AU2012245904B2 - Compositions relating to a mutant Clostridium difficile toxin and methods thereof - Google Patents
Compositions relating to a mutant Clostridium difficile toxin and methods thereof Download PDFInfo
- Publication number
- AU2012245904B2 AU2012245904B2 AU2012245904A AU2012245904A AU2012245904B2 AU 2012245904 B2 AU2012245904 B2 AU 2012245904B2 AU 2012245904 A AU2012245904 A AU 2012245904A AU 2012245904 A AU2012245904 A AU 2012245904A AU 2012245904 B2 AU2012245904 B2 AU 2012245904B2
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- acid sequence
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Gram-positive bacteria
- C07K16/1282—Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2016202903A AU2016202903B2 (en) | 2011-04-22 | 2016-05-05 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| AU2017261465A AU2017261465B2 (en) | 2011-04-22 | 2017-11-13 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| AU2018201296A AU2018201296A1 (en) | 2011-04-22 | 2018-02-22 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| AU2019246878A AU2019246878B2 (en) | 2011-04-22 | 2019-10-11 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| AU2020230248A AU2020230248B2 (en) | 2011-04-22 | 2020-09-08 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161478474P | 2011-04-22 | 2011-04-22 | |
| US61/478,474 | 2011-04-22 | ||
| US201161478899P | 2011-04-25 | 2011-04-25 | |
| US61/478,899 | 2011-04-25 | ||
| PCT/IB2012/051999 WO2012143902A1 (en) | 2011-04-22 | 2012-04-20 | Compositions relating to a mutant clostridium difficile toxin and methods thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016202903A Division AU2016202903B2 (en) | 2011-04-22 | 2016-05-05 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012245904A1 AU2012245904A1 (en) | 2013-10-17 |
| AU2012245904B2 true AU2012245904B2 (en) | 2016-04-21 |
Family
ID=46085103
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012245904A Active AU2012245904B2 (en) | 2011-04-22 | 2012-04-20 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| AU2016202903A Active AU2016202903B2 (en) | 2011-04-22 | 2016-05-05 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| AU2017261465A Active AU2017261465B2 (en) | 2011-04-22 | 2017-11-13 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| AU2018201296A Abandoned AU2018201296A1 (en) | 2011-04-22 | 2018-02-22 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| AU2019246878A Active AU2019246878B2 (en) | 2011-04-22 | 2019-10-11 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| AU2020230248A Active AU2020230248B2 (en) | 2011-04-22 | 2020-09-08 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016202903A Active AU2016202903B2 (en) | 2011-04-22 | 2016-05-05 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| AU2017261465A Active AU2017261465B2 (en) | 2011-04-22 | 2017-11-13 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| AU2018201296A Abandoned AU2018201296A1 (en) | 2011-04-22 | 2018-02-22 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| AU2019246878A Active AU2019246878B2 (en) | 2011-04-22 | 2019-10-11 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
| AU2020230248A Active AU2020230248B2 (en) | 2011-04-22 | 2020-09-08 | Compositions relating to a mutant Clostridium difficile toxin and methods thereof |
Country Status (30)
| Country | Link |
|---|---|
| US (13) | US8481692B2 (enExample) |
| EP (4) | EP4365196A3 (enExample) |
| JP (8) | JP5917682B2 (enExample) |
| KR (1) | KR101667837B1 (enExample) |
| CN (3) | CN107022532B (enExample) |
| AR (1) | AR086199A1 (enExample) |
| AU (6) | AU2012245904B2 (enExample) |
| BR (2) | BR112013027229B1 (enExample) |
| CA (1) | CA2832712C (enExample) |
| CO (1) | CO6801643A2 (enExample) |
| DK (2) | DK3549949T5 (enExample) |
| ES (3) | ES2742823T3 (enExample) |
| FI (1) | FI3549949T3 (enExample) |
| HR (2) | HRP20231631T1 (enExample) |
| HU (2) | HUE065594T2 (enExample) |
| IL (8) | IL270779B2 (enExample) |
| MX (3) | MX391236B (enExample) |
| MY (2) | MY168205A (enExample) |
| NZ (1) | NZ616035A (enExample) |
| PE (2) | PE20181334A1 (enExample) |
| PH (1) | PH12013502178B1 (enExample) |
| PL (3) | PL3505531T3 (enExample) |
| PT (2) | PT3549949T (enExample) |
| RU (2) | RU2754446C2 (enExample) |
| SA (3) | SA112330472B1 (enExample) |
| SG (3) | SG10201602668VA (enExample) |
| SI (3) | SI3549949T1 (enExample) |
| TW (6) | TWI701257B (enExample) |
| WO (1) | WO2012143902A1 (enExample) |
| ZA (1) | ZA201307818B (enExample) |
Families Citing this family (37)
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| JP5345532B2 (ja) * | 2006-08-02 | 2013-11-20 | ヨハネス・グーテンベルク−ウニヴェルジテート・マインツ | Ｌｃｔ中毒に対する医薬品 |
| KR101329374B1 (ko) * | 2008-12-09 | 2013-11-14 | 콜레이 파마시티컬 그룹, 인코포레이티드 | 면역자극성 올리고뉴클레오타이드 |
| KR101907434B1 (ko) | 2010-09-03 | 2018-10-12 | 발네바 오스트리아 게엠베하 | C. 디피실의 a 독소 및 b 독소 단백질의 분리된 폴리펩타이드 및 이의 용도 |
| GB201016742D0 (en) * | 2010-10-05 | 2010-11-17 | Health Prot Agency | Clostridium difficile antigens |
| AR086199A1 (es) | 2011-04-22 | 2013-11-27 | Wyeth Llc | Composiciones relacionadas con una toxina de clostridium difficile mutante y sus metodos |
| AU2012349753A1 (en) * | 2011-12-08 | 2014-06-19 | Novartis Ag | Clostridium difficile toxin-based vaccine |
| AR089797A1 (es) | 2012-01-27 | 2014-09-17 | Merck Sharp & Dohme | Vacunas contra clostridum difficile que comprenden toxinas recombinantes |
| PL3489261T3 (pl) | 2012-08-24 | 2021-08-16 | The Regents Of The University Of California | Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu |
| US20140081659A1 (en) | 2012-09-17 | 2014-03-20 | Depuy Orthopaedics, Inc. | Systems and methods for surgical and interventional planning, support, post-operative follow-up, and functional recovery tracking |
| BR122016023101B1 (pt) * | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| SMT201800335T1 (it) * | 2012-11-06 | 2018-09-13 | Bayer Pharma AG | Formulazione di attivatori bispecifici per linfociti t (bite) |
| US9493518B2 (en) * | 2013-03-14 | 2016-11-15 | National Health Research Institutes | Compositions and methods for treating clostridium difficile-associated diseases |
| WO2014144292A2 (en) | 2013-03-15 | 2014-09-18 | Sanofi Pasteur Biologics , Llc | Antibodies against clostridium difficile toxins and methods of using the same |
| CN105451762A (zh) * | 2013-04-22 | 2016-03-30 | 俄克拉荷马州大学评议会 | 艰难梭菌疫苗及使用方法 |
| SG11201510166YA (en) | 2013-06-14 | 2016-01-28 | Sanofi Pasteur Inc | Compositions and methods of immunizing against c. difficile |
| US9717711B2 (en) | 2014-06-16 | 2017-08-01 | The Lauridsen Group | Methods and compositions for treating Clostridium difficile associated disease |
| CN106659799B (zh) * | 2014-07-25 | 2020-07-17 | 碧奥辛斯有限责任公司 | 用于制备针对因肠致病性细菌引起的感染的广谱疫苗的包含表达内置的多个表位的分子构建体的基本单元的糖缀合物疫苗 |
| US11434264B2 (en) * | 2015-02-13 | 2022-09-06 | Quanterix Corporation | Immunoassays for differential detection of clostridium difficile |
| US11185555B2 (en) | 2016-04-11 | 2021-11-30 | Noah James Harrison | Method to kill pathogenic microbes in a patient |
| KR20230047507A (ko) | 2016-06-27 | 2023-04-07 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 암 치료 조합 |
| US20190211377A1 (en) * | 2016-12-22 | 2019-07-11 | Roche Molecular Systems, Inc. | Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile |
| MX2020003756A (es) * | 2017-09-28 | 2020-07-29 | Pfizer | Composiciones y metodos para obtener una respuesta inmune contra clostridium difficile. |
| WO2020201985A1 (en) | 2019-04-01 | 2020-10-08 | Pfizer Inc. | Compositions and methods for eliciting an immune response against clostridium difficile |
| WO2020231859A1 (en) * | 2019-05-10 | 2020-11-19 | The Board Of Regents Of The University Of Oklahoma | Clostridioides difficile tcdb variants, vaccines and methods of use |
| US12161691B2 (en) | 2019-05-11 | 2024-12-10 | The Texas A&M University System | Protein inhibitors of clostridium difficile toxin b |
| KR102376876B1 (ko) | 2020-04-09 | 2022-03-21 | 대진대학교 산학협력단 | 무독성의 클로스트리디움 디피실 독소단백질-단편 및 이의 용도 |
| AU2021267172A1 (en) * | 2020-05-06 | 2022-12-08 | Albert Einstein College Of Medicine | Agents to prevent tissue damage from clostridium difficile infections by inhibition of the gut-damaging bacterial toxins TcdA and TcdB |
| CN111755068B (zh) * | 2020-06-19 | 2021-02-19 | 深圳吉因加医学检验实验室 | 基于测序数据识别肿瘤纯度和绝对拷贝数的方法及装置 |
| WO2021255690A2 (en) | 2020-06-19 | 2021-12-23 | Pfizer Inc. | Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof |
| WO2023277166A1 (ja) * | 2021-07-02 | 2023-01-05 | 国立大学法人 東京大学 | クロストリジウム・ディフィシル菌の増殖を抑制するためのモノクローナル抗体含有組成物 |
| AU2023235562B2 (en) | 2022-03-14 | 2026-07-30 | Pfizer Inc. | Methods for producing an adjuvant |
| WO2023232901A1 (en) | 2022-06-01 | 2023-12-07 | Valneva Austria Gmbh | Clostridium difficile vaccine |
| AU2023393199A1 (en) | 2022-12-13 | 2025-05-29 | Pfizer Inc. | Immunogenic compositions and methods for eliciting an immune response against clostridioides (clostridium) difficile |
| EP4658302A1 (en) | 2023-02-02 | 2025-12-10 | GlaxoSmithKline Biologicals S.A. | Immunogenic composition |
| WO2024196707A2 (en) * | 2023-03-17 | 2024-09-26 | The Board Of Trustees Of The University Of Illinois | Chimeric antibody molecules based on tetrameric teleost immunoglobulin m |
| TWI909678B (zh) | 2023-09-13 | 2025-12-21 | 美商輝瑞股份有限公司 | 產製佐劑之方法 |
| TW202612726A (zh) * | 2024-06-12 | 2026-04-01 | 美商輝瑞股份有限公司 | 誘發針對困難梭狀芽孢桿菌的免疫反應之免疫原性組成物和方法 |
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| WO2010094970A1 (en) * | 2009-02-20 | 2010-08-26 | Health Protection Agency | Antibodies to clostridium difficile toxins |
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