ES2496916T3 - Epítopo de HPV al que se dirigen células T que infiltran tumores malignos cervicales para su uso en vacunas - Google Patents

Epítopo de HPV al que se dirigen células T que infiltran tumores malignos cervicales para su uso en vacunas Download PDF

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ES2496916T3
ES2496916T3 ES12160109.0T ES12160109T ES2496916T3 ES 2496916 T3 ES2496916 T3 ES 2496916T3 ES 12160109 T ES12160109 T ES 12160109T ES 2496916 T3 ES2496916 T3 ES 2496916T3
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hpv
epitope
til
cells
infiltrate
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Sjoerd Henricus Van Der Burg
Gemma G. Kenter
Cornelis Johannes Maria Melief
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Leiden University Medical Center
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Uso de un péptido para la fabricación de un medicamento para el tratamiento de pacientes que sufren o están en riesgo de desarrollar una enfermedad relacionada con el HPV, donde el péptido tiene una longitud que no supera los 100 aminoácidos y comprende al menos 22 aminoácidos contiguos de la secuencia de aminoácidos de una proteína E6 del HPV, donde la secuencia de aminoácidos contigua comprende un epítopo que es presentado por al menos una de una molécula de HLA-DQ y HLADP y donde el epítopo es SEC ID nº: 12, donde la enfermedad relacionada con el HPV se selecciona del grupo que consiste en: neoplasia intraepitelial cervical del cérvix (CIN), vulva (VIN), vagina (VaIN), ano (AIN) y pene (PIN) y cáncer del cérvix, vulva, vagina, ano, pene y cabeza y cuello.

Description

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E12160109
27-08-2014
287 61 carcinosarcom FIGO 2B a 289 45 adeno FIGO 1B 292 32 escamosa FIGO 1B 324 51 escamosa FIGO 1B 353 35 adeno FIGO 1A 373 55 escamosa FIGO 1B 377 85 escamosa FIGO 1B 381 80 adeno FIGO 1B 384 75 escamosa FIGO 1B 414 64 escamosa FIGO 2A CIL 348 35 escamosa CIN3 354 39 escamosa CIN3 LN 426 40 escamosa FIGO 1B
* SI= Índice de estiulación de células T respondedoras
Tabla 2: epítopos de células T reconocidos por pacientes con cáncer cervical Epítopo de tipo de célula T ha reconocido SEC ID de paciente de origen de restricción
Tipo de célula T
Epítopo reconocido Restricción Origen Paciente SEC ID
CD4
HPV16E6.11-32 DP17 LN C148 5
HPV16E6.11-32
DP1401 LN C271,C427 5
HPV16E6.37-68
DP0201 TIL C226 6
HPV16E6.52-61
DP0201 TIL C265 7
HPV16E6.55-86
desconocida LN, TIL C267 8
HPV16E6.61-82
DP1 o DP14 LN C427 9
HPV16E6.73-105
DP4 LN C148 10
HPV16E6 73-105
desconocida LN,TIL C267 10
HPV16E6.91-112
DR15 or DQ5 TIL C331 11
HPV16E6.91-112
desconocida LN C267 11
HPV16E6.101-122
DQ6 LN,TIL C427,C446 12
HPV16E6.121-142
DP0201 o DQ5 TIL C265 13
HPV16E6.121-142
desconocida TIL C187 13
HPV16E6.129-138
DR7 TIL C176 14
HPV16E7.21-42
DR4 TIL C178 15
HPV16E7.51-72
DP1901 CIL C356 16
HPV16E7.76-86
DR12 CIL C284 17
HPV18E6.51-72
DQ*0301 LN C151 18
HPV18E6.71-92
DQ*0501 LN C151 19
HPV18E7.1-32
DQ*0302, DQ*0308 TIL C214 20
HPV18E7.1-32
desconocida TIL C378 20
HPV18E7.21-42
DQ*0302 TIL C228 21
CD8
HPV16E6.13-22 HLA-B7 TIL C446 22
HPV16E6.29-38
HLA-A2 LN C427 23
26

Claims (1)

  1. imagen1
ES12160109.0T 2007-05-31 2008-05-27 Epítopo de HPV al que se dirigen células T que infiltran tumores malignos cervicales para su uso en vacunas Active ES2496916T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US94107007P 2007-05-31 2007-05-31
EP07109287 2007-05-31
US941070P 2007-05-31
EP07109281 2007-05-31
EP07109287 2007-05-31
EP07109281 2007-05-31

Publications (1)

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ES2496916T3 true ES2496916T3 (es) 2014-09-22

Family

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ES12160109.0T Active ES2496916T3 (es) 2007-05-31 2008-05-27 Epítopo de HPV al que se dirigen células T que infiltran tumores malignos cervicales para su uso en vacunas
ES08753802T Active ES2411059T3 (es) 2007-05-31 2008-05-27 Epítopos de HPV objetivos de células T que infiltran malignidades cervicales para su uso en vacunas

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US (6) US20100189742A1 (es)
EP (4) EP2468763B1 (es)
JP (3) JP6035503B2 (es)
CN (3) CN105031610B (es)
AU (1) AU2008257792B2 (es)
CA (3) CA3167595A1 (es)
ES (2) ES2496916T3 (es)
WO (1) WO2008147187A1 (es)

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