GB959699A - New pyrimidine derivatives - Google Patents

New pyrimidine derivatives

Info

Publication number
GB959699A
GB959699A GB2102261A GB2102261A GB959699A GB 959699 A GB959699 A GB 959699A GB 2102261 A GB2102261 A GB 2102261A GB 2102261 A GB2102261 A GB 2102261A GB 959699 A GB959699 A GB 959699A
Authority
GB
United Kingdom
Prior art keywords
formula
halo
reacting
acid addition
addition salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2102261A
Inventor
Elizabeth Jean Hemingway
Glyn Evan Lee
Dennis George Orton
William Robert Wragg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
May and Baker Ltd
Original Assignee
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May and Baker Ltd filed Critical May and Baker Ltd
Priority to GB2102261A priority Critical patent/GB959699A/en
Publication of GB959699A publication Critical patent/GB959699A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Abstract

The invention comprises compounds of general formula: <FORM:0959699/C2/1> wherein R1 represents a hydrogen atom or an alkyl group containing not more than four carbon atoms, Hal represents a halogen atom, and n represents 1 or 2; and their non-toxic acid addition salts; and their preparation by reacting a halo-pyrimidine of formula: <FORM:0959699/C2/2> with a compound of formula R1NH2. Halo-pyrimidines (II) may be obtained by reacting an amidine of formula: <FORM:0959699/C2/3> with an acetoacetic ester and a base to form a 2-halophenylalkyl -4- hydroxy -6- methylpyrimidine which is then treated with a phosphorus oxyhalide. p-Chlorophenacetamidine hydrochloride is prepared by the action of ammoniacal ethanol on ethyl p-chlorophenylacetiminate hydrochloride obtained from p-chlorobenzyl cyanide by treatment with hydrogen chloride in ethanol. Pharmaceutical compositions comprise pyrimidines I or their non-toxic acid addition salts in association with a pharmaceutical carrier. Solid (capsules, tablets, pills, powders, granules) and liquid (emulsions, suspensions) forms for oral administration are described. The compounds have diuretic, natriuretic and saluretic properties and act against hypertension.
GB2102261A 1961-06-09 1961-06-09 New pyrimidine derivatives Expired GB959699A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2102261A GB959699A (en) 1961-06-09 1961-06-09 New pyrimidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2102261A GB959699A (en) 1961-06-09 1961-06-09 New pyrimidine derivatives

Publications (1)

Publication Number Publication Date
GB959699A true GB959699A (en) 1964-06-03

Family

ID=10155875

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2102261A Expired GB959699A (en) 1961-06-09 1961-06-09 New pyrimidine derivatives

Country Status (1)

Country Link
GB (1) GB959699A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0384370A1 (en) * 1989-02-22 1990-08-29 Hoechst Aktiengesellschaft Substituted pyrimidine derivatives, process for their preparation, and their use as tool
WO1994007867A1 (en) * 1992-09-28 1994-04-14 Pfizer Inc. Substituted pyrimidines for control of diabetic complications

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0384370A1 (en) * 1989-02-22 1990-08-29 Hoechst Aktiengesellschaft Substituted pyrimidine derivatives, process for their preparation, and their use as tool
US5138058A (en) * 1989-02-22 1992-08-11 Hoechst Aktiengesellschaft Piperazine substituted pyrimidine derivatives and physiologically tolerated salts thereof
WO1994007867A1 (en) * 1992-09-28 1994-04-14 Pfizer Inc. Substituted pyrimidines for control of diabetic complications
US5728704A (en) * 1992-09-28 1998-03-17 Pfizer Inc. Substituted pyridmidines for control of diabetic complications

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