SG11201902988UA - Novel hpv16 non hla-restricted t-cell vaccines, compositions and methods of use thereof - Google Patents
Novel hpv16 non hla-restricted t-cell vaccines, compositions and methods of use thereofInfo
- Publication number
- SG11201902988UA SG11201902988UA SG11201902988UA SG11201902988UA SG11201902988UA SG 11201902988U A SG11201902988U A SG 11201902988UA SG 11201902988U A SG11201902988U A SG 11201902988UA SG 11201902988U A SG11201902988U A SG 11201902988UA SG 11201902988U A SG11201902988U A SG 11201902988UA
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- SG
- Singapore
- Prior art keywords
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- novel
- pct
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20071—Demonstrated in vivo effect
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
International Patent Classification: A61K 38/00 (2006.01) C07K 14/00 (2006.01) A61K 39/12 (2006.01) A61K 9/127 (2006.01) A61K 39/00 (2006.01) (21) International Application Number: (22) International Filing Date: PCT/US2017/055119 1218k9 OStim # # I _r_71111M 11 s-7 ,• (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 April 2018 (12.04.2018) WIPO I PCT ill~~~~~~~~ 011101010VIIIOH olo omoiloo Em Eno iflo oimIE (10) International Publication Number WO 2018/067689 Al 04 October 2017 (04.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/404,458 05 October 2016 (05.10.2016) US (71) Applicant: PDS BIOTECHNOLOGY CORPO- RATION [US/US]; 675 US Highway 1, North Brunswick, NJ 08902 (US). (72) Inventors: BEDU-ADDO, Frank; 24 Tamar Lane, Stam- ford, CT 06905 (US). CONN, Greg; Orense 17, Esc. Dcha. 4 Dcha., 28020 Madrid (ES). WARD, Martin; 4513 Dothan Drive, Lexington, KY 40515 (US). WOOD- WARD, Jerold; 611 Ballard Street, Lexington, KY 40508 (US). (74) Agent: KULKARNI, Sima, Singadia; DLA Piper LLP (US), 1650 Market Street, Suite 4900, Philadelphia, PA 19103 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: NOVEL HPV16 NON HLA-RESTRICTED T-CELL VACCINES, COMPOSITIONS AND METHODS OF USE THERE- OF FIGURE 1 2 3 5 7 9 2 3 5 79 2 3 5 7 9 2 3 5 7'9 2 5 7 2 3 5 7 9 C Subject 2-1 2-2 2-3 5-1 5-2 5-1 00 N O (57) : Novel human papillomovirus immunogenic compositions and methods of use thereof are provided. The compositions comprise unique combinations of multi-epitope peptide sequences specifically selected and designed to be effectively processed and 0 cross-presented to T-cells. The peptides utilized in the compositions display high levels of binding with HLA-supertypes. The immuno- \" genic compositions are broadly applicable to large proportions of target populations. The compositions comprise adjuvants such as C cationic lipids. [Continued on next page] fT X Ci) 800.00 700.00 600.00 500.00 400.00 300.00 200.00 100.00 1-1 13.00 Visit WO 2018/067689 Al MIDE111111111101111111111111111111111111111111 11111 11111 H11111110 111110111111111111 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662404458P | 2016-10-05 | 2016-10-05 | |
PCT/US2017/055119 WO2018067689A1 (en) | 2016-10-05 | 2017-10-04 | Novel hpv16 non hla-restricted t-cell vaccines, compositions and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201902988UA true SG11201902988UA (en) | 2019-05-30 |
Family
ID=61757761
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201902988UA SG11201902988UA (en) | 2016-10-05 | 2017-10-04 | Novel hpv16 non hla-restricted t-cell vaccines, compositions and methods of use thereof |
Country Status (12)
Country | Link |
---|---|
US (2) | US11401306B2 (en) |
EP (1) | EP3522908A4 (en) |
JP (3) | JP7165652B2 (en) |
KR (1) | KR20190073416A (en) |
CN (1) | CN110035765B (en) |
AU (2) | AU2017340407A1 (en) |
BR (1) | BR112019006831A2 (en) |
CA (1) | CA3039211A1 (en) |
IL (1) | IL265833A (en) |
MX (1) | MX2019003961A (en) |
SG (1) | SG11201902988UA (en) |
WO (1) | WO2018067689A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
ES2712505T3 (en) | 2008-04-17 | 2019-05-13 | Pds Biotechnology Corp | Stimulation of an immune response by enantiomers of cationic lipids |
JP2015530413A (en) | 2012-09-21 | 2015-10-15 | ベデュ−アッド,フランク | Improved vaccine compositions and methods of use |
WO2017083820A1 (en) | 2015-11-13 | 2017-05-18 | Pds Biotechnology Corporation | Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
JP2021505606A (en) * | 2017-12-05 | 2021-02-18 | ピーディーエス バイオテクノロジー コーポレイションPds Biotechnology Corporation | A method for stimulating the type I interferon gene and a composition containing a cationic lipid. |
AU2020204779A1 (en) * | 2019-01-03 | 2021-08-26 | Evaxion Biotech A/S | Vaccines targeting neoepitopes |
CN112110995A (en) * | 2019-06-19 | 2020-12-22 | 上海交通大学医学院 | Tumor neoantigen polypeptide and application thereof |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9266930B1 (en) * | 1993-03-05 | 2016-02-23 | Epimmune Inc. | Inducing cellular immune responses to Plasmodium falciparum using peptide and nucleic acid compositions |
EP2100620A1 (en) * | 1999-09-16 | 2009-09-16 | Eisai Corporation of North America | Nucleic acids encoding polyepitope polypeptides |
FR2824326B1 (en) * | 2001-05-04 | 2004-03-19 | Commissariat Energie Atomique | MIXTURE OF PEPTIDES FROM PAPILLOMAVIRUS E6 AND / OR E7 PROTEINS AND THEIR APPLICATIONS |
DE60238864D1 (en) * | 2001-11-07 | 2011-02-17 | Mankind Corp | FOR EPITOPES OF ANTIGENIC ENCODING EXPRESSION VECTORS AND METHOD FOR THEIR DESIGN |
GB0716992D0 (en) | 2007-08-31 | 2007-10-10 | Immune Targeting Systems Its L | Influenza antigen delivery vectors and constructs |
GB0417430D0 (en) * | 2004-08-05 | 2004-09-08 | Uc3 | A novel HPV vaccine comprising peptides from host cell proteins |
WO2007121895A2 (en) | 2006-04-21 | 2007-11-01 | Transgene S.A. | Hpv-16-based papillomavirus vaccine |
EP2757109B1 (en) * | 2007-05-31 | 2019-07-10 | Academisch Ziekenhuis Leiden h.o.d.n. LUMC | Hpv epitopes targeted by t cells infiltrating cervical malignancies for use in vaccines |
WO2010132867A1 (en) * | 2009-05-15 | 2010-11-18 | Irx Therapeutics, Inc. | Vaccine immunotherapy |
TWI673062B (en) * | 2011-09-12 | 2019-10-01 | 美商Pds生技公司 | Particulate vaccine formulations |
EP2639299A1 (en) * | 2012-03-16 | 2013-09-18 | Invectys | Universal cancer peptides derived from telomerase |
JP6348489B2 (en) | 2012-06-15 | 2018-07-04 | ピーディーエス バイオテクノロジー コーポレイションPds Biotechnology Corporation | Cationic lipid vaccine composition and methods of use |
JP2015530413A (en) * | 2012-09-21 | 2015-10-15 | ベデュ−アッド,フランク | Improved vaccine compositions and methods of use |
JP6788500B2 (en) * | 2013-10-23 | 2020-11-25 | アメリカ合衆国 | HLA-A24 Agonist Epitope and Composition of MUC1-C Cancer Protein and Method of Use |
WO2016146618A1 (en) * | 2015-03-16 | 2016-09-22 | Max-Delbrück-Centrum für Molekulare Medizin | Method of detecting new immunogenic t cell epitopes and isolating new antigen-specific t cell receptors by means of an mhc cell library |
-
2017
- 2017-10-04 EP EP17859111.1A patent/EP3522908A4/en active Pending
- 2017-10-04 JP JP2019518245A patent/JP7165652B2/en active Active
- 2017-10-04 SG SG11201902988UA patent/SG11201902988UA/en unknown
- 2017-10-04 US US15/724,818 patent/US11401306B2/en active Active
- 2017-10-04 AU AU2017340407A patent/AU2017340407A1/en not_active Abandoned
- 2017-10-04 MX MX2019003961A patent/MX2019003961A/en unknown
- 2017-10-04 KR KR1020197012979A patent/KR20190073416A/en not_active IP Right Cessation
- 2017-10-04 BR BR112019006831A patent/BR112019006831A2/en unknown
- 2017-10-04 WO PCT/US2017/055119 patent/WO2018067689A1/en unknown
- 2017-10-04 CN CN201780075219.XA patent/CN110035765B/en active Active
- 2017-10-04 CA CA3039211A patent/CA3039211A1/en active Pending
-
2019
- 2019-04-04 IL IL265833A patent/IL265833A/en unknown
-
2021
- 2021-01-14 AU AU2021200200A patent/AU2021200200A1/en active Pending
-
2022
- 2022-06-30 US US17/855,126 patent/US20220332768A1/en active Pending
- 2022-10-24 JP JP2022169842A patent/JP7397945B2/en active Active
-
2023
- 2023-12-01 JP JP2023204046A patent/JP2024023507A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN110035765B (en) | 2024-04-02 |
JP7165652B2 (en) | 2022-11-04 |
US20220332768A1 (en) | 2022-10-20 |
JP2022191472A (en) | 2022-12-27 |
EP3522908A1 (en) | 2019-08-14 |
IL265833A (en) | 2019-06-30 |
US11401306B2 (en) | 2022-08-02 |
AU2017340407A1 (en) | 2019-05-02 |
AU2021200200A1 (en) | 2021-03-18 |
EP3522908A4 (en) | 2020-06-24 |
MX2019003961A (en) | 2019-08-26 |
JP7397945B2 (en) | 2023-12-13 |
US20180094032A1 (en) | 2018-04-05 |
CN110035765A (en) | 2019-07-19 |
JP2019533658A (en) | 2019-11-21 |
WO2018067689A1 (en) | 2018-04-12 |
JP2024023507A (en) | 2024-02-21 |
BR112019006831A2 (en) | 2019-07-30 |
KR20190073416A (en) | 2019-06-26 |
CA3039211A1 (en) | 2018-04-12 |
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