ES2130258T3 - Compuesto amino terciario sustituido o sal de este compuesto. - Google Patents

Compuesto amino terciario sustituido o sal de este compuesto.

Info

Publication number
ES2130258T3
ES2130258T3 ES93909428T ES93909428T ES2130258T3 ES 2130258 T3 ES2130258 T3 ES 2130258T3 ES 93909428 T ES93909428 T ES 93909428T ES 93909428 T ES93909428 T ES 93909428T ES 2130258 T3 ES2130258 T3 ES 2130258T3
Authority
ES
Spain
Prior art keywords
compound
tertiary amino
substituted tertiary
salt
amino compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93909428T
Other languages
English (en)
Inventor
Minoru Okada
Toru Yoden
Eiji Kawaminami
Yoshiaki Shimada
Masafumi Kudou
Yasuo Isomura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2130258T3 publication Critical patent/ES2130258T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

UN COMPUESTO AMINO TERCIARIO SUSTITUIDO REPRESENTADO POR LA FORMULA GENERAL (() O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO. TIENEN UNA ACTIVIDAD INHIBIDORA DE LA AROMATASA Y SON UTILES COMO AGENTES PROFILACTICOS Y/O TERAPEUTICOS PARA EL CANCER DE MAMA, LA MASTOPATIA, ENDOMETRIOSIS, HIPERTROFIA PROSTATICA, ETCETERA.
ES93909428T 1992-04-28 1993-04-27 Compuesto amino terciario sustituido o sal de este compuesto. Expired - Lifetime ES2130258T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13776292 1992-04-28
JP23429892 1992-08-10

Publications (1)

Publication Number Publication Date
ES2130258T3 true ES2130258T3 (es) 1999-07-01

Family

ID=26470979

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93909428T Expired - Lifetime ES2130258T3 (es) 1992-04-28 1993-04-27 Compuesto amino terciario sustituido o sal de este compuesto.

Country Status (14)

Country Link
US (1) US5538976A (es)
EP (1) EP0640595B1 (es)
JP (1) JP2682741B2 (es)
KR (1) KR0163624B1 (es)
CN (1) CN1039228C (es)
AT (1) ATE178056T1 (es)
AU (1) AU4023093A (es)
CA (1) CA2118138A1 (es)
DE (1) DE69324141T2 (es)
DK (1) DK0640595T3 (es)
ES (1) ES2130258T3 (es)
GR (1) GR3030472T3 (es)
TW (1) TW345577B (es)
WO (1) WO1993022290A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9802251D0 (en) * 1998-02-03 1998-04-01 Ciba Geigy Ag Organic compounds
US6756367B2 (en) 1998-02-03 2004-06-29 Novartis Ag Benzo-oxadiazoles, -thiadiazoles and -1,4-diazines, pharmaceutical compositions containing them and a process for preparing them
MXPA00010805A (es) * 1998-05-06 2002-05-08 Univ Duke Metodo para el tratamiento de sindromes de la vejiga y del tracto urinario inferior.
BR0110358A (pt) * 2000-04-28 2003-03-05 Hoffmann La Roche P-(sulfonil)-arila e -heteroarilas
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
GB0127923D0 (en) * 2001-11-21 2002-01-16 Sterix Ltd Compound
US6737433B1 (en) 2002-12-16 2004-05-18 Laboratoire Theramex 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors and pharmaceutical compositions containing them
EP1993551A4 (en) * 2006-02-01 2011-10-19 Merck Sharp & Dohme INHIBITORS OF THE POTASSIUM CANAL
DE202009014107U1 (de) 2009-10-16 2010-02-25 HOKWANG INDUSTRIES CO., LTD., Rueifang Druckmechanismus eines Seifenspenders mit der Möglichkeit zur Einstellung der Dosiermenge der flüssigen Seife
ES2647566T3 (es) * 2011-01-31 2017-12-22 Lucolas-M.D. Ltd. Combinaciones de inhibidores de aromatasa y antioxidantes
CN103183669B (zh) * 2011-12-27 2015-11-18 湖南化工研究院 噻唑甲胺基吡啶类化合物及其制备方法
JP6165961B2 (ja) 2013-03-15 2017-07-19 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ 前処理カルーセルを有する診断分析装置および関連方法
JP6351703B2 (ja) 2013-03-15 2018-07-04 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ 垂直配置カルーセルを有する自動診断分析装置および関連方法
CN114137240A (zh) 2013-03-15 2022-03-04 雅培制药有限公司 具有后面可进入轨道系统的自动化诊断分析仪及相关方法
CN104387377B (zh) * 2014-10-14 2017-03-29 湖南海利常德农药化工有限公司 一种噻唑甲胺基吡啶类化合物的制备方法
CN105777741B (zh) * 2014-12-18 2019-02-01 湖南化工研究院有限公司 噻唑烷基吡啶胺类化合物及其制备方法与应用
CN104770374B (zh) * 2015-04-02 2017-10-17 湖南化工研究院有限公司 一种杀菌组合物
CN113387894B (zh) * 2021-06-22 2023-02-24 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) 1-n-苯乙腈基氨基-三氮唑和嘧啶衍生物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4762836A (en) * 1983-02-02 1988-08-09 Eli Lilly And Company Aromatase inhibitors
US4774251A (en) * 1984-06-18 1988-09-27 Eli Lilly And Company Method of inhibiting aromatase
DD239210A5 (de) * 1984-11-13 1986-09-17 Ciba-Geigy Ag,Ch Verfahren zur herstellung neuer 5-amino-4-hydroxyvaleryl-derivate
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
AU4717889A (en) * 1988-12-29 1990-07-05 Ciba-Geigy Ag Amino-substituted hydroxamic acids
DE3905364A1 (de) * 1989-02-22 1990-08-23 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool

Also Published As

Publication number Publication date
KR950701321A (ko) 1995-03-23
WO1993022290A1 (en) 1993-11-11
TW345577B (en) 1998-11-21
DK0640595T3 (da) 1999-10-11
ATE178056T1 (de) 1999-04-15
CN1079962A (zh) 1993-12-29
JP2682741B2 (ja) 1997-11-26
GR3030472T3 (en) 1999-10-29
KR0163624B1 (ko) 1998-12-01
EP0640595A1 (en) 1995-03-01
CA2118138A1 (en) 1993-10-29
DE69324141D1 (de) 1999-04-29
US5538976A (en) 1996-07-23
EP0640595B1 (en) 1999-03-24
EP0640595A4 (en) 1995-04-12
CN1039228C (zh) 1998-07-22
AU4023093A (en) 1993-11-29
DE69324141T2 (de) 1999-08-26

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