ATE308323T1 - Diaminothiazole und ihre anwendung als cdk4 inhibitoren - Google Patents
Diaminothiazole und ihre anwendung als cdk4 inhibitorenInfo
- Publication number
- ATE308323T1 ATE308323T1 AT03752731T AT03752731T ATE308323T1 AT E308323 T1 ATE308323 T1 AT E308323T1 AT 03752731 T AT03752731 T AT 03752731T AT 03752731 T AT03752731 T AT 03752731T AT E308323 T1 ATE308323 T1 AT E308323T1
- Authority
- AT
- Austria
- Prior art keywords
- diaminothiazoles
- cdk4 inhibitors
- cdk4
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38151302P | 2002-05-17 | 2002-05-17 | |
| PCT/EP2003/004939 WO2003097048A1 (en) | 2002-05-17 | 2003-05-12 | Diaminothiazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE308323T1 true ATE308323T1 (de) | 2005-11-15 |
Family
ID=29550137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03752731T ATE308323T1 (de) | 2002-05-17 | 2003-05-12 | Diaminothiazole und ihre anwendung als cdk4 inhibitoren |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6818663B2 (de) |
| EP (1) | EP1507530B1 (de) |
| JP (1) | JP4308133B2 (de) |
| KR (1) | KR100619515B1 (de) |
| CN (1) | CN100400041C (de) |
| AR (1) | AR040078A1 (de) |
| AT (1) | ATE308323T1 (de) |
| AU (1) | AU2003232754B2 (de) |
| BR (1) | BR0310081A (de) |
| CA (1) | CA2485367A1 (de) |
| DE (1) | DE60302152T2 (de) |
| ES (1) | ES2251697T3 (de) |
| MX (1) | MXPA04011372A (de) |
| PL (1) | PL374581A1 (de) |
| RU (1) | RU2311414C2 (de) |
| WO (1) | WO2003097048A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2550891A1 (en) * | 2003-12-24 | 2005-07-14 | Bayer Cropscience Gmbh | Plant growth regulation |
| US7211576B2 (en) * | 2004-04-20 | 2007-05-01 | Hoffmann-La Roche Inc. | Diaminothiazoles |
| US7405220B2 (en) | 2004-06-09 | 2008-07-29 | Hoffmann-La Roche Inc. | Pyrazolopyrimidines |
| US7705009B2 (en) * | 2005-11-22 | 2010-04-27 | Hoffman-La Roche Inc. | 4-aminopyrimidine-5-thione derivatives |
| CN101568527A (zh) | 2006-10-31 | 2009-10-28 | 先灵公司 | 作为蛋白激酶抑制剂的2-氨基噻唑-4-羧酰胺 |
| JP5063700B2 (ja) | 2006-10-31 | 2012-10-31 | シェーリング コーポレイション | アニリノピペラジン誘導体およびアニリノピペラジン誘導体を使用する方法 |
| CA2733682C (en) * | 2008-08-12 | 2014-10-14 | Air Products And Chemicals, Inc. | Polymeric compositions comprising per(phenylethynyl) arene derivatives |
| AU2011293353B2 (en) * | 2010-08-24 | 2015-02-26 | Oncternal Therapeutics, Inc. | Compounds for treatment of cancer |
| KR101616868B1 (ko) | 2011-11-18 | 2016-04-29 | 델스퍼 엘피 | 유리전이온도가 높은 폴리머를 위한 가교 화합물 |
| AU2014253932B2 (en) | 2013-04-16 | 2020-04-30 | Memorial Sloan-Kettering Cancer Center | Companion diagnostic for CDK4 inhibitors |
| WO2015051525A1 (en) * | 2013-10-11 | 2015-04-16 | Rhodia Operations | Synthesis of acetal/ketal |
| US11921116B2 (en) | 2016-03-09 | 2024-03-05 | Memorial Sloan Kettering Cancer Center | Enigma and CDH18 as companion diagnostics for CDK4 inhibitors |
| WO2017158147A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
| WO2018089902A1 (en) * | 2016-11-13 | 2018-05-17 | Apogee Biotechnology Corporation | Diaminothiazole compounds, compositions and methods of use |
| CN110950848B (zh) * | 2018-09-27 | 2024-03-26 | 徐诺药业 | 新型氨基吡唑类衍生物的合成与应用 |
| CA3132656A1 (en) | 2019-04-30 | 2020-11-05 | Instituto De Medicina Molecular Joao Lobo Antunes | Rank pathway inhibitors in combination with cdk inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU22400A (sh) * | 1997-10-27 | 2003-08-29 | Agouron Pharmaceuticals Inc. | Supstituisana 4-amino-tiazol-2-i jedinjenja kao cdks inhibitori |
| UA71971C2 (en) * | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
| CA2411928A1 (en) * | 2000-08-09 | 2002-02-14 | Agouron Pharmaceuticals, Inc. | Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclindependent kinases |
| US6756374B2 (en) | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
-
2003
- 2003-05-05 US US10/429,551 patent/US6818663B2/en not_active Expired - Fee Related
- 2003-05-12 EP EP03752731A patent/EP1507530B1/de not_active Expired - Lifetime
- 2003-05-12 MX MXPA04011372A patent/MXPA04011372A/es active IP Right Grant
- 2003-05-12 KR KR1020047018605A patent/KR100619515B1/ko not_active IP Right Cessation
- 2003-05-12 PL PL03374581A patent/PL374581A1/xx not_active Application Discontinuation
- 2003-05-12 AU AU2003232754A patent/AU2003232754B2/en not_active Ceased
- 2003-05-12 ES ES03752731T patent/ES2251697T3/es not_active Expired - Lifetime
- 2003-05-12 CA CA002485367A patent/CA2485367A1/en not_active Abandoned
- 2003-05-12 RU RU2004137110/04A patent/RU2311414C2/ru active
- 2003-05-12 WO PCT/EP2003/004939 patent/WO2003097048A1/en active IP Right Grant
- 2003-05-12 BR BR0310081-2A patent/BR0310081A/pt not_active IP Right Cessation
- 2003-05-12 AT AT03752731T patent/ATE308323T1/de not_active IP Right Cessation
- 2003-05-12 DE DE60302152T patent/DE60302152T2/de not_active Expired - Fee Related
- 2003-05-12 CN CNB038111314A patent/CN100400041C/zh not_active Expired - Fee Related
- 2003-05-12 JP JP2004505047A patent/JP4308133B2/ja not_active Expired - Fee Related
- 2003-05-15 AR ARP030101692A patent/AR040078A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0310081A (pt) | 2005-02-15 |
| RU2311414C2 (ru) | 2007-11-27 |
| CA2485367A1 (en) | 2003-11-27 |
| MXPA04011372A (es) | 2005-08-15 |
| ES2251697T3 (es) | 2006-05-01 |
| KR100619515B1 (ko) | 2006-09-08 |
| PL374581A1 (en) | 2005-10-31 |
| DE60302152T2 (de) | 2006-07-13 |
| WO2003097048A1 (en) | 2003-11-27 |
| JP2005530783A (ja) | 2005-10-13 |
| RU2004137110A (ru) | 2005-08-20 |
| KR20050006261A (ko) | 2005-01-15 |
| CN100400041C (zh) | 2008-07-09 |
| EP1507530A1 (de) | 2005-02-23 |
| AU2003232754A1 (en) | 2003-12-02 |
| US20040006058A1 (en) | 2004-01-08 |
| AR040078A1 (es) | 2005-03-16 |
| EP1507530B1 (de) | 2005-11-02 |
| DE60302152D1 (de) | 2005-12-08 |
| AU2003232754B2 (en) | 2009-03-12 |
| CN1652780A (zh) | 2005-08-10 |
| JP4308133B2 (ja) | 2009-08-05 |
| US6818663B2 (en) | 2004-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1507530 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |