WO2006015802A3 - Verfahren zur herstellung von primären alkoholen durch reduktion von aldehyden unter verwendung einer alkoholdehydrogenase bei gekoppelter cofaktor-regenerierung - Google Patents

Verfahren zur herstellung von primären alkoholen durch reduktion von aldehyden unter verwendung einer alkoholdehydrogenase bei gekoppelter cofaktor-regenerierung Download PDF

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Publication number
WO2006015802A3
WO2006015802A3 PCT/EP2005/008471 EP2005008471W WO2006015802A3 WO 2006015802 A3 WO2006015802 A3 WO 2006015802A3 EP 2005008471 W EP2005008471 W EP 2005008471W WO 2006015802 A3 WO2006015802 A3 WO 2006015802A3
Authority
WO
WIPO (PCT)
Prior art keywords
alcohol dehydrogenase
primary alcohols
producing primary
cofactor regeneration
reducing aldehydes
Prior art date
Application number
PCT/EP2005/008471
Other languages
English (en)
French (fr)
Other versions
WO2006015802A2 (de
Inventor
Harald Groeger
Francoise Chamouleau
Chad Hagedorn
Original Assignee
Maxens Gmbh
Harald Groeger
Francoise Chamouleau
Chad Hagedorn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxens Gmbh, Harald Groeger, Francoise Chamouleau, Chad Hagedorn filed Critical Maxens Gmbh
Priority to US11/659,291 priority Critical patent/US20080145904A1/en
Priority to EP05772507A priority patent/EP1784495A2/de
Priority to JP2007524287A priority patent/JP2008507989A/ja
Priority to CN2005800321764A priority patent/CN101027403B/zh
Publication of WO2006015802A2 publication Critical patent/WO2006015802A2/de
Publication of WO2006015802A3 publication Critical patent/WO2006015802A3/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Die vorliegende Erfindung bezieht sich auf ein Verfahren zur Herstellung von primären Alkoholen aus Aldehyden mit Hilfe von Ganzzellkatalysatoren oder isolierten Enzymen. Zum Einsatz kommen eine Alkoholdehydrogenase sowie ein zur Cofaktorregenerierung befähigtes Enzym, wobei vorzugsweise für die Umsetzung eine Substratkonzentration von >150 mM Aldehyd vorliegend kann.
PCT/EP2005/008471 2004-08-05 2005-08-04 Verfahren zur herstellung von primären alkoholen durch reduktion von aldehyden unter verwendung einer alkoholdehydrogenase bei gekoppelter cofaktor-regenerierung WO2006015802A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US11/659,291 US20080145904A1 (en) 2004-08-05 2005-08-04 Method For Producing Primary Alcohols
EP05772507A EP1784495A2 (de) 2004-08-05 2005-08-04 Verfahren zur herstellung von primären alkoholen durch reduktion von aldehyden unter verwendung einer alkoholdehydrogenase bei gekoppelter cofaktor-regenerierung
JP2007524287A JP2008507989A (ja) 2004-08-05 2005-08-04 第一級アルコールを生成するための方法
CN2005800321764A CN101027403B (zh) 2004-08-05 2005-08-04 生产伯醇的方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004038054.6 2004-08-05
DE102004038054A DE102004038054A1 (de) 2004-08-05 2004-08-05 Verfahren zur Herstellung primärer Alkohole

Publications (2)

Publication Number Publication Date
WO2006015802A2 WO2006015802A2 (de) 2006-02-16
WO2006015802A3 true WO2006015802A3 (de) 2006-08-31

Family

ID=35610131

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/008471 WO2006015802A2 (de) 2004-08-05 2005-08-04 Verfahren zur herstellung von primären alkoholen durch reduktion von aldehyden unter verwendung einer alkoholdehydrogenase bei gekoppelter cofaktor-regenerierung

Country Status (6)

Country Link
US (1) US20080145904A1 (de)
EP (1) EP1784495A2 (de)
JP (1) JP2008507989A (de)
CN (1) CN101027403B (de)
DE (1) DE102004038054A1 (de)
WO (1) WO2006015802A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006028817A1 (de) * 2006-06-21 2007-12-27 Evonik Degussa Gmbh Aufarbeitung von Reaktionslösungen aus Ganzzell-Biotransformationen
WO2008047656A1 (fr) * 2006-10-12 2008-04-24 Kaneka Corporation Procédé de fabrication d'un acide l-amino
US8765433B2 (en) 2009-12-29 2014-07-01 Butamax Advanced Biofuels Llc Alcohol dehydrogenases (ADH) useful for fermentive production of lower alkyl alcohols
CN102791850B (zh) * 2010-03-09 2018-01-09 三井化学株式会社 生产能力高的异丙醇生产细菌
DE102010039833A1 (de) 2010-08-26 2012-03-01 Symrise Ag Ganzzell-Biotransformation von Fettsäuren zu den um ein Kohlenstoffatom verkürzten Fettaldehyden
WO2020128644A1 (en) * 2018-12-18 2020-06-25 Tojo Vikas Biotech Pvt. Ltd. A process for bio-transformation and production of d-lactones thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186365A2 (de) * 1984-12-12 1986-07-02 United Kingdom Atomic Energy Authority Herstellung von Alkoholen
EP0645453A2 (de) * 1993-09-24 1995-03-29 Daicel Chemical Industries, Ltd. Alkohol-Dehydrogenase, dafür kodierende DNA, Herstellung und Verfahren zur Herstellung von optisch-aktiven Alkoholen
WO1995026413A1 (en) * 1994-03-25 1995-10-05 Reynolds Technologies, Inc. Method for providing green note compounds
EP1176203A1 (de) * 2000-07-27 2002-01-30 Degussa Aktiengesellschaft Enzyme mit verbesserter NAD(H)-Akzeptanz
US20020037564A1 (en) * 1998-05-18 2002-03-28 Paul Blum Hyperthermophilic enzymes for industrial chemical redox reactions: a method for biofuel ethanol production
EP1318200A2 (de) * 2001-12-07 2003-06-11 Daicel Chemical Industries, Ltd. Verfahren zur Herstellung von optisch aktiven Alkoholen
WO2003091423A1 (en) * 2002-04-26 2003-11-06 Degussa Ag Adh from rhodococcus erythropolis
WO2004022764A2 (en) * 2002-09-03 2004-03-18 Degussa Ag Use of malate dehydrogenase for nadh regeneration
DE102005008908A1 (de) * 2004-03-22 2006-01-19 Degussa Ag Neue Alkoholdehydrogenasen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225339A (en) * 1992-02-26 1993-07-06 The Scripps Research Institute Lactobacillus kefir alcohol dehydrogenase
DE10208007A1 (de) * 2002-02-26 2003-09-18 Forschungszentrum Juelich Gmbh Verfahren zur Herstellung von Alkoholen aus Substraten mittels Oxidoreduktasen, Zweiphasensystem umfassend eine wässrige Phase und eine organische Phase sowie Vorrichtung zur Durchführung des Verfahrens
DE10313971A1 (de) * 2003-03-27 2004-10-21 Degussa Ag Gekoppeltes cofaktorabhängiges enzymatisches Reaktionssystem

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0186365A2 (de) * 1984-12-12 1986-07-02 United Kingdom Atomic Energy Authority Herstellung von Alkoholen
EP0645453A2 (de) * 1993-09-24 1995-03-29 Daicel Chemical Industries, Ltd. Alkohol-Dehydrogenase, dafür kodierende DNA, Herstellung und Verfahren zur Herstellung von optisch-aktiven Alkoholen
WO1995026413A1 (en) * 1994-03-25 1995-10-05 Reynolds Technologies, Inc. Method for providing green note compounds
US20020037564A1 (en) * 1998-05-18 2002-03-28 Paul Blum Hyperthermophilic enzymes for industrial chemical redox reactions: a method for biofuel ethanol production
EP1176203A1 (de) * 2000-07-27 2002-01-30 Degussa Aktiengesellschaft Enzyme mit verbesserter NAD(H)-Akzeptanz
EP1318200A2 (de) * 2001-12-07 2003-06-11 Daicel Chemical Industries, Ltd. Verfahren zur Herstellung von optisch aktiven Alkoholen
WO2003091423A1 (en) * 2002-04-26 2003-11-06 Degussa Ag Adh from rhodococcus erythropolis
WO2004022764A2 (en) * 2002-09-03 2004-03-18 Degussa Ag Use of malate dehydrogenase for nadh regeneration
DE102005008908A1 (de) * 2004-03-22 2006-01-19 Degussa Ag Neue Alkoholdehydrogenasen

Also Published As

Publication number Publication date
CN101027403A (zh) 2007-08-29
EP1784495A2 (de) 2007-05-16
US20080145904A1 (en) 2008-06-19
WO2006015802A2 (de) 2006-02-16
CN101027403B (zh) 2012-02-01
DE102004038054A1 (de) 2006-03-16
JP2008507989A (ja) 2008-03-21

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