ATE327273T1 - Polymermatrize und ihre verwendung in pharmazeutischen zusammensetzungen - Google Patents

Polymermatrize und ihre verwendung in pharmazeutischen zusammensetzungen

Info

Publication number
ATE327273T1
ATE327273T1 AT94926894T AT94926894T ATE327273T1 AT E327273 T1 ATE327273 T1 AT E327273T1 AT 94926894 T AT94926894 T AT 94926894T AT 94926894 T AT94926894 T AT 94926894T AT E327273 T1 ATE327273 T1 AT E327273T1
Authority
AT
Austria
Prior art keywords
pharmaceutical compositions
matrice
polymer
polymer matrice
carbomate
Prior art date
Application number
AT94926894T
Other languages
English (en)
Inventor
Murat Acemoglu
Siegfried Bantle
David Bodmer
Salvatore Cammisuli
Peter Hiestand
Fritz Nimmerfall
Georg Stoll
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939317822A external-priority patent/GB9317822D0/en
Priority claimed from GB939320240A external-priority patent/GB9320240D0/en
Priority claimed from GB939325900A external-priority patent/GB9325900D0/en
Priority claimed from GB9407156A external-priority patent/GB9407156D0/en
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE327273T1 publication Critical patent/ATE327273T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/18—Block or graft polymers
    • C08G64/183—Block or graft polymers containing polyether sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/02—Aliphatic polycarbonates
    • C08G64/0208—Aliphatic polycarbonates saturated
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/20—General preparatory processes
    • C08G64/32—General preparatory processes using carbon dioxide
    • C08G64/34—General preparatory processes using carbon dioxide and cyclic ethers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT94926894T 1993-08-27 1994-08-26 Polymermatrize und ihre verwendung in pharmazeutischen zusammensetzungen ATE327273T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB939317822A GB9317822D0 (en) 1993-08-27 1993-08-27 Organic compounds
GB939320240A GB9320240D0 (en) 1993-10-01 1993-10-01 Improvements in or relating to organic compounds
GB939325900A GB9325900D0 (en) 1993-12-17 1993-12-17 Organic compounds
GB9407156A GB9407156D0 (en) 1994-04-11 1994-04-11 Organic compounds

Publications (1)

Publication Number Publication Date
ATE327273T1 true ATE327273T1 (de) 2006-06-15

Family

ID=27451062

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94926894T ATE327273T1 (de) 1993-08-27 1994-08-26 Polymermatrize und ihre verwendung in pharmazeutischen zusammensetzungen

Country Status (24)

Country Link
US (2) US6083521A (de)
EP (2) EP0719295B1 (de)
JP (2) JP3343124B2 (de)
KR (1) KR100341995B1 (de)
CN (3) CN1085687C (de)
AT (1) ATE327273T1 (de)
AU (1) AU697995B2 (de)
BR (1) BR9407370A (de)
CA (1) CA2168012C (de)
CZ (1) CZ55296A3 (de)
DE (1) DE69434743T2 (de)
DK (1) DK0719295T3 (de)
ES (1) ES2262135T3 (de)
FI (1) FI960892L (de)
HU (1) HU220637B1 (de)
IL (1) IL110787A0 (de)
NO (2) NO960721L (de)
NZ (1) NZ273319A (de)
PL (1) PL182569B1 (de)
PT (1) PT719295E (de)
SG (2) SG50724A1 (de)
SK (1) SK25496A3 (de)
TW (1) TW492863B (de)
WO (1) WO1995006077A2 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2736550B1 (fr) 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
US5942253A (en) 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
US6756060B1 (en) 1996-09-19 2004-06-29 Usbiomaterials Corp. Anti-inflammatory and antimicrobial uses for bioactive glass compositions
GB9725480D0 (en) * 1997-12-01 1998-01-28 Univ London Cytokines and their use in the treatment of established chronic infections and cancers
US8197430B1 (en) 1998-05-22 2012-06-12 Biopheresis Technologies, Inc. Method and system to remove cytokine inhibitor in patients
US6620382B1 (en) * 1998-05-22 2003-09-16 Biopheresis Technologies, Llc. Method and compositions for treatment of cancers
US6100372A (en) * 1998-08-20 2000-08-08 Akzo Nobel Nv Monocarboxylic acid-terminated polymers of carbon dioxide and an alkylene oxide
US6663878B1 (en) 1999-04-29 2003-12-16 Usbiomaterials Corp. Anti-inflammatory bioactive glass particulates
ES2245644T3 (es) 1999-06-14 2006-01-16 Imperial College Innovations Composiciones de biovidrio derivadas de sol-gel que contienen plata.
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US6911204B2 (en) 2000-08-11 2005-06-28 Favrille, Inc. Method and composition for altering a B cell mediated pathology
HK1052314A1 (zh) * 2000-08-11 2003-09-11 Favrille, Inc. 改变t细胞介导的病理的方法和组合物
DE60131177T2 (de) * 2000-09-06 2008-08-07 AP Pharma, Inc., Redwood Abbaubare polyacetal-polymere
US20030152630A1 (en) * 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6590059B2 (en) * 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
JP2005516586A (ja) * 2001-07-20 2005-06-09 ボード オブ トラスティーズ オブ ザ ユニヴァースティ オブ イリノイ 癌の処置に対する遺伝子標的を同定するための試薬および方法
US7658926B2 (en) * 2001-09-14 2010-02-09 Opexa Pharmaceuticals, Inc. Autologous T-cell vaccines materials and methods
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
US20030216315A1 (en) 2002-02-13 2003-11-20 Duke University Modulation of immune response by non-peptide binding stress response polypeptides
US8303625B2 (en) * 2002-04-18 2012-11-06 Helmholtz-Zentrum Geesthacht Zentrum Fuer Material- Und Kuestenforschung Gmbh Biodegradable shape memory polymeric sutures
WO2004015070A2 (en) * 2002-08-08 2004-02-19 Baylor College Of Medicine Isolation and identification of t cells
CA2500661A1 (en) * 2002-10-01 2004-04-15 Chiron Corporation Anti-cancer and anti-infectious disease compositions and methods for using same
GB0228571D0 (en) * 2002-12-06 2003-01-15 Novartis Ag Organic compounds
CN100571793C (zh) * 2003-12-24 2009-12-23 诺瓦提斯公司 药物组合物
RU2363497C2 (ru) * 2003-12-24 2009-08-10 Новартис Аг Фармацевтические композиции
JP2008511340A (ja) * 2004-04-30 2008-04-17 バイオフェレシス テクノロジーズ， インコーポレイテッド 患者において可溶性ｔｎｆｒ１、可溶性ｔｎｆｒ２、および可溶性ｉｌ２を除去する方法およびシステム
WO2006078320A2 (en) 2004-08-04 2006-07-27 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
WO2006100844A1 (ja) * 2005-03-18 2006-09-28 Mitsui Chemicals, Inc. 生分解性を有する水環境応答型ポリマー、その製造方法および水崩壊性材料
US20070099867A1 (en) * 2005-05-24 2007-05-03 Glycoscience Laboratories, Inc. Pharmaceutical agent containing hyaluronan as an active ingredient
ES2383303T3 (es) 2005-11-10 2012-06-20 Chemi S.P.A. Formulaciones de inhibidores de la liberación prolongada de la hormona del crecimiento análogos de la somatostatina
PT2016414E (pt) * 2006-05-05 2015-11-24 Opexa Therapeutics Vacina de células t
CA2667890C (en) * 2006-10-31 2015-01-27 Surmodics Pharmaceuticals, Inc. Spheronized polymer particles
WO2009085952A1 (en) 2007-12-20 2009-07-09 Brookwood Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
CA2736482C (en) 2008-09-08 2018-01-02 Novomer, Inc. Polycarbonate polyol compositions and methods
CN102245168B (zh) * 2008-12-15 2013-06-19 诺瓦提斯公司 纳米粒组合物
US8716204B2 (en) 2010-07-27 2014-05-06 Zimmer, Inc. Synthetic synovial fluid compositions and methods for making the same
CN112979938A (zh) 2011-07-25 2021-06-18 沙特阿美技术公司 用于聚氨酯的脂族聚碳酸酯
TR201202779A2 (tr) 2012-03-12 2013-10-21 Petkim Petrokimya Holding Anonim Sirketi Polietilen karbonat üretim yöntemi.
EP2664641B1 (de) 2012-05-18 2018-04-25 Petkim Petrokimya Holding Anonim Sirekti Verfahren zur herstellung von polyethylencarbonat mit metallsalzen
ES2707301T3 (es) * 2012-05-24 2019-04-03 Saudi Aramco Tech Co Sistema de polimerización para la copolimerización de CO2 y epóxidos y método relacionado
WO2014074706A1 (en) 2012-11-07 2014-05-15 Novomer, Inc. High strength polyurethane foam compositions and methods
AU2016229294B2 (en) 2015-03-06 2021-11-04 Beyondspring Pharmaceuticals, Inc. Method of treating cancer associated with a RAS mutation
JP6969848B2 (ja) 2015-07-13 2021-11-24 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド プリナブリン組成物
KR20180105685A (ko) 2016-02-08 2018-09-28 비욘드스프링 파마수티컬스, 인코포레이티드. 투카레솔 또는 이의 유사체를 함유하는 조성물
JP7025416B2 (ja) 2016-06-06 2022-02-24 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド 好中球減少症を低減させるための組成物および方法
WO2018129381A1 (en) 2017-01-06 2018-07-12 Beyondspring Pharmaceuticals, Inc. Tubulin binding compounds and therapeutic use thereof
BR112019015974A2 (pt) 2017-02-01 2020-03-31 Beyondspring Pharmaceuticals, Inc. Método para reduzir neutropenia
KR20200112881A (ko) * 2018-01-24 2020-10-05 비욘드스프링 파마수티컬스, 인코포레이티드. 플리나불린의 투여를 통해 혈소판감소증을 감소시키는 조성물 및 방법
WO2020028606A1 (en) 2018-08-02 2020-02-06 Saudi Aramco Technologies Company Sustainable polymer compositions and methods
JP7433606B2 (ja) * 2019-12-16 2024-02-20 帝人株式会社 コポリマー材料およびそれからなる医療用成形品
CA3215047A1 (en) 2021-04-09 2022-10-13 Lan Huang Therapeutic compositions and methods for treating tumors
US12195576B2 (en) 2021-06-23 2025-01-14 Saudi Aramco Technologies Company Polyol compositions and methods
CN121401211A (zh) * 2024-02-29 2026-01-27 珠海市华海康医药科技有限责任公司 一种双羟萘酸盐药物缓释微球及其制备方法
CN119505213B (zh) * 2024-11-25 2025-12-09 吉林大学 一种聚碳酸酯聚合物及其制备方法、纳米佐剂和疫苗

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3585168A (en) * 1968-09-21 1971-06-15 Shohei Inoue Process for producing copolymer of epoxide and carbon dioxide
US3706713A (en) * 1970-08-11 1972-12-19 Shell Oil Co Aliphatic polycarbonates
JPS5341117B2 (de) * 1971-12-21 1978-10-31
US3953383A (en) * 1972-07-21 1976-04-27 Nippon Oil Seal Industry Co., Ltd. Catalytic process for copolymerizing epoxy compounds with carbon dioxide
JPS553288B2 (de) * 1973-08-06 1980-01-24
JPS5761769B2 (de) * 1974-03-20 1982-12-25 Nippon Oil Seal Ind Co Ltd
JPS5922731B2 (ja) * 1975-09-12 1984-05-29 エヌオーケー株式会社 共重合用触媒の製造法
JPS5438397A (en) * 1977-08-31 1979-03-22 Hidetoshi Tsuchida Copolymerization catalyst consisting of carbon dioxide and oxirane compoud
US4379138A (en) * 1981-12-28 1983-04-05 Research Triangle Institute Biodegradable polymers of lactones
NZ217844A (en) * 1985-10-11 1989-10-27 Sumitomo Pharma A sustained release pharmaceutical composition containing silicone elastomer and an albumin
JPH0725688B2 (ja) * 1986-03-31 1995-03-22 住友製薬株式会社 Ｃｓｆ徐放性製剤
US4665136A (en) * 1986-04-07 1987-05-12 Air Products And Chemicals, Inc. Process for producing novel block alkylene polycarbonate copolymers
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
JPH0725689B2 (ja) * 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
US5114719A (en) * 1987-04-29 1992-05-19 Sabel Bernhard A Extended drug delivery of small, water-soluble molecules
US4783445A (en) * 1987-12-14 1988-11-08 Arco Chemical Company Soluble epoxide/carbon dioxide copolymerization catalysts
US5274074A (en) * 1987-12-17 1993-12-28 United States Surgical Corporation Medical devices fabricated from homopolymers and copolymers having recurring carbonate units
DE3853591T2 (de) * 1987-12-17 1995-09-14 United States Surgical Corp Medizinische anordnungen, hergestellt aus homo- und kopolymeren mit wiederkehrender karbonateinheiten.
US4789727A (en) * 1987-12-18 1988-12-06 Arco Chemical Company Reduction of catalyst usage in epoxide/CO2 polymerization
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
EP0358326B1 (de) * 1988-08-09 1996-12-27 Mitsui Petrochemical Industries, Ltd. Verfahren zur Herstellung eines zinkhaltigen festen Katalysators und Verfahren zur Herstellung von Polyalkylencarbonat
ATE147634T1 (de) * 1988-12-19 1997-02-15 American Cyanamid Co Produkte zur behandlung des endotoxin -schocks bei einem säugetier
EP0460101A4 (en) * 1989-02-24 1992-04-15 Immunotherapeutics, Inc. Immobilized cytokines
US4999417A (en) * 1989-03-30 1991-03-12 Nova Pharmaceutical Corporation Biodegradable polymer compositions
US4960862A (en) * 1989-03-31 1990-10-02 Air Products And Chemicals, Inc. Regeneration of metallo-organic catalyst for carbon dioxide-epoxide copolymerization
US5026676A (en) * 1989-06-07 1991-06-25 Air Products And Chemicals, Inc. Catalyst for the copolymerization of epoxides with CO2
US4943677A (en) * 1989-06-08 1990-07-24 Air Products And Chemicals, Inc. Making poly(alkylene carbonates) of controlled molecular weight
JP2693584B2 (ja) * 1989-06-26 1997-12-24 三井石油化学工業株式会社 ポリアルキレンカーボネート製造用触媒成分の製造方法
US5126147A (en) * 1990-02-08 1992-06-30 Biosearch, Inc. Sustained release dosage form
JP2930362B2 (ja) * 1990-04-09 1999-08-03 東ソー株式会社 感作ｔ細胞関与疾患の治療剤
ES2053120T3 (es) * 1990-07-02 1994-07-16 Bend Res Inc Perlas microporosas asimetricas para liberacion controlada.
IE912365A1 (en) * 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
EP0486437B1 (de) * 1990-11-13 1997-07-09 ISTITUTO SIEROVACCINOGENO ITALIANO I.S.I. S.p.A. Funktionelle Polyester aus Glycidylderivaten und cyclischen Anhydriden oder Kohlendioxid
AU653771B2 (en) * 1991-01-03 1994-10-13 Alkermes Controlled Therapeutics, Inc. Stabilization of proteins by cationic biopolymers
CA2060635A1 (en) * 1991-02-12 1992-08-13 Keith D'alessio Bioabsorbable medical implants
IT1248061B (it) * 1991-06-14 1995-01-05 Mediolanum Farmaceutici Spa Policarbonati e loro uso per la preparazione di matrici bioerodibili
US5344644A (en) * 1991-08-01 1994-09-06 Takeda Chemical Industries, Ltd. Water-soluble composition for sustained-release
EP0535937B2 (de) * 1991-10-01 2008-05-21 Takeda Chemical Industries, Ltd. Mikropartikeln-Zusammenfassung zur verlängerten Freigabe und Herstellung derselbe
WO1993011793A1 (en) * 1991-12-17 1993-06-24 Schering Corporation Use of the combination of anti-tumor necrosis factor plus interleukin-6 to treat septic shock
JPH05194253A (ja) * 1992-01-16 1993-08-03 Kirin Brewery Co Ltd 水溶性ポリペプチドホルモンを含む徐放性微小粒子状製剤及びその製造法
GB9206736D0 (en) * 1992-03-27 1992-05-13 Sandoz Ltd Improvements of organic compounds and their use in pharmaceutical compositions
ZA933926B (en) * 1992-06-17 1994-01-03 Amgen Inc Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules
GB9406094D0 (en) * 1994-03-28 1994-05-18 Univ Nottingham And University Polymer microspheres and a method of production thereof
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
JP3028227B1 (ja) 1998-12-15 2000-04-04 穎助 藤本 デスポーザル無針注射器

Also Published As

Publication number Publication date
BR9407370A (pt) 1996-07-16
CN1506116A (zh) 2004-06-23
NO20021141D0 (no) 2002-03-07
IL110787A0 (en) 1994-11-11
EP0719295B1 (de) 2006-05-24
WO1995006077A3 (en) 1995-05-04
EP1028137A3 (de) 2000-11-02
JP2003002844A (ja) 2003-01-08
PL312717A1 (en) 1996-05-13
PL182569B1 (pl) 2002-01-31
JPH09501967A (ja) 1997-02-25
EP1028137A2 (de) 2000-08-16
US6083521A (en) 2000-07-04
US6262127B1 (en) 2001-07-17
SG50724A1 (en) 1999-10-19
DK0719295T3 (da) 2006-09-25
JP3343124B2 (ja) 2002-11-11
SK25496A3 (en) 1997-03-05
SG87847A1 (en) 2002-04-16
TW492863B (en) 2002-07-01
HU220637B1 (hu) 2002-03-28
FI960892A7 (fi) 1996-04-18
CN1129947A (zh) 1996-08-28
CN1326568C (zh) 2007-07-18
AU7655794A (en) 1995-03-21
KR100341995B1 (ko) 2002-11-23
JP4477813B2 (ja) 2010-06-09
HU9600456D0 (en) 1996-04-29
CA2168012A1 (en) 1995-03-02
NO20021141L (no) 1996-04-26
CN1258551C (zh) 2006-06-07
WO1995006077A2 (en) 1995-03-02
FI960892L (fi) 1996-04-18
PT719295E (pt) 2006-10-31
NO960721L (no) 1996-04-26
HUT74568A (en) 1997-01-28
AU697995B2 (en) 1998-10-22
CA2168012C (en) 2005-08-09
CN1085687C (zh) 2002-05-29
NO960721D0 (no) 1996-02-23
CN1344755A (zh) 2002-04-17
DE69434743D1 (de) 2006-06-29
DE69434743T2 (de) 2006-11-16
FI960892A0 (fi) 1996-02-26
CZ55296A3 (en) 1996-09-11
NZ273319A (en) 1998-02-26
EP0719295A1 (de) 1996-07-03
ES2262135T3 (es) 2006-11-16

Similar Documents

Publication Publication Date Title
ATE327273T1 (de) Polymermatrize und ihre verwendung in pharmazeutischen zusammensetzungen
DE69708304D1 (de) Vernetzte copolymere auf der basis von polycarbonsäurepolymeren
DK1126822T3 (da) Flydende tilförselspræparater med reguleret frigivelse og lav initiel lægemiddelafgivelse
CA2106079A1 (en) Pegylation of polypeptides
IL136054A0 (en) Poly(vinylamine) -based superabsorbent gels and method of manufacturing the same
NO20055349D0 (no) Selvtilpassede sementsystemer
ES2094359T3 (es) Formulaciones farmaceuticas de proteinas osteogenicas.
ES2145013T3 (es) Formulaciones de coagulo de sangre-matriz polimera de proteinas osteogenicas.
CA2315034A1 (en) Polymeric material comprising n, p, s, as or se and composition for charge transport material
EP0795334A3 (de) Neuartige Prodrugs für die Therapie von Tumoren und entzündlichen Erkrankungen
PT1474425E (pt) Desazapurinas e sua utilizacao
NO20021493D0 (no) Organometallkatalysatorblandinger
EP0977296A4 (de) Aus festem elektrolyten hergestelltes formstück, elektrodenfomstück und elektrochemische elemente
DK0904063T3 (da) Fremgangsmåde til fremstilling af mikropartikler
Cho et al. A novel synthetic route for the preparation of hydrolytically degradable synthetic hydrogels
DE50005907D1 (de) Styrolhaltige popcorn-polymerisate, verfahren zu deren herstellung und ihre verwendung
FR2799196B1 (fr) Copolymeres reticules a base de copolymeres polycarboxyliques non reticules
CA2231020A1 (fr) Compositions souples a base de polyamide et aptes a l'extrusion soufflage
CA2474988A1 (en) Polymeric matrices and their uses in pharmaceutical compositions
ATE415150T1 (de) Pharmazeutische zusammensetzung mit verzögerte freisetzung enthaltend einen cephalosporin- antibiotikum
ATE288924T1 (de) Tnf inhibierendes protein tip-b1 und dessen verwendung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0719295

Country of ref document: EP