EE200600030A - Proteiinkinaasi fluorestsents-sond - Google Patents

Proteiinkinaasi fluorestsents-sond

Info

Publication number
EE200600030A
EE200600030A EEP200600030A EEP200600030A EE200600030A EE 200600030 A EE200600030 A EE 200600030A EE P200600030 A EEP200600030 A EE P200600030A EE P200600030 A EEP200600030 A EE P200600030A EE 200600030 A EE200600030 A EE 200600030A
Authority
EE
Estonia
Prior art keywords
protein kinase
fluorescence probe
kinase fluorescence
probe
protein
Prior art date
Application number
EEP200600030A
Other languages
English (en)
Inventor
Uri Asko
Enkvist Erki
Viil Indrek
Lav?gina Darja
Raidaru Gerda-Johanna
Viht Kaido
Original Assignee
Tartu �likool
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tartu �likool filed Critical Tartu �likool
Priority to EEP200600030A priority Critical patent/EE200600030A/et
Priority to JP2009524078A priority patent/JP2010500580A/ja
Priority to PCT/EE2007/000015 priority patent/WO2008019696A2/en
Priority to US12/377,839 priority patent/US8158376B2/en
Priority to EP07785783A priority patent/EP2057279A2/en
Publication of EE200600030A publication Critical patent/EE200600030A/et

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052Small organic molecules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/005Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056Peptides, proteins, polyamino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
EEP200600030A 2006-08-15 2006-08-15 Proteiinkinaasi fluorestsents-sond EE200600030A (et)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EEP200600030A EE200600030A (et) 2006-08-15 2006-08-15 Proteiinkinaasi fluorestsents-sond
JP2009524078A JP2010500580A (ja) 2006-08-15 2007-08-14 タンパク質キナーゼに結合する二基質蛍光プローブ
PCT/EE2007/000015 WO2008019696A2 (en) 2006-08-15 2007-08-14 Bisubstrate fluorescent probe binding to protein kinases
US12/377,839 US8158376B2 (en) 2006-08-15 2007-08-14 Bisubstrate fluorescent probe binding to protein kinases
EP07785783A EP2057279A2 (en) 2006-08-15 2007-08-14 Bisubstrate fluorescent probe binding to protein kinases

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EEP200600030A EE200600030A (et) 2006-08-15 2006-08-15 Proteiinkinaasi fluorestsents-sond

Publications (1)

Publication Number Publication Date
EE200600030A true EE200600030A (et) 2008-04-15

Family

ID=38669476

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200600030A EE200600030A (et) 2006-08-15 2006-08-15 Proteiinkinaasi fluorestsents-sond

Country Status (5)

Country Link
US (1) US8158376B2 (et)
EP (1) EP2057279A2 (et)
JP (1) JP2010500580A (et)
EE (1) EE200600030A (et)
WO (1) WO2008019696A2 (et)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2869953T3 (es) 2010-02-09 2021-10-26 Medinol Ltd Punta de catéter ensamblada con un resorte
EP2482072B1 (en) 2011-01-26 2016-07-06 University of Tartu A photoluminescent probe
DE102011106984B3 (de) * 2011-07-08 2012-10-11 Sartorius Stedim Biotech Gmbh Microarray-Vorrichtung für das Screenen oder Auffinden von HSP90 Inhibitoren und von Inhibitoren weiterer krankheitsrelevanter Zielstrukturen
EP2700946A1 (en) 2012-08-24 2014-02-26 University of Tartu Bisubstrate fluorescent probes for protein kinase CK2
GB201307155D0 (en) * 2013-04-19 2013-05-29 Univ Tartu Kinase inhibitors
US9789283B2 (en) 2014-02-03 2017-10-17 Medinol Ltd. Catheter tip assembled with a spring
GB201420222D0 (en) 2014-11-13 2014-12-31 Univ Edinburgh Molecular probes and methods using the same
GB201420221D0 (en) * 2014-11-13 2014-12-31 Univ Edinburgh Molecular probes and methods using the same
JP7456621B2 (ja) * 2018-08-07 2024-03-27 慶應義塾 神経機能調節物質の動態の検出剤、及び神経機能調節物質の検出方法
CN117030672B (zh) * 2023-08-11 2024-04-19 中国药科大学 一种用于检测复杂体系中凝血因子FXIa抑制剂活性的荧光探针及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9901807D0 (sv) 1999-05-17 1999-05-17 Asko Uri Method for the removal of an enzyme from a liquid
IL144583A0 (en) * 2001-07-26 2002-05-23 Peptor Ltd Chimeric protein kinase inhibitors
CA2514877A1 (en) * 2003-01-30 2004-08-12 Bellbrook Labs, Llc Assay method for group transfer reactions
IL156429A0 (en) * 2003-06-12 2004-01-04 Peptor Ltd Cell permeable conjugates of peptides for inhibition of protein kinases
ATE414701T1 (de) * 2003-10-03 2008-12-15 Boehringer Ingelheim Pharma Fluoreszenzsonden zur verwendung bei einem bindungsassay auf proteinkinaseinhibitoren

Also Published As

Publication number Publication date
US20100233743A1 (en) 2010-09-16
US8158376B2 (en) 2012-04-17
WO2008019696A3 (en) 2008-04-03
JP2010500580A (ja) 2010-01-07
EP2057279A2 (en) 2009-05-13
WO2008019696A2 (en) 2008-02-21

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Legal Events

Date Code Title Description
HC1A Change of owner name