ATE521598T1 - 5-phenylthiazol-derivate und ihre verwendung als pi3 kinase inhibitoren - Google Patents

5-phenylthiazol-derivate und ihre verwendung als pi3 kinase inhibitoren

Info

Publication number
ATE521598T1
ATE521598T1 AT03709730T AT03709730T ATE521598T1 AT E521598 T1 ATE521598 T1 AT E521598T1 AT 03709730 T AT03709730 T AT 03709730T AT 03709730 T AT03709730 T AT 03709730T AT E521598 T1 ATE521598 T1 AT E521598T1
Authority
AT
Austria
Prior art keywords
kinase inhibitors
phenylthiazole derivatives
phenylthiazole
derivatives
kinase
Prior art date
Application number
AT03709730T
Other languages
English (en)
Inventor
Ian Bruce
Peter Finan
Catherine Leblanc
Clive Mccarthy
Lewis Whitehead
Nicola Press
Graham Bloomfield
Judy Hayler
Louise Kirman
Mrinalini Oza
Lena Shukla
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27767104&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE521598(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0204765A external-priority patent/GB0204765D0/en
Priority claimed from GB0229626A external-priority patent/GB0229626D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE521598T1 publication Critical patent/ATE521598T1/de

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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
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  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
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  • Virology (AREA)
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  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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AT03709730T 2002-02-28 2003-02-27 5-phenylthiazol-derivate und ihre verwendung als pi3 kinase inhibitoren ATE521598T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0204765A GB0204765D0 (en) 2002-02-28 2002-02-28 Organic compounds
GB0229626A GB0229626D0 (en) 2002-12-19 2002-12-19 Organic compounds
PCT/EP2003/002036 WO2003072557A1 (en) 2002-02-28 2003-02-27 5-phenylthiazole derivatives and use as pi3 kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE521598T1 true ATE521598T1 (de) 2011-09-15

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AT03709730T ATE521598T1 (de) 2002-02-28 2003-02-27 5-phenylthiazol-derivate und ihre verwendung als pi3 kinase inhibitoren

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US (2) US7687637B2 (de)
EP (1) EP1480962B1 (de)
JP (2) JP4408701B2 (de)
KR (1) KR100688370B1 (de)
CN (1) CN100548996C (de)
AR (1) AR038703A1 (de)
AT (1) ATE521598T1 (de)
AU (1) AU2003214080A1 (de)
BR (1) BR0308030A (de)
CA (1) CA2477601C (de)
CO (1) CO5611131A2 (de)
CY (2) CY1112084T1 (de)
DK (2) DK2311818T3 (de)
EC (2) ECSP045253A (de)
ES (2) ES2372597T3 (de)
IL (2) IL163691A0 (de)
MX (1) MXPA04008362A (de)
MY (1) MY156407A (de)
NO (1) NO329175B1 (de)
NZ (1) NZ534657A (de)
PE (1) PE20030968A1 (de)
PL (2) PL219449B1 (de)
PT (2) PT1480962E (de)
RU (2) RU2436780C2 (de)
SI (1) SI1480962T1 (de)
TW (1) TWI314928B (de)
WO (1) WO2003072557A1 (de)

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AU770896C (en) 1998-09-29 2006-09-07 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
IL152904A0 (en) 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
WO2003062404A1 (en) 2002-01-25 2003-07-31 Gamida-Cell Ltd. Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
JP2006517234A (ja) 2003-02-10 2006-07-20 アムジエン・インコーポレーテツド バニロイド受容体リガンドおよび治療におけるこれらのリガンドの使用
GB0305152D0 (en) * 2003-03-06 2003-04-09 Novartis Ag Organic compounds
CN1794988B (zh) * 2003-03-31 2010-07-28 株式会社·R-技术上野 用于治疗血管渗透性过高疾病的组合物
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
GB0320197D0 (en) * 2003-08-28 2003-10-01 Novartis Ag Organic compounds
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