DE602005016818D1 - Verfahren zur charakterisierung einer polyklonalen zellinie - Google Patents
Verfahren zur charakterisierung einer polyklonalen zellinieInfo
- Publication number
- DE602005016818D1 DE602005016818D1 DE602005016818T DE602005016818T DE602005016818D1 DE 602005016818 D1 DE602005016818 D1 DE 602005016818D1 DE 602005016818 T DE602005016818 T DE 602005016818T DE 602005016818 T DE602005016818 T DE 602005016818T DE 602005016818 D1 DE602005016818 D1 DE 602005016818D1
- Authority
- DE
- Germany
- Prior art keywords
- cell line
- polyclonal
- platform
- polyclonal cell
- characterizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Document Processing Apparatus (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200401133 | 2004-07-20 | ||
DKPA200401991 | 2004-12-22 | ||
PCT/DK2005/000504 WO2006007853A2 (en) | 2004-07-20 | 2005-07-20 | A procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005016818D1 true DE602005016818D1 (de) | 2009-11-05 |
Family
ID=35427551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005016818T Active DE602005016818D1 (de) | 2004-07-20 | 2005-07-20 | Verfahren zur charakterisierung einer polyklonalen zellinie |
Country Status (19)
Country | Link |
---|---|
US (2) | US8288109B2 (de) |
EP (2) | EP2053408B1 (de) |
JP (1) | JP4870667B2 (de) |
KR (1) | KR101319848B1 (de) |
AT (2) | ATE443870T1 (de) |
AU (1) | AU2005263334C1 (de) |
BR (1) | BRPI0513714A (de) |
CA (1) | CA2574146C (de) |
DE (1) | DE602005016818D1 (de) |
DK (2) | DK1787126T3 (de) |
ES (2) | ES2381531T3 (de) |
HK (2) | HK1101043A1 (de) |
IL (2) | IL180169A (de) |
MX (1) | MX2007000551A (de) |
NO (1) | NO20070931L (de) |
NZ (1) | NZ552264A (de) |
PL (2) | PL2053408T3 (de) |
RU (1) | RU2426795C2 (de) |
WO (1) | WO2006007853A2 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1583830E (pt) | 2003-01-07 | 2006-11-30 | Symphogen As | Método para produzir proteínas policlonais recombinantes |
TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
AU2005263331B8 (en) | 2004-07-20 | 2011-06-16 | Symphogen A/S | Anti-Rhesus D recombinant polyclonal antibody and methods of manufacture |
KR101319848B1 (ko) | 2004-07-20 | 2013-10-18 | 심포젠 에이/에스 | 재조합 폴리클로날 단백질 또는 폴리클로날 세포주의구조적 특성화 방법 |
US7850965B2 (en) | 2005-12-05 | 2010-12-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
US8338376B2 (en) | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
NZ578851A (en) | 2007-03-01 | 2011-09-30 | Symphogen As | Method for cloning cognate antibodies |
ES2582386T3 (es) * | 2007-03-01 | 2016-09-12 | Symphogen A/S | Composiciones de anticuerpos recombinantes contra el receptor del factor de crecimiento epidérmico |
EP2134747A2 (de) * | 2007-03-06 | 2009-12-23 | Symphogen A/S | Rekombinante antikörper zur behandlung von infektionen mit dem respiratory syncytial virus |
CN101951940A (zh) * | 2007-03-15 | 2011-01-19 | 比奥根艾迪克Ma公司 | 自身免疫病的治疗 |
JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
JP5941616B2 (ja) | 2007-05-25 | 2016-06-29 | シムフォゲン・アクティーゼルスカブSymphogen A/S | 組み換えポリクローナルタンパク質を製造する方法 |
WO2009030237A2 (en) * | 2007-09-07 | 2009-03-12 | Symphogen A/S | Methods for recombinant manufacturing of anti-rsv antibodies |
US20090186423A1 (en) * | 2007-11-22 | 2009-07-23 | Symphogen A/S | Method for Characterization of a Recombinant Polyclonal Protein |
JP2011518790A (ja) * | 2008-04-23 | 2011-06-30 | シムフォゲン・アクティーゼルスカブ | ポリクローナルタンパク質を製造する方法 |
BRPI0917352A2 (pt) * | 2008-08-29 | 2017-08-22 | Symphogen As | Métodos para produção de uma biblioteca de pares cognatos que compreende sequências ligadas que codificam regiões variáveis e para gerar um vetor que codifica um anticorpo quimérico com regiões de seres humanos constantes e regiões variáveis não humanas, biblioteca de vetores, e método para produção de uma biblioteca de sequências de imunoglobulina derivadas de aves |
CN102137874B (zh) | 2008-08-29 | 2015-02-18 | 西福根有限公司 | 抗表皮生长因子受体的重组抗体组合物 |
US8821879B2 (en) | 2009-09-04 | 2014-09-02 | Xoma Technology Ltd. | Anti-botulism antibody coformulations |
AU2010305150A1 (en) * | 2009-10-09 | 2012-04-05 | Symphogen A/S | Multiplex quantitation of individual recombinant proteins in a mixture by signature peptides and mass spectrometry |
MX360403B (es) * | 2010-04-15 | 2018-10-31 | Abbvie Inc | Proteinas de union a amiloide beta. |
WO2012059858A1 (en) | 2010-11-01 | 2012-05-10 | Symphogen A/S | Anti-her3 antibodies and compositions |
EP2953970A4 (de) | 2013-02-08 | 2016-06-29 | Misfolding Diagnostics Inc | Transthyretinantikörper und verwendungen davon |
UY35517A (es) | 2013-04-04 | 2014-10-31 | Mabxience S A | Un procedimiento para aumentar la formación de ácido piroglutamico de una proteína |
WO2015093925A1 (es) * | 2013-12-19 | 2015-06-25 | CASTRO ALDRETE, Jorge Isaac | Método de producción de anticuerpos específicos |
TW201623331A (zh) * | 2014-03-12 | 2016-07-01 | 普羅帝納生物科學公司 | 抗黑色素瘤細胞黏著分子(mcam)抗體類及使用彼等之相關方法 |
US11680948B2 (en) | 2016-08-12 | 2023-06-20 | Abreos Biosciences, Inc. | Detection and quantification of natalizumab |
SG11202012713RA (en) * | 2018-06-22 | 2021-01-28 | Genmab As | Method for producing a controlled mixture of two or more different antibodies |
CN112816595A (zh) * | 2021-01-06 | 2021-05-18 | 海默斯(重庆)医学生物技术有限公司 | 一种重组角蛋白液体制剂及其纯度检测方法 |
Family Cites Families (49)
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WO1985002413A1 (en) | 1983-11-28 | 1985-06-06 | The Board Of Trustees Of The Leland Stanford Jr. U | HUMAN MONOCLONAL ANTIBODY AGAINST Rh(D) ANTIGEN AND ITS USES |
IL78775A (en) * | 1985-05-15 | 1992-06-21 | Biotech Australia Pty Ltd | Oral vaccines |
CA1293460C (en) | 1985-10-07 | 1991-12-24 | Brian Lee Sauer | Site-specific recombination of dna in yeast |
US5126130A (en) | 1986-11-24 | 1992-06-30 | The Childrens Hospital Incorporated | Monoclonal antibodies reactive with specific antigenic sites on human cytomegalovirus glycoprotein a |
GB8722020D0 (en) | 1987-09-18 | 1987-10-28 | Central Blood Lab Authority | Human anti-rh(d)monoclonal antibodies |
GB8722019D0 (en) | 1987-09-18 | 1987-10-28 | Central Blood Lab Authority | Human anti-rh(d)monoclonal antibodies |
GB8722018D0 (en) | 1987-09-18 | 1987-10-28 | Central Blood Lab Authority | Human anti-rh(d)monoclonal antibodies |
AU634186B2 (en) | 1988-11-11 | 1993-02-18 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
GB8906129D0 (en) | 1989-03-17 | 1989-05-04 | Central Blood Lab Authority | Pharmaceutical preparations |
GB8919761D0 (en) | 1989-09-01 | 1989-10-18 | Central Blood Lab Authority | Chemical compounds |
WO1992015694A1 (en) | 1991-03-08 | 1992-09-17 | The Salk Institute For Biological Studies | Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor |
US5837268A (en) * | 1991-10-16 | 1998-11-17 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
US5252216A (en) * | 1992-03-24 | 1993-10-12 | Smithkline Beecham Corporation | Protein purification |
BR9305557A (pt) | 1992-06-26 | 1997-03-25 | Aetsrn | Anticorpos monoclonais humanos anti Rhesus-D e composiçao farmacêutica que os contém |
US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
PT1231268E (pt) * | 1994-01-31 | 2005-11-30 | Univ Boston | Bancos de anticorpos policlonais |
FR2724182B1 (fr) | 1994-09-02 | 1996-12-13 | Pasteur Institut | Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations |
US6111166A (en) | 1994-09-19 | 2000-08-29 | Medarex, Incorporated | Transgenic mice expressing human Fcα and β receptors |
ES2224255T3 (es) | 1996-06-24 | 2005-03-01 | Zlb Behring Ag | Polipeptidos capaces de formar estructuras de union a antigenos con especificidad por los antigenos de rhesus d, el dna que los codifica y el proceso para su preparacion y uso. |
US5876925A (en) | 1996-10-11 | 1999-03-02 | The Trustees Of The University Of Pennsylvania | Magnetically activated cell sorting for production of proteins |
US6255455B1 (en) | 1996-10-11 | 2001-07-03 | The Trustees Of The University Of Pennsylvania | Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof |
EP0981637B1 (de) | 1997-03-14 | 2005-05-25 | Biogen Idec Inc. | Methode zur spezifischen integration von genen in säugetierzellen durch homologe rekombination, und vektoren zu deren durchführung |
JPH11174038A (ja) * | 1997-12-10 | 1999-07-02 | Tosoh Corp | 蛋白質の分離精製法 |
AU5898599A (en) | 1998-08-19 | 2000-03-14 | Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for genomic modification |
US20020155114A1 (en) | 1998-08-31 | 2002-10-24 | James D. Marks | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
EP1204855A1 (de) * | 1999-07-16 | 2002-05-15 | Human Genome Sciences, Inc. | In-situ überwachung und kontrolle eines biologischen herstellungsprozesses in echtzeit mittels infrarotspektroskopie |
ATE463569T1 (de) | 1999-07-23 | 2010-04-15 | Univ California | Dna-rekombination in eukaryotischen zellen mittels des rekombinationszentrums vom bakteriophag phic31 |
EP1106625A1 (de) | 1999-11-17 | 2001-06-13 | ZLB Bioplasma AG | Rhesus D-spezifische Peptidsequenzen |
EP1385869A2 (de) | 2000-02-08 | 2004-02-04 | The Regents Of The University Of Michigan | Proteinkartierung |
CA2400460C (en) | 2000-02-08 | 2009-01-06 | The Regents Of The University Of Michigan | Mapping of differential display of proteins |
EP1358202A2 (de) | 2000-02-08 | 2003-11-05 | The Regents Of The University Of Michigan | Proteintrennung und anzeige |
ATE359819T1 (de) | 2000-05-26 | 2007-05-15 | Symphogen As | Rekombinante oder gereinigte polyklonale antikörper zur behandlung den allergien |
US6610472B1 (en) | 2000-10-31 | 2003-08-26 | Genetastix Corporation | Assembly and screening of highly complex and fully human antibody repertoire in yeast |
JP2004514444A (ja) * | 2000-11-28 | 2004-05-20 | アプライド モレキュラー エボリューション, インコーポレイテッド | 二重lox組換えに基づく真核生物発現ライブラリーおよび使用方法 |
DE60119580T2 (de) * | 2000-12-26 | 2007-04-26 | The Institute For Systems Biology, Seattle | Schnelle und quantitative proteomanalyse und damit zusammenhängende verfahren |
WO2003079402A2 (en) * | 2001-07-17 | 2003-09-25 | Ciphergen Biosystems, Inc. | Latex based adsorbent chip |
CA2465297C (en) * | 2001-12-08 | 2011-02-15 | Micromass Uk Limited | Method of mass spectrometry |
WO2003102539A2 (en) | 2002-05-31 | 2003-12-11 | The Regents Of The University Of Michigan | Automated protein analysis system comprising capillary electrophoresis-tandem mass spectrometry |
ES2442615T5 (es) * | 2002-07-18 | 2023-03-16 | Merus Nv | Producción recombinante de mezclas de anticuerpos |
JP2004101477A (ja) * | 2002-09-12 | 2004-04-02 | Yoshio Yamauchi | 2次元高速液体クロマトグラフ装置及びそれを用いた蛋白質分析装置 |
AU2003284227A1 (en) | 2002-10-15 | 2004-05-04 | The Regents Of The University Of Michigan | Multidimensional protein separation system |
US20060275766A1 (en) * | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
PT1583830E (pt) | 2003-01-07 | 2006-11-30 | Symphogen As | Método para produzir proteínas policlonais recombinantes |
TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
KR101319848B1 (ko) | 2004-07-20 | 2013-10-18 | 심포젠 에이/에스 | 재조합 폴리클로날 단백질 또는 폴리클로날 세포주의구조적 특성화 방법 |
AU2005263331B8 (en) | 2004-07-20 | 2011-06-16 | Symphogen A/S | Anti-Rhesus D recombinant polyclonal antibody and methods of manufacture |
US7850965B2 (en) | 2005-12-05 | 2010-12-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
WO2007101441A1 (en) | 2006-03-06 | 2007-09-13 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
US20090186423A1 (en) | 2007-11-22 | 2009-07-23 | Symphogen A/S | Method for Characterization of a Recombinant Polyclonal Protein |
-
2005
- 2005-07-20 KR KR1020077003954A patent/KR101319848B1/ko not_active IP Right Cessation
- 2005-07-20 WO PCT/DK2005/000504 patent/WO2006007853A2/en active Application Filing
- 2005-07-20 RU RU2007106050/10A patent/RU2426795C2/ru not_active IP Right Cessation
- 2005-07-20 PL PL09151073T patent/PL2053408T3/pl unknown
- 2005-07-20 AT AT05760790T patent/ATE443870T1/de active
- 2005-07-20 CA CA2574146A patent/CA2574146C/en not_active Expired - Fee Related
- 2005-07-20 AU AU2005263334A patent/AU2005263334C1/en not_active Ceased
- 2005-07-20 PL PL05760790T patent/PL1787126T3/pl unknown
- 2005-07-20 DE DE602005016818T patent/DE602005016818D1/de active Active
- 2005-07-20 US US11/658,021 patent/US8288109B2/en not_active Expired - Fee Related
- 2005-07-20 ES ES09151073T patent/ES2381531T3/es active Active
- 2005-07-20 DK DK05760790T patent/DK1787126T3/da active
- 2005-07-20 NZ NZ552264A patent/NZ552264A/en not_active IP Right Cessation
- 2005-07-20 BR BRPI0513714-4A patent/BRPI0513714A/pt not_active Application Discontinuation
- 2005-07-20 EP EP09151073A patent/EP2053408B1/de active Active
- 2005-07-20 DK DK09151073.5T patent/DK2053408T3/da active
- 2005-07-20 EP EP05760790A patent/EP1787126B1/de active Active
- 2005-07-20 JP JP2007521795A patent/JP4870667B2/ja not_active Expired - Fee Related
- 2005-07-20 MX MX2007000551A patent/MX2007000551A/es active IP Right Grant
- 2005-07-20 ES ES05760790T patent/ES2332524T3/es active Active
- 2005-07-20 AT AT09151073T patent/ATE548657T1/de active
-
2006
- 2006-12-19 IL IL180169A patent/IL180169A/en not_active IP Right Cessation
-
2007
- 2007-02-19 NO NO20070931A patent/NO20070931L/no not_active Application Discontinuation
- 2007-06-07 HK HK07106079.4A patent/HK1101043A1/xx not_active IP Right Cessation
-
2009
- 2009-10-28 HK HK09109991.1A patent/HK1133076A1/xx not_active IP Right Cessation
- 2009-12-29 IL IL203017A patent/IL203017A/en not_active IP Right Cessation
-
2012
- 2012-10-16 US US13/653,316 patent/US9029091B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |