ATE458042T1 - Verfahren zur herstellung von scyllo-inositol - Google Patents
Verfahren zur herstellung von scyllo-inositolInfo
- Publication number
- ATE458042T1 ATE458042T1 AT04817164T AT04817164T ATE458042T1 AT E458042 T1 ATE458042 T1 AT E458042T1 AT 04817164 T AT04817164 T AT 04817164T AT 04817164 T AT04817164 T AT 04817164T AT E458042 T1 ATE458042 T1 AT E458042T1
- Authority
- AT
- Austria
- Prior art keywords
- inositol
- scyllo
- myo
- complex
- novel
- Prior art date
Links
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 title abstract 12
- CDAISMWEOUEBRE-CDRYSYESSA-N scyllo-inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-CDRYSYESSA-N 0.000 title abstract 10
- 238000004519 manufacturing process Methods 0.000 title 1
- VYEGBDHSGHXOGT-HYFGLKJPSA-N 2,4,6/3,5-pentahydroxycyclohexanone Chemical compound O[C@H]1[C@H](O)[C@@H](O)C(=O)[C@@H](O)[C@@H]1O VYEGBDHSGHXOGT-HYFGLKJPSA-N 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 239000003929 acidic solution Substances 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical class OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 abstract 2
- 239000004327 boric acid Substances 0.000 abstract 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 abstract 2
- 229960000367 inositol Drugs 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 241000589220 Acetobacter Species 0.000 abstract 1
- 241001453380 Burkholderia Species 0.000 abstract 1
- 101710088194 Dehydrogenase Proteins 0.000 abstract 1
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 239000002184 metal Chemical class 0.000 abstract 1
- 108010050450 myo-inositol 2-dehydrogenase Proteins 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
- C07C29/145—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones with hydrogen or hydrogen-containing gases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003353491 | 2003-10-14 | ||
| JP2003353490 | 2003-10-14 | ||
| JP2004018128 | 2004-01-27 | ||
| JP2004194088 | 2004-06-30 | ||
| PCT/JP2004/015174 WO2005035774A1 (ja) | 2003-10-14 | 2004-10-14 | シロ−イノシトールの製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE458042T1 true ATE458042T1 (de) | 2010-03-15 |
Family
ID=34437726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04817164T ATE458042T1 (de) | 2003-10-14 | 2004-10-14 | Verfahren zur herstellung von scyllo-inositol |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US7745671B2 (de) |
| EP (3) | EP2298870A1 (de) |
| JP (3) | JP4526485B2 (de) |
| KR (3) | KR101314079B1 (de) |
| AT (1) | ATE458042T1 (de) |
| CA (3) | CA2774930C (de) |
| DE (1) | DE602004025596D1 (de) |
| DK (2) | DK2058390T3 (de) |
| ES (2) | ES2341964T3 (de) |
| PT (2) | PT1674578E (de) |
| WO (1) | WO2005035774A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| EP1824496A4 (de) | 2004-11-17 | 2008-07-16 | Joanne Mclaurin | Zusammensetzungen aus scyllo-inositol-derivaten und verfahren zur behandlung von störungen der proteinaggregation |
| JP4761763B2 (ja) * | 2004-12-16 | 2011-08-31 | 北興化学工業株式会社 | ホウ酸選択的結合物質およびホウ酸の除去又は回収方法 |
| JP4659545B2 (ja) * | 2005-07-20 | 2011-03-30 | 北興化学工業株式会社 | シロ−イノソースの製造方法 |
| JP2009511568A (ja) * | 2005-10-13 | 2009-03-19 | ワラタ ファーマシューティカルズ， インコーポレイテッド | イノシトール誘導体、ならびに異常なタンパク質の折りたたみまたは凝集、あるいはアミロイドの形成、沈着、蓄積または残存を特徴とする疾患の処置におけるその使用 |
| WO2007129221A2 (en) * | 2006-02-17 | 2007-11-15 | Waratah Parmaceuticals Inc | Compositions comprising an epi-inositol compounds and methods for treatment of disorders of protein aggregation |
| US20070197452A1 (en) * | 2006-02-17 | 2007-08-23 | Mclaurin Joanne | Treatment of amyloid-related diseases |
| KR20090026247A (ko) * | 2006-03-09 | 2009-03-12 | 와라타 파마수티컬즈, 인크. | 단백질 응집 장애의 치료를 위한 사이클로헥산 폴리알콜 제형 |
| CA2652449A1 (en) * | 2006-05-19 | 2007-11-29 | Waratah Pharmaceuticals Inc. | Screening methods for amyloid beta modulators |
| JP5101841B2 (ja) * | 2006-06-15 | 2012-12-19 | オルガノ株式会社 | 高分子多孔質体の製造方法 |
| WO2008034244A1 (en) * | 2006-09-21 | 2008-03-27 | Waratah Pharmaceuticals Inc. | The combination of a cyclohexanehexol and a nsaid for the treatment of neurodegenerative diseases |
| EP2091566A4 (de) * | 2006-11-24 | 2011-07-06 | Waratah Pharmaceuticals Inc | Kombinationstherapien gegen alzheimer-krankheit und ähnliche erkrankungen |
| CN101686674A (zh) * | 2007-03-01 | 2010-03-31 | 康考斯保健科学有限责任公司 | 肌醇烟酸酯的异构体及其用途 |
| WO2008124930A1 (en) * | 2007-04-12 | 2008-10-23 | Joanne Mclaurin | Use of cyclohexanehexol derivatives for the treatment of polyglutamine diseases |
| WO2008124929A1 (en) * | 2007-04-12 | 2008-10-23 | Joanne Mclaurin | USE OF CYCLOHEXANEHEXOL DERIVATIVES IN THE TREATMENT OF α-SYNUCLEINOPATHIES |
| HRP20130768T1 (en) * | 2007-04-12 | 2013-10-25 | Waratah Pharmaceuticals, Inc. | Use of cyclohexanehexol derivatives in the treatment of ocular diseases |
| CA2683580A1 (en) * | 2007-04-12 | 2008-10-23 | Joanne Mclaurin | Treatment of amyotrophic lateral sclerosis |
| WO2010040232A1 (en) * | 2008-10-09 | 2010-04-15 | Waratah Pharmaceuticals Inc. | Use of scyllo-inositols for the treatment of macular degeneration-related disorders |
| EP2357222B1 (de) * | 2008-10-31 | 2014-08-13 | National University Corporation Kobe University | Scyllo-inositol-produzierende zelle und verfahren zur scyllo-inositol-produktion anhand dieser zellen |
| US8372367B2 (en) * | 2009-10-26 | 2013-02-12 | Emc Metals Corporation | System and method for recovering boron values from plant tailings |
| EA201290801A1 (ru) * | 2010-02-15 | 2013-03-29 | Эббви Инк. | Способ получения сциллоинозита |
| CN103402954A (zh) * | 2010-10-13 | 2013-11-20 | 依兰制药公司 | 鲨肌醇和相关化合物的合成方法 |
| JP2014515408A (ja) | 2011-06-03 | 2014-06-30 | エラン ファーマシューティカルズ，リミティド ライアビリティー カンパニー | 行動及び精神障害の治療のためのシロ−イノシトール |
| US9505795B2 (en) * | 2012-02-02 | 2016-11-29 | Asahi Kasei Chemicals Corporation | Method for producing scyllo-inositol |
| KR102017776B1 (ko) * | 2012-12-17 | 2019-09-03 | 주식회사 디와이내츄럴 | 휴면 세포 전환법을 이용한 ｄ-카이로 이노시톨의 생산 방법 |
| US10017537B2 (en) * | 2013-04-15 | 2018-07-10 | Korea Institute Of Science And Technology | Peptide selectively binding to graphitic materials and volatile organic compounds |
| JP6487852B2 (ja) * | 2013-12-16 | 2019-03-20 | 旭化成株式会社 | ２−デオキシ−シロ−イノソース還元酵素 |
| WO2017029353A1 (en) | 2015-08-20 | 2017-02-23 | Transition Therapeutics Ireland Limited | Treatment of behaviors in dementia patients |
| CN114181045B (zh) * | 2021-12-02 | 2024-04-26 | 吉林海资生物工程技术有限公司 | 一种球形无水肌醇的制备方法 |
| CN117550956A (zh) * | 2023-09-16 | 2024-02-13 | 诸城市浩天药业有限公司 | 一种鲨肌醇晶体的制备方法 |
| CN117752706B (zh) * | 2023-12-20 | 2025-10-14 | 浙江天皇药业有限公司 | 西洋参炮制品在制备治疗甲状腺功能减退症药物中的应用 |
| CN118851880B (zh) * | 2024-07-19 | 2025-08-19 | 诸城市浩天药业有限公司 | 一种鲨肌醇制备中母液的回收利用方法 |
| CN119842646B (zh) * | 2024-11-08 | 2025-10-10 | 江南大学 | 一种双酶级联催化肌肉肌醇高效合成表肌醇的方法 |
| CN119753034A (zh) * | 2024-12-27 | 2025-04-04 | 诸城市浩天药业有限公司 | 一种鲨肌醇的分离制备方法 |
| CN120590242A (zh) * | 2025-08-01 | 2025-09-05 | 诸城市浩天药业有限公司 | 鲨肌醇晶型及其制备方法 |
| CN121249612B (zh) * | 2025-12-04 | 2026-02-13 | 诸城市浩天药业有限公司 | 一种肌醇脱氢酶突变体及其制备1l-表-2-肌糖的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3405663A1 (de) | 1984-02-17 | 1985-08-22 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren zur herstellung von scyllo-inosit |
| DE3642999A1 (de) | 1986-12-17 | 1988-06-30 | Merck Patent Gmbh | Scyllo-inositverbindungen |
| JP2984043B2 (ja) | 1990-09-18 | 1999-11-29 | 旭化成工業株式会社 | ミオ・イノシトールデヒドロゲナーゼおよびその製造法 |
| JPH05192163A (ja) | 1991-09-30 | 1993-08-03 | Suntory Ltd | イノシトールデヒドロゲナーゼ遺伝子 |
| JP3251976B2 (ja) | 1992-06-23 | 2002-01-28 | 旭化成株式会社 | ミオ・イノシトールデヒドロゲナーゼを生産する実質上純粋な微生物 |
| US5412080A (en) | 1993-08-25 | 1995-05-02 | President And Fellow Of Harvard College | Enterobactin compounds |
| JP3630344B2 (ja) * | 1995-11-17 | 2005-03-16 | 北興化学工業株式会社 | イノシトール立体異性体の製造方法 |
| JP3944333B2 (ja) * | 1999-06-25 | 2007-07-11 | 北興化学工業株式会社 | Ｄ−キロ−イノシトールの新規製造方法 |
| JP3981597B2 (ja) | 2001-06-25 | 2007-09-26 | 北興化学工業株式会社 | シロ−イノソースの製造法及びシロ−イノシトールの製造法 |
-
2004
- 2004-10-14 KR KR1020127019981A patent/KR101314079B1/ko not_active Expired - Fee Related
- 2004-10-14 CA CA2774930A patent/CA2774930C/en not_active Expired - Lifetime
- 2004-10-14 EP EP10182641A patent/EP2298870A1/de not_active Withdrawn
- 2004-10-14 PT PT04817164T patent/PT1674578E/pt unknown
- 2004-10-14 KR KR1020067009224A patent/KR101191675B1/ko not_active Expired - Lifetime
- 2004-10-14 CA CA2852842A patent/CA2852842A1/en not_active Abandoned
- 2004-10-14 AT AT04817164T patent/ATE458042T1/de not_active IP Right Cessation
- 2004-10-14 JP JP2005514651A patent/JP4526485B2/ja not_active Expired - Lifetime
- 2004-10-14 EP EP04817164A patent/EP1674578B1/de not_active Expired - Lifetime
- 2004-10-14 DK DK08019987.0T patent/DK2058390T3/da active
- 2004-10-14 DK DK04817164.9T patent/DK1674578T3/da active
- 2004-10-14 WO PCT/JP2004/015174 patent/WO2005035774A1/ja not_active Ceased
- 2004-10-14 KR KR1020107026017A patent/KR101173148B1/ko not_active Expired - Lifetime
- 2004-10-14 EP EP08019987A patent/EP2058390B1/de not_active Expired - Lifetime
- 2004-10-14 ES ES04817164T patent/ES2341964T3/es not_active Expired - Lifetime
- 2004-10-14 US US10/576,030 patent/US7745671B2/en active Active
- 2004-10-14 CA CA2542560A patent/CA2542560C/en not_active Expired - Lifetime
- 2004-10-14 ES ES08019987T patent/ES2404554T3/es not_active Expired - Lifetime
- 2004-10-14 PT PT80199870T patent/PT2058390E/pt unknown
- 2004-10-14 DE DE602004025596T patent/DE602004025596D1/de not_active Expired - Lifetime
-
2010
- 2010-02-25 US US12/712,635 patent/US8409833B2/en not_active Expired - Lifetime
- 2010-04-02 JP JP2010086459A patent/JP5122599B2/ja not_active Expired - Lifetime
-
2012
- 2012-07-19 JP JP2012160384A patent/JP5674724B2/ja not_active Expired - Fee Related
-
2013
- 2013-03-08 US US13/791,172 patent/US8715974B2/en not_active Expired - Lifetime
-
2014
- 2014-03-25 US US14/224,645 patent/US20140322775A1/en not_active Abandoned
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