PE20080928A1 - Derivados de anilinopiperazina como inhibidores de proteina quinasa - Google Patents

Derivados de anilinopiperazina como inhibidores de proteina quinasa

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Publication number
PE20080928A1
PE20080928A1 PE2007001469A PE2007001469A PE20080928A1 PE 20080928 A1 PE20080928 A1 PE 20080928A1 PE 2007001469 A PE2007001469 A PE 2007001469A PE 2007001469 A PE2007001469 A PE 2007001469A PE 20080928 A1 PE20080928 A1 PE 20080928A1
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PE
Peru
Prior art keywords
alkyl
haloalkyl
hydroxyalkyl
protein kinase
heteroarilo
Prior art date
Application number
PE2007001469A
Other languages
English (en)
Inventor
Gerald W Shipps Jr
Cliff C Cheng
Xiaohua Huang
Thierry O Fischmann
Jose S Duca
Original Assignee
Schering Corp
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Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20080928A1 publication Critical patent/PE20080928A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Health & Medical Sciences (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE ANILINOPIPERAZINA DE FORMULA (I) DONDE R1 ES HETEROARILO, HETEROCICLILO O HETEROCICLENILO OPCIONALMENTE SUSTITUIDOS CON ALQUILO(C1-C20), CICLOALQUILO(C3-C10), HALO, OH, ENTRE OTROS; R2 ES H, ALQUILO(C1-C20), HALOALQUILO(C1-C20), HIDROXIALQUILO(C1-C20), ENTRE OTROS; R3 Y R3a SON CADA UNO H, ALQUILO(C1-C20), HALOALQUILO(C1-C20), HIDROXIALQUILO(C1-C20), ENTRE OTROS; R10 Y R10a SON CADA UNO H, ALQUILO(C1-C20), HALOALQUILO(C1-C20), ENTRE OTROS; R11 ES H, ALQUILO(C1-C20), HALOALQUILO(C1-C20), HIDROXIALQUILO(C1-C20), ENTRE OTROS; Ar ES ARILENO(C6-C14) O HETEROARILENO OPCIONALMENTE SUSTITUIDO CON HALO, NH2, CN, NO2, ALQUILO(C1-C20), ENTRE OTROS; W ES -N(R12)2-, -S-, -O- O -C(R4)2-, DONDE R4 ES H, ALQUILO(C1-C20), HIDROXIALQUILO(C1-C20), ENTRE OTROS; R12 ES H, ALQUILO(C1-C20), ENTRE OTROS; Y ES H, HALO, ALQUILO(C1-C20) O CN; Z ES C(R7) O N, DONDE R7 ES H, OH, ALQUILO(C1-C20), O-ALQUILO(C1-C20) O HALOALQUILO(C1-C20); n ES DE 0 A 2; p ES 0 O 1. SON COMPUESTOS PREFERIDOS LOS DE FORMULA (i), (ii), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE PROTEINA QUINASA SIENDO UTILES EN EL TRATAMIENTO DE CANCER DE MAMA, LEUCEMIA, FIBROSARCOMA, MIELOMA
PE2007001469A 2006-10-31 2007-10-29 Derivados de anilinopiperazina como inhibidores de proteina quinasa PE20080928A1 (es)

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US (1) US8318735B2 (es)
EP (1) EP2078004B1 (es)
JP (1) JP4968860B2 (es)
KR (1) KR20090082440A (es)
CN (1) CN101568527A (es)
AR (1) AR063531A1 (es)
AU (1) AU2007314305B2 (es)
CA (1) CA2668255A1 (es)
CL (1) CL2007003138A1 (es)
IL (1) IL198487A0 (es)
MX (1) MX2009004791A (es)
PE (1) PE20080928A1 (es)
TW (1) TW200827359A (es)
WO (1) WO2008054749A1 (es)

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KR101685718B1 (ko) * 2008-12-19 2016-12-12 제넨테크, 인크. 헤테로시클릭 화합물 및 사용 방법
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