BRPI0513714A - procedimento para caracterização estrutural de uma proteìna policlonal recombinante ou uma linhagem de célula policlonal - Google Patents
procedimento para caracterização estrutural de uma proteìna policlonal recombinante ou uma linhagem de célula policlonalInfo
- Publication number
- BRPI0513714A BRPI0513714A BRPI0513714-4A BRPI0513714A BRPI0513714A BR PI0513714 A BRPI0513714 A BR PI0513714A BR PI0513714 A BRPI0513714 A BR PI0513714A BR PI0513714 A BRPI0513714 A BR PI0513714A
- Authority
- BR
- Brazil
- Prior art keywords
- polyclonal
- cell line
- structural characterization
- procedure
- recombinant
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Document Processing Apparatus (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
PROCEDIMENTO PARA CARACTERIZAçãO ESTRUTURAL DE UMA PROTEìNA POLICLONAL. RECOMBINANTE OU UMA LINHAGEM DE CéLULA POLICLONAL. A presente invenção refere-se a uma plataforma de caracterizacão estrutural que pode ser empregada para avaliar a estabilidade de uma linhagem de célula policlonal durante a produção, bem como consistência de batelada para batelada dos produtos policlonais finais. A plataforma de caracterização estrutural é com base na análise genética bem como técnicas de caracterização de proteína que sozinha ou em combinação fornece a informação necessária para caracterizar a linhagem de célula policlonal e produtos finais. A coleção de proteínas homólogas diferentes a ser analisada com as técnicas de plataforma no caso de. por exemplo, um anticorpo policlonal recombinante ou uma mistura de anticorpos monoclonais.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200401133 | 2004-07-20 | ||
DKPA200401991 | 2004-12-22 | ||
PCT/DK2005/000504 WO2006007853A2 (en) | 2004-07-20 | 2005-07-20 | A procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0513714A true BRPI0513714A (pt) | 2008-05-13 |
Family
ID=35427551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0513714-4A BRPI0513714A (pt) | 2004-07-20 | 2005-07-20 | procedimento para caracterização estrutural de uma proteìna policlonal recombinante ou uma linhagem de célula policlonal |
Country Status (19)
Country | Link |
---|---|
US (2) | US8288109B2 (pt) |
EP (2) | EP2053408B1 (pt) |
JP (1) | JP4870667B2 (pt) |
KR (1) | KR101319848B1 (pt) |
AT (2) | ATE548657T1 (pt) |
AU (1) | AU2005263334C1 (pt) |
BR (1) | BRPI0513714A (pt) |
CA (1) | CA2574146C (pt) |
DE (1) | DE602005016818D1 (pt) |
DK (2) | DK2053408T3 (pt) |
ES (2) | ES2381531T3 (pt) |
HK (2) | HK1101043A1 (pt) |
IL (2) | IL180169A (pt) |
MX (1) | MX2007000551A (pt) |
NO (1) | NO20070931L (pt) |
NZ (1) | NZ552264A (pt) |
PL (2) | PL2053408T3 (pt) |
RU (1) | RU2426795C2 (pt) |
WO (1) | WO2006007853A2 (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2512647C (en) * | 2003-01-07 | 2013-10-08 | Symphogen A/S | Method for manufacturing recombinant polyclonal proteins |
TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
EP1771483A1 (en) | 2004-07-20 | 2007-04-11 | Symphogen A/S | Anti-rhesus d recombinant polyclonal antibody and methods of manufacture |
ATE548657T1 (de) | 2004-07-20 | 2012-03-15 | Symphogen As | Prozedur zur strukturellen charakterisierung rekombinanter polyclonaler proteine oder einer polyclonalen zelllinie |
JP2009518320A (ja) * | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
US8338376B2 (en) | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
DK2132229T3 (en) | 2007-03-01 | 2016-06-20 | Symphogen As | Recombinant anti-epidermal growth factor receptor-ANTIBODY COMPOSITIONS |
ES2369946T3 (es) | 2007-03-01 | 2011-12-09 | Symphogen A/S | Procedimiento para clonación de anticuerpos análogos. |
CA2678628A1 (en) | 2007-03-06 | 2008-09-12 | Symphogen A/S | Recombinant antibodies for treatment of respiratory syncytial virus infections |
CA2680792A1 (en) * | 2007-03-15 | 2008-09-18 | Biogen Idec Ma Inc. | Treatment of autoimmune disorders |
BRPI0812091A2 (pt) | 2007-05-25 | 2014-10-14 | Symphogen As | Método para fabricar uma proteína policlonal recombinante |
JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
WO2009030237A2 (en) * | 2007-09-07 | 2009-03-12 | Symphogen A/S | Methods for recombinant manufacturing of anti-rsv antibodies |
BRPI0820221A2 (pt) * | 2007-11-22 | 2015-05-26 | Symphogen As | Método para caracterização de uma proteína policlonal recombinante |
CA2722348A1 (en) * | 2008-04-23 | 2009-10-29 | Symphogen A/S | Methods for manufacturing a polyclonal protein |
KR20110058861A (ko) * | 2008-08-29 | 2011-06-01 | 심포젠 에이/에스 | 조류 유래 항체의 클로닝 방법 |
KR101706255B1 (ko) | 2008-08-29 | 2017-02-14 | 심포젠 에이/에스 | 재조합 항-표피 성장 인자 수용체 항체 조성물 |
US8821879B2 (en) | 2009-09-04 | 2014-09-02 | Xoma Technology Ltd. | Anti-botulism antibody coformulations |
CN102687020A (zh) * | 2009-10-09 | 2012-09-19 | 西福根有限公司 | 利用特征肽和质谱对混合物中的单个重组蛋白进行多重定量 |
JP2013523182A (ja) * | 2010-04-15 | 2013-06-17 | アボット・ラボラトリーズ | アミロイドベータ結合タンパク質 |
EP2635604B1 (en) | 2010-11-01 | 2016-11-30 | Symphogen A/S | Pan-her antibody composition |
JP2016514091A (ja) | 2013-02-08 | 2016-05-19 | ミスフォールディング ダイアグノスティクス, インコーポレイテッド | トランスサイレチン抗体およびその使用 |
UY35517A (es) | 2013-04-04 | 2014-10-31 | Mabxience S A | Un procedimiento para aumentar la formación de ácido piroglutamico de una proteína |
WO2015093925A1 (es) * | 2013-12-19 | 2015-06-25 | CASTRO ALDRETE, Jorge Isaac | Método de producción de anticuerpos específicos |
TW201623331A (zh) * | 2014-03-12 | 2016-07-01 | 普羅帝納生物科學公司 | 抗黑色素瘤細胞黏著分子(mcam)抗體類及使用彼等之相關方法 |
WO2018031887A1 (en) * | 2016-08-12 | 2018-02-15 | Abreos Biosciences, Inc. | Detection and quantification of natalizumab |
CA3104390A1 (en) * | 2018-06-22 | 2019-12-26 | Genmab A/S | Method for producing a controlled mixture of two or more different antibodies |
CN112816595A (zh) * | 2021-01-06 | 2021-05-18 | 海默斯(重庆)医学生物技术有限公司 | 一种重组角蛋白液体制剂及其纯度检测方法 |
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CA2512647C (en) | 2003-01-07 | 2013-10-08 | Symphogen A/S | Method for manufacturing recombinant polyclonal proteins |
US20060275766A1 (en) * | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
TWI333977B (en) * | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
EP1771483A1 (en) | 2004-07-20 | 2007-04-11 | Symphogen A/S | Anti-rhesus d recombinant polyclonal antibody and methods of manufacture |
ATE548657T1 (de) | 2004-07-20 | 2012-03-15 | Symphogen As | Prozedur zur strukturellen charakterisierung rekombinanter polyclonaler proteine oder einer polyclonalen zelllinie |
JP2009518320A (ja) | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
KR20080113223A (ko) | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
BRPI0820221A2 (pt) | 2007-11-22 | 2015-05-26 | Symphogen As | Método para caracterização de uma proteína policlonal recombinante |
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2005
- 2005-07-20 AT AT09151073T patent/ATE548657T1/de active
- 2005-07-20 EP EP09151073A patent/EP2053408B1/en active Active
- 2005-07-20 CA CA2574146A patent/CA2574146C/en not_active Expired - Fee Related
- 2005-07-20 ES ES09151073T patent/ES2381531T3/es active Active
- 2005-07-20 US US11/658,021 patent/US8288109B2/en not_active Expired - Fee Related
- 2005-07-20 RU RU2007106050/10A patent/RU2426795C2/ru not_active IP Right Cessation
- 2005-07-20 ES ES05760790T patent/ES2332524T3/es active Active
- 2005-07-20 WO PCT/DK2005/000504 patent/WO2006007853A2/en active Application Filing
- 2005-07-20 NZ NZ552264A patent/NZ552264A/en not_active IP Right Cessation
- 2005-07-20 JP JP2007521795A patent/JP4870667B2/ja not_active Expired - Fee Related
- 2005-07-20 KR KR1020077003954A patent/KR101319848B1/ko not_active IP Right Cessation
- 2005-07-20 PL PL09151073T patent/PL2053408T3/pl unknown
- 2005-07-20 AU AU2005263334A patent/AU2005263334C1/en not_active Ceased
- 2005-07-20 AT AT05760790T patent/ATE443870T1/de active
- 2005-07-20 DK DK09151073.5T patent/DK2053408T3/da active
- 2005-07-20 DE DE602005016818T patent/DE602005016818D1/de active Active
- 2005-07-20 MX MX2007000551A patent/MX2007000551A/es active IP Right Grant
- 2005-07-20 DK DK05760790T patent/DK1787126T3/da active
- 2005-07-20 EP EP05760790A patent/EP1787126B1/en active Active
- 2005-07-20 BR BRPI0513714-4A patent/BRPI0513714A/pt not_active Application Discontinuation
- 2005-07-20 PL PL05760790T patent/PL1787126T3/pl unknown
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2006
- 2006-12-19 IL IL180169A patent/IL180169A/en not_active IP Right Cessation
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2007
- 2007-02-19 NO NO20070931A patent/NO20070931L/no not_active Application Discontinuation
- 2007-06-07 HK HK07106079.4A patent/HK1101043A1/xx not_active IP Right Cessation
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2009
- 2009-10-28 HK HK09109991.1A patent/HK1133076A1/xx not_active IP Right Cessation
- 2009-12-29 IL IL203017A patent/IL203017A/en not_active IP Right Cessation
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2012
- 2012-10-16 US US13/653,316 patent/US9029091B2/en not_active Expired - Fee Related
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