AU2017246453A1 - Monofunctional intermediates for ligand-dependent target protein degradation - Google Patents
Monofunctional intermediates for ligand-dependent target protein degradation Download PDFInfo
- Publication number
- AU2017246453A1 AU2017246453A1 AU2017246453A AU2017246453A AU2017246453A1 AU 2017246453 A1 AU2017246453 A1 AU 2017246453A1 AU 2017246453 A AU2017246453 A AU 2017246453A AU 2017246453 A AU2017246453 A AU 2017246453A AU 2017246453 A1 AU2017246453 A1 AU 2017246453A1
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- Australia
- Prior art keywords
- group
- compound
- optionally substituted
- hydrogen
- pct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C*c1cc(C)ccc1 Chemical compound C*c1cc(C)ccc1 0.000 description 13
- JAHUHEDUDMTTTF-COWZOJLOSA-N C[C@@H](c(cc1)ccc1-c1c(C)nc[s]1)NC([C@H](C[C@H](C1)O)N1C([C@H](C(C)(C)C)NC(C)=O)=O)=O Chemical compound C[C@@H](c(cc1)ccc1-c1c(C)nc[s]1)NC([C@H](C[C@H](C1)O)N1C([C@H](C(C)(C)C)NC(C)=O)=O)=O JAHUHEDUDMTTTF-COWZOJLOSA-N 0.000 description 2
- IBRNELNHZMVNMV-UHFFFAOYSA-N C#Cc1c[n](CCCCNc2cccc(C(N3C(CCC(N4)=O)C4=O)=O)c2C3=O)nc1 Chemical compound C#Cc1c[n](CCCCNc2cccc(C(N3C(CCC(N4)=O)C4=O)=O)c2C3=O)nc1 IBRNELNHZMVNMV-UHFFFAOYSA-N 0.000 description 1
- AQWZSLLKFPGZDH-UHFFFAOYSA-N CC(C)(C)OC(NCCCC#Cc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O Chemical compound CC(C)(C)OC(NCCCC#Cc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O)=O AQWZSLLKFPGZDH-UHFFFAOYSA-N 0.000 description 1
- MOHJHYBGCICSLM-YRWDNINGSA-N CC(C)(C)[C@@H](C(N(C[C@@H](C1)O)[C@@H]1C(NCc(cc1)ccc1-c1c(C)nc[s]1)=O)O)NC(C)=O Chemical compound CC(C)(C)[C@@H](C(N(C[C@@H](C1)O)[C@@H]1C(NCc(cc1)ccc1-c1c(C)nc[s]1)=O)O)NC(C)=O MOHJHYBGCICSLM-YRWDNINGSA-N 0.000 description 1
- PTXXUPWOPDAWLO-PXGQBAFSSA-N CC(C)[C@@H](CS(C(C)C)(=O)=O)N([C@@H]([C@H](C[C@]1(C)CC(Nc(cc2)ccc2C(C(C)C)=O)=O)c2cccc(Cl)c2)c(cc2)ccc2Cl)C1=O Chemical compound CC(C)[C@@H](CS(C(C)C)(=O)=O)N([C@@H]([C@H](C[C@]1(C)CC(Nc(cc2)ccc2C(C(C)C)=O)=O)c2cccc(Cl)c2)c(cc2)ccc2Cl)C1=O PTXXUPWOPDAWLO-PXGQBAFSSA-N 0.000 description 1
- JZIKIPVCUXKEIS-UHFFFAOYSA-N CC(CCC(N1)=O)(C1=O)N(Cc1c(C)cccc11)C1=O Chemical compound CC(CCC(N1)=O)(C1=O)N(Cc1c(C)cccc11)C1=O JZIKIPVCUXKEIS-UHFFFAOYSA-N 0.000 description 1
- RVCYCDVKNXMIFS-QWHCGFSZSA-N CCCNC([C@H](CCC1)N1C([C@H](C(C)(C)C)NC(C)=O)=O)=O Chemical compound CCCNC([C@H](CCC1)N1C([C@H](C(C)(C)C)NC(C)=O)=O)=O RVCYCDVKNXMIFS-QWHCGFSZSA-N 0.000 description 1
- RXYPXQSKLGGKOL-UHFFFAOYSA-N CN1CCN(C)CC1 Chemical compound CN1CCN(C)CC1 RXYPXQSKLGGKOL-UHFFFAOYSA-N 0.000 description 1
- OTDSSQVGCZVQJU-UHFFFAOYSA-N CNc1c(CN(C(CCC(N2)=O)C2=O)C2=O)c2ccc1F Chemical compound CNc1c(CN(C(CCC(N2)=O)C2=O)C2=O)c2ccc1F OTDSSQVGCZVQJU-UHFFFAOYSA-N 0.000 description 1
- DDXMKUSYTIQQOG-YNBNEFOKSA-N C[C@@H](c1nnc(C)[n]1-1)OCc2c-1[s]c(C#Cc1c[n](CCCCNc3cccc(C(N4C(CCC(N5)=O)C5=O)=O)c3C4=O)nc1)c2Cc1ccccc1 Chemical compound C[C@@H](c1nnc(C)[n]1-1)OCc2c-1[s]c(C#Cc1c[n](CCCCNc3cccc(C(N4C(CCC(N5)=O)C5=O)=O)c3C4=O)nc1)c2Cc1ccccc1 DDXMKUSYTIQQOG-YNBNEFOKSA-N 0.000 description 1
- LFQSYKFVAWOSQE-UHFFFAOYSA-N Cc(cccc1N=C(C)N2C(CCC(N3)=O)C3=O)c1C2=O Chemical compound Cc(cccc1N=C(C)N2C(CCC(N3)=O)C3=O)c1C2=O LFQSYKFVAWOSQE-UHFFFAOYSA-N 0.000 description 1
- YKGGXZWHQCBXDK-UHFFFAOYSA-N Cc1c(CN(C(CCC(N2)=C)C2=O)C2=O)c2ccn1 Chemical compound Cc1c(CN(C(CCC(N2)=C)C2=O)C2=O)c2ccn1 YKGGXZWHQCBXDK-UHFFFAOYSA-N 0.000 description 1
- GZPLMRQJRIRXFL-UHFFFAOYSA-N Cc1c(CN(C(CCC(N2)=O)(C2=O)F)C2=O)c2ccc1 Chemical compound Cc1c(CN(C(CCC(N2)=O)(C2=O)F)C2=O)c2ccc1 GZPLMRQJRIRXFL-UHFFFAOYSA-N 0.000 description 1
- BMOHMMOTIMUSJR-UHFFFAOYSA-N Cc1c(CN(C(CCC(N2)=O)C2=O)C2=O)c2ccc1 Chemical compound Cc1c(CN(C(CCC(N2)=O)C2=O)C2=O)c2ccc1 BMOHMMOTIMUSJR-UHFFFAOYSA-N 0.000 description 1
- HGUAXMBSEHINHU-UHFFFAOYSA-N Cc1c(CN(C(CCC(N2)=O)C2=O)C2=O)c2cnc1 Chemical compound Cc1c(CN(C(CCC(N2)=O)C2=O)C2=O)c2cnc1 HGUAXMBSEHINHU-UHFFFAOYSA-N 0.000 description 1
- RIKMMFOAQPJVMX-UHFFFAOYSA-N Cc1c[nH]nc1 Chemical compound Cc1c[nH]nc1 RIKMMFOAQPJVMX-UHFFFAOYSA-N 0.000 description 1
- URLKBWYHVLBVBO-UHFFFAOYSA-N Cc1ccc(C)cc1 Chemical compound Cc1ccc(C)cc1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 description 1
- NPWMTBZSRRLQNJ-UHFFFAOYSA-N NC(CCC(N1)=O)C1=O Chemical compound NC(CCC(N1)=O)C1=O NPWMTBZSRRLQNJ-UHFFFAOYSA-N 0.000 description 1
- YNTRGSCLEMTSAK-UHFFFAOYSA-N NCCCCCc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O Chemical compound NCCCCCc(cccc1C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O YNTRGSCLEMTSAK-UHFFFAOYSA-N 0.000 description 1
- ZZXXBKHLDNFHCQ-UHFFFAOYSA-N NCCCCCc1c(CN(C(CCC(N2)=O)C2=O)C2=O)c2ccc1 Chemical compound NCCCCCc1c(CN(C(CCC(N2)=O)C2=O)C2=O)c2ccc1 ZZXXBKHLDNFHCQ-UHFFFAOYSA-N 0.000 description 1
- JQRWEKYMBHKDGR-UHFFFAOYSA-N NCCCC[n]1ncc(I)c1 Chemical compound NCCCC[n]1ncc(I)c1 JQRWEKYMBHKDGR-UHFFFAOYSA-N 0.000 description 1
- DXDZECNKXIVMKV-UHFFFAOYSA-N NCCOCCCc1c(CN(C(CCC(N2)=O)C2=O)C2=O)c2ccc1 Chemical compound NCCOCCCc1c(CN(C(CCC(N2)=O)C2=O)C2=O)c2ccc1 DXDZECNKXIVMKV-UHFFFAOYSA-N 0.000 description 1
- GRCPFSHICKFSOJ-UHFFFAOYSA-N O=C(CCC1N(C2OC2c2cccc(Br)c22)C2=O)NC1=O Chemical compound O=C(CCC1N(C2OC2c2cccc(Br)c22)C2=O)NC1=O GRCPFSHICKFSOJ-UHFFFAOYSA-N 0.000 description 1
- PJVSQVWDMYDJQV-UHFFFAOYSA-N O=C(c1cccc(NCCCC[n]2ncc(I)c2)c11)N(C(CCC(N2)=O)C2=O)C1=O Chemical compound O=C(c1cccc(NCCCC[n]2ncc(I)c2)c11)N(C(CCC(N2)=O)C2=O)C1=O PJVSQVWDMYDJQV-UHFFFAOYSA-N 0.000 description 1
- ZHUFUOMNKBKZIR-UHFFFAOYSA-N OC(c1cccc(Br)c11)OC1=O Chemical compound OC(c1cccc(Br)c11)OC1=O ZHUFUOMNKBKZIR-UHFFFAOYSA-N 0.000 description 1
- XMPJICVFSDYOEG-UHFFFAOYSA-N Oc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O Chemical compound Oc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O XMPJICVFSDYOEG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2021232732A AU2021232732A1 (en) | 2016-04-06 | 2021-09-15 | Monofunctional intermediates for ligand-dependent target protein degradation |
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662318974P | 2016-04-06 | 2016-04-06 | |
| US62/318,974 | 2016-04-06 | ||
| US201662321499P | 2016-04-12 | 2016-04-12 | |
| US62/321,499 | 2016-04-12 | ||
| US201662393874P | 2016-09-13 | 2016-09-13 | |
| US201662393888P | 2016-09-13 | 2016-09-13 | |
| US201662393935P | 2016-09-13 | 2016-09-13 | |
| US62/393,935 | 2016-09-13 | ||
| US62/393,874 | 2016-09-13 | ||
| US62/393,888 | 2016-09-13 | ||
| US201662409571P | 2016-10-18 | 2016-10-18 | |
| US201662409592P | 2016-10-18 | 2016-10-18 | |
| US62/409,592 | 2016-10-18 | ||
| US62/409,571 | 2016-10-18 | ||
| PCT/US2017/026275 WO2017176958A1 (en) | 2016-04-06 | 2017-04-06 | Monofunctional intermediates for ligand-dependent target protein degradation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021232732A Division AU2021232732A1 (en) | 2016-04-06 | 2021-09-15 | Monofunctional intermediates for ligand-dependent target protein degradation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2017246453A1 true AU2017246453A1 (en) | 2018-11-08 |
Family
ID=58549317
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017246453A Abandoned AU2017246453A1 (en) | 2016-04-06 | 2017-04-06 | Monofunctional intermediates for ligand-dependent target protein degradation |
| AU2021232732A Abandoned AU2021232732A1 (en) | 2016-04-06 | 2021-09-15 | Monofunctional intermediates for ligand-dependent target protein degradation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021232732A Abandoned AU2021232732A1 (en) | 2016-04-06 | 2021-09-15 | Monofunctional intermediates for ligand-dependent target protein degradation |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10759808B2 (https=) |
| EP (1) | EP3440082A1 (https=) |
| JP (2) | JP7001614B2 (https=) |
| CN (1) | CN109311900A (https=) |
| AU (2) | AU2017246453A1 (https=) |
| CA (1) | CA3020281A1 (https=) |
| WO (1) | WO2017176958A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017246452C1 (en) * | 2016-04-06 | 2021-06-03 | The Regents Of The University Of Michigan | MDM2 protein degraders |
| MX384905B (es) * | 2016-04-12 | 2025-03-14 | Univ Michigan Regents | Degradadores de proteínas de bromodominio y dominioextraterminal (bet). |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| EP4491236A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| CA3036841A1 (en) * | 2016-09-13 | 2018-03-22 | The Regents Of The University Of Michigan | Fused 1,4-diazepines as bet protein degraders |
| EP3512855B1 (en) * | 2016-09-13 | 2022-07-27 | The Regents of the University of Michigan | Fused 1,4-oxazepines as bet protein degraders |
| IL290809B2 (en) * | 2016-11-01 | 2024-01-01 | Arvinas Operations Inc | Tau-protein targeting protacs and associated methods of use |
| US11173211B2 (en) | 2016-12-23 | 2021-11-16 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides |
| WO2018144789A1 (en) * | 2017-02-03 | 2018-08-09 | The Regents Of The University Of Michigan | Fused 1,4-diazepines as bet bromodomain inhibitors |
| EP4717317A2 (en) | 2017-06-20 | 2026-04-01 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| TWI793151B (zh) | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
| CN109422751B (zh) * | 2017-09-03 | 2022-04-22 | 上海美志医药科技有限公司 | 一类具有降解酪氨酸蛋白激酶jak3活性的化合物 |
| CN118206529A (zh) | 2017-09-04 | 2024-06-18 | C4医药公司 | 二氢苯并咪唑酮 |
| CN118108706A (zh) | 2017-09-04 | 2024-05-31 | C4医药公司 | 戊二酰亚胺 |
| CN111278816B (zh) | 2017-09-04 | 2024-03-15 | C4医药公司 | 二氢喹啉酮 |
| WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| MX2020003190A (es) | 2017-09-22 | 2020-11-11 | Kymera Therapeutics Inc | Degradadores de proteinas y usos de los mismos. |
| WO2019094772A1 (en) | 2017-11-10 | 2019-05-16 | The Regents Of The University Of Michigan | Ash1l degraders and methods of treatment therewith |
| EP3710002A4 (en) | 2017-11-16 | 2021-07-07 | C4 Therapeutics, Inc. | DEGRADER AND DEGRONE FOR TARGETED PROTEIN DEGRADATION |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| WO2019140387A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
| WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| CA3087286C (en) * | 2018-02-13 | 2023-06-27 | Dana-Farber Cancer Institute, Inc. | Cyclin-dependent kinase degraders and methods of use |
| JP2021519337A (ja) * | 2018-03-26 | 2021-08-10 | シー４ セラピューティクス， インコーポレイテッド | Ｉｋａｒｏｓの分解のためのセレブロン結合剤 |
| CN110357850A (zh) * | 2018-03-26 | 2019-10-22 | 广东东阳光药业有限公司 | 一种含硫杂环化合物的制备方法 |
| US12539292B2 (en) | 2018-04-01 | 2026-02-03 | Arvinas Operations, Inc. | BRM targeting compounds and associated methods of use |
| CN110357889B (zh) * | 2018-04-09 | 2022-03-15 | 上海科技大学 | 蛋白降解靶向化合物、其抗肿瘤应用、其中间体及中间体应用 |
| CN119751456A (zh) | 2018-04-16 | 2025-04-04 | C4医药公司 | 螺环化合物 |
| EP3578561A1 (en) | 2018-06-04 | 2019-12-11 | F. Hoffmann-La Roche AG | Spiro compounds |
| WO2019242625A1 (zh) * | 2018-06-20 | 2019-12-26 | 上海科技大学 | 制备来那度胺衍生物的方法 |
| WO2020010227A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| DK3820573T3 (da) * | 2018-07-10 | 2023-10-23 | Novartis Ag | 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidin-2,6-dion-derivativer og anvendelse deraf ved behandling af ikaros family zinc finger 2 (ikzf2)-afhængige sygdomme |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
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| WO2020051235A1 (en) | 2018-09-04 | 2020-03-12 | C4 Therapeutics, Inc. | Compounds for the degradation of brd9 or mth1 |
| CN110963958B (zh) * | 2018-09-30 | 2025-10-10 | 上海长森药业有限公司 | 一种mdm2抑制剂，及其制备方法、药物组合物和应用 |
| KR102672549B1 (ko) * | 2018-09-30 | 2024-06-10 | 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 | 이소인돌린계 화합물, 이의 제조 방법, 약학 조성물 및 용도 |
| KR20210072043A (ko) * | 2018-10-08 | 2021-06-16 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 소분자 mdm 2 단백질 분해제 |
| CN111018857B (zh) | 2018-10-09 | 2023-06-02 | 嘉兴优博生物技术有限公司 | 靶向蛋白酶降解平台(ted) |
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-
2021
- 2021-09-15 AU AU2021232732A patent/AU2021232732A1/en not_active Abandoned
- 2021-12-24 JP JP2021210079A patent/JP2022050469A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN109311900A (zh) | 2019-02-05 |
| JP2022050469A (ja) | 2022-03-30 |
| WO2017176958A1 (en) | 2017-10-12 |
| CA3020281A1 (en) | 2017-10-12 |
| US10759808B2 (en) | 2020-09-01 |
| US20190119289A1 (en) | 2019-04-25 |
| JP2019513746A (ja) | 2019-05-30 |
| JP7001614B2 (ja) | 2022-02-03 |
| AU2021232732A1 (en) | 2021-10-14 |
| US20210002289A1 (en) | 2021-01-07 |
| EP3440082A1 (en) | 2019-02-13 |
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