ATE548657T1 - Prozedur zur strukturellen charakterisierung rekombinanter polyclonaler proteine oder einer polyclonalen zelllinie - Google Patents

Prozedur zur strukturellen charakterisierung rekombinanter polyclonaler proteine oder einer polyclonalen zelllinie

Info

Publication number
ATE548657T1
ATE548657T1 AT09151073T AT09151073T ATE548657T1 AT E548657 T1 ATE548657 T1 AT E548657T1 AT 09151073 T AT09151073 T AT 09151073T AT 09151073 T AT09151073 T AT 09151073T AT E548657 T1 ATE548657 T1 AT E548657T1
Authority
AT
Austria
Prior art keywords
polyclonal
cell line
structural characterization
procedure
recombinant
Prior art date
Application number
AT09151073T
Other languages
English (en)
Inventor
Lone Rasmussen
Torben Frandsen
Soren Rasmussen
Peter Andersen
Original Assignee
Symphogen As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphogen As filed Critical Symphogen As
Application granted granted Critical
Publication of ATE548657T1 publication Critical patent/ATE548657T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Document Processing Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT09151073T 2004-07-20 2005-07-20 Prozedur zur strukturellen charakterisierung rekombinanter polyclonaler proteine oder einer polyclonalen zelllinie ATE548657T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200401133 2004-07-20
DKPA200401991 2004-12-22

Publications (1)

Publication Number Publication Date
ATE548657T1 true ATE548657T1 (de) 2012-03-15

Family

ID=35427551

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05760790T ATE443870T1 (de) 2004-07-20 2005-07-20 Verfahren zur charakterisierung einer polyklonalen zellinie
AT09151073T ATE548657T1 (de) 2004-07-20 2005-07-20 Prozedur zur strukturellen charakterisierung rekombinanter polyclonaler proteine oder einer polyclonalen zelllinie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT05760790T ATE443870T1 (de) 2004-07-20 2005-07-20 Verfahren zur charakterisierung einer polyklonalen zellinie

Country Status (19)

Country Link
US (2) US8288109B2 (de)
EP (2) EP2053408B1 (de)
JP (1) JP4870667B2 (de)
KR (1) KR101319848B1 (de)
AT (2) ATE443870T1 (de)
AU (1) AU2005263334C1 (de)
BR (1) BRPI0513714A (de)
CA (1) CA2574146C (de)
DE (1) DE602005016818D1 (de)
DK (2) DK1787126T3 (de)
ES (2) ES2381531T3 (de)
HK (2) HK1101043A1 (de)
IL (2) IL180169A (de)
MX (1) MX2007000551A (de)
NO (1) NO20070931L (de)
NZ (1) NZ552264A (de)
PL (2) PL2053408T3 (de)
RU (1) RU2426795C2 (de)
WO (1) WO2006007853A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101024443B1 (ko) 2003-01-07 2011-03-23 심포젠 에이/에스 재조합 폴리클로날 단백질의 제조 방법
TWI333977B (en) 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
BRPI0513706A (pt) 2004-07-20 2008-05-13 Symphogen As anticorpo policlonal recombinante anti-rhesus d e métodos de produção
WO2006007853A2 (en) 2004-07-20 2006-01-26 Symphogen A/S A procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line
US7850965B2 (en) 2005-12-05 2010-12-14 Symphogen A/S Anti-orthopoxvirus recombinant polyclonal antibody
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
ATE521704T1 (de) * 2007-03-01 2011-09-15 Symphogen As Verfahren zur klonierung verwandter antikörper
JP5726417B2 (ja) * 2007-03-01 2015-06-03 シムフォゲン・アクティーゼルスカブＳｙｍｐｈｏｇｅｎ Ａ／Ｓ 組み換え抗上皮成長因子受容体抗体組成物
BRPI0808673A2 (pt) * 2007-03-06 2014-08-12 Symphogen As Anticorpos recombinantes para tratamento de infecções com vírus sinciciais respiratórios.
CA2680792A1 (en) * 2007-03-15 2008-09-18 Biogen Idec Ma Inc. Treatment of autoimmune disorders
JP2008289483A (ja) * 2007-05-25 2008-12-04 Symphogen As 真核生物系において発現可能な形質転換体のスクリーニング
DK2152872T3 (da) * 2007-05-25 2010-12-06 Symphogen As Fremgangsmåde til fremstilling af et rekombinant polyklonalt protein
AU2008295248A1 (en) * 2007-09-07 2009-03-12 Symphogen A/S Methods for recombinant manufacturing of anti-RSV antibodies
KR20100092030A (ko) 2007-11-22 2010-08-19 심포젠 에이/에스 재조합 폴리클로날 단백질을 특성화하는 방법
SG189793A1 (en) * 2008-04-23 2013-05-31 Symphogen As Methods for manufacturing a polyclonal protein
WO2010022736A2 (en) 2008-08-29 2010-03-04 Symphogen A/S Recombinant anti-epidermal growth factor receptor antibody compositions
EP2331689A4 (de) * 2008-08-29 2012-10-31 Symphogen As Verfahren zum klonen von antikörpern aus vögeln
US8821879B2 (en) 2009-09-04 2014-09-02 Xoma Technology Ltd. Anti-botulism antibody coformulations
AU2010305150A1 (en) * 2009-10-09 2012-04-05 Symphogen A/S Multiplex quantitation of individual recombinant proteins in a mixture by signature peptides and mass spectrometry
JP2013523182A (ja) * 2010-04-15 2013-06-17 アボット・ラボラトリーズ アミロイドベータ結合タンパク質
DK2635604T3 (en) 2010-11-01 2017-02-27 Symphogen As PAN-HER-ANTIBODY COMPOSITION
US9790269B2 (en) 2013-02-08 2017-10-17 Misfolding Diagnostics, Inc. Transthyretin antibodies and uses thereof
UY35517A (es) 2013-04-04 2014-10-31 Mabxience S A Un procedimiento para aumentar la formación de ácido piroglutamico de una proteína
WO2015093925A1 (es) * 2013-12-19 2015-06-25 CASTRO ALDRETE, Jorge Isaac Método de producción de anticuerpos específicos
TW201623331A (zh) * 2014-03-12 2016-07-01 普羅帝納生物科學公司 抗黑色素瘤細胞黏著分子（ｍｃａｍ）抗體類及使用彼等之相關方法
US11680948B2 (en) 2016-08-12 2023-06-20 Abreos Biosciences, Inc. Detection and quantification of natalizumab
US20210269509A1 (en) * 2018-06-22 2021-09-02 Genmab A/S Method for producing a controlled mixture of two or more different antibodies
CN112816595A (zh) * 2021-01-06 2021-05-18 海默斯（重庆）医学生物技术有限公司 一种重组角蛋白液体制剂及其纯度检测方法

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0162918A1 (de) 1983-11-28 1985-12-04 The Board Of Trustees Of The Leland Stanford Junior University Menschlicher monoklonaler antikörper gegen das antigen rh(d) sowie dessen verwendungen
IL78775A (en) * 1985-05-15 1992-06-21 Biotech Australia Pty Ltd Oral vaccines
CA1293460C (en) 1985-10-07 1991-12-24 Brian Lee Sauer Site-specific recombination of dna in yeast
US5126130A (en) 1986-11-24 1992-06-30 The Childrens Hospital Incorporated Monoclonal antibodies reactive with specific antigenic sites on human cytomegalovirus glycoprotein a
GB8722018D0 (en) 1987-09-18 1987-10-28 Central Blood Lab Authority Human anti-rh(d)monoclonal antibodies
GB8722020D0 (en) 1987-09-18 1987-10-28 Central Blood Lab Authority Human anti-rh(d)monoclonal antibodies
GB8722019D0 (en) 1987-09-18 1987-10-28 Central Blood Lab Authority Human anti-rh(d)monoclonal antibodies
EP0368684B2 (de) 1988-11-11 2004-09-29 Medical Research Council Klonierung von Immunglobulin sequenzen aus den variabelen Domänen.
GB8906129D0 (en) 1989-03-17 1989-05-04 Central Blood Lab Authority Pharmaceutical preparations
GB8919761D0 (en) 1989-09-01 1989-10-18 Central Blood Lab Authority Chemical compounds
WO1992015694A1 (en) 1991-03-08 1992-09-17 The Salk Institute For Biological Studies Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor
US5837268A (en) 1991-10-16 1998-11-17 University Of Saskatchewan GnRH-leukotoxin chimeras
US5252216A (en) * 1992-03-24 1993-10-12 Smithkline Beecham Corporation Protein purification
AU678364B2 (en) 1992-06-26 1997-05-29 Association Pour L'essor De La Transfusion Sanguine Dans La Region Du Nord Human monoclonal anti-rhesus (D) antibodies and cell lines producing same
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
EP1231268B1 (de) 1994-01-31 2005-07-27 Trustees Of Boston University Bibliotheken aus Polyklonalen Antikörpern
FR2724182B1 (fr) * 1994-09-02 1996-12-13 Pasteur Institut Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations
US6111166A (en) 1994-09-19 2000-08-29 Medarex, Incorporated Transgenic mice expressing human Fcα and β receptors
SK284879B6 (sk) 1996-06-24 2006-01-05 Zlb Behring Ag Polypeptidy so schopnosťou tvorby väzbových štruktúr na antigén so špecificitou pre Rhesus D antigény, DNA kódujúce také polypeptidy, spôsob ich prípravy a použitie
US6255455B1 (en) * 1996-10-11 2001-07-03 The Trustees Of The University Of Pennsylvania Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof
US5876925A (en) * 1996-10-11 1999-03-02 The Trustees Of The University Of Pennsylvania Magnetically activated cell sorting for production of proteins
WO1998041645A1 (en) 1997-03-14 1998-09-24 Idec Pharmaceuticals Corporation Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same
JPH11174038A (ja) * 1997-12-10 1999-07-02 Tosoh Corp 蛋白質の分離精製法
US6632672B2 (en) 1998-08-19 2003-10-14 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for genomic modification
US20020155114A1 (en) * 1998-08-31 2002-10-24 James D. Marks Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
JP2003504638A (ja) * 1999-07-16 2003-02-04 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド 赤外分光法に応じたリアルタイムのインサイチュバイオマニュファクチャリングプロセスのモニタリングおよび制御
WO2001007572A2 (en) 1999-07-23 2001-02-01 The Regents Of The University Of California Dna recombination in eukaryotic cells by the bacteriophage phic31 recombination system
EP1106625A1 (de) 1999-11-17 2001-06-13 ZLB Bioplasma AG Rhesus D-spezifische Peptidsequenzen
JP2003534533A (ja) 2000-02-08 2003-11-18 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン タンパク質のディファレンシャルディスプレイのマッピング
EP1358202A2 (de) 2000-02-08 2003-11-05 The Regents Of The University Of Michigan Proteintrennung und anzeige
MXPA02007771A (es) 2000-02-08 2003-03-10 Univ Michigan Mapeo de proteinas.
CN1437482A (zh) 2000-05-26 2003-08-20 西福根有限公司 用于治疗变态反应的重组的或纯化的多克隆抗体
US6610472B1 (en) 2000-10-31 2003-08-26 Genetastix Corporation Assembly and screening of highly complex and fully human antibody repertoire in yeast
EP1337631A2 (de) * 2000-11-28 2003-08-27 Applied Molecular Evolution, Inc. Eukaryontische expressionsgenbanken basierend auf der doppel lox rekombiantion und methoden zu deren verwendung
CA2433281C (en) * 2000-12-26 2011-02-22 The Institute For Systems Biology Rapid and quantitative proteome analysis and related methods
JP4264002B2 (ja) * 2001-07-17 2009-05-13 バイオ−ラド ラボラトリーズ インコーポレイテッド ラテックスベース吸着チップ
EP1456667B2 (de) * 2001-12-08 2010-01-20 Micromass UK Limited Massenspektrometrie-verfahren
WO2003102539A2 (en) 2002-05-31 2003-12-11 The Regents Of The University Of Michigan Automated protein analysis system comprising capillary electrophoresis-tandem mass spectrometry
SI1523496T1 (sl) * 2002-07-18 2011-11-30 Merus B V Rekombinantno proizvajanje zmesi protiteles
JP2004101477A (ja) * 2002-09-12 2004-04-02 Yoshio Yamauchi ２次元高速液体クロマトグラフ装置及びそれを用いた蛋白質分析装置
WO2004035169A2 (en) 2002-10-15 2004-04-29 The Regents Of The University Of Michigan Multidimensional protein separation system
KR101024443B1 (ko) * 2003-01-07 2011-03-23 심포젠 에이/에스 재조합 폴리클로날 단백질의 제조 방법
US20060275766A1 (en) * 2003-01-07 2006-12-07 Haurum John S Method for manufacturing recombinant polyclonal proteins
TWI333977B (en) * 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
BRPI0513706A (pt) 2004-07-20 2008-05-13 Symphogen As anticorpo policlonal recombinante anti-rhesus d e métodos de produção
WO2006007853A2 (en) 2004-07-20 2006-01-26 Symphogen A/S A procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line
US7850965B2 (en) 2005-12-05 2010-12-14 Symphogen A/S Anti-orthopoxvirus recombinant polyclonal antibody
CN101395182A (zh) 2006-03-06 2009-03-25 西福根有限公司 用于治疗呼吸道合胞病毒感染的重组多克隆抗体
KR20100092030A (ko) 2007-11-22 2010-08-19 심포젠 에이/에스 재조합 폴리클로날 단백질을 특성화하는 방법

Also Published As

Publication number Publication date
EP2053408B1 (de) 2012-03-07
AU2005263334A1 (en) 2006-01-26
HK1101043A1 (en) 2007-10-05
CA2574146A1 (en) 2006-01-26
HK1133076A1 (en) 2010-03-12
RU2007106050A (ru) 2008-08-27
JP2008506960A (ja) 2008-03-06
IL180169A (en) 2011-04-28
KR20070032078A (ko) 2007-03-20
DK2053408T3 (da) 2012-06-04
PL2053408T3 (pl) 2012-08-31
ES2332524T3 (es) 2010-02-08
US20130203063A1 (en) 2013-08-08
NZ552264A (en) 2010-03-26
ES2381531T3 (es) 2012-05-29
AU2005263334C1 (en) 2011-01-20
BRPI0513714A (pt) 2008-05-13
DE602005016818D1 (de) 2009-11-05
NO20070931L (no) 2007-04-17
EP2053408A2 (de) 2009-04-29
EP2053408A3 (de) 2009-07-29
ATE443870T1 (de) 2009-10-15
MX2007000551A (es) 2007-03-30
EP1787126B1 (de) 2009-09-23
AU2005263334B2 (en) 2010-08-05
DK1787126T3 (da) 2009-12-21
EP1787126A2 (de) 2007-05-23
US20080131882A1 (en) 2008-06-05
IL180169A0 (en) 2007-06-03
IL203017A (en) 2013-08-29
WO2006007853A2 (en) 2006-01-26
RU2426795C2 (ru) 2011-08-20
PL1787126T3 (pl) 2010-03-31
JP4870667B2 (ja) 2012-02-08
WO2006007853A3 (en) 2006-05-18
US9029091B2 (en) 2015-05-12
CA2574146C (en) 2015-06-30
KR101319848B1 (ko) 2013-10-18
US8288109B2 (en) 2012-10-16

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