998C (zh) | 2003-11-11 | 2009-01-14 | 卫材R&D管理有限公司 | 脲衍生物的制备方法 |
EP1718367A1 (de) * | 2004-02-23 | 2006-11-08 | Genzyme Corporation | Muc1-antagonisten-verstärkung von durch todes-rezeptor-ligand ausgelöster apoptose |
JP4834553B2 (ja) | 2004-09-17 | 2011-12-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 医薬組成物 |
JP4989476B2 (ja) | 2005-08-02 | 2012-08-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を検定する方法 |
RU2448708C3 (ru) | 2006-05-18 | 2017-09-28 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Противоопухолевое средство против рака щитовидной железы |
JP5368096B2 (ja) | 2006-08-28 | 2013-12-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 未分化型胃癌に対する抗腫瘍剤 |
KR101445892B1 (ko) | 2007-01-29 | 2014-09-29 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 미분화형 위암 치료용 조성물 |
WO2008097844A2 (en) * | 2007-02-02 | 2008-08-14 | Dana -Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of apoptosis by muc1 and bh3- containing proapoptotic proteins |
US7972870B2 (en) | 2007-02-02 | 2011-07-05 | Dana-Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3 |
CA2704000C (en) | 2007-11-09 | 2016-12-13 | Eisai R&D Management Co., Ltd. | Combination of anti-angiogenic substance and anti-tumor platinum complex |
US9012458B2 (en) | 2010-06-25 | 2015-04-21 | Eisai R&D Management Co., Ltd. | Antitumor agent using compounds having kinase inhibitory effect in combination |
CA2828946C (en) | 2011-04-18 | 2016-06-21 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
ES2841809T3 (es) | 2011-06-03 | 2021-07-09 | Eisai R&D Man Co Ltd | Biomarcadores para pronosticar y evaluar el grado de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib |
MX2015004979A (es) | 2012-12-21 | 2015-07-17 | Eisai R&D Man Co Ltd | Forma amorfa de derivado de quinolina y metodo para su produccion. |
AU2014266223B2 (en) | 2013-05-14 | 2020-06-25 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
ES2926687T3 (es) | 2014-08-28 | 2022-10-27 | Eisai R&D Man Co Ltd | Derivado de quinolina muy puro y método para su producción |
HUE064614T2 (hu) | 2015-02-25 | 2024-04-28 | Eisai R&D Man Co Ltd | Eljárás egy kinolin-származék keserû ízének elnyomására |
KR102662228B1 (ko) | 2015-03-04 | 2024-05-02 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
AU2016279474B2 (en) | 2015-06-16 | 2021-09-09 | Eisai R&D Management Co., Ltd. | Anticancer agent |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2802097B2 (ja) * | 1989-05-31 | 1998-09-21 | 財団法人微生物化学研究会 | 新規な制癌抗生物質mi43―37f11及びその製造法 |
JP3041022B2 (ja) * | 1990-08-31 | 2000-05-15 | メルシャン株式会社 | 抗性物質m143―37f11の製造方法及び製造中間体 |
JPH0597841A (ja) * | 1991-10-04 | 1993-04-20 | Mercian Corp | イソクマリン誘導体 |
JP3233709B2 (ja) * | 1992-12-18 | 2001-11-26 | メルシャン株式会社 | 免疫調節剤 |
-
1994
- 1994-12-19 JP JP6333769A patent/JPH08176138A/ja active Pending
-
1996
- 1996-06-17 AT AT96917702T patent/ATE235482T1/de not_active IP Right Cessation
- 1996-06-17 US US09/202,606 patent/US6020363A/en not_active Expired - Fee Related
- 1996-06-17 AU AU60172/96A patent/AU6017296A/en not_active Abandoned
- 1996-06-17 CA CA002259621A patent/CA2259621C/en not_active Expired - Fee Related
- 1996-06-17 EP EP96917702A patent/EP0930310B1/de not_active Expired - Lifetime
- 1996-06-17 DE DE69627042T patent/DE69627042T2/de not_active Expired - Fee Related
- 1996-06-17 JP JP50264698A patent/JP3150709B2/ja not_active Expired - Fee Related
- 1996-06-17 ES ES96917702T patent/ES2190469T3/es not_active Expired - Lifetime
- 1996-06-17 WO PCT/JP1996/001657 patent/WO1997048693A1/ja active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0930310A4 (de) | 2001-08-22 |
JPH08176138A (ja) | 1996-07-09 |
US6020363A (en) | 2000-02-01 |
ATE235482T1 (de) | 2003-04-15 |
JP3150709B2 (ja) | 2001-03-26 |
DE69627042T2 (de) | 2003-11-20 |
EP0930310B1 (de) | 2003-03-26 |
CA2259621A1 (en) | 1997-12-24 |
EP0930310A1 (de) | 1999-07-21 |
WO1997048693A1 (fr) | 1997-12-24 |
CA2259621C (en) | 2007-09-18 |
ES2190469T3 (es) | 2003-08-01 |
AU6017296A (en) | 1998-01-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |