ATE414701T1 - Fluoreszenzsonden zur verwendung bei einem bindungsassay auf proteinkinaseinhibitoren - Google Patents
Fluoreszenzsonden zur verwendung bei einem bindungsassay auf proteinkinaseinhibitorenInfo
- Publication number
- ATE414701T1 ATE414701T1 AT04789404T AT04789404T ATE414701T1 AT E414701 T1 ATE414701 T1 AT E414701T1 AT 04789404 T AT04789404 T AT 04789404T AT 04789404 T AT04789404 T AT 04789404T AT E414701 T1 ATE414701 T1 AT E414701T1
- Authority
- AT
- Austria
- Prior art keywords
- protein kinase
- kinase inhibitor
- binding assay
- fluorescence probe
- inhibitor binding
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 238000000159 protein binding assay Methods 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 abstract 3
- 239000000523 sample Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 231100000673 dose–response relationship Toxicity 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000007423 screening assay Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B11/00—Diaryl- or thriarylmethane dyes
- C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
- C09B11/10—Amino derivatives of triarylmethanes
- C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B55/00—Azomethine dyes
- C09B55/002—Monoazomethine dyes
- C09B55/003—Monoazomethine dyes with the -C=N- group attached to an heteroring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50853903P | 2003-10-03 | 2003-10-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE414701T1 true ATE414701T1 (de) | 2008-12-15 |
Family
ID=34421754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04789404T ATE414701T1 (de) | 2003-10-03 | 2004-09-30 | Fluoreszenzsonden zur verwendung bei einem bindungsassay auf proteinkinaseinhibitoren |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7125996B2 (de) |
| EP (1) | EP1670789B1 (de) |
| JP (1) | JP4949845B2 (de) |
| AT (1) | ATE414701T1 (de) |
| CA (1) | CA2541059C (de) |
| DE (1) | DE602004017884D1 (de) |
| ES (1) | ES2315713T3 (de) |
| WO (1) | WO2005033330A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003082280A1 (en) * | 2002-03-26 | 2003-10-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| ES2349164T3 (es) * | 2002-08-29 | 2010-12-28 | Boehringer Ingelheim Pharmaceuticals Inc. | Derivados de 3-(sulfonamidoetil)-indol para uso como compuestos miméticos de glucocorticoides en el tratamiento de enfermedades inflamatorias, alérgicas y proliferativas. |
| UY28526A1 (es) * | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
| US7795272B2 (en) * | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
| CA2592514A1 (en) * | 2004-12-27 | 2006-07-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| WO2007057397A1 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer |
| EE200600030A (et) * | 2006-08-15 | 2008-04-15 | Tartu �likool | Proteiinkinaasi fluorestsents-sond |
| KR20090097908A (ko) * | 2006-12-06 | 2009-09-16 | 베링거 인겔하임 인터내셔날 게엠베하 | 글루코코르티코이드 모사물, 이의 제조 방법, 이의 약제학적 조성물 및 용도 |
| US20100311072A1 (en) * | 2008-01-28 | 2010-12-09 | Bristol-Myers Squibb Company | Fluorescence polarization binding assay for characterizing glucokinase ligands |
| CN102112476A (zh) * | 2008-06-06 | 2011-06-29 | 贝林格尔.英格海姆国际有限公司 | 糖皮质激素模拟物、其制备方法、药物组合物及其用途 |
| EP2445969B1 (de) | 2009-06-26 | 2014-08-27 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Neue fluorierte rhodamine als photostabile fluoreszensfarbstoffe für markierungsverfahren und zur bildgebung |
| EP2482072B1 (de) | 2011-01-26 | 2016-07-06 | University of Tartu | Photolumineszierenden sonde |
| EP2700946A1 (de) | 2012-08-24 | 2014-02-26 | University of Tartu | Bisubstratfluoreszente Sonden für Proteinkinase CK2 |
| CN114292281B (zh) * | 2021-12-22 | 2023-10-24 | 东南大学 | 一种用于实现细胞内脂滴动态成像的小分子荧光探针及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06172312A (ja) * | 1992-03-04 | 1994-06-21 | Wako Pure Chem Ind Ltd | １級アミノ基を有する化合物の蛍光標識化方法 |
| JP3851706B2 (ja) * | 1996-05-20 | 2006-11-29 | 日清紡績株式会社 | 蛍光性基含有カルボジイミド化合物 |
| US6169106B1 (en) | 1998-04-15 | 2001-01-02 | Boehringer Ingelheim Pharma Kg | Indolinones having kinase inhibitory activity |
| DE19816624A1 (de) * | 1998-04-15 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| PL346898A1 (en) * | 1998-09-25 | 2002-03-11 | Boehringer Ingelheim Pharma | Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes |
| AU2002322775A1 (en) | 2001-07-27 | 2003-02-17 | The Regents Of The University Of California | Stk15 (stk6) gene polymorphism and methods of determining cancer risk |
| GB0124299D0 (en) | 2001-10-10 | 2001-11-28 | Astrazeneca Ab | Crystal structure of enzyme and uses thereof |
| PT1438053E (pt) * | 2001-10-17 | 2008-09-25 | Boehringer Ingelheim Int | Derivados de pirimidina, medicamento contendo estes compostos, sua utilização e processo para a sua preparação |
| ATE440087T1 (de) * | 2003-01-30 | 2009-09-15 | Boehringer Ingelheim Pharma | 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen |
-
2004
- 2004-09-30 JP JP2006534117A patent/JP4949845B2/ja not_active Expired - Lifetime
- 2004-09-30 CA CA2541059A patent/CA2541059C/en not_active Expired - Lifetime
- 2004-09-30 WO PCT/US2004/032253 patent/WO2005033330A2/en not_active Ceased
- 2004-09-30 DE DE602004017884T patent/DE602004017884D1/de not_active Expired - Lifetime
- 2004-09-30 AT AT04789404T patent/ATE414701T1/de active
- 2004-09-30 US US10/955,129 patent/US7125996B2/en not_active Expired - Lifetime
- 2004-09-30 ES ES04789404T patent/ES2315713T3/es not_active Expired - Lifetime
- 2004-09-30 EP EP04789404A patent/EP1670789B1/de not_active Expired - Lifetime
-
2006
- 2006-07-25 US US11/492,654 patent/US7588899B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7125996B2 (en) | 2006-10-24 |
| US20060263841A1 (en) | 2006-11-23 |
| EP1670789A2 (de) | 2006-06-21 |
| EP1670789B1 (de) | 2008-11-19 |
| ES2315713T3 (es) | 2009-04-01 |
| US7588899B2 (en) | 2009-09-15 |
| JP4949845B2 (ja) | 2012-06-13 |
| DE602004017884D1 (de) | 2009-01-02 |
| CA2541059C (en) | 2013-09-17 |
| JP2007509845A (ja) | 2007-04-19 |
| CA2541059A1 (en) | 2005-04-14 |
| WO2005033330A3 (en) | 2005-07-28 |
| WO2005033330A2 (en) | 2005-04-14 |
| US20050100978A1 (en) | 2005-05-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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