AU2011305476B2 - Multimeric IL-15 soluble fusion molecules and methods of making and using same - Google Patents

Multimeric IL-15 soluble fusion molecules and methods of making and using same Download PDF

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Publication number
AU2011305476B2
AU2011305476B2 AU2011305476A AU2011305476A AU2011305476B2 AU 2011305476 B2 AU2011305476 B2 AU 2011305476B2 AU 2011305476 A AU2011305476 A AU 2011305476A AU 2011305476 A AU2011305476 A AU 2011305476A AU 2011305476 B2 AU2011305476 B2 AU 2011305476B2
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fusion protein
complex
cells
15rasu
domain
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AU2011305476A1 (en
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Kai-Ping Han
Bai LIU
Peter Rhode
Hing C. Wong
Xiaoyun Zhu
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Altor Bioscience LLC
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Altor Bioscience LLC
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/62—DNA sequences coding for fusion proteins
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AU2011305476A 2010-09-21 2011-09-21 Multimeric IL-15 soluble fusion molecules and methods of making and using same Active AU2011305476B2 (en)

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US38481710P 2010-09-21 2010-09-21
US61/384,817 2010-09-21
US201161527911P 2011-08-26 2011-08-26
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EP (5) EP4385570A3 (cg-RX-API-DMAC7.html)
JP (4) JP6251570B2 (cg-RX-API-DMAC7.html)
KR (2) KR20140020228A (cg-RX-API-DMAC7.html)
CN (3) CN107880136B (cg-RX-API-DMAC7.html)
AU (2) AU2011305476B2 (cg-RX-API-DMAC7.html)
CA (1) CA2811734C (cg-RX-API-DMAC7.html)
DK (3) DK2918607T3 (cg-RX-API-DMAC7.html)
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Cited By (4)

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Publication number Priority date Publication date Assignee Title
US11046747B2 (en) 2010-09-21 2021-06-29 Altor Bioscience Llc Multimeric IL-15 soluble fusion molecules and methods of making and using same
US11053299B2 (en) 2010-09-21 2021-07-06 Immunity Bio, Inc. Superkine
US11173191B2 (en) 2014-06-30 2021-11-16 Altor BioScience, LLC. IL-15-based molecules and methods of use thereof
US11365231B2 (en) 2007-05-11 2022-06-21 Altor Bioscience, Llc Interleukin 15 (IL-15) variants

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NZ581779A (en) 2005-05-17 2011-09-30 Univ Connecticut Composition and methods for immunomodulation in an organism comprising interleukin-15 polypeptide and interleukin-15 receptor subunit A polypeptide complex
EA016217B1 (ru) 2005-12-02 2012-03-30 Маунт Синай Скул Оф Медсин Химерные вирусы, представляющие неприродные поверхностные белки, и их применение
US9303080B2 (en) 2006-01-13 2016-04-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells
NZ616254A (en) 2007-06-27 2015-04-24 Us Sec Dep Of Health And Human Services Complexes of il-15 and il-15ralpha and uses thereof
WO2018112219A1 (en) * 2016-12-14 2018-06-21 Nant Holdings Ip, Llc Superkine
PT2663579T (pt) 2011-01-14 2017-07-28 Univ California Terapêutica de anticorpos contra a proteína r0r-1 e métodos para sua utilização
HUE037849T2 (hu) * 2012-06-08 2018-09-28 Alkermes Pharma Ireland Ltd Cirkuláris permutációval módosított ligandumok agonistaként és antagonistaként
CA2888896A1 (en) 2012-10-24 2014-05-01 Admune Therapeutics Llc Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes
EP3640375A3 (en) 2012-12-11 2020-07-29 Albert Einstein College of Medicine Methods for high throughput receptor/ligand identification
CA2905272A1 (en) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Newcastle disease viruses and uses thereof
ES2906615T3 (es) 2013-04-19 2022-04-19 Cytune Pharma Tratamiento derivado de citocinas con síndrome de fuga vascular reducido
US9629877B2 (en) 2013-05-14 2017-04-25 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (CAR) T-cells
MX374291B (es) 2013-08-08 2025-03-06 Cytune Pharma Modulocinas basadas en dominio sushi de interleucina-15 (il-15) y receptor alfa de interleucina-15 (il-15ra).
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