ES2145013T3 - Formulaciones de coagulo de sangre-matriz polimera de proteinas osteogenicas. - Google Patents
Formulaciones de coagulo de sangre-matriz polimera de proteinas osteogenicas.Info
- Publication number
- ES2145013T3 ES2145013T3 ES92921634T ES92921634T ES2145013T3 ES 2145013 T3 ES2145013 T3 ES 2145013T3 ES 92921634 T ES92921634 T ES 92921634T ES 92921634 T ES92921634 T ES 92921634T ES 2145013 T3 ES2145013 T3 ES 2145013T3
- Authority
- ES
- Spain
- Prior art keywords
- osteogenic protein
- polymer matrix
- blood coagulation
- protein polymer
- formulations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000002188 osteogenic effect Effects 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 239000011159 matrix material Substances 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 title abstract 2
- 230000023555 blood coagulation Effects 0.000 title 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
UNA COMPOSICION CONSTA DE UNA MEZCLA ACEPTABLE FARMACEUTICAMENTE DE UNA PROTEINA OSTEOGENICA, UNA MATRIZ POLIMERA DE PARTICULAS POROSAS, Y UNA CANTIDAD DE AISLADOR DE PROTEINA OSTEOGENICA DE COAGULO SANGUINEO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/776,514 US5171579A (en) | 1991-10-11 | 1991-10-11 | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2145013T3 true ES2145013T3 (es) | 2000-07-01 |
Family
ID=25107596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92921634T Expired - Lifetime ES2145013T3 (es) | 1991-10-11 | 1992-10-09 | Formulaciones de coagulo de sangre-matriz polimera de proteinas osteogenicas. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5171579A (es) |
EP (1) | EP0608313B1 (es) |
JP (1) | JP3336010B2 (es) |
KR (1) | KR0181984B1 (es) |
AT (1) | ATE189611T1 (es) |
AU (1) | AU669133B2 (es) |
DE (1) | DE69230670T2 (es) |
DK (1) | DK0608313T3 (es) |
ES (1) | ES2145013T3 (es) |
GR (1) | GR3033204T3 (es) |
WO (1) | WO1993006872A1 (es) |
Families Citing this family (67)
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---|---|---|---|---|
US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
US6197325B1 (en) * | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US7189410B1 (en) * | 1990-11-27 | 2007-03-13 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US6117425A (en) * | 1990-11-27 | 2000-09-12 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, method of their production and use |
US6559119B1 (en) | 1990-11-27 | 2003-05-06 | Loyola University Of Chicago | Method of preparing a tissue sealant-treated biomedical material |
US6054122A (en) * | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US5739107A (en) * | 1991-03-11 | 1998-04-14 | Creative Biomolecules, Inc. | Morphogen treatment of gastrointestinal ulcers |
DE69233022T2 (de) | 1991-11-04 | 2004-02-12 | Genetics Institute, LLC, Cambridge | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
DE69433530T2 (de) * | 1993-05-12 | 2005-01-05 | Genetics Institute, LLC, Cambridge | Bmp-11 zusammensetzungen |
NZ260909A (en) * | 1993-07-05 | 1995-04-27 | Takeda Chemical Industries Ltd | Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution |
US5385887A (en) * | 1993-09-10 | 1995-01-31 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
ATE319823T1 (de) | 1993-12-07 | 2006-03-15 | Inst Genetics Llc | Bmp-12, bmp-13 und diese enthaltende sehne- induzierende zusammensetzungen |
US5763416A (en) * | 1994-02-18 | 1998-06-09 | The Regent Of The University Of Michigan | Gene transfer into bone cells and tissues |
US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
US6074840A (en) * | 1994-02-18 | 2000-06-13 | The Regents Of The University Of Michigan | Recombinant production of latent TGF-beta binding protein-3 (LTBP-3) |
US5962427A (en) * | 1994-02-18 | 1999-10-05 | The Regent Of The University Of Michigan | In vivo gene transfer methods for wound healing |
US6620406B1 (en) | 1994-03-08 | 2003-09-16 | Genetics Institute, Llc. | Methods for treatment of periodontal diseases and lesions using bone morphogenetic proteins |
US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
CA2151547C (en) | 1994-06-10 | 2010-10-12 | Elliott A. Gruskin | Recombinant chimeric proteins and methods of use thereof |
US5520923A (en) * | 1994-09-19 | 1996-05-28 | Genetics Institute, Inc. | Formulations for delivery of osteogenic proteins |
EA000582B1 (ru) * | 1995-04-19 | 1999-12-29 | Хехст Марион Руссел Лтд. | Белок, соответствующий зрелому участку морфогенетического белка кости мр-52, фармацевтическая композиция для лечения заболеваний и дефектов хрящей и костей и способ получения белка |
DK1364656T3 (da) | 1995-06-05 | 2013-12-16 | Genetics Inst Llc | Brug af knoglemorfogenetiske proteiner til heling og reparation af bindevævsvedhæftning |
US6352972B1 (en) * | 1995-06-06 | 2002-03-05 | Marcel E. Nimni | Bone morphogenetic proteins and their use in bone growth |
US5674292A (en) * | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
DE19548476A1 (de) * | 1995-12-22 | 1997-06-26 | Bioph Biotech Entw Pharm Gmbh | Zielgerichtete Verbindungen mit knorpel- und/oder knocheninduzierender Aktivität |
US5756652A (en) * | 1996-02-29 | 1998-05-26 | Depuy Orthopaedics, Inc. | Poly (ester-anhydrides) and intermediates therefor |
US5668288A (en) * | 1996-04-16 | 1997-09-16 | Depuy Orthopaedics, Inc. | Polyester ionomers for implant fabrication |
US6299905B1 (en) | 1996-04-16 | 2001-10-09 | Depuy Orthopaedics, Inc. | Bioerodable polymeric adhesives for tissue repair |
US5733868A (en) * | 1996-04-16 | 1998-03-31 | Depuy Orthopaedics, Inc. | Poly(amino acid) adhesive tissue grafts |
AU3143197A (en) * | 1996-05-24 | 1998-01-21 | Buford Biomedical, Inc. | Fibrin-based systems for the controlled release of medicinals |
US6927287B1 (en) * | 1996-06-03 | 2005-08-09 | United States Surgical Corporation | Nucleic acid encoding extracellular matrix protein or fragment thereof |
US6492508B1 (en) * | 1996-06-03 | 2002-12-10 | United States Surgical Corp. A Division Of Tyco Healthcare Group | Nucleic acids encoding extracellular matrix proteins |
US20040132653A1 (en) * | 1997-01-30 | 2004-07-08 | Biopharm Gmbh | Lyophilized composition of bone morphogenetic factor human MP52 |
US7923250B2 (en) | 1997-07-30 | 2011-04-12 | Warsaw Orthopedic, Inc. | Methods of expressing LIM mineralization protein in non-osseous cells |
JP4302877B2 (ja) | 1997-07-30 | 2009-07-29 | エモリー・ユニバーシテイ | 新規な骨鉱化蛋白質、dna、ベクター及び発現系 |
US6762336B1 (en) | 1998-01-19 | 2004-07-13 | The American National Red Cross | Hemostatic sandwich bandage |
US20040081704A1 (en) | 1998-02-13 | 2004-04-29 | Centerpulse Biologics Inc. | Implantable putty material |
US6004937A (en) | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
JP2003508130A (ja) * | 1999-08-31 | 2003-03-04 | ヴァージニア コモンウェルス ユニバーシティ インテレクチュアル プロパティー ファンデーション | 加工された筋肉 |
EP2286847A1 (en) | 1999-10-15 | 2011-02-23 | Genetics Institute, LLC | Formulations of hyaluronic acid for delivery of osteogenic proteins |
DE10043151A1 (de) * | 2000-08-31 | 2002-03-28 | Peter Steinruecke | Knochenzement mit antimikrobieller Wirksamkeit |
US6648911B1 (en) | 2000-11-20 | 2003-11-18 | Avantec Vascular Corporation | Method and device for the treatment of vulnerable tissue site |
US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
TWI329129B (en) | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
EP1399023B1 (en) | 2001-06-01 | 2008-04-30 | Wyeth | COMPOSITIONS FOR SYSTEMIC ADMINISTRATION OF SEQUENCES ENCODING BONE MORPHOGENETIC PROTEINS& x9; |
TWI267378B (en) * | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
EP1578348A4 (en) * | 2002-02-08 | 2011-03-16 | Wyeth Llc | FORMULATION WITH BIOACTIVE AGENTS AND METHOD OF USE THEREOF |
US20040037819A1 (en) * | 2002-06-06 | 2004-02-26 | The Brigham And Women's Hospital, Inc. | Non-polymeric hematopoeitic cell clots for delivery of active agents |
CA2498212C (en) | 2002-09-10 | 2012-07-17 | American National Red Cross | Multi-layered hemostatic dressing comprising thrombin and fibrinogen |
DE10340277B4 (de) * | 2003-08-29 | 2006-11-23 | Bio-Gate Bioinnovative Materials Gmbh | Körperpflegemittel mit Silber-Agglomeraten |
BRPI0413720A (pt) | 2003-09-12 | 2006-10-17 | Wyeth Corp | bastões e pastas sólidas de fosfato de cálcio injetável para liberação de proteìnas osteogênicas |
JP2007509609A (ja) * | 2003-10-02 | 2007-04-19 | ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン | 幹細胞拘束および骨形成を誘導するヒト前立腺癌細胞因子 |
JP4694163B2 (ja) * | 2004-07-26 | 2011-06-08 | 株式会社ジーシー | 生体吸収性顆粒状多孔質骨補填材の製造方法 |
WO2006078211A1 (en) * | 2005-01-19 | 2006-07-27 | Bonoss Medical Ab | Growth factor composition |
BRPI0712496A2 (pt) | 2006-06-02 | 2012-09-25 | Wyeth Corp | peptìdeo isolado, composição compreendendo o referido peptìdeo, ácido nucléico isolado e métodos de purificar uma proteìna na superfamìlia do fator beta de transformação do crescimento (tgf-?) e de estabilizar uma solução contendo uma proteìna na superfamìlia tgf-b. |
US7754689B2 (en) * | 2006-06-02 | 2010-07-13 | Wyeth Llc | Finger-1 peptide analogs of the TGF-β superfamily |
CA2657819C (en) * | 2006-07-21 | 2014-05-20 | Genera Doo | Whole blood-derived coagulum device for treating bone defects |
WO2008019128A2 (en) * | 2006-08-04 | 2008-02-14 | Stb Lifesaving Technologies, Inc. | Solid dressing for treating wounded tissue |
US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
WO2009020612A1 (en) * | 2007-08-06 | 2009-02-12 | Stb Lifesaving Technologies, Inc. | Methods and dressing for sealing internal injuries |
WO2012068135A1 (en) | 2010-11-15 | 2012-05-24 | Zimmer Orthobiologics, Inc. | Bone void fillers |
US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
CN107753138A (zh) * | 2017-11-09 | 2018-03-06 | 中山大学附属口腔医院 | 一种评估微量元素成骨作用的方法及其动物模型的构建方法 |
Family Cites Families (21)
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US4186448A (en) * | 1976-04-16 | 1980-02-05 | Brekke John H | Device and method for treating and healing a newly created bone void |
US4526909A (en) * | 1984-01-09 | 1985-07-02 | Regents Of The University Of California | Polymethylmethacrylate delivery system for bone morphogenetic protein |
US4563489A (en) * | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
US4609551A (en) * | 1984-03-20 | 1986-09-02 | Arnold Caplan | Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites |
US4639366A (en) * | 1984-06-06 | 1987-01-27 | Merck & Co., Inc. | Polymers containing pendant acid functionalities and labile backbone bonds |
US4620327A (en) * | 1984-07-05 | 1986-11-04 | Caplan Arnold I | Process of adapting soluble bone protein for use in stimulating osteoinduction |
HUT42329A (en) * | 1984-11-29 | 1987-07-28 | Curatech Inc | Process for producing compositions for curing wounds |
US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
US4902296A (en) * | 1986-10-29 | 1990-02-20 | The University Of Virginia Alumni Patents Foundation | Use of demineralized bone matrix in the repair of segmental defects |
US4743259A (en) * | 1986-10-29 | 1988-05-10 | The University Of Virginia Alumni Patents Foundation | Use of demineralized bone matrix in the repair of segmental defects |
WO1989004646A1 (en) * | 1987-11-13 | 1989-06-01 | Jefferies Steven R | Bone repair material and delayed drug delivery |
GB2215209B (en) * | 1988-03-14 | 1992-08-26 | Osmed Inc | Method and apparatus for biodegradable, osteogenic, bone graft substitute device |
US4975526A (en) * | 1989-02-23 | 1990-12-04 | Creative Biomolecules, Inc. | Bone collagen matrix for zenogenic implants |
DE68918155T2 (de) * | 1988-05-02 | 1995-03-02 | Project Hear | Chirurgisches Klebstoffmaterial. |
US5024841A (en) * | 1988-06-30 | 1991-06-18 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US5284756A (en) * | 1988-10-11 | 1994-02-08 | Lynn Grinna | Heterodimeric osteogenic factor |
EP0476045B1 (en) * | 1989-06-05 | 1996-08-28 | Massachusetts Institute Of Technology | Bioerodible polymers for drug delivery in bone |
CA2042577A1 (en) * | 1989-10-17 | 1991-04-18 | Hermann Oppermann | Osteogenic devices |
US5645591A (en) * | 1990-05-29 | 1997-07-08 | Stryker Corporation | Synthetic bone matrix |
US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
KR0145278B1 (ko) * | 1991-06-21 | 1998-07-15 | 브루스 엠. 에이센 | 골형성원 단백질 약제 |
-
1991
- 1991-10-11 US US07/776,514 patent/US5171579A/en not_active Expired - Lifetime
-
1992
- 1992-10-09 DK DK92921634T patent/DK0608313T3/da active
- 1992-10-09 EP EP92921634A patent/EP0608313B1/en not_active Expired - Lifetime
- 1992-10-09 KR KR1019940701180A patent/KR0181984B1/ko not_active IP Right Cessation
- 1992-10-09 AU AU27885/92A patent/AU669133B2/en not_active Ceased
- 1992-10-09 DE DE69230670T patent/DE69230670T2/de not_active Expired - Fee Related
- 1992-10-09 WO PCT/US1992/008628 patent/WO1993006872A1/en active IP Right Grant
- 1992-10-09 AT AT92921634T patent/ATE189611T1/de not_active IP Right Cessation
- 1992-10-09 ES ES92921634T patent/ES2145013T3/es not_active Expired - Lifetime
- 1992-10-09 JP JP50721193A patent/JP3336010B2/ja not_active Expired - Fee Related
-
2000
- 2000-04-12 GR GR20000400898T patent/GR3033204T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE189611T1 (de) | 2000-02-15 |
DE69230670T2 (de) | 2000-09-21 |
AU2788592A (en) | 1993-05-03 |
US5171579A (en) | 1992-12-15 |
EP0608313A1 (en) | 1994-08-03 |
JPH07500038A (ja) | 1995-01-05 |
DK0608313T3 (da) | 2000-05-15 |
EP0608313B1 (en) | 2000-02-09 |
KR0181984B1 (ko) | 1999-04-01 |
WO1993006872A1 (en) | 1993-04-15 |
AU669133B2 (en) | 1996-05-30 |
GR3033204T3 (en) | 2000-08-31 |
DE69230670D1 (de) | 2000-03-16 |
JP3336010B2 (ja) | 2002-10-21 |
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