GB1311334A - 2-substituted aminohexahydrobenzo alpha-quinolizines - Google Patents

Abstract

1311334 Substituted aminohexahydrobenzo- [a]quinolizines MILES LABORATORIES Inc 14 July 1970 [22 Dec 1969(2)] 34154/70 Addition to 1,192,520 Heading C2C Novel compounds of Formula I wherein R is hydrogen, hydroxy or lower alkoxy, R<SP>1</SP> is hydrogen, hydroxy or lower alkoxy, R<SP>3</SP> is hydrogen, lower alkyl, cycloalkyl, phenyl, substituted phenyl, diphenyl, or substituted phenyl (lower alkyl), the said substitution being by halogen, lower alkyl, lower alkoxy, cyano, lower alkoxycarbonyl or nitro, R<SP>4</SP> is hydrogen, -CO-alkyl, -CO-cycloalkyl, -CO-phenyl, -CH 2 CH 2 NHC(: NH)NH 2 , -C(: NH) NH 2 , or -CH 2 CH 2 -C(: NOH)NH 2 , and R<SP>6</SP> is hydrogen, lower alkyl, or phenyl, with the proviso that, when R<SP>3</SP> is hydrogen or phenyl, R<SP>4</SP> is -CO- cycloalkyl or -CO-phenyl, and its pharmacologically acceptable salts (lower denotes radicals containing (1-4 C atoms) are prepared by forming the Schiff base from a ketone of Formula II and an amine R<SP>3</SP>NH 2 and reducing it to give an amine of formula and, where the product desired is one in which R<SP>4</SP> is other than hydrogen, reacting the amine with a compound of formula: (R<SP>8</SP>) 2 O or R<SP>4</SP>X in which R<SP>4</SP> is as defined in claim 1 but is not hydrogen, R<SP>8</SP> is -CO-alkyl, -CO-cycloalkyl, or -CO-phenyl, and X is halogen, to form the desired basic product of Formula I above and optionally forming a pharmaceutically acceptable salt thereof. Pharmaceutical compositions in conventional forms for oral or subcutaneous administration and having antihypertensive activity comprise an above novel compound or salt and a carrier, filler, extender and/or excipient.