WO2003061575A3 - Anti-idiotype antibody of disintegrin and uses thereof - Google Patents

Anti-idiotype antibody of disintegrin and uses thereof Download PDF

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Publication number
WO2003061575A3
WO2003061575A3 PCT/US2003/001544 US0301544W WO03061575A3 WO 2003061575 A3 WO2003061575 A3 WO 2003061575A3 US 0301544 W US0301544 W US 0301544W WO 03061575 A3 WO03061575 A3 WO 03061575A3
Authority
WO
WIPO (PCT)
Prior art keywords
idiotype antibody
disintegrin
integrin
function
therapy
Prior art date
Application number
PCT/US2003/001544
Other languages
French (fr)
Other versions
WO2003061575A2 (en
Inventor
Qing Zhou
Peisheng Hu
Radu O Minea
Francis S Markland
Alan L Epstein
Original Assignee
Univ Southern California
Qing Zhou
Peisheng Hu
Radu O Minea
Francis S Markland
Alan L Epstein
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southern California, Qing Zhou, Peisheng Hu, Radu O Minea, Francis S Markland, Alan L Epstein filed Critical Univ Southern California
Priority to AU2003209284A priority Critical patent/AU2003209284A1/en
Publication of WO2003061575A2 publication Critical patent/WO2003061575A2/en
Publication of WO2003061575A3 publication Critical patent/WO2003061575A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Abstract

Anti-idiotype antibody of a disintegrin, preferably contortrostatin, mimics the structure and function of the disintegrin, allowing its use as an integrin antagonist. Thus, monoclonal or polyclonal anti-idiotype antibody of disintegr'iin can be administered to a patient in need of anti-angiogenic or anti-metastatic therapy. The anti-idiotype antibody blocks integrin function on newly growing vessels, endothelial cells, or tumor cells. Such antibodies can be used for diagnosis and therapy of diseases in which integrin receptors play a role.
PCT/US2003/001544 2002-01-16 2003-01-16 Anti-idiotype antibody of disintegrin and uses thereof WO2003061575A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003209284A AU2003209284A1 (en) 2002-01-16 2003-01-16 Anti-idiotype antibody of disintegrin and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34962302P 2002-01-16 2002-01-16
US60/349,623 2002-01-16

Publications (2)

Publication Number Publication Date
WO2003061575A2 WO2003061575A2 (en) 2003-07-31
WO2003061575A3 true WO2003061575A3 (en) 2004-07-01

Family

ID=27613298

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/001544 WO2003061575A2 (en) 2002-01-16 2003-01-16 Anti-idiotype antibody of disintegrin and uses thereof

Country Status (2)

Country Link
AU (1) AU2003209284A1 (en)
WO (1) WO2003061575A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2858326A1 (en) * 2003-08-01 2005-02-04 Abtech Preparing antibodies that mimic a selected substance, useful particularly for activating or inhibiting biological processes, e.g. for inhibiting angiogenesis, comprises series of three immunizations
CN108314701A (en) * 2018-04-09 2018-07-24 青岛汉德森生物科技有限公司 A method of utilizing magnetic bead extraction and antibody purification

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5667967A (en) * 1990-05-01 1997-09-16 The Board Of Trustees Of The Leland Stanford Junior University T-cell receptor varible transcripts as disease related markers
US5731288A (en) * 1993-10-22 1998-03-24 University Of Southern California Compositions containing contortrostatin and methods for the use thereof
US5814609A (en) * 1993-10-22 1998-09-29 University Of Southern California Compositions containing a disintegrin and methods for its use in preventing metastasis and other conditions
US6255064B1 (en) * 1996-03-01 2001-07-03 The Procter & Gamble Company Disintegrin metalloprotease and its use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5667967A (en) * 1990-05-01 1997-09-16 The Board Of Trustees Of The Leland Stanford Junior University T-cell receptor varible transcripts as disease related markers
US5731288A (en) * 1993-10-22 1998-03-24 University Of Southern California Compositions containing contortrostatin and methods for the use thereof
US5814609A (en) * 1993-10-22 1998-09-29 University Of Southern California Compositions containing a disintegrin and methods for its use in preventing metastasis and other conditions
US6255064B1 (en) * 1996-03-01 2001-07-03 The Procter & Gamble Company Disintegrin metalloprotease and its use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TRIKHA ET AL.: "Contortrostatin, a snake venom disintegrin, inhibits beta 1 integrin-mediated human metastatic melanoma cell adhesion and blocks experimental metastasis", CANCER RES., vol. 54, no. 18, 15 September 1994 (1994-09-15), pages 4993 - 4998, XP002941109 *

Also Published As

Publication number Publication date
WO2003061575A2 (en) 2003-07-31
AU2003209284A1 (en) 2003-09-02

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