ES2193133T3 - Uso de peptidos derivados de los genes e6 y e7 de hpv-16 para fines. - Google Patents

Uso de peptidos derivados de los genes e6 y e7 de hpv-16 para fines.

Info

Publication number
ES2193133T3
ES2193133T3 ES92110367T ES92110367T ES2193133T3 ES 2193133 T3 ES2193133 T3 ES 2193133T3 ES 92110367 T ES92110367 T ES 92110367T ES 92110367 T ES92110367 T ES 92110367T ES 2193133 T3 ES2193133 T3 ES 2193133T3
Authority
ES
Spain
Prior art keywords
hpv
genes
purposes
peptides derived
fot
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92110367T
Other languages
English (en)
Inventor
Martin Muller
Lutz Gissmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Dade Behring Marburg GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Marburg GmbH filed Critical Dade Behring Marburg GmbH
Application granted granted Critical
Publication of ES2193133T3 publication Critical patent/ES2193133T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LA PRESENTE INVENCION ESTA RELACIONADA CON EL USO DE LOS PEPTIDOS DERIVADOS DEL GEN HUMANO PAILLOMAVIRUS 16 (HPV-16) E7 PARA LA IDENTIFICACION DIAGNOSTICA DEL CANCER CERVICAL INVASIVO ASOCIADO AL HPV-16.
ES92110367T 1991-07-13 1992-06-19 Uso de peptidos derivados de los genes e6 y e7 de hpv-16 para fines. Expired - Lifetime ES2193133T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91111720 1991-07-13

Publications (1)

Publication Number Publication Date
ES2193133T3 true ES2193133T3 (es) 2003-11-01

Family

ID=8206929

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92110367T Expired - Lifetime ES2193133T3 (es) 1991-07-13 1992-06-19 Uso de peptidos derivados de los genes e6 y e7 de hpv-16 para fines.

Country Status (10)

Country Link
US (1) US5629161A (es)
EP (1) EP0523391B1 (es)
JP (1) JP3366350B2 (es)
AT (1) ATE234860T1 (es)
AU (1) AU667470B2 (es)
CA (1) CA2073616C (es)
DE (1) DE69232963T2 (es)
DK (1) DK0523391T3 (es)
ES (1) ES2193133T3 (es)
PT (1) PT523391E (es)

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* Cited by examiner, † Cited by third party
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CA2097916C (en) * 1990-12-12 2001-08-21 Robert Tindle Subunit papillomavirus vaccine and peptides for use therein
US5736318A (en) * 1995-03-17 1998-04-07 President And Fellows Of Harvard College Method and kit for evaluating human papillomavirus transformed cells
DE19925235A1 (de) 1999-06-01 2000-12-07 Medigene Ag Zytotoxische T-Zellepitope des Papillomavirus L1-Proteins und ihre Verwendung in Diagnostik und Therapie
DE19925199A1 (de) 1999-06-01 2000-12-07 Medigene Ag Zytotoxische T-Zellepitope des Papillomavirus L1-Proteins und ihre Verwendung in Diagnostik und Therapie
FR2794370B1 (fr) 1999-06-03 2003-10-17 Biovector Therapeutics Fragments proteiques polyepitopiques, leur obtention et leurs utilisations notamment en vaccination
US6641994B2 (en) 1999-08-25 2003-11-04 Pharmacia & Upjohn Company Methods of identifying anti-viral agents
US6200746B1 (en) 1999-08-25 2001-03-13 Pharmacia & Upjohn Company Methods of identifying anti-viral agents
JP2003509035A (ja) * 1999-09-16 2003-03-11 ザイコス インク． ポリエピトープポリペプチドをコードする核酸
US20050100928A1 (en) * 1999-09-16 2005-05-12 Zycos Inc., A Delaware Corporation Nucleic acids encoding polyepitope polypeptides
FR2794371B1 (fr) * 1999-10-07 2004-06-18 Biovector Therapeutics Fragments proteiquespolyepitopiques, leur obtention et leurs utilisations notamment en vaccination
US8128922B2 (en) * 1999-10-20 2012-03-06 Johns Hopkins University Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen
CN1433428A (zh) * 2000-04-05 2003-07-30 冲击诊断公司 辨别人乳头瘤病毒的免疫学方法
AU2001290520A1 (en) * 2000-08-01 2002-02-13 The Johns Hokpins University Intercellular transport protein linked to an antigen as a molecular vaccine
ES2454640T3 (es) * 2000-08-03 2014-04-11 Johns Hopkins University Vacuna molecular que lleva unida un polipéptido de chaperona del retículo endoplasmático a un antígeno
US7312041B2 (en) 2001-02-16 2007-12-25 Arbor Vita Corporation Methods of diagnosing cervical cancer
US6933123B2 (en) * 2001-04-05 2005-08-23 Yao Xiong Hu Peptides from the E2, E6, and E7 proteins of human papilloma viruses 16 and 18 for detecting and/or diagnosing cervical and other human papillomavirus associated cancers
FR2824326B1 (fr) * 2001-05-04 2004-03-19 Commissariat Energie Atomique Melange de peptides issus des proteines e6 et/ou e7 de papillomavirus et leurs applications
US20060147906A1 (en) * 2002-03-22 2006-07-06 Amynon Biotech Gmbh Anti-hpv-16 e7 antibodies and their use
EP1537415B1 (en) * 2002-09-09 2008-12-17 Arbor Vita Corporation Methods of diagnosing cervical cancer
EP1644048B1 (en) * 2003-05-05 2015-04-29 Johns Hopkins University Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein
LT5228B (lt) 2003-07-16 2005-06-27 Uždaroji akcinė bendrovė Melofarma Gimdos kaklelio displazijų ir vėžio, susijusių su žmogaus papilomos virusais ankstyvos diagnostikos in vitro būdas
AU2004308964B2 (en) * 2003-12-23 2010-09-16 Arbor Vita Corporation Antibodies for oncogenic strains of HPV and methods of their use
CA2594040A1 (en) * 2005-01-06 2006-07-13 The Johns Hopkins University Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines
EP1846026A4 (en) * 2005-01-26 2008-07-02 Univ Johns Hopkins ANTICANCER DNA VACCINE USING PLASMID CODING ANTIGEN AND CALRETICULIN SUCH AS MUTANT ONCOPROTEINS
US7732166B2 (en) * 2005-11-15 2010-06-08 Oncohealth Corporation Detection method for human pappilomavirus (HPV) and its application in cervical cancer
US7972776B2 (en) * 2005-11-15 2011-07-05 Oncohealth Corporation Protein chips for HPV detection
US20100330105A1 (en) * 2006-08-22 2010-12-30 John Hopkins University Anticancer Combination Therapies
WO2010129821A1 (en) 2009-05-07 2010-11-11 Oncohealth Corporation Identification of high grade or ≥cin2 for early stages and late stages detection, screening, and diagnosis of human papillomavirus (hpv) and hpv-associated cancers
US8968995B2 (en) * 2008-11-12 2015-03-03 Oncohealth Corp. Detection, screening, and diagnosis of HPV-associated cancers
US20100003704A1 (en) * 2008-06-13 2010-01-07 Shuling Cheng IN SITU detection of early stages and late stages HPV infection
US9085638B2 (en) 2007-03-07 2015-07-21 The Johns Hopkins University DNA vaccine enhancement with MHC class II activators
US20080260765A1 (en) * 2007-03-15 2008-10-23 Johns Hopkins University HPV DNA Vaccines and Methods of Use Thereof
WO2008124091A2 (en) * 2007-04-05 2008-10-16 Genera Biosystems Limited Compositions and methods of detection
AU2015213420B2 (en) * 2007-05-31 2017-02-16 Isa Pharmaceuticals B.V. HPV epitopes targeted by T cells infiltrating cervical malignancies for use in vaccines
ES2496916T3 (es) 2007-05-31 2014-09-22 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Epítopo de HPV al que se dirigen células T que infiltran tumores malignos cervicales para su uso en vacunas
US20090285861A1 (en) * 2008-04-17 2009-11-19 Tzyy-Choou Wu Tumor cell-based cancer immunotherapeutic compositions and methods
WO2011084598A1 (en) 2010-01-08 2011-07-14 Oncohealth Corporation High throughput cell-based hpv immunoassays for diagnosis and screening of hpv-associated cancers
CN104004067B (zh) * 2013-02-22 2017-09-01 艾托金生物医药（苏州）有限公司 用于检测抗人乳头瘤病毒抗体的抗原及相关免疫检测试剂盒
CN109053879B (zh) * 2018-08-22 2020-12-25 深圳市宝安区中心医院 一种治疗宫颈癌的scFv抗体及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4777239A (en) * 1986-07-10 1988-10-11 The Board Of Trustees Of The Leland Stanford Junior University Diagnostic peptides of human papilloma virus
US5180806A (en) * 1988-05-16 1993-01-19 The Scripps Research Institute Polypeptides and compositions of human papillomavirus latent proteins, diagnostic systems and methods
FR2641081A1 (es) * 1988-12-23 1990-06-29 Medgenix Group
DE3907721A1 (de) * 1989-03-10 1990-09-20 Behringwerke Ag Immunogene regionen auf dem e7-protein des humanen papillomvierus typ 16
US5045447A (en) * 1989-03-15 1991-09-03 Minson Anthony C Method of producing antibodies to HPV
PT97073A (pt) * 1990-03-20 1991-10-31 Behringwerke Ag Processo para a preparacao de epitopos soro-reactivos de proteinas de papillomavirus 16 humano (hpv)
SE9001705D0 (sv) * 1990-05-11 1990-05-11 Medscand Ab Saett foer diagnostik av virusbaerande tumoerer genom immunoassay
WO1992005248A1 (en) * 1990-09-26 1992-04-02 Bristol-Myers Squibb Company Human papilloma viral protein expression for use in vaccine compositions

Also Published As

Publication number Publication date
JPH06169781A (ja) 1994-06-21
PT523391E (pt) 2003-08-29
DE69232963D1 (de) 2003-04-24
EP0523391A1 (en) 1993-01-20
JP3366350B2 (ja) 2003-01-14
EP0523391B1 (en) 2003-03-19
CA2073616C (en) 2003-11-04
DK0523391T3 (da) 2003-06-23
DE69232963T2 (de) 2004-03-04
AU667470B2 (en) 1996-03-28
AU1959092A (en) 1993-01-14
ATE234860T1 (de) 2003-04-15
US5629161A (en) 1997-05-13
CA2073616A1 (en) 1993-01-14

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