AU2010315243B2 - Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection - Google Patents

Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection Download PDF

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AU2010315243B2
AU2010315243B2 AU2010315243A AU2010315243A AU2010315243B2 AU 2010315243 B2 AU2010315243 B2 AU 2010315243B2 AU 2010315243 A AU2010315243 A AU 2010315243A AU 2010315243 A AU2010315243 A AU 2010315243A AU 2010315243 B2 AU2010315243 B2 AU 2010315243B2
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AU2010315243A1 (en
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Michael C. Jensen
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City of Hope
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • A—HUMAN NECESSITIES
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Developmental Biology & Embryology (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2010315243A 2009-11-03 2010-11-03 Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection Active AU2010315243B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2016262738A AU2016262738A1 (en) 2009-11-03 2016-11-24 Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection
AU2018263993A AU2018263993A1 (en) 2009-11-03 2018-11-12 Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection
AU2021203288A AU2021203288B2 (en) 2009-11-03 2021-05-21 Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25756709P 2009-11-03 2009-11-03
US61/257,567 2009-11-03
PCT/US2010/055329 WO2011056894A2 (en) 2009-11-03 2010-11-03 TRUNCATED EPIDERIMAL GROWTH FACTOR RECEPTOR (EGFRt) FOR TRANSDUCED T CELL SELECTION

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AU2016262738A Division AU2016262738A1 (en) 2009-11-03 2016-11-24 Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection

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AU2010315243A1 AU2010315243A1 (en) 2012-05-24
AU2010315243B2 true AU2010315243B2 (en) 2016-08-25

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AU2010315243A Active AU2010315243B2 (en) 2009-11-03 2010-11-03 Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection
AU2016262738A Abandoned AU2016262738A1 (en) 2009-11-03 2016-11-24 Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection
AU2018263993A Abandoned AU2018263993A1 (en) 2009-11-03 2018-11-12 Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection
AU2021203288A Active AU2021203288B2 (en) 2009-11-03 2021-05-21 Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection

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AU2016262738A Abandoned AU2016262738A1 (en) 2009-11-03 2016-11-24 Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection
AU2018263993A Abandoned AU2018263993A1 (en) 2009-11-03 2018-11-12 Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection
AU2021203288A Active AU2021203288B2 (en) 2009-11-03 2021-05-21 Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection

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US (5) US8802374B2 (enExample)
EP (3) EP4049674B1 (enExample)
JP (6) JP5956342B2 (enExample)
AU (4) AU2010315243B2 (enExample)
CA (1) CA2779526C (enExample)
DK (1) DK2496698T3 (enExample)
ES (2) ES2717629T3 (enExample)
HR (1) HRP20190556T1 (enExample)
HU (1) HUE044461T2 (enExample)
PL (1) PL2496698T3 (enExample)
PT (1) PT2496698T (enExample)
SI (1) SI2496698T1 (enExample)
TR (1) TR201904484T4 (enExample)
WO (1) WO2011056894A2 (enExample)

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