ATE554106T1 - Antikörper für onkogene stämme von hpv und verfahren zu deren verwendung - Google Patents

Antikörper für onkogene stämme von hpv und verfahren zu deren verwendung

Info

Publication number
ATE554106T1
ATE554106T1 AT04815434T AT04815434T ATE554106T1 AT E554106 T1 ATE554106 T1 AT E554106T1 AT 04815434 T AT04815434 T AT 04815434T AT 04815434 T AT04815434 T AT 04815434T AT E554106 T1 ATE554106 T1 AT E554106T1
Authority
AT
Austria
Prior art keywords
antibodies
hpv
subject
strains
proteins
Prior art date
Application number
AT04815434T
Other languages
English (en)
Inventor
Peter Lu
Jonathan Garman
Michael Belmares
Diaz-Sarmiento Chamorro Somoza
Johannes Schweizer
Original Assignee
Arbor Vita Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arbor Vita Corp filed Critical Arbor Vita Corp
Application granted granted Critical
Publication of ATE554106T1 publication Critical patent/ATE554106T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/084Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57411Specifically defined cancers of cervix
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01DNA viruses
    • G01N2333/025Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
AT04815434T 2003-12-23 2004-12-23 Antikörper für onkogene stämme von hpv und verfahren zu deren verwendung ATE554106T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53237303P 2003-12-23 2003-12-23
PCT/US2004/043356 WO2005063286A1 (en) 2003-12-23 2004-12-23 Antibodies for oncogenic strains of hpv and methods of their use

Publications (1)

Publication Number Publication Date
ATE554106T1 true ATE554106T1 (de) 2012-05-15

Family

ID=34738792

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04815434T ATE554106T1 (de) 2003-12-23 2004-12-23 Antikörper für onkogene stämme von hpv und verfahren zu deren verwendung

Country Status (7)

Country Link
US (5) US7399467B2 (de)
EP (1) EP1708745B1 (de)
JP (1) JP5030594B2 (de)
AT (1) ATE554106T1 (de)
AU (1) AU2004308964B2 (de)
CA (1) CA2551560A1 (de)
WO (1) WO2005063286A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL105554A (en) * 1992-05-05 1999-08-17 Univ Leiden Peptides of human papillomavirus for use in preparations elicit a human T cell response
US7312041B2 (en) * 2001-02-16 2007-12-25 Arbor Vita Corporation Methods of diagnosing cervical cancer
WO2005063286A1 (en) * 2003-12-23 2005-07-14 Arbor Vita Corporation Antibodies for oncogenic strains of hpv and methods of their use
US7732166B2 (en) * 2005-11-15 2010-06-08 Oncohealth Corporation Detection method for human pappilomavirus (HPV) and its application in cervical cancer
US7972776B2 (en) * 2005-11-15 2011-07-05 Oncohealth Corporation Protein chips for HPV detection
JP2009536958A (ja) * 2006-05-11 2009-10-22 ベクトン・ディキンソン・アンド・カンパニー 細胞からのタンパク質抽出方法
US8859218B2 (en) * 2008-06-13 2014-10-14 Oncohealth Corp. In situ detection of early stages and late stages HPV infection
US8968995B2 (en) 2008-11-12 2015-03-03 Oncohealth Corp. Detection, screening, and diagnosis of HPV-associated cancers
US8916342B2 (en) 2006-11-13 2014-12-23 Oncohealth Corp. Identification of high grade or ≧ CIN2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (HPV) and HPV-associated cancers
WO2009002159A2 (en) 2007-05-31 2008-12-31 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Intradermal hpv peptide vaccination
AU2015213420B2 (en) * 2007-05-31 2017-02-16 Isa Pharmaceuticals B.V. HPV epitopes targeted by T cells infiltrating cervical malignancies for use in vaccines
CA2692652C (en) * 2007-05-31 2018-10-23 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Hpv epitopes targeted by t cells infiltrating cervical malignancies for use in vaccines
US7838215B2 (en) * 2007-09-25 2010-11-23 Canvir, Inc. Advanced cervical cell screening methods
US9207240B2 (en) * 2007-11-14 2015-12-08 Arbor Vita Corporation Method of efficient extraction of protein from cells
US20120141502A1 (en) * 2009-04-20 2012-06-07 Eric Dixon Antibodies specific to e6 proteins of hpv and use thereof
TWI497075B (zh) * 2009-06-11 2015-08-21 Oncohealth Corp 早期及晚期人類乳突病毒感染之偵測
JP5819851B2 (ja) 2010-01-08 2015-11-24 オンコヘルス コーポレーション Hpv関連の癌の治療及びスクリーニングのための細胞に基づいた高処理能力hpv免疫アッセイ
WO2012135666A1 (en) * 2011-04-01 2012-10-04 University Of Louisiana At Monroe Inhibitors of metastasis, methods of generating such inhibitors and their therapeutic applications
CN105264384B (zh) * 2013-05-06 2018-04-27 生物辐射实验室股份有限公司 参比材料中不稳定分析物的稳定化
EP3015863A1 (de) * 2014-10-31 2016-05-04 Mikrogen GmbH Immunologischer Test zum Nachweis von E7-Onkoproteinen in biologischen Proben
EP3519433A1 (de) 2016-10-03 2019-08-07 Juno Therapeutics, Inc. Hpv-spezifische bindungsmoleküle
KR20200104284A (ko) 2017-10-03 2020-09-03 주노 쎄러퓨티크스 인코퍼레이티드 Hpv-특이적 결합 분자
US20210046114A1 (en) * 2018-01-24 2021-02-18 The Council Of The Queensland Institute Of Medical Research Hpv immunotherapy
MA52193A (fr) 2018-04-05 2021-02-17 Juno Therapeutics Inc Récepteurs de lymphocytes t et cellules modifiées les exprimant
EP3801602A1 (de) 2018-05-30 2021-04-14 Deutsches Krebsforschungszentrum Kombinierte prophylaktische und therapeutische impfstoffe
CN115925888B (zh) * 2022-11-26 2023-06-27 山西省中医药研究院(山西省中医院) 与人乳头瘤病毒hpv特异性结合的羊驼源纳米抗体及其应用

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
EP0111762B1 (de) 1980-06-20 1987-11-19 Unilever Plc Verfahren und Gerät zur Durchführung spezifischer Bindungsbestimmungen
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5876922A (en) * 1985-07-31 1999-03-02 Institute Pasteur Papillomavirus probe and a process for in vitro diagnosis of papillomavirus infections
FR2586428B1 (fr) * 1985-08-26 1988-11-25 Pasteur Institut Polypeptides et anticorps, caracteristiques du papillomavirus et leurs applications au diagnostic in vitro, a la prevention et/ou la lutte contre des infections a papillomavirus
WO1987005630A1 (en) 1986-03-21 1987-09-24 Institut Pasteur Determined dna sequences derived from a papillomavirus genome, their uses for in vitro diagnostic purposes and the production of antigenic compositions
US4777239A (en) 1986-07-10 1988-10-11 The Board Of Trustees Of The Leland Stanford Junior University Diagnostic peptides of human papilloma virus
US5204061A (en) 1987-10-08 1993-04-20 Becton, Dickinson And Company Depositing a binder on a solid support
US5180806A (en) * 1988-05-16 1993-01-19 The Scripps Research Institute Polypeptides and compositions of human papillomavirus latent proteins, diagnostic systems and methods
EP1026253B2 (de) 1989-03-21 2012-12-19 Vical Incorporated Expression von exogenen Polynukleotidsequenzen in Wirbeltieren
US5814460A (en) * 1990-02-14 1998-09-29 Diatide, Inc. Method for generating and screening useful peptides
US5753233A (en) 1990-05-10 1998-05-19 Behring Diagnostics Gmbh Seroreactive epitopes on proteins of human papilloma-virus (HPV) 18
DE4015044A1 (de) * 1990-05-10 1991-11-14 Behringwerke Ag Seroreaktive epitope auf proteinen des menschlichen papillomavirus (hpv) 18
US5932412A (en) * 1990-05-11 1999-08-03 Euro-Diagnostica Ab Synthetic peptides in human papillomaviruses 1, 5, 6, 8, 11, 16, 18, 31, 33 and 56, useful in immunoassay for diagnostic purposes
US5604105B1 (en) 1990-10-12 1999-08-24 Spectral Diagnostics Inc Method and device for diagnosingand distinguishing chest pain in early onset thereof
FR2670797A1 (fr) * 1990-12-20 1992-06-26 Pasteur Institut Sequences d'adn determinees derivees du genome du papillomavirus hpv39, application de ces sequences au diagnostic in vitro d'infection par ce papillomavirus, et a la production de composition immunogene.
ATE234860T1 (de) * 1991-07-13 2003-04-15 Dade Behring Marburg Gmbh Verwendung von hpv-16 e6 und e7-gen gewonnen peptiden für den diagnostischen zweck
ATE156710T1 (de) 1992-06-25 1997-08-15 Smithkline Beecham Biolog Adjuvantien enthaltende impfstoffzusammensetzung
US5571680A (en) 1994-01-21 1996-11-05 Beckman Instruments, Inc. Homogeneous immunoassays and enzyme based assays of analytes using capillary electrophoresis
US6194388B1 (en) 1994-07-15 2001-02-27 The University Of Iowa Research Foundation Immunomodulatory oligonucleotides
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
US6352842B1 (en) 1995-12-07 2002-03-05 Diversa Corporation Exonucease-mediated gene assembly in directed evolution
WO1997024447A1 (en) 1996-01-02 1997-07-10 Chiron Corporation Immunostimulation mediated by gene-modified dendritic cells
US5643752A (en) 1996-01-18 1997-07-01 Incyte Pharmaceuticals, Inc. Tissue inhibitor of metalloproteinases
AU729231B2 (en) 1996-02-22 2001-01-25 Merck & Co., Inc. Synthetic HIV genes
JP2000516445A (ja) 1996-06-21 2000-12-12 メルク エンド カンパニー インコーポレーテッド 合成遺伝子を含むワクチン
AU743616B2 (en) 1997-02-07 2002-01-31 Merck & Co., Inc. Synthetic HIV gag genes
KR20010042573A (ko) 1998-04-09 2001-05-25 장 스테판느 애쥬번트 조성물
ES2257068T3 (es) 1998-08-10 2006-07-16 Antigenics Inc. Mezclas de adyuvantes de cpg y saponinas y metodos de empleo de las mismas.
WO2000035274A1 (en) * 1998-12-17 2000-06-22 The Johns Hopkins University School Of Medicine Olfactory receptor expression libraries and methods of making and using them
DE19901008A1 (de) * 1999-01-13 2000-07-20 Deutsches Krebsforsch Peptide zur Inhibierung von HPV E6-Proteinen
AU778603B2 (en) * 1999-01-25 2004-12-09 Yale University Novel odorant receptors in drosophila
JP2003525022A (ja) * 1999-02-25 2003-08-26 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク 昆虫の臭い物質受容体をコードする遺伝子およびその使用
EP2322210A1 (de) 1999-04-19 2011-05-18 GlaxoSmithKline Biologicals S.A. Adjuvans Zusammensetzung enthaltend Saponin und ein Immunstimulatorisches Oligonukleotid
US6242266B1 (en) 1999-04-30 2001-06-05 Agilent Technologies Inc. Preparation of biopolymer arrays
WO2003014303A2 (en) 2001-08-03 2003-02-20 Arbor Vita Corporation Molecular interactions in cells
WO2001005833A1 (en) * 1999-07-20 2001-01-25 The Regents Of The University Of California Odorant receptors
US6440696B1 (en) 1999-07-28 2002-08-27 New England Medical Center E6 targeted protein (E6TP1)
GB0017990D0 (en) 2000-07-21 2000-09-13 Glaxo Group Ltd Papilloma virus sequences
GB0018140D0 (en) * 2000-07-24 2000-09-13 Medical Res Council Screening for abnormalities
AU2001277986A1 (en) 2000-07-25 2002-02-05 Axcell Biosciences Corporation Identification and isolation of novel polypeptides having pdz domains and methods of using same
US6346416B1 (en) 2000-08-29 2002-02-12 Isis Pharmaceuticals, Inc. Antisense inhibition of HPK/GCK-like kinase expression
US8613907B2 (en) * 2000-10-12 2013-12-24 University Of Rochester Compositions that inhibit proliferation of cancer cells
US20040229298A1 (en) * 2000-11-11 2004-11-18 Lu Peter S. Methods and compositions for treating cervical cancer
US7312041B2 (en) * 2001-02-16 2007-12-25 Arbor Vita Corporation Methods of diagnosing cervical cancer
CA2441947C (en) * 2001-03-23 2014-05-13 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Human papilloma virus immunoreactive peptides
EP1243655B1 (de) 2001-03-23 2007-02-21 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Modifizierte HPV E6- und E7-Gene und -Proteine als Impfstoff
TWI229132B (en) * 2001-05-04 2005-03-11 King Car Food Ind Co Ltd Method and detector for identifying subtypes of human papilloma viruses
EP1427443A4 (de) 2001-08-23 2006-03-08 Merck & Co Inc Vakzine mit papilloma-virus-e-proteinen, die durch einen viralen vektor abgegeben werden
ATE418072T1 (de) 2002-09-09 2009-01-15 Arbor Vita Corp Verfahren zur diagnose von gebärmutterhalskrebs
WO2005063286A1 (en) * 2003-12-23 2005-07-14 Arbor Vita Corporation Antibodies for oncogenic strains of hpv and methods of their use
US20130017572A1 (en) 2009-04-30 2013-01-17 Lu Peter S Codon modified polynucleotide sequences for enhanced expression in a host system

Also Published As

Publication number Publication date
US20120164629A1 (en) 2012-06-28
CA2551560A1 (en) 2005-07-14
AU2004308964A1 (en) 2005-07-14
US20100209904A1 (en) 2010-08-19
EP1708745B1 (de) 2012-04-18
JP5030594B2 (ja) 2012-09-19
JP2007522108A (ja) 2007-08-09
EP1708745A4 (de) 2007-12-19
US9611315B2 (en) 2017-04-04
WO2005063286A1 (en) 2005-07-14
EP1708745A1 (de) 2006-10-11
US20090047660A1 (en) 2009-02-19
AU2004308964B2 (en) 2010-09-16
US20150093742A1 (en) 2015-04-02
US20050142541A1 (en) 2005-06-30
US7399467B2 (en) 2008-07-15

Similar Documents

Publication Publication Date Title
ATE554106T1 (de) Antikörper für onkogene stämme von hpv und verfahren zu deren verwendung
ATE230487T1 (de) Verfahren zur frühen diagnose von carcinomen
DE60041839D1 (de) Auto-Antikörper gegen Annexin-Proteine als Marker für Lungenkrebs
DE50204883D1 (de) Verfahren zum qualitativen und/oder quantitativen nachweis von zellen
CA2480466A1 (en) Detection and/or monitoring of synuclein-related diseases
BRPI0820885B8 (pt) "anticorpo ou fraguimento do mesmo, célula de hibridoma, polinucleotídeo, polipeptídeo compreendendoum domínio de cadeia pesada ou leve de anticorpo, método para detecção de gravidez em um animal bovino, kit e método de purificação de um antígeno principal associado à gravidez (pag)".
DE69939121D1 (de) Verfahren und materialien zum nachweis und zur messung von durch freie radikale verursachten schäden
ATE462803T1 (de) Kit und verfahren zum nachweis von urothelkarzinom
ATE535546T1 (de) Humane monoklonale antikörper, die spezifisch an ifg-ii binden
DE60315715D1 (de) Verwendung von nicotinamide n-methyltransferase zur diagnose von kolorektalem krebs
DE60325382D1 (de) Verfahren zur diagnose von gebärmutterhalskrebs
ATE529533T1 (de) Verfahren zum nachweis von analyten in einer probe
DE60129239D1 (de) Kit und verfahren zur bestimmung von protein esm-1
WO2005019831B1 (en) Methods for reducing complexity of a sample using small epitope antibodies
ATE397215T1 (de) Entstörung von immunoassays durch substanzen, die aus den framework-regionen von antikörpern abgeleitet sind
ATE288589T1 (de) Verfahren zur analyse von proteinen
ATE433463T1 (de) Monospezifische antikörper gegen fibrinogen und fibrinopeptide b
ATE383418T1 (de) Verfahren und zusammensetzungen zur bestimmung glycierter proteine
DE602004017317D1 (de) Verwendung der proteine proteinase 3 (prn3) und leukozyten elastatse inhibitor (ileu) als marker für kolorektale karzinome
BRPI0416270A (pt) método para detectar um analito em uma amostra, e, método e kit para detectar um anticorpo especìfico de uma amostra
ATE408832T1 (de) Verfahren zum nachweis von blutzell-antigenen und gegen diese gerichtete antikörper
DE602005015627D1 (de) Verfahren zur messung von proinsulin und c-peptid sowie kit dafür
DE60228952D1 (de) Nachweis von Legionella durch ein PCR und FRET verwendendes Verfahren
ATE534037T1 (de) Verwendung des proteins asc als marker für brustkrebs
ATE532796T1 (de) Immunassays zur spezifischen bestimmung von scca- isoformen