DE69711965T2 - Verwendung von Sorbitol-Dehydrogenase-Inhibitoren zum Reduzieren von Ischämie-assozierten Gewebeschäden - Google Patents
Verwendung von Sorbitol-Dehydrogenase-Inhibitoren zum Reduzieren von Ischämie-assozierten GewebeschädenInfo
- Publication number
- DE69711965T2 DE69711965T2 DE69711965T DE69711965T DE69711965T2 DE 69711965 T2 DE69711965 T2 DE 69711965T2 DE 69711965 T DE69711965 T DE 69711965T DE 69711965 T DE69711965 T DE 69711965T DE 69711965 T2 DE69711965 T2 DE 69711965T2
- Authority
- DE
- Germany
- Prior art keywords
- tissue damage
- sorbitol dehydrogenase
- dehydrogenase inhibitors
- associated tissue
- reduce ischemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000028867 ischemia Diseases 0.000 title abstract 2
- 230000000451 tissue damage Effects 0.000 title abstract 2
- 231100000827 tissue damage Toxicity 0.000 title abstract 2
- 108010009384 L-Iditol 2-Dehydrogenase Proteins 0.000 title 1
- 102100026974 Sorbitol dehydrogenase Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229940123659 Sorbitol dehydrogenase inhibitor Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1270896P | 1996-02-29 | 1996-02-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69711965D1 DE69711965D1 (de) | 2002-05-23 |
| DE69711965T2 true DE69711965T2 (de) | 2003-01-23 |
Family
ID=21756305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69711965T Expired - Fee Related DE69711965T2 (de) | 1996-02-29 | 1997-02-13 | Verwendung von Sorbitol-Dehydrogenase-Inhibitoren zum Reduzieren von Ischämie-assozierten Gewebeschäden |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5932581A (de) |
| EP (1) | EP0791355B1 (de) |
| JP (1) | JPH09316004A (de) |
| KR (1) | KR100219972B1 (de) |
| CN (1) | CN1165000A (de) |
| AT (1) | ATE216226T1 (de) |
| AU (1) | AU714038B2 (de) |
| CA (1) | CA2198536C (de) |
| DE (1) | DE69711965T2 (de) |
| DK (1) | DK0791355T3 (de) |
| ES (1) | ES2174176T3 (de) |
| IL (1) | IL120271A (de) |
| MY (1) | MY118982A (de) |
| PT (1) | PT791355E (de) |
| ZA (1) | ZA971715B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ514144A (en) * | 1999-04-01 | 2001-09-28 | Pfizer Prod Inc | Aminopyrimidines as sorbitol dehydrogenase inhibitors |
| US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| CN104346404B (zh) * | 2013-08-08 | 2018-05-18 | 华为技术有限公司 | 一种访问数据的方法、设备及系统 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3905364A1 (de) | 1989-02-22 | 1990-08-23 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool |
| DE4025387A1 (de) | 1990-08-10 | 1992-02-13 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als reagenzien |
| AU683620B2 (en) | 1992-09-28 | 1997-11-20 | Pfizer Inc. | Substituted pyrimidines for control of diabetic complications |
-
1997
- 1997-02-13 DE DE69711965T patent/DE69711965T2/de not_active Expired - Fee Related
- 1997-02-13 PT PT97200415T patent/PT791355E/pt unknown
- 1997-02-13 DK DK97200415T patent/DK0791355T3/da active
- 1997-02-13 EP EP97200415A patent/EP0791355B1/de not_active Expired - Lifetime
- 1997-02-13 AT AT97200415T patent/ATE216226T1/de not_active IP Right Cessation
- 1997-02-13 ES ES97200415T patent/ES2174176T3/es not_active Expired - Lifetime
- 1997-02-20 IL IL12027197A patent/IL120271A/en not_active IP Right Cessation
- 1997-02-20 US US08/803,302 patent/US5932581A/en not_active Expired - Fee Related
- 1997-02-25 JP JP9040466A patent/JPH09316004A/ja active Pending
- 1997-02-26 CA CA002198536A patent/CA2198536C/en not_active Expired - Fee Related
- 1997-02-27 KR KR1019970006295A patent/KR100219972B1/ko not_active IP Right Cessation
- 1997-02-27 MY MYPI97000795A patent/MY118982A/en unknown
- 1997-02-27 ZA ZA971715A patent/ZA971715B/xx unknown
- 1997-02-28 AU AU15009/97A patent/AU714038B2/en not_active Ceased
- 1997-02-28 CN CN97103411A patent/CN1165000A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1165000A (zh) | 1997-11-19 |
| DE69711965D1 (de) | 2002-05-23 |
| EP0791355A1 (de) | 1997-08-27 |
| IL120271A0 (en) | 1997-06-10 |
| KR100219972B1 (ko) | 1999-09-01 |
| EP0791355B1 (de) | 2002-04-17 |
| ZA971715B (en) | 1998-08-27 |
| PT791355E (pt) | 2002-08-30 |
| AU1500997A (en) | 1997-09-04 |
| MY118982A (en) | 2005-02-28 |
| KR970061257A (ko) | 1997-09-12 |
| IL120271A (en) | 2001-06-14 |
| CA2198536C (en) | 2000-06-20 |
| DK0791355T3 (da) | 2002-06-17 |
| ATE216226T1 (de) | 2002-05-15 |
| CA2198536A1 (en) | 1997-08-29 |
| JPH09316004A (ja) | 1997-12-09 |
| MX9701527A (es) | 1998-06-30 |
| AU714038B2 (en) | 1999-12-16 |
| US5932581A (en) | 1999-08-03 |
| ES2174176T3 (es) | 2002-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de | ||
| 8370 | Indication related to discontinuation of the patent is to be deleted | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |